Compounds > metformin

metformin and tetraethylammonium

metformin has been researched along with tetraethylammonium in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (47.37)	29.6817
2010's	10 (52.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dresser, MJ; Giacomini, KM; Gray, AT; Leabman, MK; Xiao, G	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Horikawa, M; Ishiwata, N; Kato, Y; Matsubara, K; Nakamichi, N; Silver, DL; Sugiura, T; Takeuchi, K; Umeda, S	1
Babu, E; Ganapathy, V; Ho, HT; Itagaki, S; Wang, J; Zhou, M	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cailleaux, S; Gomes, MB; Tibiriçá, E	1
Balaraman, R; Majithiya, JB	1
Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI	2
Inui, K; Katsura, T; Masuda, S; Sato, T; Tanihara, Y; Yonezawa, A	1
Doi, T; Fukatsu, A; Inui, K; Iwano, J; Kajiwara, M; Katsura, T; Ogasawara, K; Terada, T	1
Chen, Y; Ferrin, TE; Giacomini, KM; Hesselson, S; Johns, SJ; Kwok, P; Li, S; Stryke, D; Teranishi, K; Yee, SW	1
Horita, S; Inoue, K; Ito, S; Kondo, T; Kuroiwa, Y; Kusuhara, H; Moriyama, Y; Nakayama, H; Sugiyama, Y; Wu, C; Yuasa, H	1
Inoue, K; Ito, S; Kusuhara, H; Sugiyama, Y; Toyoshima, J; Yokochi, M; Yuasa, H	1
Choi, MK; Song, IS	1
Harper, JN; Wright, SH	1
Azad, RV; Biswas, NR; Nirmal, J; Singh, SB; Thavaraj, V; Velpandian, T	1

Reviews

1 review(s) available for metformin and tetraethylammonium

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010

Other Studies

18 other study(ies) available for metformin and tetraethylammonium

Article	Year
Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharmaceutical research, 2002, Volume: 19, Issue:8 Topics: Animals; Biguanides; Female; Humans; Organic Cation Transport Proteins; Organic Cation Transporter 2; Quaternary Ammonium Compounds; Xenopus laevis	2002
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:6 Topics: Animals; Benzoates; Blood Platelets; Cell Line; Dose-Response Relationship, Drug; Hepatocytes; Humans; Hydrazines; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membrane Proteins; Mice; Mice, Knockout; Organic Anion Transporters; Organic Cation Transporter 1; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Thrombopoietin; Tissue Distribution	2011
Electrophysiological characterization of the polyspecific organic cation transporter plasma membrane monoamine transporter. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:6 Topics: Animals; Cell Membrane; Electrophysiological Phenomena; Equilibrative Nucleoside Transport Proteins; Female; Humans; Membrane Potentials; Organic Cation Transport Proteins; Xenopus laevis; Xenopus Proteins	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Metformin prevents the impairment of endothelium-dependent vascular relaxation induced by high glucose challenge in rabbit isolated perfused kidneys. Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:1 Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Glucose; Hypoglycemic Agents; Kidney; Male; Metformin; Perfusion; Rabbits; Renal Circulation; Tetraethylammonium; Vasodilation; Vasodilator Agents	2005
Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life sciences, 2006, Apr-25, Volume: 78, Issue:22 Topics: 4-Aminopyridine; Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Combinations; Endothelium, Vascular; Hypoglycemic Agents; In Vitro Techniques; Lipid Peroxidation; Male; Metformin; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Recovery of Function; Tetraethylammonium; Vasoconstriction; Vasodilation	2006
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium	2007
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:8 Topics: Animals; Carbon Radioisotopes; Cell Line; Cimetidine; Cryopreservation; DNA, Complementary; Hepatocytes; Humans; Metformin; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; Pyridinium Compounds; Rats; Tetraethylammonium; Transfection; Tritium	2007
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochemical pharmacology, 2008, Oct-01, Volume: 76, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Cimetidine; Dogs; Humans; Metformin; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Procainamide; Quinidine; Tetraethylammonium; Transfection	2008
Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity. Journal of human genetics, 2009, Volume: 54, Issue:1 Topics: Amino Acid Sequence; Biological Transport; Biotinylation; Blotting, Western; Cell Line; Cell Membrane; Humans; Kinetics; Metformin; Molecular Sequence Data; Mutant Proteins; Organic Cation Transport Proteins; Polymorphism, Single Nucleotide; Tetraethylammonium	2009
Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. The pharmacogenomics journal, 2009, Volume: 9, Issue:2 Topics: Asian; Biological Transport; Black or African American; Cell Line; Cell Membrane; Cell Survival; Gene Frequency; Genotype; Hispanic or Latino; Humans; Kinetics; Metformin; Microscopy, Confocal; Organic Cation Transport Proteins; Organoplatinum Compounds; Oxaliplatin; Paraquat; Phenotype; Polymorphism, Single Nucleotide; Tetraethylammonium; Transfection; White People	2009
Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:1 Topics: Animals; Bile Canaliculi; Biological Transport; Cell Line; Humans; In Vitro Techniques; Kidney; Lactic Acid; Liver; Male; Metformin; Mice; Microvilli; Organic Cation Transport Proteins; Pyrimethamine; Tetraethylammonium	2010
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; 3-Iodobenzylguanidine; Animals; Binding, Competitive; Biological Transport; Cephalexin; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Humans; Kidney; Kinetics; Liver; Male; Metformin; Mice; Mice, Inbred Strains; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pyridines; Tetraethylammonium; Transfection	2012
Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Biopharmaceutics & drug disposition, 2012, Volume: 33, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Substitution; Asian People; Humans; Lamivudine; Metformin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymorphism, Single Nucleotide; Tetraethylammonium	2012
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2. American journal of physiology. Renal physiology, 2013, Jan-01, Volume: 304, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Androstenes; Animals; Benzhydryl Compounds; Carbazoles; Carvedilol; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperidines; Propanolamines; Tetraethylammonium	2013
Potential pharmacokinetic role of organic cation transporters in modulating the transcorneal penetration of its substrates administered topically. Eye (London, England), 2013, Volume: 27, Issue:10 Topics: Administration, Topical; Animals; Aqueous Humor; Atropine; Biological Transport; Chromatography, Liquid; Cornea; Mass Spectrometry; Metformin; Models, Animal; Organic Cation Transport Proteins; Quinidine; Rabbits; Tetraethylammonium; Tomography, Optical Coherence; Voltage-Gated Sodium Channel Blockers	2013