metformin has been researched along with tamoxifen in 37 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (10.81) | 29.6817 |
2010's | 27 (72.97) | 24.3611 |
2020's | 6 (16.22) | 2.80 |
Authors | Studies |
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Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Duarte, D; Esteves da Silva, JCG; Ferreira, PJO; González-Berdullas, P; Magalhães, CM; Núnez-Montenegro, A; Pinto da Silva, L; Rodríguez-Borges, JE; Vale, N | 1 |
Correia, C; Duarte, D; Ferreira, A; Moreira, S; Vale, N; Vasconcelos, MH; Xavier, CPR | 1 |
Erdemoglu, E; Giray, SG; Güney, M; Mungan, T; Take, G | 1 |
Berstein, LM; Santen, RJ; Wang, JP; Yue, W | 1 |
Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H | 1 |
Flomenberg, N; Goldberg, A; Howell, A; Ko, YH; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pavlides, S; Pestell, RG; Sotgia, F; Wang, C | 1 |
Bershteĭn, LM; Semiglazov, VF | 1 |
Marc, J; Mlakar, V | 1 |
Chen, S; Guo, Y; Lai, X; Liu, W; Ma, J; Wei, Y; Xue, Y; Yu, S; Zhang, J; Zhang, Y; Zhong, C | 1 |
Böhmer, FD; Kirches, E; Mawrin, C; Pachow, D; Petermann, A; Wallesch, M; Wilisch-Neumann, A | 1 |
Asara, JM; German, NJ; Gonzalez-Herrera, KN; Haigis, MC; Janzer, A; Struhl, K | 1 |
Cho, YH; Jang, SY; Kim, A; Kim, C; Kim, CH; Kim, JH; Kim, JK; Lee, JY | 1 |
Cuzick, J; Sestak, I | 1 |
Blake, C; Lucic, A | 1 |
Choi, J; Kim, A; Kim, C; Kim, J; Lee, J | 1 |
Berstein, LM; Krasil'nikov, MA; Prokhorov, NS; Scherbakov, AM; Semina, SE; Sorokin, DV; Tatarskiy, VV | 1 |
Choi, Y; Jang, SY; Kim, A; Kim, C; Kim, J; Lee, J | 1 |
Esteban, S; Peper, FE; Terrasa, SA | 1 |
Bell, RJ; Brown, KA; Chipman, M; Davis, SR; Edwards, A; Jane, F; McNeilage, J; Piessens, S; Robinson, PJ; White, S; Woinarski, J | 1 |
Bens, A; Bernstein, JL; Cronin-Fenton, D; Friis, S; Langballe, R; Mellemkjaer, L | 1 |
Guo, M; Huang, W; Zhou, JJ | 1 |
Chen, H; Li, J; Li, P; Liu, J; Liu, P; Miao, Y; Wang, R | 1 |
Burov, SV; Haq, S; Harless, W; Markvicheva, E; Qorri, B; Sambi, M; Samuel, V; Szewczuk, MR | 1 |
Dietze, EC; Jones, VC; Jovanovic-Talisman, T; McCune, JS; Seewaldt, VL | 1 |
Gao, H; Ingle, JN; Kim, W; Qin, S; Wang, L; Weinshilboum, RM | 1 |
6 review(s) available for metformin and tamoxifen
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Preventive therapy for breast cancer: a consensus statement.
Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles | 2011 |
[Breast cancer subtypes and their endocrine-metabolic basis; practical aspects].
Topics: Age Factors; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; BRCA1 Protein; Breast Neoplasms; Female; Gastrointestinal Hormones; Gonadal Steroid Hormones; Humans; Hypoglycemic Agents; Metformin; Molecular Targeted Therapy; Neoplasms, Hormone-Dependent; Postmenopause; Premenopause; Receptor, ErbB-2; Tamoxifen | 2011 |
Update on breast cancer risk prediction and prevention.
Topics: Age of Onset; Aromatase Inhibitors; Aspirin; Biomarkers, Tumor; Breast Neoplasms; Diphosphonates; Female; Humans; Metformin; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome | 2015 |
Preventive drug therapy and contralateral breast cancer: summary of the evidence of clinical trials and observational studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Diphosphonates; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Neoplasms, Second Primary; Observational Studies as Topic; Randomized Controlled Trials as Topic; Retinoids; Tamoxifen | 2019 |
Metformin and Chemoprevention: Potential for Heart-Healthy Targeting of Biologically Aggressive Breast Cancer.
Topics: Breast Neoplasms; Female; Humans; Metformin; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen | 2020 |
1 trial(s) available for metformin and tamoxifen
Article | Year |
---|---|
The benefits of adding metformin to tamoxifen to protect the endometrium-A randomized placebo-controlled trial.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Double-Blind Method; Endometrium; Fasting; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Middle Aged; Postmenopause; Tamoxifen; Waist Circumference | 2018 |
30 other study(ies) available for metformin and tamoxifen
Article | Year |
---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer.
Topics: Cell Line, Tumor; Cell Survival; Computer Simulation; Humans; Imidazoles; Light; Neoplasms; Photochemotherapy; Photosensitizing Agents; Proof of Concept Study; Pyrazines; Singlet Oxygen; Thermodynamics | 2019 |
Development of potent CPP6-gemcitabine conjugates against human prostate cancer cell line (PC-3).
Topics: | 2020 |
Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia.
Topics: Animals; Carrier Proteins; Cell Proliferation; Disease Models, Animal; Endometrial Hyperplasia; Endometrium; Estradiol; Female; Metformin; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Ribosomal Protein S6 Kinases, 90-kDa; Tamoxifen; TOR Serine-Threonine Kinases | 2009 |
Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells.
Topics: Adenylate Kinase; Antineoplastic Agents, Hormonal; Apoptosis; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Estrogens; Female; Humans; Metformin; Phosphorylation; Proliferating Cell Nuclear Antigen; Ribosomal Protein S6 Kinases, 70-kDa; Tamoxifen | 2011 |
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Doxorubicin; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor Modulators; Female; Fibroblasts; Fulvestrant; Humans; Hypoglycemic Agents; Intracellular Signaling Peptides and Proteins; Ketone Bodies; Lactic Acid; Metformin; Mitochondria; Oxides; Phosphoric Monoester Hydrolases; Poly(ADP-ribose) Polymerase Inhibitors; Tamoxifen; Tumor Microenvironment | 2011 |
Highlights from the latest pharmacogenomic genome-wide association studies.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Biomedical Research; Breast Neoplasms; Cell Cycle Proteins; Chromosomes, Human, Pair 10; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Drug Industry; Exons; Female; Genetic Loci; Genetic Variation; Genome-Wide Association Study; Humans; Male; Metabolism; Metformin; Methotrexate; Neoplasm Proteins; Organic Anion Transporters; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Tamoxifen; Tumor Suppressor Proteins | 2013 |
Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mammary Neoplasms, Experimental; MCF-7 Cells; Metformin; Mice; Mice, Nude; Receptors, Estrogen; Signal Transduction; Tamoxifen; Xenograft Model Antitumor Assays | 2014 |
Re-evaluation of cytostatic therapies for meningiomas in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Erlotinib Hydrochloride; Humans; Hydroxyurea; Losartan; Meningeal Neoplasms; Meningioma; Metformin; Mifepristone; Neurofibromin 2; Promoter Regions, Genetic; Quinazolines; Radiation Tolerance; Tamoxifen; Temozolomide; Tumor Suppressor Proteins; Verapamil | 2014 |
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.
Topics: Aminoimidazole Carboxamide; Biguanides; Cell Line, Transformed; Cell Line, Tumor; Citric Acid Cycle; Endoplasmic Reticulum; Folic Acid; Glycerophosphates; Glycolysis; Humans; Lactates; Metabolome; Metformin; Neoplastic Stem Cells; Nucleotides; Phenformin; Ribonucleotides; src-Family Kinases; Tamoxifen | 2014 |
Metformin inhibits tumor cell migration via down-regulation of MMP9 in tamoxifen-resistant breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; Drug Resistance, Neoplasm; Female; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Metformin; Neoplasm Invasiveness; Promoter Regions, Genetic; Tamoxifen | 2014 |
Automatic endpoint detection to support the systematic review process.
Topics: Algorithms; Blood Glucose; Comparative Effectiveness Research; Data Mining; Electronic Data Processing; Evidence-Based Medicine; Female; Humans; Insulin; Language; Linear Models; Linguistics; Machine Learning; Metformin; Natural Language Processing; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Reproducibility of Results; Support Vector Machine; Systematic Reviews as Topic; Tamoxifen; Uterus | 2015 |
Anti-cancer effect of metformin by suppressing signaling pathway of HER2 and HER3 in tamoxifen-resistant breast cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Drug Resistance, Neoplasm; Enzyme Induction; ErbB Receptors; Estradiol; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-1; Genes, erbB-2; Humans; Lapatinib; MCF-7 Cells; Metformin; Neoplasm Proteins; Neuregulin-1; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; RNA Interference; RNA, Small Interfering; Signal Transduction; Tamoxifen; Tumor Stem Cell Assay | 2016 |
The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Hormonal; Cadherins; Cell Proliferation; Cyclin D1; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; MCF-7 Cells; Metformin; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Snail Family Transcription Factors; Tamoxifen; TOR Serine-Threonine Kinases | 2016 |
Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; MCF-7 Cells; Metformin; Tamoxifen; Transcriptional Activation | 2016 |
[Evaluation of primary adherence to medications in patients with chronic conditions: A retrospective cohort study].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chronic Disease; Cohort Studies; Diabetes Mellitus, Type 2; Diphosphonates; Female; Humans; Hypoglycemic Agents; Insulin; Male; Medication Adherence; Metformin; Middle Aged; Osteoporotic Fractures; Retrospective Studies; Tamoxifen | 2018 |
Metformin alleviates endometrial hyperplasia through the UCA1/miR‑144/TGF‑β1/AKT signaling pathway.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Cell Line, Tumor; Endometrial Hyperplasia; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Metformin; Mice; MicroRNAs; Proto-Oncogene Proteins c-akt; Signal Transduction; Tamoxifen; Transforming Growth Factor beta1 | 2020 |
Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Female; Hippo Signaling Pathway; Humans; MAP Kinase Kinase Kinases; Membrane Proteins; Metformin; Mice, Inbred BALB C; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Paclitaxel; Protein Serine-Threonine Kinases; Protein Transport; Signal Transduction; Tamoxifen; Transcription Factors; Tumor Suppressor Proteins; YAP-Signaling Proteins | 2020 |
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer.
Topics: Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents; Apoptosis; Aspirin; Breast Neoplasms; CD24 Antigen; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Hyaluronan Receptors; Metformin; Oseltamivir; Retinal Dehydrogenase; Spheroids, Cellular; Tamoxifen; Triple Negative Breast Neoplasms; Tumor Cells, Cultured | 2020 |
ZNF423 modulates the AMP-activated protein kinase pathway and metformin response in a single nucleotide polymorphisms, estrogen and selective estrogen receptor modulator dependent fashion.
Topics: AMP-Activated Protein Kinases; Animals; Breast Neoplasms; Estrogens; Female; Humans; Metformin; Mice; Polymorphism, Single Nucleotide; Selective Estrogen Receptor Modulators; Tamoxifen | 2021 |