metformin and simvastatin

metformin has been researched along with simvastatin in 68 studies

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.47)18.2507
2000's11 (16.18)29.6817
2010's41 (60.29)24.3611
2020's15 (22.06)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Taskinen, MR1
Abourjaily, HM; Alsheikh-Ali, AA; Karas, RH1
Hoogwerf, BJ; Nambi, V; Sprecher, DL1
Bulcão, C; Ferreira, SR; Giuffrida, FM; Ribeiro-Filho, FF1
Bulcão, C; Ribeiro-Filho, FF; Roberta Ferreira, SG; Sañudo, A1
Arulmozhi, DK; Bodhankar, SL; Kurian, R; Veeranjaneyulu, A1
De Flines, J; Jandrain, BJ; Radermecker, RP; Scheen, AJ1
Akinci, B; Bayraktar, F; Comlekci, A; Demir, T; Ozcan, MA; Yener, S; Yesil, S; Yuksel, F1
Banaszewska, B; Duleba, AJ; Pawelczyk, L; Spaczynski, RZ2
Asadi, N; Dehbashi, S; Ghaffarpasand, F; Kazerooni, T; Kazerooni, Y; Shojaei-Baghini, A1
Gdula-Dymek, A; Krysiak, R; Okopien, B1
Balink, H; de Graaf, W; Grond, J; Hemmelder, MH1
Hart, RJ; Hunter, T; Raval, AD; Stuckey, B1
Fouladi, RF; Navali, N; Nikpour, MA; Pourabolghasem, S1
Krysiak, R; Okopien, B3
Cai, L; Farabaugh, J; Farber, L; Li, F; Zhang, D1
Banaszewska, B; Duleba, A; Karakas, SE; Pawelczyk, L; Spaczynski, RZ1
Björnsson, E; Enders, F; Lindor, KD; Suwanwalaikorn, S; Treeprasertsuk, S1
Gao, Q; Shen, S; Wang, Y; Xia, Yj; Yi, L; Zhang, C; Zhang, X1
Babcook, MA; Daneshgari, F; Flask, CA; Fu, P; Gupta, S; Lindner, DJ; MacLennan, GT; Molter, JP; Oak, CZ; Parker, Y; Puchowicz, MA; Shukla, S; Vazquez, EJ1
Almasan, A; Babcook, MA; Daneshgari, F; Fujioka, H; Gupta, S; Nanavaty, RR; Shukla, S; Sramkoski, RM1
Chen, XY; Lan, D; Li, T; Liu, LM; Tian, KL; Wu, Y; Yang, GM; Zhu, Y1
Choudhry, NK; Gagne, JJ; Kesselheim, AS; Landon, J; Wang, B1
Bourre, B; Lefaucheur, R; Maltête, D; Ozkul-Wermester, O; Wallon, D1
Bednarska-Czerwińska, A; Kowalcze, K; Krysiak, R; Okopień, B1
Bläuer, M; Murtola, TJ; Pennanen, P; Savinainen, K; Syvälä, H; Tammela, TLJ; Ylikomi, T1
Klein, JD; Sands, JM1
Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S1
El-Zaher, AA; Elkady, EF; Elwy, HM; Saleh, MAEM1
Aicher, B; Ammer, N; Britz, H; Hanke, N; Lehr, T; Moj, D; Sindermann, H; Teifel, M; Wojtyniak, JG1
Ampuero, J; Del Campo, JA; Gallego, P; Gallego-Durán, R; García-Valdecasas, M; Gil-Gómez, A; Grande, L; Muntané, J; Padillo, FJ; Pastor, H; Rojas, Á; Romero-Gómez, M1
Mahmud, G; Malik, M; Tasnim, N1
Bech, AP; Nijenhuis, T; Wetzels, JFM1
Hefzy, E; Seyam, E1
Bumbasirevic, V; Ciric, D; Kravic-Stevovic, T; Martinovic, T; Petricevic, S; Trajkovic, V1
Gu, YY; Guan, QB; Jing, F; Yang, S; Yu, CX1
Bhakoo, KK; Boominathan, R; Chan, K; Cheng, P; Goggi, JL; Haslop, A; Robins, EG; Soh, V1
Kim, JS; Rodriguez, GC; Rosales, R; Thaete, LG; Turbov, J1
Bakar, NKA; Kafeenah, HIS; Osman, R1
Alhambra-Expósito, MR; Barrera-Martín, A; Blanco-Acevedo, C; Castaño, JP; Dios, E; Fanciulli, A; Fuentes-Fayos, AC; Gahete, MD; Gálvez-Moreno, MA; Granata, R; Herrera-Martínez, AD; Kineman, RD; L-López, F; Luque, RM; Moreno-Moreno, P; Solivera, J; Soto-Moreno, A; Vázquez-Borrego, MC; Venegas-Moreno, E1
d'Auriol, M; de Souza Santos, LV; Jacob, RS; Lange, LC; Lebron, YAR; Moreira, VR1
Brunicardi, FC; Creeden, JF; Damoiseaux, R; Erhardt, P; Kalinoski, A; Liu, SH; Markowiak, S; Nemunaitis, J; Sanchez, R; Sutton, JM; Yu, J; Zhang, JT1
Hansen, HS; Jessen, JB; Johannsen, ML; Munkboel, CH; Styrishave, B1
Glick, A; Johnson, C; Sista, V1
Meng, J; Zhu, Y1
Chen, L; Liu, Y; Shao, Y; Xie, J; Zhu, G1
Ćosić, V; Jakab, J; Mikšić, Š; Miškić, B; Nakić, D; Tušek, I; Včev, A; Volarić, N; Zjalić, M1
da Silva, SVS; de Carvalho, WC; de Freitas Santos Júnior, A; de Jesus, ACL; de Sousa, TL; Dos Santos, LC; Korn, MDGA; Santos, DCMB; Souza, LA1
Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE1
Chen, H; Gao, X; Li, J; Li, Y; Liu, J; Liu, P; Ren, Y; Song, S; Wang, B; Wang, H; Wang, R; Wang, Y; Zhang, M1
Castro-Santos, P; Díaz-Peña, R; Olloquequi, J1
Bumbasirevic, V; Ciric, D; Jovanovic, S; Kravic-Stevovic, T; Martinovic, T; Petricevic, S; Trajkovic, V1
Blanco-Acevedo, C; Castaño, JP; Doval-Rosa, C; Fuentes-Fayos, AC; G-García, ME; Gahete, MD; Jiménez-Vacas, JM; López, M; Luque, RM; Martín-Colom, J; Montero-Hidalgo, AJ; Ortega-Salas, RM; Peralbo-Santaella, E; Pérez-Gómez, JM; Sánchez-Sánchez, R; Solivera, J; Tena-Sempere, M; Toledano-Delgado, Á; Torres, E1
Hao, SL; Meng, XY; Zhang, CL1

Reviews

9 review(s) available for metformin and simvastatin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Strategies for the management of diabetic dyslipidaemia.
    Drugs, 1999, Volume: 58 Suppl 1

    Topics: Arteriosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metformin; Risk Factors; Simvastatin

1999
A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia.
    Cleveland Clinic journal of medicine, 2002, Volume: 69, Issue:12

    Topics: Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Hyperinsulinism; Hypertension; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metabolic Syndrome; Metformin; Motor Activity; Obesity; Simvastatin; Thiazoles; Thiazolidinediones; Weight Loss

2002
Statins for women with polycystic ovary syndrome not actively trying to conceive.
    The Cochrane database of systematic reviews, 2011, Oct-05, Issue:10

    Topics: Adult; Atorvastatin; Female; Heptanoic Acids; Hirsutism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Menstruation Disturbances; Metformin; Polycystic Ovary Syndrome; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Young Adult

2011
Physiological insights into novel therapies for nephrogenic diabetes insipidus.
    American journal of physiology. Renal physiology, 2016, 12-01, Volume: 311, Issue:6

    Topics: Adenylate Kinase; Animals; Aquaporin 2; Diabetes Insipidus, Nephrogenic; Erlotinib Hydrochloride; Humans; Metformin; Mutation; Phosphorylation; Receptors, Vasopressin; Sildenafil Citrate; Simvastatin

2016
The Effect of Statins on Levels of Dehydroepiandrosterone (DHEA) in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Jan-20, Volume: 25

    Topics: Adult; Atorvastatin; China; Dehydroepiandrosterone; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Middle Aged; Polycystic Ovary Syndrome; Simvastatin

2019
Efficacy of simvastatin plus metformin for polycystic ovary syndrome: A meta-analysis of randomized controlled trials.
    European journal of obstetrics, gynecology, and reproductive biology, 2021, Volume: 257

    Topics: Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Simvastatin

2021
The efficacy and safety of metformin combined with simvastatin in the treatment of polycystic ovary syndrome: A meta-analysis and systematic review.
    Medicine, 2021, Aug-06, Volume: 100, Issue:31

    Topics: Blood Glucose; Cholesterol; Drug Therapy, Combination; Female; Gonadal Steroid Hormones; Humans; Insulin; Lipoproteins, LDL; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Simvastatin; Triglycerides

2021
Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
    Medicine, 2023, Oct-13, Volume: 102, Issue:41

    Topics: Atorvastatin; Female; Humans; Metformin; Network Meta-Analysis; Polycystic Ovary Syndrome; Simvastatin; Spironolactone; Testosterone

2023

Trials

16 trial(s) available for metformin and simvastatin

ArticleYear
Are the beneficial cardiovascular effects of simvastatin and metformin also associated with a hormone-dependent mechanism improving insulin sensitivity?
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:2

    Topics: Adiponectin; Adolescent; Adult; Aged; Anticholesteremic Agents; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Female; Humans; Hypoglycemic Agents; Leptin; Male; Metabolic Syndrome; Metformin; Middle Aged; Simvastatin

2007
Effects of simvastatin and metformin on inflammation and insulin resistance in individuals with mild metabolic syndrome.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2007, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Apolipoproteins B; Biomarkers; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Female; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Inflammation; Insulin Resistance; Interleukin-6; Male; Metabolic Syndrome; Metformin; Middle Aged; Simvastatin

2007
Soluble CD40 ligand, plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor-1-antigen in normotensive type 2 diabetic subjects without diabetic complications. Effects of metformin and rosiglitazone.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2009, Volume: 18, Issue:4

    Topics: Adult; Aged; Anticholesteremic Agents; Blood Pressure; Carboxypeptidase B2; CD40 Ligand; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Fibrinolysis; Humans; Hypoglycemic Agents; Inflammation; Male; Metformin; Middle Aged; Plasminogen Activator Inhibitor 1; Rosiglitazone; Simvastatin; Thiazolidinediones

2009
Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:12

    Topics: Adult; Cardiovascular Diseases; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Lipids; Metformin; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Sex Hormone-Binding Globulin; Simvastatin; Testosterone

2009
Effects of metformin plus simvastatin on polycystic ovary syndrome: a prospective, randomized, double-blind, placebo-controlled study.
    Fertility and sterility, 2010, Volume: 94, Issue:6

    Topics: Adolescent; Adult; Anticholesteremic Agents; Cholesterol, HDL; Double-Blind Method; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Metformin; Placebos; Polycystic Ovary Syndrome; Simvastatin; Testosterone; Young Adult

2010
Effect of simvastatin and fenofibrate on cytokine release and systemic inflammation in type 2 diabetes mellitus with mixed dyslipidemia.
    The American journal of cardiology, 2011, Apr-01, Volume: 107, Issue:7

    Topics: Blood Glucose; C-Reactive Protein; Cytokines; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fenofibrate; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Life Style; Lymphocytes; Male; Metformin; Middle Aged; Monocytes; Prospective Studies; Simvastatin; Systemic Inflammatory Response Syndrome

2011
Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:11

    Topics: Adult; C-Reactive Protein; Drug Therapy, Combination; Female; Hirsutism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Lipoproteins, LDL; Metformin; Polycystic Ovary Syndrome; Simvastatin; Treatment Outcome

2011
Therapeutic effects of biguanide vs. statin in polycystic ovary syndrome: a randomized clinical trial.
    Pakistan journal of biological sciences : PJBS, 2011, Jun-01, Volume: 14, Issue:11

    Topics: Adult; Anticholesteremic Agents; Biguanides; Blood Glucose; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Simvastatin; Treatment Outcome; Young Adult

2011
Haemostatic effects of metformin in simvastatin-treated volunteers with impaired fasting glucose.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:6

    Topics: Antigens; Blood Coagulation; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Factor VII; Fasting; Female; Fibrinogen; Fibrinolysis; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Plasminogen Activator Inhibitor 1; Prediabetic State; Simvastatin

2012
The effect of metformin on monocyte secretory function in simvastatin-treated patients with impaired fasting glucose.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Blood Glucose; C-Reactive Protein; Chemokine CCL2; Drug Therapy, Combination; Fasting; Glucose Metabolism Disorders; Humans; Hypoglycemic Agents; Interleukins; Metformin; Middle Aged; Monocytes; Secretory Rate; Simvastatin; Tumor Necrosis Factor-alpha; Young Adult

2013
Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose.
    Atherosclerosis, 2012, Volume: 225, Issue:2

    Topics: Anti-Inflammatory Agents; Biomarkers; Blood Glucose; C-Reactive Protein; Cytokines; Drug Synergism; Fasting; Female; Glucose Metabolism Disorders; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipids; Lymphocytes; Male; Metformin; Middle Aged; Poland; Simvastatin; Time Factors; Treatment Outcome

2012
Free fatty acid binding protein-4 and retinol binding protein-4 in polycystic ovary syndrome: response to simvastatin and metformin therapies.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:5

    Topics: Adult; Drug Therapy, Combination; Fatty Acid-Binding Proteins; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Metformin; Polycystic Ovary Syndrome; Retinol-Binding Proteins, Plasma; Simvastatin; Young Adult

2013
A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis.
    Cancer chemotherapy and pharmacology, 2018, Volume: 81, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biotransformation; Computer Simulation; Doxorubicin; Drug Interactions; Female; Gonadotropin-Releasing Hormone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Metformin; Middle Aged; Models, Biological; Octamer Transcription Factor-2; Simvastatin; Solute Carrier Organic Anion Transporter Family Member 1B3

2018
Effect of Metformin Alone Compared with Metformin Plus Simvastatin on Polycystic Ovarian Syndrome in Pakistani Women.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Lipids; Metformin; Middle Aged; Ovary; Pakistan; Polycystic Ovary Syndrome; Simvastatin; Testosterone; Treatment Outcome

2018
Effects of sildenafil, metformin, and simvastatin on ADH-independent urine concentration in healthy volunteers.
    Physiological reports, 2018, Volume: 6, Issue:7

    Topics: Adult; Diabetes Insipidus, Nephrogenic; Female; Healthy Volunteers; Humans; Kidney; Male; Metformin; Neurophysins; Osmolar Concentration; Protein Precursors; Sildenafil Citrate; Simvastatin; Urine; Vasopressins; Young Adult

2018
Long-term effects of combined simvastatin and metformin treatment on the clinical abnormalities and ovulation dysfunction in single young women with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:12

    Topics: Adolescent; Anticholesteremic Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Metformin; Ovary; Polycystic Ovary Syndrome; Simvastatin; Young Adult

2018

Other Studies

43 other study(ies) available for metformin and simvastatin

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose).
    The American journal of cardiology, 2002, Jun-01, Volume: 89, Issue:11

    Topics: Acarbose; Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Atorvastatin; Chromans; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Pyrroles; Simvastatin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone

2002
Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:9

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Male; Metformin; Mice; Peroxisome Proliferator-Activated Receptors; Rosiglitazone; Simvastatin; Streptozocin; Sulfonylurea Compounds; Thiazolidinediones; Triglycerides

2008
[Optimisation of pharmacological therapy in a patient with a newly diagnosed type 2 diabetes].
    Revue medicale de Liege, 2009, Volume: 64, Issue:2

    Topics: Anticholesteremic Agents; Cardiovascular Diseases; Decision Making; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Simvastatin

2009
Scintigraphic diagnosis of Erdheim-Chester disease.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jun-01, Volume: 29, Issue:16

    Topics: Aged; Amlodipine; Antihypertensive Agents; Diabetes Mellitus, Type 2; Drug Combinations; Erdheim-Chester Disease; Gated Blood-Pool Imaging; Humans; Hydrochlorothiazide; Hypoglycemic Agents; Hypolipidemic Agents; Imidazoles; Knee Joint; Losartan; Male; Metformin; Positron-Emission Tomography; Prostatic Neoplasms; Simvastatin

2011
A new methodology for high drug loading wet granulation formulation development.
    International journal of pharmaceutics, 2013, Jan-30, Volume: 441, Issue:1-2

    Topics: Animals; Dogs; Drug Compounding; Etoricoxib; Excipients; Metformin; Particle Size; Polymers; Pyridines; Simvastatin; Solubility; Sulfones; Wettability

2013
NAFLD fibrosis score: a prognostic predictor for mortality and liver complications among NAFLD patients.
    World journal of gastroenterology, 2013, Feb-28, Volume: 19, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Biopsy; Cause of Death; Chi-Square Distribution; Decision Support Techniques; Fatty Liver; Female; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Liver Cirrhosis; Logistic Models; Male; Metformin; Middle Aged; Minnesota; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Odds Ratio; Predictive Value of Tests; Prognosis; Risk Factors; Severity of Illness Index; Simvastatin; Time Factors; Young Adult

2013
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:11

    Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metformin; Ovarian Diseases; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta; Uterine Diseases

2013
Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:10

    Topics: Animals; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Movement; Drug Synergism; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Neoplasm Metastasis; Prostatic Neoplasms, Castration-Resistant; Simvastatin

2014
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.
    Cell death & disease, 2014, Nov-20, Volume: 5

    Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Line, Tumor; Chloroquine; Drug Combinations; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Imidazoles; Indoles; Male; Metformin; Microtubule-Associated Proteins; Necrosis; Prostate; Prostatic Neoplasms, Castration-Resistant; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Simvastatin

2014
Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway.
    American journal of physiology. Endocrinology and metabolism, 2015, Feb-15, Volume: 308, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Connexins; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Drug Therapy, Combination; Female; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metformin; MicroRNAs; Muscle, Smooth, Vascular; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Renal Artery; rho-Associated Kinases; Simvastatin; Vasculitis

2015
Availability and utilization of cardiovascular fixed-dose combination drugs in the United States.
    American heart journal, 2015, Volume: 169, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus; Drug Combinations; Dyslipidemias; Humans; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Lisinopril; Metformin; Practice Patterns, Physicians'; Simvastatin; United States; United States Food and Drug Administration

2015
Stroke mimicking relapse in a patient with CLIPPERS syndrome.
    Acta neurologica Belgica, 2015, Volume: 115, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Brain Stem; Encephalomyelitis; Gadolinium; Humans; Hypoglycemic Agents; Inflammation; Magnetic Resonance Imaging; Male; Metformin; Middle Aged; Recurrence; Simvastatin; Stroke

2015
The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women with Non-Classic Congenital Adrenal Hyperplasia.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2016, Volume: 124, Issue:4

    Topics: Adrenal Hyperplasia, Congenital; Adult; Female; Gonadal Steroid Hormones; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Middle Aged; Simvastatin

2016
The effects of metformin and simvastatin on the growth of LNCaP and RWPE-1 prostate epithelial cell lines.
    European journal of pharmacology, 2016, Oct-05, Volume: 788

    Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Male; Metformin; Necrosis; Prostate; Simvastatin

2016
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Xenograft Model Antitumor Assays

2017
A Versatile Liquid Chromatographic Method for the Simultaneous Determination of Metformin, Sitagliptin, Simvastatin, and Ezetimibe in Different Dosage Forms.
    Journal of AOAC International, 2018, Mar-01, Volume: 101, Issue:2

    Topics: Chromatography, High Pressure Liquid; Dosage Forms; Ezetimibe; Limit of Detection; Metformin; Simvastatin; Sitagliptin Phosphate

2018
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Autophagy; Biomarkers, Tumor; Carcinoma, Hepatocellular; Caspase 3; Cell Line; Cell Proliferation; Cells, Cultured; Drug Therapy, Combination; Gene Expression; Hepacivirus; Hepatitis C, Chronic; Hepatocytes; Humans; Liver Neoplasms; Metformin; Microtubule-Associated Proteins; PTEN Phosphohydrolase; Simvastatin; TOR Serine-Threonine Kinases; Tumor Protein, Translationally-Controlled 1

2018
Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice.
    Neuropathology : official journal of the Japanese Society of Neuropathology, 2018, Volume: 38, Issue:5

    Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diet, High-Fat; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Metabolic Syndrome; Metformin; Mice; Mice, Inbred C57BL; Myelin Sheath; Sciatic Nerve; Simvastatin

2018
Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia.
    Contrast media & molecular imaging, 2019, Volume: 2019

    Topics: Animals; Cardiovascular Agents; Diabetes Mellitus, Experimental; Hindlimb; Immunohistochemistry; Ischemia; Magnetic Resonance Imaging; Male; Metformin; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Oligopeptides; Simvastatin

2019
Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth.
    Gynecologic oncology, 2019, Volume: 154, Issue:2

    Topics: Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Drug Therapy, Combination; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Metformin; Simvastatin; TOR Serine-Threonine Kinases

2019
Effect of Mobile Phase pH on the Electrospray Ionization Efficiency and Qualitative Analysis of Pharmaceuticals in ESI + LC-MS/MS.
    Journal of chromatographic science, 2019, Oct-17, Volume: 57, Issue:9

    Topics: Chromatography, Liquid; Hydrogen-Ion Concentration; Ions; Limit of Detection; Linear Models; Metformin; Models, Chemical; Reproducibility of Results; Simvastatin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2019
Statins Directly Regulate Pituitary Cell Function and Exert Antitumor Effects in Pituitary Tumors.
    Neuroendocrinology, 2020, Volume: 110, Issue:11-12

    Topics: Adult; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Metformin; Mice; Middle Aged; Neuroendocrine Tumors; Papio anubis; Pituitary Gland; Pituitary Neoplasms; Rats; Simvastatin; Somatostatin; Young Adult

2020
Diazepam, metformin, omeprazole and simvastatin: a full discussion of individual and mixture acute toxicity.
    Ecotoxicology (London, England), 2020, Volume: 29, Issue:7

    Topics: Aliivibrio fischeri; Diazepam; Metformin; Omeprazole; Simvastatin; Toxicity Tests, Acute

2020
Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.
    Cancer letters, 2020, 10-28, Volume: 491

    Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Digoxin; Drug Combinations; Drug Repositioning; Drug Synergism; High-Throughput Screening Assays; Homeodomain Proteins; Humans; Male; Metformin; Mice; Molecular Targeted Therapy; Pancreatic Neoplasms; Simvastatin; Survivin; Trans-Activators

2020
Oral anti-diabetic drugs as endocrine disruptors in vitro - No evidence for additive effects in binary mixtures.
    Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 70

    Topics: Administration, Oral; Cell Line; Chromatography, Liquid; Drug Interactions; Endocrine Disruptors; Humans; Hypoglycemic Agents; Metformin; Simvastatin; Sitagliptin Phosphate; Steroids; Sulfonylurea Compounds; Tandem Mass Spectrometry

2021
Oral Manifestations of Commonly Prescribed Drugs.
    American family physician, 2020, 11-15, Volume: 102, Issue:10

    Topics: Albuterol; Amlodipine; Anticonvulsants; Antihypertensive Agents; Atorvastatin; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bronchodilator Agents; Deprescriptions; Drug Hypersensitivity; Fluorides; Gingival Overgrowth; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperpigmentation; Hypoglycemic Agents; Lisinopril; Losartan; Metformin; Metoprolol; Mouth Diseases; Omeprazole; Oral Hygiene; Proton Pump Inhibitors; Simvastatin; Thyroxine; Toothpastes; Xerostomia

2020
Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors.
    Current issues in molecular biology, 2021, Nov-25, Volume: 43, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation; Immunohistochemistry; Lipid Metabolism; Metformin; Mice; Simvastatin; Transcription Factors; Transcriptome

2021
Effect of losartan potassium, metformin hydrochloride, and simvastatin on in vitro bioaccessibility of Cu, Fe, Mn, and Zn in oat flour from Brazil.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2022, Volume: 73

    Topics: Avena; Brazil; Flour; Humans; Losartan; Metformin; Micronutrients; Simvastatin; Zinc

2022
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
    Drug safety, 2022, Volume: 45, Issue:11

    Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; Case-Control Studies; Ciprofloxacin; Diclofenac; Furosemide; Humans; Ibuprofen; Metformin; Naproxen; Omeprazole; Primary Health Care; Ramipril; Simvastatin; Spironolactone; Sulfamethoxazole; Telmisartan; Trimethoprim; Valacyclovir; Zoledronic Acid

2022
Metformin and simvastatin synergistically suppress endothelin 1-induced hypoxia and angiogenesis in multiple cancer types.
    Cancer science, 2023, Volume: 114, Issue:2

    Topics: Animals; Cell Line, Tumor; Endothelin-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Metformin; Mice; Neoplasms; Neovascularization, Pathologic; Simvastatin

2023
Pharmacogenetic Variation and Its Clinical Relevance in a Latin American Rural Population.
    International journal of molecular sciences, 2022, Oct-04, Volume: 23, Issue:19

    Topics: DNA, Intergenic; Gene Frequency; Genetics, Population; HLA-G Antigens; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Latin America; Metformin; Pharmacogenetics; Pharmacogenomic Testing; Polymorphism, Single Nucleotide; Rural Population; Ryanodine Receptor Calcium Release Channel; Simvastatin; Solute Carrier Family 22 Member 5

2022
Effects of metformin and simvastatin treatment on ultrastructural features of liver macrophages in HFD mice.
    Ultrastructural pathology, 2023, Jan-02, Volume: 47, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Liver; Macrophages; Metformin; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Simvastatin

2023
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
    EBioMedicine, 2023, Volume: 90

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Mice; Proto-Oncogene Proteins c-akt; Retrospective Studies; Simvastatin; Transforming Growth Factor beta

2023