metformin has been researched along with sirolimus in 132 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (3.79) | 29.6817 |
2010's | 96 (72.73) | 24.3611 |
2020's | 31 (23.48) | 2.80 |
Authors | Studies |
---|---|
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y | 1 |
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S | 1 |
Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME | 1 |
Blagosklonny, MV | 3 |
Bevan, MJ; Prlic, M | 1 |
Del Barco, S; Martin-Castillo, B; Menendez, JA; Oliveras-Ferraros, C; Vazquez-Martin, A | 1 |
Blouin, MJ; Piura, E; Pollak, MN; Zakikhani, M | 1 |
Allison, DB; Nagy, TR; Smith, DL | 1 |
Sharp, ZD | 1 |
Ernst, S; Johnson, C; MacKenzie, MJ; Winquist, E | 1 |
Antonoff, MB; D'Cunha, J | 1 |
Apontes, P; Blagosklonny, MV; Demidenko, ZN; Leontieva, OV; Li, F | 1 |
Ebersole, J; González, O; Novak, MJ; Tobia, C | 1 |
McCarty, MF | 1 |
Steinman, TI | 1 |
Chen, SJ; Chen, Y; Dong, LH; Shen, ZX; Shi, WY; Wang, L; Xiao, D; Yan, ZX; Zhao, WL | 1 |
Duan, T; Feng, Y; Gu, Y; Liao, H; Zhou, Q | 1 |
Eucker, J; Habbel, P; Liu, H; Possinger, K; Regierer, AC; Schefe, JH; Scholz, C; Schulz, CO; Zang, C | 1 |
Alain, T; Blouin, MJ; Larsson, O; Morita, M; Pollak, M; Sonenberg, N; Topisirovic, I | 1 |
Huang, H; Kang, R; Luo, G; Wang, J; Yang, W; Zhao, Z | 1 |
Bennett, RG; Clure, CC; Hamel, FG; Larsen, JL; Shivaswamy, V | 1 |
Korsse, SE; Peppelenbosch, MP; van Veelen, W | 1 |
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H | 1 |
Kisfalvi, K; Ni, Y; Rozengurt, E; Sinnett-Smith, J; Soares, HP | 1 |
Akahori, H; Davis, T; Finn, AV; Habib, A; Karmali, V; Kolodgie, FD; Nakano, M; Narula, J; Otsuka, F; Pachura, K; Polavarapu, R; Virmani, R; Yazdani, S | 1 |
Baur, JA; Lamming, DW; Sabatini, DM; Ye, L | 1 |
Anisimov, VN | 2 |
Akahori, H; Finn, AV; Habib, A; Karmali, V; Pachura, K; Polavarapu, R | 1 |
Brooks, HL; Chew, WM; Ghosh, S; Goldberg, EL; Hapak, SM; Kusne, Y; Limesand, KH; Maskaykina, IY; Nikolich-Zugich, J; Parker, SS; Price, TJ; Sanai, N | 1 |
Abraham, E; Deshane, J; Gao, Y; Jiang, S; Park, DW; Stigler, WS; Tadie, JM; Zmijewski, JW | 1 |
Audrezet, MP; Bultynck, G; Corvelyn, A; De Smedt, H; Dechênes, G; Decuypere, JP; Levtchenko, E; Mekahli, D; Missiaen, L; Ong, AC; Parys, JB; Sammels, E; Schoeber, J; van den Heuvel, L; Welkenhuyzen, K; Wilmer, MJ | 1 |
Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O | 1 |
Endo, H; Hosono, K; Nakajima, A; Takahashi, H | 1 |
Selman, C | 1 |
Cai, GY; Chen, XM; Cui, SY; Fu, B; Guo, YN; Hong, Q; Hu, X; Lv, Y; Wang, JC; Yin, Z | 1 |
De Loof, H; De Meyer, GRY; Martinet, W | 1 |
Asatiani, E; Chen, HX; Doyle, LA; Fu, S; Hess, KR; Hong, DS; Kurzrock, R; Liu, X; Lorusso, P; McQuinn, L; Mita, M; Naing, A; Piha-Paul, S | 1 |
Wang, XW; Zhang, YJ | 1 |
Carlock, C; Chen, J; Chen, JS; Choi, HH; Chou, PC; Ensor, J; Esteva, FJ; Fraser Symmans, W; Fuentes-Mattei, E; Gully, C; Hortobagyi, GN; Lee, MH; Luo, Y; McKeehan, WL; Phan, L; Pusztai, L; Qi, Y; Shin, JH; Velazquez-Torres, G; Wu, Y; Yeung, SC; Zhang, F; Zhang, Y; Zhao, R | 1 |
Fontana, L; Kennedy, BK; Longo, VD; Melov, S; Seals, D | 1 |
Beijnen, JH; Huitema, AD; Opdam, FL; Schellens, JH | 1 |
Bhonde, R; Prakhya, BM; Sharma, S; Venkatesan, V | 1 |
Cifarelli, V; Devlin, KL; Dunlap, SM; Huang, J; Hursting, SD; Kaaks, R; Lashinger, LM; Pollak, MN | 1 |
Guan, KL; Kim, YC | 1 |
Ahmetaga, A; Bano, G; Mason, HD; Pellat, L; Rice, S; Whitehead, SA | 1 |
Davogustto, G; Keller, SR; Kundu, BK; Sen, S; Taegtmeyer, H; Zhong, M | 1 |
Géranton, SM; Hunt, SP; Jiménez-Díaz, L; Medrano, MC; Obara, I; Signoret-Genest, J | 1 |
Blando, J; DiGiovanni, J; Saha, A; Tremmel, L | 1 |
Chen, Y; Fang, W; Gao, Y; Huang, S; Jiao, X; Li, Z; Wang, J; Xia, T; Xie, K; Yu, G | 1 |
Arnon, R; Goldis, M; Regelmann, MO | 1 |
Weintraub, K | 1 |
Bednarczyk, RB; Darzynkiewicz, Z; Geliebter, J; Halicka, HD; Hanly, EK; Li, J; Moscatello, AL; Tiwari, RK; Tuli, NY | 1 |
Abid, S; Adnot, S; Amsellem, V; Czibik, G; Derumeaux, G; Dubois-Randé, JL; Houssaini, A; Kebe, K; Li, Z; Lipskaia, L; Marcos, E; Parpaleix, A; Pende, M; Rideau, D; Sawaki, D; Treins, C; Wan, F | 1 |
Fu, S; Hong, D; Janku, F; Karp, D; Khawaja, MR; Lu, KH; Madhusudanannair, V; McQuinn, LM; Meric-Bernstam, F; Naing, A; Ng, CS; Nick, AM; Piha-Paul, SA; Subbiah, V; Tsimberidou, A | 1 |
Bertrand, L; Colin, IM; Craps, J; De Jongh, B; Gérard, AC; Horman, S; Joris, V; Lengelé, B; Many, MC; Sonveaux, P | 1 |
Chung, BH; Jin, J; Jin, L; Lim, SW; Yang, CW | 1 |
Huffman, DM; LeBrasseur, NK; Schafer, MJ | 1 |
Antebi, A; Astle, CM; Bogue, M; de Magalhães, JP; Denzel, MS; Fernandez, E; Flurkey, K; Hamilton, KL; Harrison, DE; Javors, MA; Lamming, DW; Martinez, PA; McCord, JM; Miller, BF; Miller, RA; Müller, M; Nadon, NL; Ndukum, J; Nelson, JF; Rainger, GE; Richardson, A; Sabatini, DM; Salmon, AB; Simpkins, JW; Steegenga, WT; Strong, R | 1 |
Austad, SN; Barzilai, N; Halter, JB; Hashmi, SK; Kirkland, JL; Milman, S; Newman, JC | 1 |
Li, T; Peng, C; Shen, B; Shen, C; Xie, J; Xu, N; Zhu, Z | 1 |
Chung, BH; Jin, J; Jin, L; Kim, HS; Lim, SW; Yang, CW; Yu, JH | 1 |
Gifford, B | 1 |
Akamatsu, W; Fujioka, M; Hosoya, M; Matsunaga, T; Ogawa, K; Okamoto, S; Okano, H; Sone, T; Ueda, HR; Ukai, H | 1 |
Nistala, R; Pulakat, L; Raja, A | 1 |
Koliada, A; Lushchak, O; Piskovatska, V; Storey, KB; Strilbytska, O; Vaiserman, A | 1 |
Garg, G; Rizvi, SI; Singh, AK; Singh, S | 1 |
Niedernhofer, LJ; Robbins, PD | 1 |
Chen, J; Fei, DD; Hu, CH; Huang, WT; Jin, Y; Liu, N; Lu, YB; Lv, YJ; Pang, DL; Sui, BD; Xuan, K; Zhao, P; Zheng, CX; Zhou, CH | 1 |
Ahn, SW; Hong, SK; Kim, H; Kim, HS; Lee, KW; Mussin, N; Oh, DK; Oh, SC; Park, MY; Seo, S; Suh, KS; Yi, NJ; Yoon, KC | 1 |
Gladyshev, VN; Ma, S | 1 |
Byun, S; Lee, E; Lee, KW | 1 |
Domae, S; Eikawa, S; Furusawa, Y; Hase, K; Hori, S; Kunisada, Y; Sasaki, A; Tomonobu, N; Udono, H; Uehara, T | 1 |
Białas, AJ; Górski, P; Makowska, J; Miłkowska-Dymanowska, J; Piotrowski, WJ; Wardzynska, A | 1 |
Aliper, A; Artemov, A; Cortese, F; Jellen, L; Karpinsky-Semper, D; Moskalev, A; Swick, AG; Zhavoronkov, A | 1 |
Klimova, B; Kuca, K; Novotny, M | 1 |
Chung, BH; Jin, J; Jin, L; Lim, SW; Sun, IO; Yang, CW | 1 |
Savage, N | 1 |
Dembitz, V; Lalic, H; Visnjic, D | 1 |
Abrams, SL; Candido, S; Cervello, M; Cocco, L; Follo, MY; Gizak, A; Lertpiriyapong, K; Libra, M; Lombardi, P; Martelli, AM; McCubrey, JA; Montalto, G; Murata, RM; Rakus, D; Ratti, S; Rosalen, PL; Steelman, L; Suh, PG | 1 |
Fernandez, E; Liu, Y; Salmon, AB; Strong, R; Weiss, R | 1 |
Abdollahi, A; Dehpour, AR; Ghasemnejad-Berenji, H; Ghasemnejad-Berenji, M; Ghazi-Khansari, M; Jafari, A; Mohajer Ansari, J; Nobakht, M; Pashapour, S; Sadeghpour, S; Saeedi Saravi, SS; Yazdani, I | 1 |
Bissonnette, MB; Cohen, EEW; Fleming, GF; Gajewski, TF; Janisch, L; Karrison, T; Maitland, M; Pinto, N; Polite, BN; Ratain, MJ; Salgia, R; Sehdev, A; Sharma, MR; Turcich, M; Zha, Y | 1 |
Dash, PK; Edagwa, B; Gelbard, H; Gendelman, HE; Gnanadhas, DP; Gorantla, S; Lin, Z; Machhi, J; McMillan, J; Thomas, MB | 1 |
Admasu, TD; Barardo, D; Cazenave-Gassiot, A; Chaithanya Batchu, K; Gruber, J; Lam, VYM; Ng, LF; Tolwinski, NS; Wenk, MR; Xiao, L | 1 |
Abdellatif, M; Carmona-Gutierrez, D; Kroemer, G; Madeo, F; Sedej, S | 1 |
Cai, GY; Chen, XM; Wang, SY | 1 |
Abd-Rabbo, D; Aulakh, SK; Garneau, P; Kowarzyk, J; Michnick, SW; Miller-Fleming, L; Ralser, M; Stynen, B | 1 |
Korolenko, TA; Pupyshev, AB; Tikhonova, MA | 1 |
Bauer, PV; Duca, FA; Lam, TKT; Rasti, M; Rhodes, CJ; Waise, TMZ; Zhang, SY | 1 |
Guo, Y; Li, H; Li, J; Li, Z; Liu, Y; Liu, Z; Shang, Y | 1 |
Bruns, DR; Hamilton, KL; Konopka, AR; Linden, MA; Miller, BF; Musci, RV; Peelor, FF; Reid, JJ; Wolff, CA | 1 |
Hamilton, KL; Linden, MA; Miller, BF; Miller, RA; Peelor, FF; Reid, JJ | 1 |
Bernier, M; de Cabo, R; Di Germanio, C; Moats, JM; Palliyaguru, DL | 1 |
Ding, Y; Ji, N; Wang, Q; Xia, S; Zhang, P; Zhou, X | 1 |
Atrih, A; Cantrell, DA; Dandapani, M; Foretz, M; Grzes, KM; Hardie, DG; Lamont, DJ; Russell, FM; Vara-Ciruelos, D; Viollet, B | 1 |
Chai, M; Chu, J; Crooks, GM; de Barros, SC; Doan, NB; Fu, X; Herschman, H; Huang, J; Huang, W; Jiang, M; Jiao, J; Reue, K; Vergnes, L | 1 |
Gu, HF; Ma, RD; Nie, YX; Qu, M; Tang, YL; Yang, XY; Yi, JH; Zhou, GJ | 1 |
Ghahremani, MH; Montazeri, H; Navabi, S; Nikougoftar, M; Ostad, SN; Roohi, A; Shokri, F | 1 |
Azar, ST; Barakat, R; Boutary, S; Costantine, J; Eid, AA; Eid, AH; Eid, S; Haddad, M; Harb, F; Irani, SAM; Kanj, R; Mroueh, FM; Noureldein, M; Ouhtit, A; Sauleau, EA; Zeidan, YH | 1 |
Bee, YS; Li, MS; Lin, SH; Sheu, SJ; Shu, CW; Tsen, CL | 1 |
O'Neill, LAJ; Pålsson-McDermott, EM | 1 |
Yurova, MN | 1 |
Cho, ML; Choi, JW; Jung, KA; Kim, DS; Kim, EK; Lee, SY; Min, HK; Na, HS; Park, SH; Ryu, JG | 1 |
Choi, YJ | 1 |
Carson, RH; Creery, JS; Cutler, KJ; Hamilton, KL; Laurin, JL; Lawrence, MM; Linden, MA; Miller, BF; Musci, RV; Peelor, FF; Porter, H; Price, JC; Reid, JJ; Wolff, CA; Wren, JD; Zhang, Q | 1 |
Willyard, C | 1 |
Amin, PP; Luu, HS; Mifflin, L; Mookhtiar, AK; Najafov, A; Ordureau, A; Wang, H; Xia, HG; Yuan, J | 1 |
Benedetti, F; Buriani, A; Fortinguerra, S; Scapagnini, G; Sorrenti, V; Zella, D | 1 |
Chen, MJ; Chen, SU; Chou, CH; Ho, HN; Huang, CC; Shun, CT; Wen, WF; Yang, YS | 1 |
Ferraresi, A; Isidoro, C; Jamjuntra, P; Therasakvichya, S; Thongchot, S; Thuwajit, C; Thuwajit, P; Warnnissorn, M | 1 |
Cipolli, W; Jimenez, AG; Lalwani, S | 1 |
Crane, ED; Crane, JD; O'Neil, G; Wong, W; Zhang, H | 1 |
An, H; An, X; Chen, Y; Dai, X; Guan, S; Huang, B; Huang, Q; Liang, L; Lu, M; Lu, X; Nie, H; Wang, H; Wang, J; Wang, Z; Zhang, H | 1 |
Garay, RP | 1 |
Chen, X; Han, J; Jia, Z; Lin, Y; Liu, H; Mi, Z; Pan, Q; Shi, W; Wang, M; Wang, Z | 1 |
Brandon, AE; Cogger, VC; Cooney, GJ; Gokarn, R; Hunt, NJ; James, DE; Le Couteur, DG; Parker, BL; Pulpitel, T; Raubenheimer, D; Senior, AM; Simpson, SJ; Solon-Biet, SM; Wali, JA | 1 |
Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J | 1 |
Chen, H; Gu, X; Jin, J; Li, Q; Liang, J; Mao, Z; Miao, D; Wang, R; Xie, C; Zhang, Y; Zhou, J; Zuo, G | 1 |
Gao, Z; Jin, Z; Sun, C; Yang, X | 1 |
Abzalimov, RR; He, Y; Soliman, GA | 1 |
Gerasymchuk, M; Kovalchuk, I; Kovalchuk, O; Robinson, GI | 1 |
Calcutt, NA; Doty, R; Flurkey, K; Harrison, DE; Koza, RA; Reifsnyder, PC | 1 |
Arsenijevic, M; Basta, I; Berisavac, I; Bozovic, I; Mandic, M; Milosevic, E; Nikolic, M; Paunovic, V; Peric, S; Stamenkovic, M; Stevanovic, D; Stevic, Z; Trajkovic, V; Vukovic, I | 1 |
Chen, M; Li, M; Liu, S; Ma, F; Su, B; Wang, C; Yuan, L; Zhang, S; Zhang, Y; Zheng, Q | 1 |
Albawardi, A; Almarzooqi, S; Elomami, A; Saraswathiamma, D; Sharma, C; Souid, AK | 1 |
Cao, J; Chen, M; Gao, Y; Li, K; Li, R; Li, T; Liu, J; Shi, R; Wang, Y; Zhang, W; Zhang, X | 1 |
34 review(s) available for metformin and sirolimus
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
An anti-aging drug today: from senescence-promoting genes to anti-aging pill.
Topics: Aging; Animals; Antioxidants; Caloric Restriction; Cell Cycle Proteins; Cellular Senescence; Drug Delivery Systems; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Longevity; Metformin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Resveratrol; Saccharomyces cerevisiae Proteins; Sirolimus; Sirtuins; Stilbenes | 2007 |
Validation of anti-aging drugs by treating age-related diseases.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Antioxidants; Biomarkers; Chronic Disease; Humans; Hypoglycemic Agents; Metformin; Resveratrol; Sirolimus; Stilbenes; Validation Studies as Topic | 2009 |
Calorie restriction: what recent results suggest for the future of ageing research.
Topics: Animals; Antimetabolites; Biomedical Research; Biomimetics; Caloric Restriction; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Longevity; Metformin; Primates; Quality of Life; Resveratrol; Sirolimus; Stilbenes | 2010 |
Aging and TOR: interwoven in the fabric of life.
Topics: Aging; Animals; Anti-Infective Agents; Humans; Hypoglycemic Agents; Metformin; Sirolimus; TOR Serine-Threonine Kinases | 2011 |
Caloric restriction and chronic inflammatory diseases.
Topics: Adaptive Immunity; Animals; Biomimetics; Caloric Restriction; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Insulin-Like Growth Factor I; Metformin; Periodontitis; Resveratrol; Signal Transduction; Sirolimus; Sirtuins; Stilbenes; TOR Serine-Threonine Kinases | 2012 |
Polycystic kidney disease: a 2011 update.
Topics: Antineoplastic Agents; Benzazepines; Curcumin; Everolimus; Gastrointestinal Agents; Glomerular Filtration Rate; Humans; Hypertension; Hypoglycemic Agents; Immunosuppressive Agents; Indazoles; Kidney; Metformin; Octreotide; Organ Size; Polycystic Kidney, Autosomal Dominant; Sirolimus; Sodium; Tolvaptan | 2012 |
Targeting LKB1 signaling in cancer.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cell Polarity; Humans; Metformin; Neoplasms; Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Rapalogs and mTOR inhibitors as anti-aging therapeutics.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Autophagy; Humans; Metformin; Molecular Targeted Therapy; Neoplasms; Sirolimus; Stem Cells; TOR Serine-Threonine Kinases | 2013 |
Colon epithelial proliferation and carcinogenesis in diet-induced obesity.
Topics: Aberrant Crypt Foci; Adiponectin; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Diet, High-Fat; Disease Models, Animal; Epithelial Cells; Humans; Hypoglycemic Agents; Metformin; Mice; Obesity, Abdominal; Risk Factors; Signal Transduction; Sirolimus | 2013 |
Dietary restriction and the pursuit of effective mimetics.
Topics: Animals; Caloric Restriction; Energy Intake; Genetic Variation; Health; Humans; Longevity; Metformin; Resveratrol; Sirolimus; Stilbenes | 2014 |
mTOR inhibition: a promising strategy for stabilization of atherosclerotic plaques.
Topics: Absorbable Implants; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Cholesterol; Clinical Trials as Topic; Coronary Artery Disease; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Dyslipidemias; Everolimus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Macrophages; Metformin; Mice; Mice, Knockout; Plaque, Atherosclerotic; Rabbits; Receptors, LDL; Rupture, Spontaneous; Sirolimus; Swine; Tissue Scaffolds; TOR Serine-Threonine Kinases; Triglycerides | 2014 |
Targeting mTOR network in colorectal cancer therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Autophagy; Colorectal Neoplasms; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; MAP Kinase Signaling System; Metformin; Models, Biological; Prognosis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Wnt Proteins | 2014 |
Koschei the immortal and anti-aging drugs.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Caloric Restriction; Exercise; Folklore; Gene Expression; Glucose; Humans; Insulin Resistance; Longevity; Metformin; Propranolol; Russia; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
mTOR: a pharmacologic target for autophagy regulation.
Topics: Animals; Autophagy; Humans; Metformin; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis.
Topics: 3-O-Methylglucose; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Acids; Glucose-6-Phosphate; Heart Failure; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Hypoglycemic Agents; Metformin; Mice; Myocardium; Positron-Emission Tomography; Rats; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Function, Left | 2015 |
New-onset diabetes mellitus after pediatric liver transplantation.
Topics: Albuminuria; Child; Cyclosporine; Diabetes Mellitus; Diabetic Retinopathy; Glucocorticoids; Humans; Hyperlipidemias; Hypertension; Immunosuppressive Agents; Insulin; Liver Failure; Liver Transplantation; Metformin; Pediatrics; Risk Factors; Sirolimus; Tacrolimus | 2015 |
Energetic interventions for healthspan and resiliency with aging.
Topics: Aging; Caloric Restriction; Diet; Energy Intake; Exercise; Female; Humans; Longevity; Male; Metformin; Resveratrol; Sirolimus; Stilbenes | 2016 |
The role of the TOR pathway in mediating the link between nutrition and longevity.
Topics: Animals; Humans; Longevity; Metformin; Nutritional Physiological Phenomena; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Molecular signatures of longevity: Insights from cross-species comparative studies.
Topics: Animals; Bowhead Whale; Caloric Restriction; Chiroptera; Gene Expression Regulation, Developmental; Genome; Humans; Insulin-Like Growth Factor I; Killifishes; Longevity; Metabolome; Metformin; Methionine; Mole Rats; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome | 2017 |
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer.
Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Humans; Immune System Diseases; Immunity, Innate; Indoles; Infections; Isoquinolines; Lysosomes; Maprotiline; Metformin; Neoplasms; Phenols; Pyrroles; Resveratrol; Sirolimus; Spermidine; Stilbenes; Tetrahydroisoquinolines; Trehalose | 2017 |
Geroprotectors as a therapeutic strategy for COPD - where are we now?
Topics: Aging; Disease Progression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Melatonin; Metformin; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quality of Life; Sirolimus; Testosterone; Vitamin D | 2017 |
Anti-Aging Drugs - Prospect of Longer Life?
Topics: Animals; Humans; Longevity; Metformin; NAD; Quality of Life; Resveratrol; Sirolimus; Stilbenes | 2018 |
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Metformin; Ribonucleosides; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Autophagy in Cardiovascular Aging.
Topics: Age Factors; Aging; Animals; Autophagy; Caloric Restriction; Cardiovascular Diseases; Cardiovascular System; Health Status; Humans; Longevity; Metformin; Protective Factors; Risk Factors; Sirolimus; Spermidine | 2018 |
Energy restriction in renal protection.
Topics: Aging; Animals; Autophagy; Caloric Restriction; Diet; Energy Metabolism; Female; Humans; Inflammation; Insulin; Kidney; Kidney Diseases; Male; Metformin; Models, Animal; Oxidative Stress; Phosphorus; Resveratrol; Salts; Sirolimus; Sirtuin 1 | 2018 |
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Clinical Trials as Topic; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Metformin; Molecular Chaperones; Molecular Targeted Therapy; Neuroprotective Agents; Parkinson Disease; Proteasome Endopeptidase Complex; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin | 2016 |
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.
Topics: Animals; Caloric Restriction; Frailty; Humans; Longevity; Metformin; Resveratrol; Sirolimus | 2019 |
Targeting immunometabolism as an anti-inflammatory strategy.
Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Dimethyl Fumarate; Glycolysis; Humans; Immunomodulation; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Sirolimus | 2020 |
[Geroprotective drugs - mTOR inhibitors in the treatment of cancer patients.]
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Humans; Metformin; Neoplasms; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology.
Topics: Animals; Caloric Restriction; Dermatologic Agents; Fasting; Humans; Inflammation; Metformin; Peroxisome Proliferator-Activated Receptors; Resveratrol; Sirolimus; Skin; Skin Aging; Wound Healing | 2020 |
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways.
Topics: Animals; Antiviral Agents; Host-Pathogen Interactions; Humans; Metformin; Resveratrol; Signal Transduction; Sirolimus; Virus Diseases; Virus Replication | 2020 |
Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu.
Topics: Acarbose; Aging; Animals; Drugs, Investigational; Humans; Longevity; Metformin; Nutrients; Sirolimus | 2021 |
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
4 trial(s) available for metformin and sirolimus
Article | Year |
---|---|
A phase I study of temsirolimus and metformin in advanced solid tumours.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Metformin; Middle Aged; Neoplasms; Ontario; Pilot Projects; Protein Kinase Inhibitors; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Treatment Outcome; Young Adult | 2012 |
Incidence of mucositis in patients treated with temsirolimus-based regimens and correlation to treatment response.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Metformin; Middle Aged; Mucositis; Niacinamide; Protein Kinase Inhibitors; Retrospective Studies; Sirolimus; TOR Serine-Threonine Kinases; Treatment Outcome; Young Adult | 2014 |
Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Maximum Tolerated Dose; Metformin; Middle Aged; Neoplasms; Response Evaluation Criteria in Solid Tumors; Sirolimus; TOR Serine-Threonine Kinases; Young Adult | 2016 |
A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Drug Synergism; Female; Humans; Leukocytes, Mononuclear; Male; Metformin; Middle Aged; Neoplasms; Phosphorylation; Pilot Projects; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; TOR Serine-Threonine Kinases; Young Adult | 2018 |
94 other study(ies) available for metformin and sirolimus
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins | 2020 |
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2022 |
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Elongation Factor 2 Kinase; Enzyme Activation; Green Fluorescent Proteins; Hypertrophy; Hypoglycemic Agents; Immunoblotting; Luminescent Proteins; Metformin; Microscopy, Fluorescence; Multienzyme Complexes; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Ribose; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Time Factors | 2004 |
Immunology: A metabolic switch to memory.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Differentiation; Fatty Acids; Hypoglycemic Agents; Immunologic Memory; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Multiprotein Complexes; Protein Kinases; Proteins; Sirolimus; TNF Receptor-Associated Factor 6; TOR Serine-Threonine Kinases; Transcription Factors | 2009 |
If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Clinical Trials as Topic; Drug Delivery Systems; Female; Humans; Metformin; Protein Kinases; Receptor, IGF Type 1; Risk Assessment; Sensitivity and Specificity; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2009 |
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Separation; Enzyme Activation; Female; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Metformin; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection | 2010 |
Teaching an old drug new tricks: metformin as a targeted therapy for lung cancer.
Topics: Antineoplastic Agents; Humans; Hypoglycemic Agents; Lung Neoplasms; Metformin; Sirolimus; Smoking; TOR Serine-Threonine Kinases | 2010 |
Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cytoprotection; Epithelial Cells; Fibroblasts; G1 Phase; Humans; Imidazoles; Metformin; Nocodazole; Paclitaxel; Piperazines; Sirolimus; Tumor Suppressor Protein p53 | 2011 |
mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets.
Topics: Adiponectin; Diet, Vegetarian; Dietary Proteins; Down-Regulation; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Neoplasms; Proteins; Sirolimus; TOR Serine-Threonine Kinases | 2011 |
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Synergism; Enzyme Activation; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell; Metformin; Mice; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2012 |
Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway.
Topics: Cell Line, Tumor; Female; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Metformin; Neovascularization, Pathologic; Nerve Tissue Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2012 |
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Autophagy; Breast Neoplasms; Carboplatin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Everolimus; Female; Humans; Metformin; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
Distinct perturbation of the translatome by the antidiabetic drug metformin.
Topics: Analysis of Variance; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Metformin; Microarray Analysis; Neoplasms; Protein Biosynthesis; Purines; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Knockdown Techniques; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Metformin; Models, Biological; Multiprotein Complexes; Phenylbutyrates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Virus Replication | 2013 |
Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats.
Topics: Animals; Apoptosis; Biomarkers; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Immunohistochemistry; Immunosuppressive Agents; In Situ Nick-End Labeling; Insulin; Male; Metformin; Pancreas, Exocrine; Rats; Rats, Sprague-Dawley; Sirolimus; Tacrolimus; Time Factors | 2013 |
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2012 |
Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
Topics: Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Indoles; Insulin; Metformin; Morpholines; Neurotensin; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Purines; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of rapamycin inhibitors via S6 kinase-dependent inhibition of cell proliferation.
Topics: Administration, Oral; Animals; Aorta; Apoptosis; Cell Proliferation; Cells, Cultured; Drug Interactions; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Humans; Iliac Artery; Metformin; Microscopy, Electron, Scanning; Rabbits; Ribosomal Protein S6 Kinases; Sirolimus | 2013 |
Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer.
Topics: Aging; Animals; Cellular Senescence; Gene Expression Regulation; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Metformin; Neoplasms; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Multifaceted aging and rapamycin.
Topics: Aging; Animals; Gene Expression Regulation; Hypoglycemic Agents; Immunosuppressive Agents; Mammals; Metformin; Signal Transduction; Sirolimus | 2013 |
Metformin impairs endothelialization after placement of newer generation drug eluting stents.
Topics: Angioplasty, Balloon; Animals; Disease Models, Animal; Drug-Eluting Stents; Endothelium, Vascular; Everolimus; Hypoglycemic Agents; Iliac Artery; Immunosuppressive Agents; Male; Metformin; Paclitaxel; Rabbits; Sirolimus; Thrombosis; Tubulin Modulators | 2013 |
Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice.
Topics: Animals; Apoptosis; Hippocampus; Immunohistochemistry; Injections, Intraperitoneal; Longevity; Metformin; Mice; Mice, Inbred C57BL; Phosphorylation; Signal Transduction; Sirolimus; Stem Cells; TOR Serine-Threonine Kinases | 2014 |
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing.
Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bacteremia; Chemotaxis, Leukocyte; Enzyme Activation; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Male; Metformin; Mice; Mice, Inbred C57BL; Neutrophils; Peritonitis; Phagocytosis; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Sirolimus | 2013 |
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
Topics: Animals; Drug Synergism; Gene Knockdown Techniques; Humans; Metformin; Mice; Mutation; Polycystic Kidney, Autosomal Dominant; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; TRPP Cation Channels; Up-Regulation | 2014 |
Metformin inhibits skin tumor promotion in overweight and obese mice.
Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Insulin; Insulin-Like Growth Factor I; Leptin; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Obese; Multiprotein Complexes; Neoplasms, Experimental; Obesity; Overweight; Papilloma; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions.
Topics: AMP-Activated Protein Kinases; Cells, Cultured; Cellular Senescence; Connexin 43; Cyclin-Dependent Kinase Inhibitor p21; Diabetic Nephropathies; Down-Regulation; Glucose; Humans; Hypoglycemic Agents; Kidney Glomerulus; Mesangial Cells; Metformin; Signal Transduction; Sirolimus; Sweetening Agents; TOR Serine-Threonine Kinases | 2014 |
Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.
Topics: Adipocytes; Adipokines; Aged; Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Everolimus; Female; Humans; Kaplan-Meier Estimate; Metformin; Mice; Mice, Transgenic; Middle Aged; Obesity; Postmenopause; Prospective Studies; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome | 2014 |
Medical research: treat ageing.
Topics: Age of Onset; Aging; Animals; Biomarkers; Biomedical Research; Caloric Restriction; Clinical Trials as Topic; Diet; Exercise; Geriatrics; Health; Humans; Longevity; Metformin; Models, Animal; Precision Medicine; Preventive Medicine; Rejuvenation; Sirolimus | 2014 |
[Hyperglycaemia during treatment with everolimus].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Everolimus; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Metformin; Neoplasm Recurrence, Local; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Human mesenchymal stem cells as a novel platform for simultaneous evaluation of cytotoxicity and genotoxicity of pharmaceuticals.
Topics: Adult; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dimethyl Sulfoxide; DNA Damage; Drug Evaluation, Preclinical; Ethanol; Female; Humans; Mesenchymal Stem Cells; Metformin; Micronucleus Tests; Mutagens; Sirolimus | 2015 |
Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms.
Topics: Animals; Body Weight; Cell Cycle; Diet, Diabetic; Energy Intake; Glucose Intolerance; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; MicroRNAs; Neoplasms, Experimental; Pancreatic Neoplasms; Prediabetic State; Random Allocation; Sirolimus; Snail Family Transcription Factors; Transcription Factors; Vimentin | 2015 |
Dual effect of metformin on growth inhibition and oestradiol production in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Metformin; Sirolimus | 2015 |
Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice.
Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Histamine; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Neuralgia; Phosphoproteins; Protein Kinase Inhibitors; Pruritus; Signal Transduction; Sirolimus; Skin; TOR Serine-Threonine Kinases; Treatment Outcome | 2015 |
Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Proliferation; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Metformin; Mice; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Sirolimus | 2015 |
Metformin potentiates rapamycin and cisplatin in gastric cancer in mice.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Cycle; Cisplatin; Disease Models, Animal; Female; Flow Cytometry; Humans; Immunohistochemistry; Male; Metformin; Mice; Middle Aged; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Signal Transduction; Sirolimus; Stomach Neoplasms; Transcriptome; Xenograft Model Antitumor Assays | 2015 |
Can We Stop Aging?
Topics: Aged, 80 and over; Aging; Animals; Bone Morphogenetic Proteins; Chronic Disease; Everolimus; Growth Differentiation Factors; Humans; Longevity; Metformin; Sirolimus | 2015 |
mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hypoglycemic Agents; Indoles; Metformin; Microscopy, Fluorescence; Mutation; Proto-Oncogene Proteins B-raf; Sirolimus; Sulfonamides; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Vemurafenib | 2015 |
Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chronic Disease; Gene Deletion; Hyperplasia; Hypertension, Pulmonary; Hypoxia; Lung; Male; Metformin; Mice; Microfilament Proteins; Muscle Proteins; Muscle, Smooth; Myocytes, Smooth Muscle; Pulmonary Artery; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2016 |
Involvement of mTOR and Regulation by AMPK in Early Iodine Deficiency-Induced Thyroid Microvascular Activation.
Topics: AMP-Activated Protein Kinases; Animals; Cell Proliferation; Female; Humans; In Vitro Techniques; Iodine; Male; Metformin; Mice; Mice, Knockout; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Thyroid Gland; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2016 |
Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus.
Topics: Animals; Apoptosis; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Exenatide; Hyperglycemia; Islets of Langerhans; Male; Metformin; Mitochondria; Oxidative Stress; Peptides; Piperidones; Pyrimidines; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Venoms | 2016 |
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.
Topics: Acarbose; alpha-Glucosidases; Animals; Antioxidants; Drugs, Chinese Herbal; Estradiol; Fish Oils; Glycoside Hydrolase Inhibitors; Hand Strength; Longevity; Male; Masoprocol; Metformin; Mice; NF-E2-Related Factor 2; Rotarod Performance Test; Sirolimus; Survival Analysis; Ursodeoxycholic Acid | 2016 |
Strategies and Challenges in Clinical Trials Targeting Human Aging.
Topics: Acarbose; Aging; Animals; Anti-Bacterial Agents; Biomedical Research; Clinical Trials as Topic; Congresses as Topic; Disease Models, Animal; Drug Evaluation; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Research Design; Sirolimus | 2016 |
Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Female; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Metformin; Mice; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Transplantation; Phosphorylation; Sirolimus; Treatment Outcome | 2016 |
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Islets of Langerhans; Kidney Transplantation; Metformin; Rats; Rats, Sprague-Dawley; Sirolimus; Tacrolimus | 2017 |
Living to 120.
Topics: Acarbose; Aging; AMP-Activated Protein Kinases; Animals; Diet; Humans; Life Expectancy; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.
Topics: Adolescent; Adult; Cell Line; Child; Child, Preschool; Cochlea; Female; Goiter, Nodular; Hearing Loss; Hearing Loss, Sensorineural; Human Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Infant, Newborn; Ion Exchange; Membrane Transport Proteins; Metformin; Phenotype; Protein Aggregates; Sirolimus; Sulfate Transporters; Vestibular Aqueduct | 2017 |
mTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Protein Kinase Inhibitors; Proteinuria; Rats, Zucker; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases | 2017 |
Synergistic Effect of Rapamycin and Metformin Against Age-Dependent Oxidative Stress in Rat Erythrocytes.
Topics: Acetylcholinesterase; Aging; Animals; Cell Membrane; Erythrocytes; Glutathione; Iron; Lipid Peroxidation; Male; Metformin; Oxidation-Reduction; Oxidative Stress; Plasma; Protective Agents; Protein Carbonylation; Rats, Wistar; Reactive Oxygen Species; Sirolimus | 2017 |
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2
Topics: Animals; Cellular Senescence; Drug Evaluation, Preclinical; Free Radical Scavengers; Healthy Lifestyle; Humans; Longevity; Metformin; Models, Animal; NAD; Sirolimus; Stem Cell Factor; Stem Cell Transplantation; Stem Cells | 2017 |
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.
Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; Female; Gene Expression Regulation; Metformin; Mice; Neovascularization, Physiologic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Resveratrol; Ribosomal Protein S6 Kinases; Sirolimus; Skin; Skin Aging; Stilbenes; Tumor Suppressor Protein p53; Wound Healing; Wounds, Nonpenetrating | 2017 |
Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; HCT116 Cells; HT29 Cells; Humans; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Smad3 Protein; Tacrolimus; Transplantation, Heterologous | 2017 |
Attenuation of CD4
Topics: AMP-Activated Protein Kinase Kinases; Antigens, CD; Cell Differentiation; CTLA-4 Antigen; Forkhead Transcription Factors; Gene Expression Regulation; Glucose Transporter Type 1; Humans; Integrin alpha Chains; Interleukin-10; Lectins, C-Type; Mechanistic Target of Rapamycin Complex 1; Metformin; Neoplasms; Protein Kinases; Receptors, Immunologic; Sirolimus; T-Lymphocytes, Regulatory; Trans-Activators; Tumor Microenvironment | 2017 |
Towards natural mimetics of metformin and rapamycin.
Topics: Computational Biology; Databases, Genetic; Dietary Supplements; Drug Discovery; Gene Regulatory Networks; High-Throughput Screening Assays; Humans; Machine Learning; Metformin; Molecular Mimicry; Molecular Structure; Molecular Targeted Therapy; Neural Networks, Computer; Protein Interaction Maps; Protein Kinase Inhibitors; Signal Transduction; Sirolimus; Structure-Activity Relationship; TOR Serine-Threonine Kinases | 2017 |
The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Hypoglycemic Agents; Islets of Langerhans; Male; Metformin; Mitochondria; Random Allocation; Rats, Sprague-Dawley; Sirolimus; Ubiquinone; Vitamins | 2019 |
New tricks from old dogs join the fight against ageing.
Topics: Aging; Animals; Autophagy; Biomedical Research; Caenorhabditis elegans; Cellular Senescence; Diet, Healthy; DNA Damage; Dogs; Drosophila melanogaster; Everolimus; Exercise; Health; Heart; Humans; Immunity; Life Expectancy; Longevity; Metformin; Mice; Quality of Life; Rejuvenation; Saccharomyces cerevisiae; Sirolimus; Social Support; Stress, Psychological; Telomere Shortening; TOR Serine-Threonine Kinases | 2017 |
Metformin influences drug sensitivity in pancreatic cancer cells.
Topics: Animals; Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Metformin; Pancreatic Neoplasms; Signal Transduction; Sirolimus | 2018 |
Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice.
Topics: Aging; Animals; Female; Glucose; Glucose Intolerance; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Mice; Random Allocation; Sex Factors; Sirolimus | 2018 |
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats.
Topics: Animals; Apoptosis; Drug Synergism; Male; Metformin; Oxidative Stress; Rats, Wistar; Reperfusion Injury; Sirolimus; Spermatic Cord Torsion; Testis | 2018 |
Modulating cellular autophagy for controlled antiretroviral drug release.
Topics: Anti-HIV Agents; Atazanavir Sulfate; Autophagy; beta-Cyclodextrins; Cell Survival; Clomipramine; Clonidine; Drug Carriers; Drug Interactions; Drug Liberation; HIV-1; Humans; Macrophages; Metformin; Nanoparticles; Particle Size; Pyridines; Pyrroles; Sirolimus; Tissue Distribution | 2018 |
Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.
Topics: Aging; Allantoin; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Drosophila melanogaster; Drug Synergism; Ficusin; Gene Expression Regulation; Gene Regulatory Networks; Insulin-Like Growth Factor I; Lipid Metabolism; Lipids; Longevity; Metformin; Rifampin; Signal Transduction; Sirolimus; Sterol Regulatory Element Binding Protein 1; Transcriptome; Transforming Growth Factor beta | 2018 |
Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics.
Topics: Diabetes Mellitus, Type 2; Genetic Complementation Test; Humans; Iron; Metalloproteins; Metformin; Saccharomyces cerevisiae; Sirolimus | 2018 |
Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
Topics: Adenoviridae; Animals; Blood Glucose; Diet, High-Fat; Glucose; Homeostasis; Insulin Resistance; Intestine, Small; Male; Metformin; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; Male; Metformin; Neurons; Nucleus Pulposus; Pain; Phosphorylation; Radiculopathy; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Spinal Nerve Roots; TOR Serine-Threonine Kinases | 2019 |
Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes.
Topics: Autophagy; Blotting, Western; Cells, Cultured; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Longevity; Lysosomes; Metformin; Muscle Fibers, Skeletal; Myoblasts; Protein Biosynthesis; Proteostasis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2020 |
Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin.
Topics: Animals; Blotting, Western; Brain; Female; Hypoglycemic Agents; Immunosuppressive Agents; Longevity; Male; Metformin; Mice; Models, Animal; Protein Biosynthesis; Signal Transduction; Sirolimus | 2020 |
Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression.
Topics: Animals; Diabetes Mellitus, Experimental; Interleukin-1beta; Metformin; Mice; NIMA-Related Kinases; NLR Family, Pyrin Domain-Containing 3 Protein; Periodontitis; Sirolimus; TOR Serine-Threonine Kinases; X-Ray Microtomography | 2019 |
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Disease Models, Animal; Disease-Free Survival; Female; Glycolysis; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenformin; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; PTEN Phosphohydrolase; Signal Transduction; Sirolimus | 2019 |
Stimulation of Hair Growth by Small Molecules that Activate Autophagy.
Topics: Aging; Allyl Compounds; Alopecia; AMP-Activated Protein Kinases; Animals; Autophagy; Butyrates; Cell Division; Female; Hair; Hair Follicle; Ketoglutaric Acids; Male; Metformin; Mice; Mice, Inbred C57BL; Oligomycins; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Corticosterone; Enzyme Activation; Flow Cytometry; Lysosomes; Metformin; Microtubule-Associated Proteins; PC12 Cells; Phagosomes; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2020 |
High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells.
Topics: Apoptosis; Blood Glucose; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Gene Expression; Glucose; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Metformin; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus | 2019 |
Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer.
Topics: AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Blood Glucose; Caco-2 Cells; Diabetes Mellitus, Experimental; DNA Damage; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidase 4; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation | 2019 |
Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo.
Topics: Adult; Animals; Apoptosis; Cell Survival; Cells, Cultured; Coloring Agents; Disease Models, Animal; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Metformin; Rats; Retinal Diseases; Retinal Pigment Epithelium; Sirolimus | 2020 |
Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Hypoglycemic Agents; Immunosuppressive Agents; Metabolic Syndrome; Metformin; Mice; Mitochondria; Obesity; Sirolimus | 2020 |
Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin.
Topics: Animals; Female; Longevity; Male; Metformin; Mice; Protein Biosynthesis; Sex Characteristics; Sirolimus | 2021 |
How anti-ageing drugs could boost COVID vaccines in older people.
Topics: Adult; Aged; Aging; Animals; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Female; Humans; Male; Metformin; Mice; Pandemics; Pneumonia, Viral; Rejuvenation; Sirolimus; TOR Serine-Threonine Kinases; Viral Vaccines | 2020 |
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Autophagy-Related Protein 5; Caspase 8; Cell Death; Fas-Associated Death Domain Protein; Gene Expression Regulation; Glucose; HEK293 Cells; HT29 Cells; Humans; Intestine, Large; Jurkat Cells; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus; Tuberous Sclerosis Complex 2 Protein | 2021 |
Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cells, Cultured; Cyclophosphamide; Everolimus; Female; Fertility; Hypoglycemic Agents; Metformin; Mice; Mice, Inbred C57BL; Ovarian Follicle; Protective Agents; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2021 |
Interleukin‑8 released by cancer‑associated fibroblasts attenuates the autophagy and promotes the migration of ovarian cancer cells.
Topics: Autophagy; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Movement; Cell Proliferation; Culture Media, Conditioned; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Metformin; Microtubule-Associated Proteins; Ovarian Neoplasms; Sirolimus; Tumor Microenvironment; Up-Regulation | 2021 |
Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age.
Topics: Animals; Dogs; Fibroblasts; Longevity; Metformin; Resveratrol; Sirolimus | 2021 |
AMPK Inhibits mTOR-Driven Keratinocyte Proliferation after Skin Damage and Stress.
Topics: Adenylate Kinase; Animals; Cell Proliferation; Cells, Cultured; Energy Metabolism; Keratin-14; Keratinocytes; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Transgenic; Sirolimus; Skin; Stress, Physiological; Ultraviolet Rays | 2021 |
Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment.
Topics: Ascorbic Acid; Cell Differentiation; Cellular Senescence; Humans; Hypoglycemic Agents; Lipidomics; Mesenchymal Stem Cells; Metformin; Pyrazines; Reverse Transcriptase Inhibitors; Sirolimus; Thiones; Thiophenes; Transcriptome | 2021 |
Topical metformin suppresses angiogenesis pathways induced by pulsed dye laser irradiation in animal models.
Topics: Administration, Cutaneous; Animals; Lasers, Dye; Metformin; Models, Animal; Neovascularization, Pathologic; Port-Wine Stain; Rabbits; Rats; Rats, Sprague-Dawley; Sirolimus; Treatment Outcome | 2022 |
Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin.
Topics: Animals; Liver; Metformin; Mice; Proteome; Resveratrol; Sirolimus | 2021 |
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
Topics: Animals; Atrial Natriuretic Factor; Autophagy; Cardiomegaly; Cytomegalovirus Infections; GATA4 Transcription Factor; Metformin; Mice; Myocytes, Cardiac; Polycomb Repressive Complex 1; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Sirolimus; Ubiquitin-Protein Ligases | 2022 |
Combination of mTOR inhibitor PP242 and AMPK activator metformin exerts enhanced inhibitory effects on colorectal carcinoma cells in vitro by blocking multiple kinase pathways.
Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Metformin; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2023 |
mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, Liquid; Energy Metabolism; Insulin-Secreting Cells; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Metformin; Mice; Oxygen; Signal Transduction; Sirolimus; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases | 2022 |
The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts.
Topics: Animals; Cannabidiol; Cellular Senescence; Fibroblasts; Humans; Metformin; Nutrients; Phenotype; Sirolimus | 2022 |
Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Liver; Hyperglycemia; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Inflammation; Insulin; Insulin Resistance; Male; Metabolic Syndrome; Metformin; Mice; Sirolimus | 2022 |
Downregulation of LKB1/AMPK Signaling in Blood Mononuclear Cells Is Associated with the Severity of Guillain-Barre Syndrome.
Topics: AMP-Activated Protein Kinases; Beclin-1; Down-Regulation; Guillain-Barre Syndrome; Humans; Insulins; Metformin; Proto-Oncogene Proteins c-akt; Retrospective Studies; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Treatment effect of metformin combined with atorvastatin in reducing in-stent restenosis after percutaneous coronary intervention in coronary artery disease patients with type 2 diabetic patients.
Topics: Atorvastatin; Blood Glucose; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Diabetes Mellitus, Type 2; Drug-Eluting Stents; Humans; Metformin; Percutaneous Coronary Intervention; Risk Factors; Sirolimus; Stents; Treatment Outcome | 2022 |
Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice.
Topics: Adenosine Triphosphate; Animals; Cell Respiration; Glucose; Graft Rejection; Hyperglycemia; Immunosuppressive Agents; Insulins; Metformin; Mice; Mice, Inbred BALB C; Sirolimus | 2023 |
Metformin Alleviates Sepsis-Associated Myocardial Injury by Enhancing AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway-Mediated Autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Lipopolysaccharides; Mammals; Metformin; Mice; Mice, Inbred C57BL; Sepsis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2023 |