metformin and thiamine

metformin has been researched along with thiamine in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.67)29.6817
2010's11 (73.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW1
Alston, TA1
Ashrafi, K; Chen, EC; Chen, L; Chien, HC; Giacomini, KM; Keshari, KR; Kurhanewicz, J; Li, S; Liang, X; Lin, MJ; Liu, J; Morrissey, KM; Ostrem, J; Shokat, KM; Shu, Y; Xu, L; Yee, SW; Younger, NS; Zhang, Y; Zur, AA1
Chen, L; Giacomini, KM; Yee, SW1
Chen, EC; Chien, HC; Giacomini, KM; Giacomini, MM; Hao, J; Lepist, EI; Liang, X; Piao, M; Ray, AS; Twelves, J; Yee, SW1
Fukuhara, A; Ishiguro, N; Kusuhara, H; Lechner, C; Nishiyama, K; Ohtsu, N; Shimizu, H; Takatani, M; Washio, I; Yamamura, N1
Bynevelt, M; Franconi, C; McGarvey, C; Prentice, D1
Aleshin, VA; Bunik, VI; Mkrtchyan, GV1
Brockmöller, J; Gaedcke, J; Meyer, MJ; Oswald, S; Römer, S; Seitz, T; Tuerkova, A; Tzvetkov, MV; Wenzel, C; Zdrazil, B1
Hatakeyama, M; Inoue, K; Kishimoto, H; Kurokawa, Y; Seki, M; Shirasaka, Y; Takemura, M; Tamai, I; Uchiyama, H; Wang, J; Yasugi, Y1
Jimura, F; Kachi, N; Tamaki, H; Tsushima, H1

Reviews

2 review(s) available for metformin and thiamine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Mechanisms of Non-coenzyme Action of Thiamine: Protein Targets and Medical Significance.
    Biochemistry. Biokhimiia, 2019, Volume: 84, Issue:8

    Topics: Animals; Brain; Coenzymes; Humans; Hypoglycemic Agents; Metformin; Mice; Phosphorylation; Protein Transport; Rats; Thiamine; Thiamine Deficiency; Thiamine Pyrophosphate; Vitamin B Complex

2019

Other Studies

13 other study(ies) available for metformin and thiamine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
    Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7

    Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries

2017
Does metformin interfere with thiamine?
    Archives of internal medicine, 2003, Apr-28, Volume: 163, Issue:8

    Topics: Drug Interactions; Humans; Hypoglycemic Agents; Metformin; Thiamine; Thiamine Deficiency; Vitamin B 12 Deficiency

2003
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jul-08, Volume: 111, Issue:27

    Topics: AMP-Activated Protein Kinases; Animals; Carrier Proteins; Fatty Liver; Hypoglycemic Agents; Metformin; Mice; Mice, Knockout; Octamer Transcription Factor-1; Oxidation-Reduction; Thiamine

2014
OCT1 in hepatic steatosis and thiamine disposition.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:3

    Topics: Animals; Energy Metabolism; Fatty Liver; Humans; Metformin; Mice; Models, Biological; Organic Cation Transporter 1; Thiamine

2015
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
    Molecular pharmaceutics, 2015, Dec-07, Volume: 12, Issue:12

    Topics: Animals; Biological Transport; Cell Line; Drug Interactions; HEK293 Cells; Humans; Intestinal Absorption; Intestine, Small; Membrane Transport Proteins; Metformin; Mice; Substrate Specificity; Thiamine

2015
Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

    Topics: 1-Methyl-4-phenylpyridinium; Biological Transport; Buffers; Dose-Response Relationship, Drug; Drug Interactions; Estrone; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Modulators; Metformin; Organic Cation Transport Proteins; Rhodamine 123; Risk Assessment; Thiamine; Transfection

2016
Metformin-induced encephalopathy: the role of thiamine.
    Internal medicine journal, 2018, Volume: 48, Issue:2

    Topics: Adult; Brain Diseases; Diabetic Nephropathies; Female; Humans; Hypoglycemic Agents; Metformin; Thiamine; Vitamin B Complex

2018
Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations.
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:12

    Topics: Animals; Drug Evaluation, Preclinical; HEK293 Cells; Hepatocytes; Humans; Liver; Male; Metformin; Mice; Organic Cation Transporter 1; Protein Conformation, alpha-Helical; Rats; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Species Specificity; Structure-Activity Relationship; Thiamine

2020
Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:5

    Topics: Animals; Biological Transport; Caco-2 Cells; Humans; Intestinal Absorption; Kinetics; Membrane Transport Proteins; Metformin; Rats; Thiamine

2022
Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis.
    Internal medicine (Tokyo, Japan), 2022, Oct-01, Volume: 61, Issue:19

    Topics: Acidosis, Lactic; Beriberi; Biguanides; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis; Thiamine; Thiamine Deficiency

2022