Compounds > metformin

metformin and serine

metformin has been researched along with serine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's7 (58.33)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Fromm, MF; König, J; Solbach, TF; Zolk, O1
Dong, Y; Neumann, D; Scholz, R; Xie, Z; Zhang, J; Zou, MH1
Bouillet, E; Christ-Crain, M; Dembinski, K; Frey, DM; Grisouard, J; Keller, U; Müller, B; Peterli, R; Radimerski, T; Timper, K; Zulewski, H1
Deepa, SS; DeFronzo, RA; Dong, LQ; Li, C; Liu, F; Mao, X; Musi, N; Ryu, J; Wang, C; Zhang, N; Zhou, L1
Moriasi, CM; Zhang, M; Zhao, Y; Zhu, H; Zou, MH1
Germain-Lee, EL; He, L; Meng, S; Radovick, S; Wondisford, FE1
Ciociaro, A; Di Monte, DA; Hettich, MM; Kahle, PJ; Krauss, S; Pérez-Revuelta, BI; Rotermund, C1
Birman, E; Blouin, MJ; Gravel, SP; Hulea, L; Pollak, M; St-Pierre, J; Toban, N; Topisirovic, I; Zakikhani, M; Zhao, Y1
Cai, S; Cha, JH; Chan, LC; Chang, SS; Chang, WC; Chen, CH; Hadad, S; Hsu, JL; Hung, MC; Khoo, KH; Kim, T; Kuo, CW; Lee, HH; Li, CW; Lim, SO; Litton, JK; McCoy, AM; Mittendorf, EA; Moulder, SL; Piwnica-Worms, H; Purdie, CA; Symmans, WF; Thompson, AM; Tu, Y; Wang, HL; Wei, Y; Xia, W; Yang, WH1
De Repentigny, Y; Gouveia, A; He, L; Ilin, J; Kosaraju, J; Kothary, R; Lagace, D; Lu, KJ; Sarma, SN; Seegobin, M; Syal, C; Wang, J; Wondisford, FE1
Huang, C; Huo, L; Khan, FA; Pandupuspitasari, NS; Sun, F; Wang, Y; Wu, D; Zhang, K1

Other Studies

12 other study(ies) available for metformin and serine

ArticleYear
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:6

    Topics: Alanine; Amino Acid Substitution; Biological Transport; Cell Line; Genetic Variation; Humans; Kidney; Metabolic Clearance Rate; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 1; Protein Conformation; Protein Isoforms; Serine; Subcellular Fractions

2009
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.
    Molecular and cellular biology, 2009, Volume: 29, Issue:13

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Vesicular Transport; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line; Endothelial Cells; Enzyme Activation; Exportin 1 Protein; Humans; Hydrogen Peroxide; Hypoglycemic Agents; Karyopherins; Metformin; Mice; Neovascularization, Physiologic; Oxidants; Peroxynitrous Acid; Phosphorylation; Point Mutation; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Serine

2009
Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.
    Archives of physiology and biochemistry, 2011, Volume: 117, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adult; Aged; Colforsin; Female; Humans; Hypoglycemic Agents; Inflammation; Interleukin-1beta; Isoproterenol; Lipolysis; Lipopolysaccharides; Male; Metformin; Middle Aged; Phosphorylation; Primary Cell Culture; Serine; Sterol Esterase; Tumor Necrosis Factor-alpha

2011
APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.
    Molecular endocrinology (Baltimore, Md.), 2011, Volume: 25, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Adiponectin; AMP-Activated Protein Kinases; Animals; Cell Line; Cytosol; Down-Regulation; Enzyme Activation; Humans; Metformin; Mice; Models, Biological; Muscle Fibers, Skeletal; Phosphorylation; Protein Kinase C; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Transport; Serine; Signal Transduction

2011
Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation.
    The Journal of biological chemistry, 2013, Jun-07, Volume: 288, Issue:23

    Topics: Active Transport, Cell Nucleus; Amino Acid Substitution; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Cell Nucleus; Enzyme Activation; Exportin 1 Protein; HeLa Cells; Humans; Hypoglycemic Agents; Karyopherins; Metformin; Mutation, Missense; Peroxynitrous Acid; Phosphorylation; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Serine

2013
Potential biomarker of metformin action.
    The Journal of endocrinology, 2014, Volume: 221, Issue:3

    Topics: Adolescent; Adult; Animals; Biomarkers; Cells, Cultured; CREB-Binding Protein; Fasting; Female; Gluconeogenesis; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Immunoblotting; Leukocytes; Liver; Metformin; Mice; Mutation; Obesity; Phosphorylation; Serine

2014
Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.
    Cell death & disease, 2014, May-08, Volume: 5

    Topics: alpha-Synuclein; AMP-Activated Protein Kinases; Animals; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Gestational Age; HeLa Cells; Hippocampus; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Inbred C57BL; Neurons; Phosphorylation; Primary Cell Culture; Protein Kinase Inhibitors; Protein Phosphatase 2; Serine; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection

2014
Serine deprivation enhances antineoplastic activity of biguanides.
    Cancer research, 2014, Dec-15, Volume: 74, Issue:24

    Topics: Animals; Biguanides; Cell Line, Tumor; Glycolysis; Humans; Metformin; Mice; Neoplasms; Oxidative Phosphorylation; Phenformin; Serine; Xenograft Model Antitumor Assays

2014
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
    Molecular cell, 2018, 08-16, Volume: 71, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; B7-H1 Antigen; Cell Line, Tumor; CTLA-4 Antigen; Endoplasmic Reticulum; Endoplasmic Reticulum-Associated Degradation; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Hypoglycemic Agents; Mammary Glands, Human; Melanoma, Experimental; Metformin; Mice; Mice, Inbred NOD; Phosphorylation; Serine; T-Lymphocytes, Cytotoxic

2018
Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation.
    Experimental neurology, 2020, Volume: 334

    Topics: Animals; Demyelinating Diseases; Female; Histone Acetyltransferases; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligodendroglia; Phosphorylation; Remyelination; Serine; Social Interaction

2020
Perfluorooctanoic acid alters the developmental trajectory of female germ cells and embryos in rodents and its potential mechanism.
    Ecotoxicology and environmental safety, 2022, May-01, Volume: 236

    Topics: Animals; Caprylates; Female; Fetal Growth Retardation; Fluorocarbons; Germ Cells; Humans; Melatonin; Metformin; Rodentia; Serine

2022