metformin and tolbutamide

metformin has been researched along with tolbutamide in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (56.06)	18.7374
1990's	7 (10.61)	18.2507
2000's	5 (7.58)	29.6817
2010's	17 (25.76)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kumahara, A; Matsuda, H; Morikawa, T; Nakamura, S; Ozaki, K; Yoshikawa, M	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bloom, A; Bulpitt, CJ; Shaw, KM	1
Di Saverio, S; Roncaia, R; Torri, A; Zanni, A	1
Streda, M	1
Bennett, MA; Fitzgerald, MG; Malins, JM; Pentecost, BL; Soler, NG	1
Brearley, BF	1
Cooper, GJ; Moore, CX	1
Josephkutty, S; Potter, JM	1
Alberti, KG; Ferner, RE; Rawlins, MD	1
Beringer, A	1
Abdel-Khalek, A; Khayyal, MT; Masri, AM; Saleh, S; Sharat, AA	1
Bloom, A	1
Chhetri, MK	1
Jackson, WP; Vinik, AI	1
Lopis, S; Schneider, T	1
Clarke, BF; Duncan, LJ	1
Harris, EL	1
Bianchini, P; Bramanti, G; De Fina, V; Dell'Omodarme, G	1
Chakrabarti, R; Evans, J; Fearnley, GR; Hocking, ED	1
Geyer, G; Sokopp, B	1
Khoo, OT; Lim, P	1
Cabezas Cerrato, J; Fernández-Cruz, A	1
Erkurt, R; Ipbüker, A	1
Fossati, P; Fourlinnie, JC; Linquette, M	1
Bittles, AH; Hadden, DR; Montgomery, DA; Rigas, AN	1
Parrow, A	1
Plauchu, M; Thevenon, P	1
Fearnley, GR	1
Bernard, C; Bernard, R	1
Clarke, BF; Duncan, LJ; Munro, JF	1
Brugi, A; Emanueli, A; Selvini, A	1
Kimura, M; Suzuki, J	1
Cristani, A; Sticchi, G; Tarozzi, A; Zandomeneghi, R	1
Howes, LG; Lykos, D; Sundaresan, P	1
Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A	1
Atkinson, AB; Bell, PM; Hadden, DR; Levy, J; McCance, DR	1
Hector, R; Hobensack, CK; Luo, J; Quan, J; Reaven, GM; Sullivan, C; Tsai, J	1
Lopez-Liuchi, JV; Meier, CA	1
Damm, P; Hellmuth, E; Mølsted-Pedersen, L	1
NABARRO, JD	1
POULSEN, JE	1
GRAUPNER, K; WIEZOREK, WD	1
SZANTO, S	1
PADFIELD, CJ	1
CAGLI, V	1
Bailey, CJ; Flatt, PR; Irwin, N; McClenaghan, NH; McKinney, JM	1
Heller, C; Kühn, MC; Mülders-Opgenoorth, B; Scherbaum, WA; Schinner, S; Schott, M; Willenberg, HS	1
Bo, S; Castiglione, A; Cavallo-Perin, P; Ciccone, G; Durazzo, M; Gentile, L; Ghigo, E	1
Andersson, C; Fosbøl, EL; Gislason, G; Køber, L; Mogensen, UM; Scheller, NM; Schramm, TK; Torp-Pedersen, C; Vaag, A	1
Brown, J; Crowther, CA; Hughes, B; Martis, R; Rowan, J	1
Gong, J; Jia, L; Wu, S	1

Reviews

8 review(s) available for metformin and tolbutamide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Glucose tolerance tests in the clinical picture of chronic liver diseases. Acta Universitatis Carolinae. Medica. Monographia, 1975, Issue:67 Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Body Weight; Carbohydrate Metabolism; Chlorpropamide; Chronic Disease; Glucose Tolerance Test; Hepatitis; Humans; Hydrocortisone; Hypoglycemic Agents; Jaundice; Liver; Liver Cirrhosis; Liver Diseases; Metformin; Middle Aged; Porphyrias; Tolbutamide	1975
Oral treatment of diabetes mellitus. Journal of the Indian Medical Association, 1968, May-16, Volume: 50, Issue:10 Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Phenformin; Sulfonamides; Tolbutamide	1968
Advances in the treatment of diabetes mellitus. The Practitioner, 1971, Volume: 207, Issue:240 Topics: Blood Glucose; Chlorpropamide; Clofibrate; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Diabetic Retinopathy; Diet Therapy; Humans; Hypoglycemia; Insulin; Kidney Transplantation; Lactates; Light Coagulation; Metformin; Methods; Pancreas Transplantation; Phenformin; Pituitary Gland; Renal Dialysis; Sulfonylurea Compounds; Tolbutamide	1971
Cardiovascular effects of oral hypoglycaemic drugs. Clinical and experimental pharmacology & physiology, 1996, Volume: 23, Issue:3 Topics: Biguanides; Diabetes Mellitus, Type 2; Glyburide; Heart; Hemodynamics; Humans; Hypoglycemic Agents; Lipoproteins; Metformin; Myocardial Contraction; Potassium Channel Blockers; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide	1996
Therapy for type 2 diabetes: where do we stand after the UK prospective diabetes study? European journal of endocrinology, 1999, Volume: 140, Issue:1 Topics: Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diet Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Prospective Studies; Randomized Controlled Trials as Topic; Tolbutamide	1999
ADVANCES IN THE TREATMENT OF DIABETES MELLITUS. The Practitioner, 1963, Volume: 191 Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Tolbutamide	1963
Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes. The Cochrane database of systematic reviews, 2017, 01-25, Volume: 1 Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Pregnancy; Randomized Controlled Trials as Topic; Tolbutamide	2017

Trials

4 trial(s) available for metformin and tolbutamide

Article	Year
Comparison of tolbutamide and metformin in elderly diabetic patients. Diabetic medicine : a journal of the British Diabetic Association, 1990, Volume: 7, Issue:6 Topics: Aged; Aged, 80 and over; Blood Glucose; Body Weight; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Glycated Hemoglobin; Humans; Insulin; Male; Metformin; Random Allocation; Tolbutamide	1990
Preliminary trial of a powerful new sulphonylurea in maturity-onset diabetes--HB419 (glibenclamide). South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Aug-09, Volume: 43, Issue:32 Topics: Adult; Age Factors; Aged; Blood Chemical Analysis; Chlorpropamide; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Sulfonamides; Tolbutamide	1969
HB419 (glibenclamide) in the treatment of diabetes mellitus. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Aug-09, Volume: 43, Issue:32 Topics: Adult; Age Factors; Aged; Biguanides; Chlorpropamide; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Female; Gallbladder Diseases; Gastrointestinal Diseases; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseases; Male; Metformin; Middle Aged; Phenformin; Sulfonamides; Tolbutamide; Urea; Vascular Diseases	1969
Circadian variation of glucose, insulin, and free fatty acids during long-term use of oral hypoglycaemic agents in diabetes mellitus. British medical journal, 1968, Oct-05, Volume: 4, Issue:5622 Topics: Aged; Blood Glucose; Chlorpropamide; Circadian Rhythm; Diabetes Mellitus; Diet, Diabetic; Fatty Acids, Nonesterified; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Metformin; Middle Aged; Obesity; Starvation; Tolbutamide	1968

Other Studies

54 other study(ies) available for metformin and tolbutamide

Article	Year
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum. Journal of natural products, 2007, Volume: 70, Issue:2 Topics: Alkaloids; alpha-Glucosidases; Animals; Blood Glucose; Brazil; Glycosides; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Molecular Structure; Plants, Medicinal; Rats; Rats, Wistar; Solanum; Steroids	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Side effects of therapy in diabetes evaluated by a self-administered questionnaire. Journal of chronic diseases, 1977, Volume: 30, Issue:1 Topics: Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Patient Acceptance of Health Care; Phenformin; Surveys and Questionnaires; Tolbutamide	1977
[Clinico-statistical studies of the use of oral hypoglycemic agents in the therapy of diabetes: critical evaluation of their effectiveness and tolerance]. La Clinica terapeutica, 1977, Jul-15, Volume: 82, Issue:1 Topics: Adult; Aged; Chlorpropamide; Diabetes Mellitus; Drug Evaluation; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Tolbutamide	1977
Myocardial infarction in diabetics. The Quarterly journal of medicine, 1975, Volume: 44, Issue:173 Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Coronary Care Units; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Sex Factors; Sulfonylurea Compounds; Tolbutamide	1975
The management of pregnancy in diabetes mellitus. The Practitioner, 1975, Volume: 215, Issue:1289 Topics: Birth Weight; Blood Glucose; Chlorpropamide; Delivery, Obstetric; Diet, Diabetic; Female; Fetal Death; Humans; Infant, Newborn; Insulin; Ketosis; Maternal Age; Metformin; Phenformin; Pregnancy; Pregnancy in Diabetics; Time Factors; Tolbutamide	1975
Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents. Biochemical and biophysical research communications, 1991, Aug-30, Volume: 179, Issue:1 Topics: Amyloid; Animals; Arginine; Cell Line; Cricetinae; Glucagon; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Kinetics; Metformin; Somatostatin; Tolbutamide	1991
Impaired beta-cell responses improve when fasting blood glucose concentration is reduced in non-insulin-dependent diabetes. The Quarterly journal of medicine, 1988, Volume: 66, Issue:250 Topics: Adult; Aged; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Islets of Langerhans; Male; Metformin; Middle Aged; Tolbutamide	1988
[Oral antidiabetic therapy with delayed-action glibenclamide and phenformin in fixed combination]. Minerva medica, 1974, Sep-01, Volume: 65, Issue:60 Topics: Adult; Aged; Blood Glucose; Carbutamide; Cholesterol; Delayed-Action Preparations; Diabetes Mellitus; Drug Combinations; Evaluation Studies as Topic; Fatty Acids, Nonesterified; Female; Glyburide; Glycosuria; Humans; Lipids; Male; Metformin; Middle Aged; Phenformin; Tolbutamide; Triglycerides	1974
Studies on the effect of oral hypoglycaemic agents on hepatic glycogenolysis. Pharmacological research communications, 1974, Volume: 6, Issue:6 Topics: Acetohexamide; Animals; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Experimental; Glucose-6-Phosphatase; Hypoglycemic Agents; In Vitro Techniques; Liver; Liver Glycogen; Male; Metformin; Phenformin; Phosphorylases; Rats; Sulfonamides; Tolbutamide	1974
Oral therapy in diabetes. Journal of the Royal College of Physicians of London, 1972, Volume: 7, Issue:1 Topics: Acetohexamide; Administration, Oral; Animals; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Evaluation Studies as Topic; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Obesity; Phenformin; Pyrimidines; Sulfonamides; Time Factors; Tolbutamide	1972
Adverse reactions to oral antidiabetic agents. British medical journal, 1971, Jul-03, Volume: 3, Issue:5765 Topics: Acetohexamide; Acidosis; Administration, Oral; Anemia; Chlorpropamide; Drug Antagonism; Drug Synergism; England; Ethanol; Female; Fetus; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Pregnancy; Scotland; Skin Diseases; Skin Manifestations; Tolazamide; Tolbutamide; Wales	1971
[Comparative activity of some biguanides, sulfonylureas and their combinations on blood sugar and lactic acid in the guinea pig. II]. Bollettino chimico farmaceutico, 1971, Volume: 110, Issue:4 Topics: Amantadine; Animals; Biguanides; Blood Glucose; Chlorpropamide; Guinea Pigs; Lactates; Metformin; Phenformin; Sulfonylurea Compounds; Tolbutamide	1971
Fibrinolytic effect of biguanides. Annals of the New York Academy of Sciences, 1968, Mar-26, Volume: 148, Issue:3 Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis Obliterans; Biguanides; Chlorpropamide; Coronary Disease; Ethylestrenol; Female; Fibrinolysis; Fibrinolytic Agents; Humans; Male; Metformin; Methenolone; Middle Aged; Phenformin; Tolbutamide	1968
[Influence of 3,5-dimethylisoxazol short-term administration on the carbohydrate metabolism in elderly diabetics with secondary failure of sulfonylurea treatment]. Wiener klinische Wochenschrift, 1969, Oct-08, Volume: 81, Issue:40 Topics: Aged; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glycosuria; Humans; Hypoglycemic Agents; Injections, Intramuscular; Injections, Intravenous; Male; Metformin; Middle Aged; Oxazoles; Time Factors; Tolbutamide	1969
Metformin compared with tolbutamide in the treatment of maturity-onset diabetes mellitus. The Medical journal of Australia, 1970, Feb-07, Volume: 1, Issue:6 Topics: Adult; Diabetes Mellitus; Diarrhea; Female; Humans; Hyperglycemia; Male; Metformin; Middle Aged; Tolbutamide	1970
[Glybenclamide and its place among sulfanylureas in the treatment of diabetes mellitus]. Revista clinica espanola, 1970, May-31, Volume: 117, Issue:4 Topics: Adolescent; Adult; Aged; Carbutamide; Child; Cyclohexanes; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Sulfones; Tolbutamide; Urea	1970
[Results of oral Diabomet therapy of diabetes mellitus]. Turk Tip Cemiyeti mecmuasi, 1970, Volume: 36, Issue:8 Topics: Administration, Oral; Adult; Aged; Diabetes Mellitus; Female; Gastrointestinal Diseases; Humans; Male; Metformin; Middle Aged; Tolbutamide	1970
[Clinical action of a therapeutic combination of a hypoglycemia-inducing sulfonamide and a biguanide in diabetes]. Semaine therapeutique, 1967, Volume: 43, Issue:8 Topics: Adolescent; Adult; Aged; Diabetes Mellitus; Humans; Metformin; Middle Aged; Tolbutamide	1967
[Treatment of diabetes mellitus with metformin]. Lakartidningen, 1968, Nov-20, Volume: 65, Issue:47 Topics: Adult; Aged; Body Weight; Chlorpropamide; Diabetes Mellitus; Drug Synergism; Female; Humans; Male; Metformin; Middle Aged; Tolbutamide	1968
[A hypoglycemizing sulfamide associated with biguanide in the treatment of type I diabetes in adults]. Lyon medical, 1968, Oct-20, Volume: 220, Issue:42 Topics: Adult; Age Factors; Aged; Biguanides; Diabetes Mellitus; Drug Synergism; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Tolbutamide	1968
Oral hypoglycaemic drugs. British medical journal, 1969, Mar-29, Volume: 1, Issue:5647 Topics: Acetohexamide; Animals; Chlorpropamide; Guinea Pigs; Humans; Hypoglycemic Agents; Metformin; Phenformin; Tolbutamide	1969
Pharmacological fibrinolysis. Bristol medico-chirurgical journal (1963), 1969, Volume: 84, Issue:312 Topics: Aged; Androsterone; Anticholesteremic Agents; Butyrates; Chlorpropamide; Coronary Disease; Ethylestrenol; Female; Fibrinogen; Fibrinolysis; Humans; Intermittent Claudication; Male; Metformin; Middle Aged; Phenformin; Platelet Adhesiveness; Tolbutamide	1969
[Tolbutamide-dimethyl-biguanide association in the treatment of diabetes mellitus]. Gazette medicale de France, 1965, Jul-25, Volume: 72, Issue:14 Topics: Aged; Diabetes Mellitus; Female; Humans; Metformin; Middle Aged; Tolbutamide	1965
The treatment of diabetes mellitus with oral hypoglycaemic drugs. Current medicine and drugs, 1965, Volume: 5, Issue:10 Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Phenformin; Tolbutamide	1965
[On the use of ER 102 in the treatment of diabetes mellitus]. Minerva medica, 1967, Jan-24, Volume: 58, Issue:7 Topics: Adolescent; Adult; Aged; Diabetes Mellitus; Female; Humans; Insulin; Liver Cirrhosis; Male; Metformin; Middle Aged; Obesity; Tolbutamide	1967
[Hypoglycemic effects of the blended Chinese traditional medicines in genetically and chemically diabetic mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 83, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Metformin; Mice; Tolbutamide	1984
[Insulin receptors: the in vitro effect of oral hypoglycemic agents]. Bollettino della Societa italiana di biologia sperimentale, 1981, Apr-15, Volume: 57, Issue:7 Topics: Administration, Oral; Adult; Binding Sites; Erythrocytes; Humans; In Vitro Techniques; Insulin; Metformin; Receptor, Insulin; Tolbutamide	1981
Effects of glycosylation of hypoglycaemic drug binding to serum albumin. Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:9 Topics: Acetohexamide; Binding Sites; Binding, Competitive; Gliclazide; Glyburide; Glycated Serum Albumin; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Tolbutamide	1997
Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabetic medicine : a journal of the British Diabetic Association, 1998, Volume: 15, Issue:4 Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Metformin; Middle Aged; Northern Ireland; Time Factors; Tolbutamide; Treatment Failure	1998
Nongenetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:6 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Dietary Sucrose; Disease Models, Animal; Fructose; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Tolbutamide	1998
Oral hypoglycaemic agents in 118 diabetic pregnancies. Diabetic medicine : a journal of the British Diabetic Association, 2000, Volume: 17, Issue:7 Topics: Abruptio Placentae; Adult; Birth Weight; Cesarean Section; Cohort Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Fetal Death; Humans; Hypoglycemic Agents; Infant, Newborn; Infant, Newborn, Diseases; Insulin; Metformin; Morbidity; Pre-Eclampsia; Pregnancy; Pregnancy in Diabetics; Pregnancy Outcome; Tolbutamide	2000
[ORAL DIABETIC DRUGS]. Nordisk medicin, 1964, Feb-20, Volume: 71 Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Female; Humans; Metformin; Phenformin; Pregnancy; Pregnancy in Diabetics; Tolbutamide	1964
[THE INFLUENCE OF THE CONSTITUENTS OF THE LYTIC COCKTAIL ON THE ACTION OF HYPOGLYCEMIC AGENTS]. Archives internationales de pharmacodynamie et de therapie, 1963, Dec-01, Volume: 146 Topics: Alcoholic Beverages; Cardiovascular Agents; Chlorpromazine; Ergot Alkaloids; Guinea Pigs; Hypoglycemic Agents; Insulin; Meperidine; Metformin; Oxytocics; Pharmacology; Phenformin; Promethazine; Research; Tolbutamide	1963
COMBINED TRIAL OF ACETOHEXAMIDE AND TWO DIGUANIDE PREPARATIONS. Irish journal of medical science, 1964, Volume: 457 Topics: Acetohexamide; Chlorpropamide; Diabetes Mellitus; Geriatrics; Hypoglycemic Agents; Insulin; Metformin; Pharmacology; Phenformin; Tolbutamide; Toxicology	1964
A REVIEW OF THE HISTORY OF THE TREATMENT OF DIABETES MELLITUS AND THE SEARCH FOR ORAL HYPOGLYCAEMIC AGENTS. Guy's Hospital reports, 1964, Volume: 113 Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Guanidine; Guanidines; History; Humans; Hypoglycemic Agents; Metformin; Phenformin; Sulfonylurea Compounds; Tolbutamide	1964
[THE THERAPY OF DIABETES MELLITUS]. Il Policlinico. Sezione pratica, 1964, Jan-06, Volume: 71 Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Diabetic Coma; Diet, Diabetic; Female; Globins; Hypoglycemic Agents; Insulin; Insulin, Long-Acting; Insulin, Regular, Pork; Metformin; Pregnancy; Pregnancy in Diabetics; Protamines; Surgical Procedures, Operative; Tolbutamide; Toxicology	1964
Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas. Diabetes, obesity & metabolism, 2010, Volume: 12, Issue:12 Topics: Cell Line; Culture Media; Glyburide; Humans; Insulin-Secreting Cells; Metformin; Sulfonylurea Compounds; Tolbutamide	2010
Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation. American journal of physiology. Endocrinology and metabolism, 2011, Volume: 301, Issue:5 Topics: Animals; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; Exenatide; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Metformin; Mice; Mice, Inbred C57BL; Peptides; Receptors, Glucagon; RNA, Small Interfering; Rosiglitazone; Thiazolidinediones; Tolbutamide; Up-Regulation; Venoms; Wnt4 Protein	2011
Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients. European journal of endocrinology, 2013, Volume: 169, Issue:1 Topics: Adult; Aged; Cardiovascular Diseases; Cause of Death; Cohort Studies; Confounding Factors, Epidemiologic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Insulin; Kaplan-Meier Estimate; Male; Metformin; Middle Aged; Neoplasms; Odds Ratio; Proportional Hazards Models; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonylurea Compounds; Tolbutamide	2013
Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study. Diabetes research and clinical practice, 2015, Volume: 107, Issue:1 Topics: Aged; Carbamates; Cardiovascular Diseases; Denmark; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Morbidity; Myocardial Infarction; Piperidines; Registries; Retrospective Studies; Risk Factors; Stroke; Sulfonylurea Compounds; Tolbutamide	2015
A tolbutamide-metformin salt based on antidiabetic drug combinations: synthesis, crystal structure analysis and pharmaceutical properties. Acta crystallographica. Section C, Structural chemistry, 2019, 09-01, Volume: 75, Issue:Pt 9 Topics: Crystallography, X-Ray; Drug Combinations; Hydrogen Bonding; Hypoglycemic Agents; Metformin; Molecular Structure; Solubility; Tolbutamide	2019