metformin and rotenone

metformin has been researched along with rotenone in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (11.54)	29.6817
2010's	13 (50.00)	24.3611
2020's	10 (38.46)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bankhead, A; Neamati, N; Xu, Y; Xue, D	1
Althaym, A; Brunmair, B; Clara, R; Fürnsinn, C; Gnaiger, E; Gras, F; Nohl, H; Roden, M; Scharf, N; Staniek, K; Waldhäusl, W	1
Batandier, C; Detaille, D; El-Mir, MY; Fontaine, E; Guigas, B; Leverve, XM; Rigoulet, M	1
Abraham, E; Liu, G; Lorne, E; Sha, Y; Siegal, GP; Tsuruta, Y; Zhao, X; Zmijewski, JW	1
Ochs, RS; Ouyang, J; Parakhia, RA	1
Bernardi, P; Chauvin, C; De Oliveira, F; De Paulis, D; Fontaine, E; Gharib, A; Lablanche, S; Leverve, X; Li, B; Ovize, M; Vial, G	1
Billen, J; Braeckman, BP; De Haes, W; Depuydt, G; Frooninckx, L; Schoofs, L; Smolders, A; Temmerman, L; Van Assche, R	1
Jimenez-Del-Rio, M; Mendivil-Perez, M; Velez-Pardo, C	1
Chi, CW; Hsia, CY; Hsu, CC; Lee, HC; Wu, LC; Yeh, TS; Yin, PH	1
Kelly, B; Murphy, MP; O'Neill, LA; Tannahill, GM	1
Andreeff, M; Bornmann, W; Duque, JE; Enciso, L; Jaramillo, D; Konopleva, M; Krystal, G; Lee, JT; Lopez, C; Morales, L; Pan, R; Samudio, I; Suarez, M; Velez, J	1
D'Agostino, DP; Koutnik, AP; Poff, AM; Ward, NP	1
Chen, K; Feng, T; Ling, S; Liu, J; Liu, P; Shan, Q; Song, P; Xiang, P; Xie, H; Xu, X; Zhang, X; Zheng, S; Zhou, L	1
Akhtar, F; Chaudhary, A; Rizvi, SI; Singh, AK; Tripathi, SS	1
Ellinger-Ziegelbauer, H; Freyberger, A; Heinz, S; Lawrenz, B; Schladt, L; Schmuck, G	1
Cho, K; Patti, GJ; Sindelar, M; Stancliffe, E; Wang, L; Wang, Y; Yao, CH; Yin, W	1
Chen, AD; Jing, YH; Wang, DX; Wang, QJ; Xin, YY; Yin, J	1
Agar, A; Aslan, M; Nemutlu-Samur, D; Ozbey, G; Parlak, H; Tanriover, G; Yildirim, S	1
Dong, H; Feng, B; Gao, C; Gao, X; Mao, W; Sun, C; Wang, J; Wang, Y; Yang, Y; Zhang, B; Zhang, H; Zhang, J; Zhang, L	1
Bhurtel, S; Choi, DY; Katila, N; Park, PH	1
Borutaite, V; Jankeviciute, S; Svirskiene, N; Svirskis, G	1
Arita, K; Ito, T; Kambe, Y; Kasamo, Y; Kawahara, KI; Kikuchi, K; Maruyama, I; Otsuka, S; Takada, S; Yamakuchi, M; Yoshimoto, K	1
da Silva, RS; de Melo, MG; de Paiva, IHR; do Nascimento, MIX; Duarte-Silva, EP; Mendonça, IP; Peixoto, CA	1

Reviews

1 review(s) available for metformin and rotenone

Article	Year
Why All the Fuss about Oxidative Phosphorylation (OXPHOS)? Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23 Topics: Animals; Binding Sites; Humans; Molecular Structure; Mutation; Neoplastic Stem Cells; Oxidative Phosphorylation; Tumor Microenvironment; Up-Regulation	2020

Other Studies

25 other study(ies) available for metformin and rotenone

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes, 2004, Volume: 53, Issue:4 Topics: Animals; Electron Transport Complex I; Energy Metabolism; Hypoglycemic Agents; Male; Metformin; Mitochondria; Muscle, Skeletal; Oxygen Consumption; Pioglitazone; Potassium Chloride; Rats; Rats, Sprague-Dawley; Rosiglitazone; Rotenone; Thiazolidinediones	2004
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin. Journal of bioenergetics and biomembranes, 2006, Volume: 38, Issue:1 Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Electron Transport; Electron Transport Complex I; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Malates; Malonates; Membrane Potentials; Metformin; Mitochondria, Liver; Oxidation-Reduction; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Succinic Acid	2006
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. American journal of respiratory and critical care medicine, 2008, Jul-15, Volume: 178, Issue:2 Topics: Animals; Cytokines; Electron Transport Complex I; Hypoglycemic Agents; Lipopolysaccharides; Male; Metformin; Mice; Mice, Inbred C57BL; Mitochondria; Neutrophil Activation; NF-kappa B; Reactive Oxygen Species; Respiratory Distress Syndrome; Rotenone; Toll-Like Receptor 4; Uncoupling Agents	2008
Metformin activates AMP kinase through inhibition of AMP deaminase. The Journal of biological chemistry, 2011, Jan-07, Volume: 286, Issue:1 Topics: Adenylate Kinase; AMP Deaminase; AMP-Activated Protein Kinases; Animals; Biological Transport; Cattle; Enzyme Activation; Enzyme Inhibitors; Fatty Acids; Glucose; Hypoglycemic Agents; Metformin; Muscle, Skeletal; Oxidation-Reduction; Rats; Reactive Oxygen Species; Rotenone	2011
Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D. Biochimica et biophysica acta, 2012, Volume: 1817, Issue:9 Topics: Animals; Cyclophilins; Cyclosporine; Electron Transport Complex I; Humans; Metformin; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Peptidyl-Prolyl Isomerase F; Rotenone	2012
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jun-17, Volume: 111, Issue:24 Topics: Acyl-CoA Dehydrogenase; Amino Acids, Branched-Chain; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Gene Expression Regulation; Green Fluorescent Proteins; Hormesis; Hot Temperature; Hydrogen Peroxide; Hypoglycemic Agents; Longevity; Metformin; Mitochondria; Models, Animal; Oxidative Stress; Oxygen Consumption; Peroxiredoxins; Protein Unfolding; Proteomics; Reactive Oxygen Species; Rotenone; Signal Transduction; Time Factors	2014
Response to rotenone is glucose-sensitive in a model of human acute lymphoblastic leukemia: involvement of oxidative stress mechanism, DJ-1, Parkin, and PINK-1 proteins. Oxidative medicine and cellular longevity, 2014, Volume: 2014 Topics: Apoptosis; Biomarkers; Caspase 3; Cell Nucleus Shape; Enzyme Activation; Glucose; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Membrane Potential, Mitochondrial; Metformin; Models, Biological; Oncogene Proteins; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Deglycase DJ-1; Protein Kinases; Rotenone; Signal Transduction; Superoxides; Transcription Factors; Ubiquitin-Protein Ligases	2014
Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs. Oncology reports, 2015, Volume: 34, Issue:3 Topics: Adenosine Triphosphate; Apoptosis; Carcinoma, Hepatocellular; Energy Metabolism; Glycolysis; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mitochondria; Oligomycins; Oxygen Consumption; Phenformin; Rotenone	2015
Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages. The Journal of biological chemistry, 2015, Aug-14, Volume: 290, Issue:33 Topics: Adenylate Kinase; Animals; Electron Transport Complex I; Interleukin-10; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages; Metformin; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Rotenone	2015
Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget, 2016, Aug-09, Volume: 7, Issue:32 Topics: Apoptosis; Biguanides; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Electron Transport; Humans; Metformin; Mitochondria; Nitrophenols; Phenformin; Piperazines; Rotenone; Sulfonamides; U937 Cells	2016
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells. PloS one, 2017, Volume: 12, Issue:6 Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Electron Transport Complex I; Glioblastoma; Membrane Potential, Mitochondrial; Metformin; Mice; Oxidative Stress; Rotenone; Superoxides	2017
Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I. Cell death & disease, 2017, 11-02, Volume: 8, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line; Chemical and Drug Induced Liver Injury; Electron Transport Complex I; Glucose; Glycolysis; Humans; Leukemia, Myeloid; Male; Metformin; Mice; NAD; Oxidative Phosphorylation; Oxides; Reactive Oxygen Species; Rotenone	2017
Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity. Archives of physiology and biochemistry, 2021, Volume: 127, Issue:2 Topics: Animals; Erythrocytes; Hypoglycemic Agents; Insecticides; Male; Metformin; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Rotenone	2021
Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart. Archives of toxicology, 2019, Volume: 93, Issue:9 Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Energy Metabolism; Gluconeogenesis; Heart; Lactic Acid; Liver; Male; Metformin; Mitochondria; Oxidative Phosphorylation; Phenformin; Rats, Wistar; Rotenone; Transcriptome	2019
Dose-Response Metabolomics To Understand Biochemical Mechanisms and Off-Target Drug Effects with the TOXcms Software. Analytical chemistry, 2020, 01-21, Volume: 92, Issue:2 Topics: Algorithms; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Dose-Response Relationship, Drug; Epoxy Compounds; Gene Knockdown Techniques; HEK293 Cells; Humans; Metabolomics; Metformin; RNA, Small Interfering; Rotenone; Software	2020
Protective effect of metformin against rotenone-induced parkinsonism in mice. Toxicology mechanisms and methods, 2020, Volume: 30, Issue:5 Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Inflammation; Interleukin-1beta; Male; Metformin; Mice; Mice, Inbred C57BL; Microglia; Parkinson Disease, Secondary; Protective Agents; Rotenone; Tumor Necrosis Factor-alpha	2020
Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation. Pharmacological reports : PR, 2020, Volume: 72, Issue:5 Topics: alpha-Synuclein; Animals; Dopamine; Dopaminergic Neurons; Lipid Peroxidation; Male; Metformin; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase	2020
Inhibition of mitochondria NADH-Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 129 Topics: Brain Neoplasms; Cell Line, Tumor; Electron Transport Complex I; Enzyme Inhibitors; Glioma; Humans; Metformin; Mitochondria; Radiation Tolerance; Radiation-Sensitizing Agents; Rotenone	2020
Metformin attenuates rotenone-induced oxidative stress and mitochondrial damage via the AKT/Nrf2 pathway. Neurochemistry international, 2021, Volume: 148 Topics: Cell Line; Cell Survival; Humans; Hypoglycemic Agents; Metformin; Mitochondrial Diseases; NF-E2-Related Factor 2; Oncogene Protein v-akt; Oxidative Stress; Reactive Oxygen Species; Rotenone; Signal Transduction; Uncoupling Agents	2021
Effects of Metformin on Spontaneous Ca International journal of molecular sciences, 2021, Aug-31, Volume: 22, Issue:17 Topics: Animals; Caffeine; Calcium Signaling; Chromans; Cyclosporine; Electron Transport Complex I; Female; Hypoxia; Male; Metformin; Microglia; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Primary Cell Culture; Rats; Reactive Oxygen Species; Rotenone	2021
1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis. International journal of molecular sciences, 2021, Sep-14, Volume: 22, Issue:18 Topics: Adenylate Kinase; Animals; Cell Death; Fructose; Gene Silencing; Metformin; Mitochondria; Neurons; Neuroprotective Agents; Organelle Biogenesis; PC12 Cells; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Rats; Rotenone	2021
Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus. Inflammopharmacology, 2022, Volume: 30, Issue:5 Topics: Animals; Antidepressive Agents; Autophagy; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Parkinson Disease; Quality of Life; Rotenone; Substantia Nigra; Sucrose; Transcription Factors	2022