Compounds > metformin

metformin and sirolimus

metformin has been researched along with sirolimus in 132 studies

Research

Studies (132)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (3.79)29.6817
2010's96 (72.73)24.3611
2020's31 (23.48)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME1
Blagosklonny, MV3
Bevan, MJ; Prlic, M1
Del Barco, S; Martin-Castillo, B; Menendez, JA; Oliveras-Ferraros, C; Vazquez-Martin, A1
Blouin, MJ; Piura, E; Pollak, MN; Zakikhani, M1
Allison, DB; Nagy, TR; Smith, DL1
Sharp, ZD1
Ernst, S; Johnson, C; MacKenzie, MJ; Winquist, E1
Antonoff, MB; D'Cunha, J1
Apontes, P; Blagosklonny, MV; Demidenko, ZN; Leontieva, OV; Li, F1
Ebersole, J; González, O; Novak, MJ; Tobia, C1
McCarty, MF1
Steinman, TI1
Chen, SJ; Chen, Y; Dong, LH; Shen, ZX; Shi, WY; Wang, L; Xiao, D; Yan, ZX; Zhao, WL1
Duan, T; Feng, Y; Gu, Y; Liao, H; Zhou, Q1
Eucker, J; Habbel, P; Liu, H; Possinger, K; Regierer, AC; Schefe, JH; Scholz, C; Schulz, CO; Zang, C1
Alain, T; Blouin, MJ; Larsson, O; Morita, M; Pollak, M; Sonenberg, N; Topisirovic, I1
Huang, H; Kang, R; Luo, G; Wang, J; Yang, W; Zhao, Z1
Bennett, RG; Clure, CC; Hamel, FG; Larsen, JL; Shivaswamy, V1
Korsse, SE; Peppelenbosch, MP; van Veelen, W1
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H1
Kisfalvi, K; Ni, Y; Rozengurt, E; Sinnett-Smith, J; Soares, HP1
Akahori, H; Davis, T; Finn, AV; Habib, A; Karmali, V; Kolodgie, FD; Nakano, M; Narula, J; Otsuka, F; Pachura, K; Polavarapu, R; Virmani, R; Yazdani, S1
Baur, JA; Lamming, DW; Sabatini, DM; Ye, L1
Anisimov, VN2
Akahori, H; Finn, AV; Habib, A; Karmali, V; Pachura, K; Polavarapu, R1
Brooks, HL; Chew, WM; Ghosh, S; Goldberg, EL; Hapak, SM; Kusne, Y; Limesand, KH; Maskaykina, IY; Nikolich-Zugich, J; Parker, SS; Price, TJ; Sanai, N1
Abraham, E; Deshane, J; Gao, Y; Jiang, S; Park, DW; Stigler, WS; Tadie, JM; Zmijewski, JW1
Audrezet, MP; Bultynck, G; Corvelyn, A; De Smedt, H; Dechênes, G; Decuypere, JP; Levtchenko, E; Mekahli, D; Missiaen, L; Ong, AC; Parys, JB; Sammels, E; Schoeber, J; van den Heuvel, L; Welkenhuyzen, K; Wilmer, MJ1
Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O1
Endo, H; Hosono, K; Nakajima, A; Takahashi, H1
Selman, C1
Cai, GY; Chen, XM; Cui, SY; Fu, B; Guo, YN; Hong, Q; Hu, X; Lv, Y; Wang, JC; Yin, Z1
De Loof, H; De Meyer, GRY; Martinet, W1
Asatiani, E; Chen, HX; Doyle, LA; Fu, S; Hess, KR; Hong, DS; Kurzrock, R; Liu, X; Lorusso, P; McQuinn, L; Mita, M; Naing, A; Piha-Paul, S1
Wang, XW; Zhang, YJ1
Carlock, C; Chen, J; Chen, JS; Choi, HH; Chou, PC; Ensor, J; Esteva, FJ; Fraser Symmans, W; Fuentes-Mattei, E; Gully, C; Hortobagyi, GN; Lee, MH; Luo, Y; McKeehan, WL; Phan, L; Pusztai, L; Qi, Y; Shin, JH; Velazquez-Torres, G; Wu, Y; Yeung, SC; Zhang, F; Zhang, Y; Zhao, R1
Fontana, L; Kennedy, BK; Longo, VD; Melov, S; Seals, D1
Beijnen, JH; Huitema, AD; Opdam, FL; Schellens, JH1
Bhonde, R; Prakhya, BM; Sharma, S; Venkatesan, V1
Cifarelli, V; Devlin, KL; Dunlap, SM; Huang, J; Hursting, SD; Kaaks, R; Lashinger, LM; Pollak, MN1
Guan, KL; Kim, YC1
Ahmetaga, A; Bano, G; Mason, HD; Pellat, L; Rice, S; Whitehead, SA1
Davogustto, G; Keller, SR; Kundu, BK; Sen, S; Taegtmeyer, H; Zhong, M1
Géranton, SM; Hunt, SP; Jiménez-Díaz, L; Medrano, MC; Obara, I; Signoret-Genest, J1
Blando, J; DiGiovanni, J; Saha, A; Tremmel, L1
Chen, Y; Fang, W; Gao, Y; Huang, S; Jiao, X; Li, Z; Wang, J; Xia, T; Xie, K; Yu, G1
Arnon, R; Goldis, M; Regelmann, MO1
Weintraub, K1
Bednarczyk, RB; Darzynkiewicz, Z; Geliebter, J; Halicka, HD; Hanly, EK; Li, J; Moscatello, AL; Tiwari, RK; Tuli, NY1
Abid, S; Adnot, S; Amsellem, V; Czibik, G; Derumeaux, G; Dubois-Randé, JL; Houssaini, A; Kebe, K; Li, Z; Lipskaia, L; Marcos, E; Parpaleix, A; Pende, M; Rideau, D; Sawaki, D; Treins, C; Wan, F1
Fu, S; Hong, D; Janku, F; Karp, D; Khawaja, MR; Lu, KH; Madhusudanannair, V; McQuinn, LM; Meric-Bernstam, F; Naing, A; Ng, CS; Nick, AM; Piha-Paul, SA; Subbiah, V; Tsimberidou, A1
Bertrand, L; Colin, IM; Craps, J; De Jongh, B; Gérard, AC; Horman, S; Joris, V; Lengelé, B; Many, MC; Sonveaux, P1
Chung, BH; Jin, J; Jin, L; Lim, SW; Yang, CW1
Huffman, DM; LeBrasseur, NK; Schafer, MJ1
Antebi, A; Astle, CM; Bogue, M; de Magalhães, JP; Denzel, MS; Fernandez, E; Flurkey, K; Hamilton, KL; Harrison, DE; Javors, MA; Lamming, DW; Martinez, PA; McCord, JM; Miller, BF; Miller, RA; Müller, M; Nadon, NL; Ndukum, J; Nelson, JF; Rainger, GE; Richardson, A; Sabatini, DM; Salmon, AB; Simpkins, JW; Steegenga, WT; Strong, R1
Austad, SN; Barzilai, N; Halter, JB; Hashmi, SK; Kirkland, JL; Milman, S; Newman, JC1
Li, T; Peng, C; Shen, B; Shen, C; Xie, J; Xu, N; Zhu, Z1
Chung, BH; Jin, J; Jin, L; Kim, HS; Lim, SW; Yang, CW; Yu, JH1
Gifford, B1
Akamatsu, W; Fujioka, M; Hosoya, M; Matsunaga, T; Ogawa, K; Okamoto, S; Okano, H; Sone, T; Ueda, HR; Ukai, H1
Nistala, R; Pulakat, L; Raja, A1
Koliada, A; Lushchak, O; Piskovatska, V; Storey, KB; Strilbytska, O; Vaiserman, A1
Garg, G; Rizvi, SI; Singh, AK; Singh, S1
Niedernhofer, LJ; Robbins, PD1
Chen, J; Fei, DD; Hu, CH; Huang, WT; Jin, Y; Liu, N; Lu, YB; Lv, YJ; Pang, DL; Sui, BD; Xuan, K; Zhao, P; Zheng, CX; Zhou, CH1
Ahn, SW; Hong, SK; Kim, H; Kim, HS; Lee, KW; Mussin, N; Oh, DK; Oh, SC; Park, MY; Seo, S; Suh, KS; Yi, NJ; Yoon, KC1
Gladyshev, VN; Ma, S1
Byun, S; Lee, E; Lee, KW1
Domae, S; Eikawa, S; Furusawa, Y; Hase, K; Hori, S; Kunisada, Y; Sasaki, A; Tomonobu, N; Udono, H; Uehara, T1
Białas, AJ; Górski, P; Makowska, J; Miłkowska-Dymanowska, J; Piotrowski, WJ; Wardzynska, A1
Aliper, A; Artemov, A; Cortese, F; Jellen, L; Karpinsky-Semper, D; Moskalev, A; Swick, AG; Zhavoronkov, A1
Klimova, B; Kuca, K; Novotny, M1
Chung, BH; Jin, J; Jin, L; Lim, SW; Sun, IO; Yang, CW1
Savage, N1
Dembitz, V; Lalic, H; Visnjic, D1
Abrams, SL; Candido, S; Cervello, M; Cocco, L; Follo, MY; Gizak, A; Lertpiriyapong, K; Libra, M; Lombardi, P; Martelli, AM; McCubrey, JA; Montalto, G; Murata, RM; Rakus, D; Ratti, S; Rosalen, PL; Steelman, L; Suh, PG1
Fernandez, E; Liu, Y; Salmon, AB; Strong, R; Weiss, R1
Abdollahi, A; Dehpour, AR; Ghasemnejad-Berenji, H; Ghasemnejad-Berenji, M; Ghazi-Khansari, M; Jafari, A; Mohajer Ansari, J; Nobakht, M; Pashapour, S; Sadeghpour, S; Saeedi Saravi, SS; Yazdani, I1
Bissonnette, MB; Cohen, EEW; Fleming, GF; Gajewski, TF; Janisch, L; Karrison, T; Maitland, M; Pinto, N; Polite, BN; Ratain, MJ; Salgia, R; Sehdev, A; Sharma, MR; Turcich, M; Zha, Y1
Dash, PK; Edagwa, B; Gelbard, H; Gendelman, HE; Gnanadhas, DP; Gorantla, S; Lin, Z; Machhi, J; McMillan, J; Thomas, MB1
Admasu, TD; Barardo, D; Cazenave-Gassiot, A; Chaithanya Batchu, K; Gruber, J; Lam, VYM; Ng, LF; Tolwinski, NS; Wenk, MR; Xiao, L1
Abdellatif, M; Carmona-Gutierrez, D; Kroemer, G; Madeo, F; Sedej, S1
Cai, GY; Chen, XM; Wang, SY1
Abd-Rabbo, D; Aulakh, SK; Garneau, P; Kowarzyk, J; Michnick, SW; Miller-Fleming, L; Ralser, M; Stynen, B1
Korolenko, TA; Pupyshev, AB; Tikhonova, MA1
Bauer, PV; Duca, FA; Lam, TKT; Rasti, M; Rhodes, CJ; Waise, TMZ; Zhang, SY1
Guo, Y; Li, H; Li, J; Li, Z; Liu, Y; Liu, Z; Shang, Y1
Bruns, DR; Hamilton, KL; Konopka, AR; Linden, MA; Miller, BF; Musci, RV; Peelor, FF; Reid, JJ; Wolff, CA1
Hamilton, KL; Linden, MA; Miller, BF; Miller, RA; Peelor, FF; Reid, JJ1
Bernier, M; de Cabo, R; Di Germanio, C; Moats, JM; Palliyaguru, DL1
Ding, Y; Ji, N; Wang, Q; Xia, S; Zhang, P; Zhou, X1
Atrih, A; Cantrell, DA; Dandapani, M; Foretz, M; Grzes, KM; Hardie, DG; Lamont, DJ; Russell, FM; Vara-Ciruelos, D; Viollet, B1
Chai, M; Chu, J; Crooks, GM; de Barros, SC; Doan, NB; Fu, X; Herschman, H; Huang, J; Huang, W; Jiang, M; Jiao, J; Reue, K; Vergnes, L1
Gu, HF; Ma, RD; Nie, YX; Qu, M; Tang, YL; Yang, XY; Yi, JH; Zhou, GJ1
Ghahremani, MH; Montazeri, H; Navabi, S; Nikougoftar, M; Ostad, SN; Roohi, A; Shokri, F1
Azar, ST; Barakat, R; Boutary, S; Costantine, J; Eid, AA; Eid, AH; Eid, S; Haddad, M; Harb, F; Irani, SAM; Kanj, R; Mroueh, FM; Noureldein, M; Ouhtit, A; Sauleau, EA; Zeidan, YH1
Bee, YS; Li, MS; Lin, SH; Sheu, SJ; Shu, CW; Tsen, CL1
O'Neill, LAJ; Pålsson-McDermott, EM1
Yurova, MN1
Cho, ML; Choi, JW; Jung, KA; Kim, DS; Kim, EK; Lee, SY; Min, HK; Na, HS; Park, SH; Ryu, JG1
Choi, YJ1
Carson, RH; Creery, JS; Cutler, KJ; Hamilton, KL; Laurin, JL; Lawrence, MM; Linden, MA; Miller, BF; Musci, RV; Peelor, FF; Porter, H; Price, JC; Reid, JJ; Wolff, CA; Wren, JD; Zhang, Q1
Willyard, C1
Amin, PP; Luu, HS; Mifflin, L; Mookhtiar, AK; Najafov, A; Ordureau, A; Wang, H; Xia, HG; Yuan, J1
Benedetti, F; Buriani, A; Fortinguerra, S; Scapagnini, G; Sorrenti, V; Zella, D1
Chen, MJ; Chen, SU; Chou, CH; Ho, HN; Huang, CC; Shun, CT; Wen, WF; Yang, YS1
Ferraresi, A; Isidoro, C; Jamjuntra, P; Therasakvichya, S; Thongchot, S; Thuwajit, C; Thuwajit, P; Warnnissorn, M1
Cipolli, W; Jimenez, AG; Lalwani, S1
Crane, ED; Crane, JD; O'Neil, G; Wong, W; Zhang, H1
An, H; An, X; Chen, Y; Dai, X; Guan, S; Huang, B; Huang, Q; Liang, L; Lu, M; Lu, X; Nie, H; Wang, H; Wang, J; Wang, Z; Zhang, H1
Garay, RP1
Chen, X; Han, J; Jia, Z; Lin, Y; Liu, H; Mi, Z; Pan, Q; Shi, W; Wang, M; Wang, Z1
Brandon, AE; Cogger, VC; Cooney, GJ; Gokarn, R; Hunt, NJ; James, DE; Le Couteur, DG; Parker, BL; Pulpitel, T; Raubenheimer, D; Senior, AM; Simpson, SJ; Solon-Biet, SM; Wali, JA1
Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J1
Chen, H; Gu, X; Jin, J; Li, Q; Liang, J; Mao, Z; Miao, D; Wang, R; Xie, C; Zhang, Y; Zhou, J; Zuo, G1
Gao, Z; Jin, Z; Sun, C; Yang, X1
Abzalimov, RR; He, Y; Soliman, GA1
Gerasymchuk, M; Kovalchuk, I; Kovalchuk, O; Robinson, GI1
Calcutt, NA; Doty, R; Flurkey, K; Harrison, DE; Koza, RA; Reifsnyder, PC1
Arsenijevic, M; Basta, I; Berisavac, I; Bozovic, I; Mandic, M; Milosevic, E; Nikolic, M; Paunovic, V; Peric, S; Stamenkovic, M; Stevanovic, D; Stevic, Z; Trajkovic, V; Vukovic, I1
Chen, M; Li, M; Liu, S; Ma, F; Su, B; Wang, C; Yuan, L; Zhang, S; Zhang, Y; Zheng, Q1
Albawardi, A; Almarzooqi, S; Elomami, A; Saraswathiamma, D; Sharma, C; Souid, AK1
Cao, J; Chen, M; Gao, Y; Li, K; Li, R; Li, T; Liu, J; Shi, R; Wang, Y; Zhang, W; Zhang, X1

Reviews

34 review(s) available for metformin and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
An anti-aging drug today: from senescence-promoting genes to anti-aging pill.
    Drug discovery today, 2007, Volume: 12, Issue:5-6

    Topics: Aging; Animals; Antioxidants; Caloric Restriction; Cell Cycle Proteins; Cellular Senescence; Drug Delivery Systems; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Longevity; Metformin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Resveratrol; Saccharomyces cerevisiae Proteins; Sirolimus; Sirtuins; Stilbenes

2007
Validation of anti-aging drugs by treating age-related diseases.
    Aging, 2009, Mar-28, Volume: 1, Issue:3

    Topics: Aging; Animals; Antibiotics, Antineoplastic; Antioxidants; Biomarkers; Chronic Disease; Humans; Hypoglycemic Agents; Metformin; Resveratrol; Sirolimus; Stilbenes; Validation Studies as Topic

2009
Calorie restriction: what recent results suggest for the future of ageing research.
    European journal of clinical investigation, 2010, Volume: 40, Issue:5

    Topics: Animals; Antimetabolites; Biomedical Research; Biomimetics; Caloric Restriction; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Longevity; Metformin; Primates; Quality of Life; Resveratrol; Sirolimus; Stilbenes

2010
Aging and TOR: interwoven in the fabric of life.
    Cellular and molecular life sciences : CMLS, 2011, Volume: 68, Issue:4

    Topics: Aging; Animals; Anti-Infective Agents; Humans; Hypoglycemic Agents; Metformin; Sirolimus; TOR Serine-Threonine Kinases

2011
Caloric restriction and chronic inflammatory diseases.
    Oral diseases, 2012, Volume: 18, Issue:1

    Topics: Adaptive Immunity; Animals; Biomimetics; Caloric Restriction; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Insulin-Like Growth Factor I; Metformin; Periodontitis; Resveratrol; Signal Transduction; Sirolimus; Sirtuins; Stilbenes; TOR Serine-Threonine Kinases

2012
Polycystic kidney disease: a 2011 update.
    Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:2

    Topics: Antineoplastic Agents; Benzazepines; Curcumin; Everolimus; Gastrointestinal Agents; Glomerular Filtration Rate; Humans; Hypertension; Hypoglycemic Agents; Immunosuppressive Agents; Indazoles; Kidney; Metformin; Octreotide; Organ Size; Polycystic Kidney, Autosomal Dominant; Sirolimus; Sodium; Tolvaptan

2012
Targeting LKB1 signaling in cancer.
    Biochimica et biophysica acta, 2013, Volume: 1835, Issue:2

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Cell Polarity; Humans; Metformin; Neoplasms; Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2013
Rapalogs and mTOR inhibitors as anti-aging therapeutics.
    The Journal of clinical investigation, 2013, Volume: 123, Issue:3

    Topics: Aging; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Autophagy; Humans; Metformin; Molecular Targeted Therapy; Neoplasms; Sirolimus; Stem Cells; TOR Serine-Threonine Kinases

2013
Colon epithelial proliferation and carcinogenesis in diet-induced obesity.
    Journal of gastroenterology and hepatology, 2013, Volume: 28 Suppl 4

    Topics: Aberrant Crypt Foci; Adiponectin; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Diet, High-Fat; Disease Models, Animal; Epithelial Cells; Humans; Hypoglycemic Agents; Metformin; Mice; Obesity, Abdominal; Risk Factors; Signal Transduction; Sirolimus

2013
Dietary restriction and the pursuit of effective mimetics.
    The Proceedings of the Nutrition Society, 2014, Volume: 73, Issue:2

    Topics: Animals; Caloric Restriction; Energy Intake; Genetic Variation; Health; Humans; Longevity; Metformin; Resveratrol; Sirolimus; Stilbenes

2014
mTOR inhibition: a promising strategy for stabilization of atherosclerotic plaques.
    Atherosclerosis, 2014, Volume: 233, Issue:2

    Topics: Absorbable Implants; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Cholesterol; Clinical Trials as Topic; Coronary Artery Disease; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Dyslipidemias; Everolimus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Macrophages; Metformin; Mice; Mice, Knockout; Plaque, Atherosclerotic; Rabbits; Receptors, LDL; Rupture, Spontaneous; Sirolimus; Swine; Tissue Scaffolds; TOR Serine-Threonine Kinases; Triglycerides

2014
Targeting mTOR network in colorectal cancer therapy.
    World journal of gastroenterology, 2014, Apr-21, Volume: 20, Issue:15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Autophagy; Colorectal Neoplasms; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; MAP Kinase Signaling System; Metformin; Models, Biological; Prognosis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Wnt Proteins

2014
Koschei the immortal and anti-aging drugs.
    Cell death & disease, 2014, Dec-04, Volume: 5

    Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Caloric Restriction; Exercise; Folklore; Gene Expression; Glucose; Humans; Insulin Resistance; Longevity; Metformin; Propranolol; Russia; Sirolimus; TOR Serine-Threonine Kinases

2014
mTOR: a pharmacologic target for autophagy regulation.
    The Journal of clinical investigation, 2015, Volume: 125, Issue:1

    Topics: Animals; Autophagy; Humans; Metformin; Sirolimus; TOR Serine-Threonine Kinases

2015
Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis.
    Cardiology, 2015, Volume: 130, Issue:4

    Topics: 3-O-Methylglucose; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Acids; Glucose-6-Phosphate; Heart Failure; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Hypoglycemic Agents; Metformin; Mice; Myocardium; Positron-Emission Tomography; Rats; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Function, Left

2015
New-onset diabetes mellitus after pediatric liver transplantation.
    Pediatric transplantation, 2015, Volume: 19, Issue:5

    Topics: Albuminuria; Child; Cyclosporine; Diabetes Mellitus; Diabetic Retinopathy; Glucocorticoids; Humans; Hyperlipidemias; Hypertension; Immunosuppressive Agents; Insulin; Liver Failure; Liver Transplantation; Metformin; Pediatrics; Risk Factors; Sirolimus; Tacrolimus

2015
Energetic interventions for healthspan and resiliency with aging.
    Experimental gerontology, 2016, 12-15, Volume: 86

    Topics: Aging; Caloric Restriction; Diet; Energy Intake; Exercise; Female; Humans; Longevity; Male; Metformin; Resveratrol; Sirolimus; Stilbenes

2016
The role of the TOR pathway in mediating the link between nutrition and longevity.
    Mechanisms of ageing and development, 2017, Volume: 164

    Topics: Animals; Humans; Longevity; Metformin; Nutritional Physiological Phenomena; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2017
Molecular signatures of longevity: Insights from cross-species comparative studies.
    Seminars in cell & developmental biology, 2017, Volume: 70

    Topics: Animals; Bowhead Whale; Caloric Restriction; Chiroptera; Gene Expression Regulation, Developmental; Genome; Humans; Insulin-Like Growth Factor I; Killifishes; Longevity; Metabolome; Metformin; Methionine; Mole Rats; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome

2017
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer.
    International journal of molecular sciences, 2017, Sep-12, Volume: 18, Issue:9

    Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Humans; Immune System Diseases; Immunity, Innate; Indoles; Infections; Isoquinolines; Lysosomes; Maprotiline; Metformin; Neoplasms; Phenols; Pyrroles; Resveratrol; Sirolimus; Spermidine; Stilbenes; Tetrahydroisoquinolines; Trehalose

2017
Geroprotectors as a therapeutic strategy for COPD - where are we now?
    Clinical interventions in aging, 2017, Volume: 12

    Topics: Aging; Disease Progression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Melatonin; Metformin; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quality of Life; Sirolimus; Testosterone; Vitamin D

2017
Anti-Aging Drugs - Prospect of Longer Life?
    Current medicinal chemistry, 2018, Volume: 25, Issue:17

    Topics: Animals; Humans; Longevity; Metformin; NAD; Quality of Life; Resveratrol; Sirolimus; Stilbenes

2018
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia.
    Current medicinal chemistry, 2019, Volume: 26, Issue:12

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Metformin; Ribonucleosides; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2019
Autophagy in Cardiovascular Aging.
    Circulation research, 2018, 09-14, Volume: 123, Issue:7

    Topics: Age Factors; Aging; Animals; Autophagy; Caloric Restriction; Cardiovascular Diseases; Cardiovascular System; Health Status; Humans; Longevity; Metformin; Protective Factors; Risk Factors; Sirolimus; Spermidine

2018
Energy restriction in renal protection.
    The British journal of nutrition, 2018, Volume: 120, Issue:10

    Topics: Aging; Animals; Autophagy; Caloric Restriction; Diet; Energy Metabolism; Female; Humans; Inflammation; Insulin; Kidney; Kidney Diseases; Male; Metformin; Models, Animal; Oxidative Stress; Phosphorus; Resveratrol; Salts; Sirolimus; Sirtuin 1

2018
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 2016, Volume: 66, Issue:5

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Clinical Trials as Topic; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Metformin; Molecular Chaperones; Molecular Targeted Therapy; Neuroprotective Agents; Parkinson Disease; Proteasome Endopeptidase Complex; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin

2016
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.
    Mechanisms of ageing and development, 2019, Volume: 180

    Topics: Animals; Caloric Restriction; Frailty; Humans; Longevity; Metformin; Resveratrol; Sirolimus

2019
Targeting immunometabolism as an anti-inflammatory strategy.
    Cell research, 2020, Volume: 30, Issue:4

    Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Dimethyl Fumarate; Glycolysis; Humans; Immunomodulation; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Sirolimus

2020
[Geroprotective drugs - mTOR inhibitors in the treatment of cancer patients.]
    Advances in gerontology = Uspekhi gerontologii, 2019, Volume: 32, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Humans; Metformin; Neoplasms; Sirolimus; TOR Serine-Threonine Kinases

2019
Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology.
    Nutrients, 2020, May-24, Volume: 12, Issue:5

    Topics: Animals; Caloric Restriction; Dermatologic Agents; Fasting; Humans; Inflammation; Metformin; Peroxisome Proliferator-Activated Receptors; Resveratrol; Sirolimus; Skin; Skin Aging; Wound Healing

2020
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways.
    Viruses, 2020, 12-17, Volume: 12, Issue:12

    Topics: Animals; Antiviral Agents; Host-Pathogen Interactions; Humans; Metformin; Resveratrol; Signal Transduction; Sirolimus; Virus Diseases; Virus Replication

2020
Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu.
    Expert opinion on investigational drugs, 2021, Volume: 30, Issue:7

    Topics: Acarbose; Aging; Animals; Drugs, Investigational; Humans; Longevity; Metformin; Nutrients; Sirolimus

2021
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
    Mini reviews in medicinal chemistry, 2022, Volume: 22, Issue:20

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases

2022

Trials

4 trial(s) available for metformin and sirolimus

ArticleYear
A phase I study of temsirolimus and metformin in advanced solid tumours.
    Investigational new drugs, 2012, Volume: 30, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Metformin; Middle Aged; Neoplasms; Ontario; Pilot Projects; Protein Kinase Inhibitors; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Treatment Outcome; Young Adult

2012
Incidence of mucositis in patients treated with temsirolimus-based regimens and correlation to treatment response.
    The oncologist, 2014, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Metformin; Middle Aged; Mucositis; Niacinamide; Protein Kinase Inhibitors; Retrospective Studies; Sirolimus; TOR Serine-Threonine Kinases; Treatment Outcome; Young Adult

2014
Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers.
    Cancer chemotherapy and pharmacology, 2016, Volume: 77, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Maximum Tolerated Dose; Metformin; Middle Aged; Neoplasms; Response Evaluation Criteria in Solid Tumors; Sirolimus; TOR Serine-Threonine Kinases; Young Adult

2016
A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2018, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Drug Synergism; Female; Humans; Leukocytes, Mononuclear; Male; Metformin; Middle Aged; Neoplasms; Phosphorylation; Pilot Projects; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; TOR Serine-Threonine Kinases; Young Adult

2018

Other Studies

94 other study(ies) available for metformin and sirolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
    Nature, 2020, Volume: 583, Issue:7816

    Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins

2020
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
    The Journal of biological chemistry, 2004, Jul-30, Volume: 279, Issue:31

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Elongation Factor 2 Kinase; Enzyme Activation; Green Fluorescent Proteins; Hypertrophy; Hypoglycemic Agents; Immunoblotting; Luminescent Proteins; Metformin; Microscopy, Fluorescence; Multienzyme Complexes; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Ribose; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Time Factors

2004
Immunology: A metabolic switch to memory.
    Nature, 2009, Jul-02, Volume: 460, Issue:7251

    Topics: Animals; CD8-Positive T-Lymphocytes; Cell Differentiation; Fatty Acids; Hypoglycemic Agents; Immunologic Memory; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Multiprotein Complexes; Protein Kinases; Proteins; Sirolimus; TNF Receptor-Associated Factor 6; TOR Serine-Threonine Kinases; Transcription Factors

2009
If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Nov-20, Volume: 27, Issue:33

    Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Clinical Trials as Topic; Drug Delivery Systems; Female; Humans; Metformin; Protein Kinases; Receptor, IGF Type 1; Risk Assessment; Sensitivity and Specificity; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2009
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.
    Breast cancer research and treatment, 2010, Volume: 123, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Separation; Enzyme Activation; Female; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Metformin; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection

2010
Teaching an old drug new tricks: metformin as a targeted therapy for lung cancer.
    Seminars in thoracic and cardiovascular surgery, 2010,Autumn, Volume: 22, Issue:3

    Topics: Antineoplastic Agents; Humans; Hypoglycemic Agents; Lung Neoplasms; Metformin; Sirolimus; Smoking; TOR Serine-Threonine Kinases

2010
Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture.
    Oncotarget, 2011, Volume: 2, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cytoprotection; Epithelial Cells; Fibroblasts; G1 Phase; Humans; Imidazoles; Metformin; Nocodazole; Paclitaxel; Piperazines; Sirolimus; Tumor Suppressor Protein p53

2011
mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets.
    Medical hypotheses, 2011, Volume: 77, Issue:4

    Topics: Adiponectin; Diet, Vegetarian; Dietary Proteins; Down-Regulation; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Neoplasms; Proteins; Sirolimus; TOR Serine-Threonine Kinases

2011
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.
    Cell death & disease, 2012, Mar-01, Volume: 3

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Synergism; Enzyme Activation; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell; Metformin; Mice; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2012
Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway.
    Oncology reports, 2012, Volume: 27, Issue:6

    Topics: Cell Line, Tumor; Female; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Metformin; Neovascularization, Pathologic; Nerve Tissue Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

2012
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.
    Anticancer research, 2012, Volume: 32, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Autophagy; Breast Neoplasms; Carboplatin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Everolimus; Female; Humans; Metformin; Sirolimus; TOR Serine-Threonine Kinases

2012
Distinct perturbation of the translatome by the antidiabetic drug metformin.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Jun-05, Volume: 109, Issue:23

    Topics: Analysis of Variance; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Metformin; Microarray Analysis; Neoplasms; Protein Biosynthesis; Purines; Sirolimus; TOR Serine-Threonine Kinases

2012
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
    Autophagy, 2013, Feb-01, Volume: 9, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Knockdown Techniques; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Metformin; Models, Biological; Multiprotein Complexes; Phenylbutyrates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Virus Replication

2013
Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats.
    Transplantation, 2013, Jan-27, Volume: 95, Issue:2

    Topics: Animals; Apoptosis; Biomarkers; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Immunohistochemistry; Immunosuppressive Agents; In Situ Nick-End Labeling; Insulin; Male; Metformin; Pancreas, Exocrine; Rats; Rats, Sprague-Dawley; Sirolimus; Tacrolimus; Time Factors

2013
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
    Aging, 2012, Volume: 4, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins

2012
Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Antibiotics, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Indoles; Insulin; Metformin; Morpholines; Neurotensin; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Purines; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2013
Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of rapamycin inhibitors via S6 kinase-dependent inhibition of cell proliferation.
    Journal of the American College of Cardiology, 2013, Mar-05, Volume: 61, Issue:9

    Topics: Administration, Oral; Animals; Aorta; Apoptosis; Cell Proliferation; Cells, Cultured; Drug Interactions; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Humans; Iliac Artery; Metformin; Microscopy, Electron, Scanning; Rabbits; Ribosomal Protein S6 Kinases; Sirolimus

2013
Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer.
    Aging, 2013, Volume: 5, Issue:5

    Topics: Aging; Animals; Cellular Senescence; Gene Expression Regulation; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Metformin; Neoplasms; Sirolimus; TOR Serine-Threonine Kinases

2013
Multifaceted aging and rapamycin.
    Aging, 2013, Volume: 5, Issue:7

    Topics: Aging; Animals; Gene Expression Regulation; Hypoglycemic Agents; Immunosuppressive Agents; Mammals; Metformin; Signal Transduction; Sirolimus

2013
Metformin impairs endothelialization after placement of newer generation drug eluting stents.
    Atherosclerosis, 2013, Volume: 229, Issue:2

    Topics: Angioplasty, Balloon; Animals; Disease Models, Animal; Drug-Eluting Stents; Endothelium, Vascular; Everolimus; Hypoglycemic Agents; Iliac Artery; Immunosuppressive Agents; Male; Metformin; Paclitaxel; Rabbits; Sirolimus; Thrombosis; Tubulin Modulators

2013
Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Animals; Apoptosis; Hippocampus; Immunohistochemistry; Injections, Intraperitoneal; Longevity; Metformin; Mice; Mice, Inbred C57BL; Phosphorylation; Signal Transduction; Sirolimus; Stem Cells; TOR Serine-Threonine Kinases

2014
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing.
    Molecular medicine (Cambridge, Mass.), 2013, Nov-08, Volume: 19

    Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bacteremia; Chemotaxis, Leukocyte; Enzyme Activation; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Male; Metformin; Mice; Mice, Inbred C57BL; Neutrophils; Peritonitis; Phagocytosis; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Sirolimus

2013
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
    Pflugers Archiv : European journal of physiology, 2014, Volume: 466, Issue:8

    Topics: Animals; Drug Synergism; Gene Knockdown Techniques; Humans; Metformin; Mice; Mutation; Polycystic Kidney, Autosomal Dominant; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; TRPP Cation Channels; Up-Regulation

2014
Metformin inhibits skin tumor promotion in overweight and obese mice.
    Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:1

    Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Insulin; Insulin-Like Growth Factor I; Leptin; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Obese; Multiprotein Complexes; Neoplasms, Experimental; Obesity; Overweight; Papilloma; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases

2014
AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions.
    Experimental gerontology, 2014, Volume: 51

    Topics: AMP-Activated Protein Kinases; Cells, Cultured; Cellular Senescence; Connexin 43; Cyclin-Dependent Kinase Inhibitor p21; Diabetic Nephropathies; Down-Regulation; Glucose; Humans; Hypoglycemic Agents; Kidney Glomerulus; Mesangial Cells; Metformin; Signal Transduction; Sirolimus; Sweetening Agents; TOR Serine-Threonine Kinases

2014
Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.
    Journal of the National Cancer Institute, 2014, Volume: 106, Issue:7

    Topics: Adipocytes; Adipokines; Aged; Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Everolimus; Female; Humans; Kaplan-Meier Estimate; Metformin; Mice; Mice, Transgenic; Middle Aged; Obesity; Postmenopause; Prospective Studies; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome

2014
Medical research: treat ageing.
    Nature, 2014, Jul-24, Volume: 511, Issue:7510

    Topics: Age of Onset; Aging; Animals; Biomarkers; Biomedical Research; Caloric Restriction; Clinical Trials as Topic; Diet; Exercise; Geriatrics; Health; Humans; Longevity; Metformin; Models, Animal; Precision Medicine; Preventive Medicine; Rejuvenation; Sirolimus

2014
[Hyperglycaemia during treatment with everolimus].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158

    Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Everolimus; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Metformin; Neoplasm Recurrence, Local; Sirolimus; TOR Serine-Threonine Kinases

2014
Human mesenchymal stem cells as a novel platform for simultaneous evaluation of cytotoxicity and genotoxicity of pharmaceuticals.
    Mutagenesis, 2015, Volume: 30, Issue:3

    Topics: Adult; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dimethyl Sulfoxide; DNA Damage; Drug Evaluation, Preclinical; Ethanol; Female; Humans; Mesenchymal Stem Cells; Metformin; Micronucleus Tests; Mutagens; Sirolimus

2015
Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms.
    Diabetes, 2015, Volume: 64, Issue:5

    Topics: Animals; Body Weight; Cell Cycle; Diet, Diabetic; Energy Intake; Glucose Intolerance; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; MicroRNAs; Neoplasms, Experimental; Pancreatic Neoplasms; Prediabetic State; Random Allocation; Sirolimus; Snail Family Transcription Factors; Transcription Factors; Vimentin

2015
Dual effect of metformin on growth inhibition and oestradiol production in breast cancer cells.
    International journal of molecular medicine, 2015, Volume: 35, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Metformin; Sirolimus

2015
Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice.
    Pain, 2015, Volume: 156, Issue:8

    Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Histamine; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Neuralgia; Phosphoproteins; Protein Kinase Inhibitors; Pruritus; Signal Transduction; Sirolimus; Skin; TOR Serine-Threonine Kinases; Treatment Outcome

2015
Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice.
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:7

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Proliferation; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Metformin; Mice; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Sirolimus

2015
Metformin potentiates rapamycin and cisplatin in gastric cancer in mice.
    Oncotarget, 2015, May-20, Volume: 6, Issue:14

    Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Cycle; Cisplatin; Disease Models, Animal; Female; Flow Cytometry; Humans; Immunohistochemistry; Male; Metformin; Mice; Middle Aged; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Signal Transduction; Sirolimus; Stomach Neoplasms; Transcriptome; Xenograft Model Antitumor Assays

2015
Can We Stop Aging?
    Scientific American, 2015, Volume: 313, Issue:1

    Topics: Aged, 80 and over; Aging; Animals; Bone Morphogenetic Proteins; Chronic Disease; Everolimus; Growth Differentiation Factors; Humans; Longevity; Metformin; Sirolimus

2015
mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib.
    Oncotarget, 2015, Nov-24, Volume: 6, Issue:37

    Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hypoglycemic Agents; Indoles; Metformin; Microscopy, Fluorescence; Mutation; Proto-Oncogene Proteins B-raf; Sirolimus; Sulfonamides; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Vemurafenib

2015
Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:3

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chronic Disease; Gene Deletion; Hyperplasia; Hypertension, Pulmonary; Hypoxia; Lung; Male; Metformin; Mice; Microfilament Proteins; Muscle Proteins; Muscle, Smooth; Myocytes, Smooth Muscle; Pulmonary Artery; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins

2016
Involvement of mTOR and Regulation by AMPK in Early Iodine Deficiency-Induced Thyroid Microvascular Activation.
    Endocrinology, 2016, Volume: 157, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Cell Proliferation; Female; Humans; In Vitro Techniques; Iodine; Male; Metformin; Mice; Mice, Knockout; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Thyroid Gland; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

2016
Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus.
    Translational research : the journal of laboratory and clinical medicine, 2016, Volume: 174

    Topics: Animals; Apoptosis; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Exenatide; Hyperglycemia; Islets of Langerhans; Male; Metformin; Mitochondria; Oxidative Stress; Peptides; Piperidones; Pyrimidines; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Venoms

2016
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.
    Aging cell, 2016, Volume: 15, Issue:5

    Topics: Acarbose; alpha-Glucosidases; Animals; Antioxidants; Drugs, Chinese Herbal; Estradiol; Fish Oils; Glycoside Hydrolase Inhibitors; Hand Strength; Longevity; Male; Masoprocol; Metformin; Mice; NF-E2-Related Factor 2; Rotarod Performance Test; Sirolimus; Survival Analysis; Ursodeoxycholic Acid

2016
Strategies and Challenges in Clinical Trials Targeting Human Aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2016, Volume: 71, Issue:11

    Topics: Acarbose; Aging; Animals; Anti-Bacterial Agents; Biomedical Research; Clinical Trials as Topic; Congresses as Topic; Disease Models, Animal; Drug Evaluation; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Research Design; Sirolimus

2016
Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantation.
    Oncotarget, 2016, Sep-20, Volume: 7, Issue:38

    Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Female; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Metformin; Mice; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Transplantation; Phosphorylation; Sirolimus; Treatment Outcome

2016
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats.
    The Korean journal of internal medicine, 2017, Volume: 32, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Islets of Langerhans; Kidney Transplantation; Metformin; Rats; Rats, Sprague-Dawley; Sirolimus; Tacrolimus

2017
Living to 120.
    Scientific American, 2016, Aug-16, Volume: 315, Issue:3

    Topics: Acarbose; Aging; AMP-Activated Protein Kinases; Animals; Diet; Humans; Life Expectancy; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Sirolimus; TOR Serine-Threonine Kinases

2016
Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.
    Cell reports, 2017, 01-03, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Cell Line; Child; Child, Preschool; Cochlea; Female; Goiter, Nodular; Hearing Loss; Hearing Loss, Sensorineural; Human Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Infant, Newborn; Ion Exchange; Membrane Transport Proteins; Metformin; Phenotype; Protein Aggregates; Sirolimus; Sulfate Transporters; Vestibular Aqueduct

2017
mTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:3

    Topics: Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Protein Kinase Inhibitors; Proteinuria; Rats, Zucker; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases

2017
Synergistic Effect of Rapamycin and Metformin Against Age-Dependent Oxidative Stress in Rat Erythrocytes.
    Rejuvenation research, 2017, Volume: 20, Issue:5

    Topics: Acetylcholinesterase; Aging; Animals; Cell Membrane; Erythrocytes; Glutathione; Iron; Lipid Peroxidation; Male; Metformin; Oxidation-Reduction; Oxidative Stress; Plasma; Protective Agents; Protein Carbonylation; Rats, Wistar; Reactive Oxygen Species; Sirolimus

2017
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2
    Aging cell, 2017, Volume: 16, Issue:4

    Topics: Animals; Cellular Senescence; Drug Evaluation, Preclinical; Free Radical Scavengers; Healthy Lifestyle; Humans; Longevity; Metformin; Models, Animal; NAD; Sirolimus; Stem Cell Factor; Stem Cell Transplantation; Stem Cells

2017
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.
    Aging cell, 2017, Volume: 16, Issue:5

    Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; Female; Gene Expression Regulation; Metformin; Mice; Neovascularization, Physiologic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Resveratrol; Ribosomal Protein S6 Kinases; Sirolimus; Skin; Skin Aging; Stilbenes; Tumor Suppressor Protein p53; Wound Healing; Wounds, Nonpenetrating

2017
Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
    Journal of Korean medical science, 2017, Volume: 32, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; HCT116 Cells; HT29 Cells; Humans; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Smad3 Protein; Tacrolimus; Transplantation, Heterologous

2017
Attenuation of CD4
    EBioMedicine, 2017, Volume: 25

    Topics: AMP-Activated Protein Kinase Kinases; Antigens, CD; Cell Differentiation; CTLA-4 Antigen; Forkhead Transcription Factors; Gene Expression Regulation; Glucose Transporter Type 1; Humans; Integrin alpha Chains; Interleukin-10; Lectins, C-Type; Mechanistic Target of Rapamycin Complex 1; Metformin; Neoplasms; Protein Kinases; Receptors, Immunologic; Sirolimus; T-Lymphocytes, Regulatory; Trans-Activators; Tumor Microenvironment

2017
Towards natural mimetics of metformin and rapamycin.
    Aging, 2017, 11-15, Volume: 9, Issue:11

    Topics: Computational Biology; Databases, Genetic; Dietary Supplements; Drug Discovery; Gene Regulatory Networks; High-Throughput Screening Assays; Humans; Machine Learning; Metformin; Molecular Mimicry; Molecular Structure; Molecular Targeted Therapy; Neural Networks, Computer; Protein Interaction Maps; Protein Kinase Inhibitors; Signal Transduction; Sirolimus; Structure-Activity Relationship; TOR Serine-Threonine Kinases

2017
The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus.
    The Korean journal of internal medicine, 2019, Volume: 34, Issue:2

    Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Hypoglycemic Agents; Islets of Langerhans; Male; Metformin; Mitochondria; Random Allocation; Rats, Sprague-Dawley; Sirolimus; Ubiquinone; Vitamins

2019
New tricks from old dogs join the fight against ageing.
    Nature, 2017, 12-14, Volume: 552, Issue:7684

    Topics: Aging; Animals; Autophagy; Biomedical Research; Caenorhabditis elegans; Cellular Senescence; Diet, Healthy; DNA Damage; Dogs; Drosophila melanogaster; Everolimus; Exercise; Health; Heart; Humans; Immunity; Life Expectancy; Longevity; Metformin; Mice; Quality of Life; Rejuvenation; Saccharomyces cerevisiae; Sirolimus; Social Support; Stress, Psychological; Telomere Shortening; TOR Serine-Threonine Kinases

2017
Metformin influences drug sensitivity in pancreatic cancer cells.
    Advances in biological regulation, 2018, Volume: 68

    Topics: Animals; Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Metformin; Pancreatic Neoplasms; Signal Transduction; Sirolimus

2018
Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice.
    Aging, 2018, 03-22, Volume: 10, Issue:3

    Topics: Aging; Animals; Female; Glucose; Glucose Intolerance; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Mice; Random Allocation; Sex Factors; Sirolimus

2018
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 105

    Topics: Animals; Apoptosis; Drug Synergism; Male; Metformin; Oxidative Stress; Rats, Wistar; Reperfusion Injury; Sirolimus; Spermatic Cord Torsion; Testis

2018
Modulating cellular autophagy for controlled antiretroviral drug release.
    Nanomedicine (London, England), 2018, Volume: 13, Issue:17

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Autophagy; beta-Cyclodextrins; Cell Survival; Clomipramine; Clonidine; Drug Carriers; Drug Interactions; Drug Liberation; HIV-1; Humans; Macrophages; Metformin; Nanoparticles; Particle Size; Pyridines; Pyrroles; Sirolimus; Tissue Distribution

2018
Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.
    Developmental cell, 2018, 10-08, Volume: 47, Issue:1

    Topics: Aging; Allantoin; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Drosophila melanogaster; Drug Synergism; Ficusin; Gene Expression Regulation; Gene Regulatory Networks; Insulin-Like Growth Factor I; Lipid Metabolism; Lipids; Longevity; Metformin; Rifampin; Signal Transduction; Sirolimus; Sterol Regulatory Element Binding Protein 1; Transcriptome; Transforming Growth Factor beta

2018
Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics.
    Cell, 2018, 11-15, Volume: 175, Issue:5

    Topics: Diabetes Mellitus, Type 2; Genetic Complementation Test; Humans; Iron; Metalloproteins; Metformin; Saccharomyces cerevisiae; Sirolimus

2018
Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
    Nature communications, 2019, 02-12, Volume: 10, Issue:1

    Topics: Adenoviridae; Animals; Blood Glucose; Diet, High-Fat; Glucose; Homeostasis; Insulin Resistance; Intestine, Small; Male; Metformin; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2019
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
    Spine, 2019, Aug-01, Volume: 44, Issue:15

    Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; Male; Metformin; Neurons; Nucleus Pulposus; Pain; Phosphorylation; Radiculopathy; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Spinal Nerve Roots; TOR Serine-Threonine Kinases

2019
Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 01-01, Volume: 75, Issue:1

    Topics: Autophagy; Blotting, Western; Cells, Cultured; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Longevity; Lysosomes; Metformin; Muscle Fibers, Skeletal; Myoblasts; Protein Biosynthesis; Proteostasis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2020
Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 01-01, Volume: 75, Issue:1

    Topics: Animals; Blotting, Western; Brain; Female; Hypoglycemic Agents; Immunosuppressive Agents; Longevity; Male; Metformin; Mice; Models, Animal; Protein Biosynthesis; Signal Transduction; Sirolimus

2020
Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression.
    Journal of periodontology, 2019, Volume: 90, Issue:9

    Topics: Animals; Diabetes Mellitus, Experimental; Interleukin-1beta; Metformin; Mice; NIMA-Related Kinases; NLR Family, Pyrin Domain-Containing 3 Protein; Periodontitis; Sirolimus; TOR Serine-Threonine Kinases; X-Ray Microtomography

2019
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.
    Cell reports, 2019, 04-16, Volume: 27, Issue:3

    Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Disease Models, Animal; Disease-Free Survival; Female; Glycolysis; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenformin; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; PTEN Phosphohydrolase; Signal Transduction; Sirolimus

2019
Stimulation of Hair Growth by Small Molecules that Activate Autophagy.
    Cell reports, 2019, 06-18, Volume: 27, Issue:12

    Topics: Aging; Allyl Compounds; Alopecia; AMP-Activated Protein Kinases; Animals; Autophagy; Butyrates; Cell Division; Female; Hair; Hair Follicle; Ketoglutaric Acids; Male; Metformin; Mice; Mice, Inbred C57BL; Oligomycins; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2019
Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling.
    CNS neuroscience & therapeutics, 2020, Volume: 26, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Corticosterone; Enzyme Activation; Flow Cytometry; Lysosomes; Metformin; Microtubule-Associated Proteins; PC12 Cells; Phagosomes; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2020
High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells.
    Current molecular medicine, 2019, Volume: 19, Issue:9

    Topics: Apoptosis; Blood Glucose; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Gene Expression; Glucose; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Metformin; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus

2019
Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:12

    Topics: AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Blood Glucose; Caco-2 Cells; Diabetes Mellitus, Experimental; DNA Damage; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidase 4; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation

2019
Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020, Volume: 258, Issue:3

    Topics: Adult; Animals; Apoptosis; Cell Survival; Cells, Cultured; Coloring Agents; Disease Models, Animal; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Metformin; Rats; Retinal Diseases; Retinal Pigment Epithelium; Sirolimus

2020
Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome.
    Arthritis research & therapy, 2020, 04-10, Volume: 22, Issue:1

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Hypoglycemic Agents; Immunosuppressive Agents; Metabolic Syndrome; Metformin; Mice; Mitochondria; Obesity; Sirolimus

2020
Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin.
    GeroScience, 2021, Volume: 43, Issue:2

    Topics: Animals; Female; Longevity; Male; Metformin; Mice; Protein Biosynthesis; Sex Characteristics; Sirolimus

2021
How anti-ageing drugs could boost COVID vaccines in older people.
    Nature, 2020, Volume: 586, Issue:7829

    Topics: Adult; Aged; Aging; Animals; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Female; Humans; Male; Metformin; Mice; Pandemics; Pneumonia, Viral; Rejuvenation; Sirolimus; TOR Serine-Threonine Kinases; Viral Vaccines

2020
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
    Molecular cell, 2021, 01-21, Volume: 81, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Autophagy-Related Protein 5; Caspase 8; Cell Death; Fas-Associated Death Domain Protein; Gene Expression Regulation; Glucose; HEK293 Cells; HT29 Cells; Humans; Intestine, Large; Jurkat Cells; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus; Tuberous Sclerosis Complex 2 Protein

2021
Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy.
    Molecular human reproduction, 2021, 01-22, Volume: 27, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cells, Cultured; Cyclophosphamide; Everolimus; Female; Fertility; Hypoglycemic Agents; Metformin; Mice; Mice, Inbred C57BL; Ovarian Follicle; Protective Agents; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2021
Interleukin‑8 released by cancer‑associated fibroblasts attenuates the autophagy and promotes the migration of ovarian cancer cells.
    International journal of oncology, 2021, Volume: 58, Issue:5

    Topics: Autophagy; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Movement; Cell Proliferation; Culture Media, Conditioned; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Metformin; Microtubule-Associated Proteins; Ovarian Neoplasms; Sirolimus; Tumor Microenvironment; Up-Regulation

2021
Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age.
    GeroScience, 2021, Volume: 43, Issue:4

    Topics: Animals; Dogs; Fibroblasts; Longevity; Metformin; Resveratrol; Sirolimus

2021
AMPK Inhibits mTOR-Driven Keratinocyte Proliferation after Skin Damage and Stress.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:9

    Topics: Adenylate Kinase; Animals; Cell Proliferation; Cells, Cultured; Energy Metabolism; Keratin-14; Keratinocytes; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Transgenic; Sirolimus; Skin; Stress, Physiological; Ultraviolet Rays

2021
Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment.
    Aging, 2021, 03-26, Volume: 13, Issue:7

    Topics: Ascorbic Acid; Cell Differentiation; Cellular Senescence; Humans; Hypoglycemic Agents; Lipidomics; Mesenchymal Stem Cells; Metformin; Pyrazines; Reverse Transcriptase Inhibitors; Sirolimus; Thiones; Thiophenes; Transcriptome

2021
Topical metformin suppresses angiogenesis pathways induced by pulsed dye laser irradiation in animal models.
    Experimental dermatology, 2022, Volume: 31, Issue:3

    Topics: Administration, Cutaneous; Animals; Lasers, Dye; Metformin; Models, Animal; Neovascularization, Pathologic; Port-Wine Stain; Rabbits; Rats; Rats, Sprague-Dawley; Sirolimus; Treatment Outcome

2022
Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin.
    Cell metabolism, 2021, 12-07, Volume: 33, Issue:12

    Topics: Animals; Liver; Metformin; Mice; Proteome; Resveratrol; Sirolimus

2021
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.
    Clinical and translational medicine, 2022, Volume: 12, Issue:4

    Topics: Animals; Atrial Natriuretic Factor; Autophagy; Cardiomegaly; Cytomegalovirus Infections; GATA4 Transcription Factor; Metformin; Mice; Myocytes, Cardiac; Polycomb Repressive Complex 1; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Sirolimus; Ubiquitin-Protein Ligases

2022
Combination of mTOR inhibitor PP242 and AMPK activator metformin exerts enhanced inhibitory effects on colorectal carcinoma cells in vitro by blocking multiple kinase pathways.
    Journal of chemotherapy (Florence, Italy), 2023, Volume: 35, Issue:3

    Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Metformin; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2023
mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
    Nutrients, 2022, Jul-22, Volume: 14, Issue:15

    Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, Liquid; Energy Metabolism; Insulin-Secreting Cells; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Metformin; Mice; Oxygen; Signal Transduction; Sirolimus; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases

2022
The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts.
    International journal of molecular sciences, 2022, Aug-08, Volume: 23, Issue:15

    Topics: Animals; Cannabidiol; Cellular Senescence; Fibroblasts; Humans; Metformin; Nutrients; Phenotype; Sirolimus

2022
Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice.
    Aging cell, 2022, Volume: 21, Issue:9

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Liver; Hyperglycemia; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Inflammation; Insulin; Insulin Resistance; Male; Metabolic Syndrome; Metformin; Mice; Sirolimus

2022
Downregulation of LKB1/AMPK Signaling in Blood Mononuclear Cells Is Associated with the Severity of Guillain-Barre Syndrome.
    Cells, 2022, 09-16, Volume: 11, Issue:18

    Topics: AMP-Activated Protein Kinases; Beclin-1; Down-Regulation; Guillain-Barre Syndrome; Humans; Insulins; Metformin; Proto-Oncogene Proteins c-akt; Retrospective Studies; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2022
Treatment effect of metformin combined with atorvastatin in reducing in-stent restenosis after percutaneous coronary intervention in coronary artery disease patients with type 2 diabetic patients.
    Medicine, 2022, Oct-14, Volume: 101, Issue:41

    Topics: Atorvastatin; Blood Glucose; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Diabetes Mellitus, Type 2; Drug-Eluting Stents; Humans; Metformin; Percutaneous Coronary Intervention; Risk Factors; Sirolimus; Stents; Treatment Outcome

2022
Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice.
    International journal of molecular sciences, 2023, Jan-08, Volume: 24, Issue:2

    Topics: Adenosine Triphosphate; Animals; Cell Respiration; Glucose; Graft Rejection; Hyperglycemia; Immunosuppressive Agents; Insulins; Metformin; Mice; Mice, Inbred BALB C; Sirolimus

2023
Metformin Alleviates Sepsis-Associated Myocardial Injury by Enhancing AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway-Mediated Autophagy.
    Journal of cardiovascular pharmacology, 2023, 10-01, Volume: 82, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Lipopolysaccharides; Mammals; Metformin; Mice; Mice, Inbred C57BL; Sepsis; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2023