metformin has been researched along with pyruvic acid in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Benzi, L; Brunetti, P; Cecchetti, P; Di Carlo, A; Di Cianni, G; Giannarelli, R; Gregorio, F; Marchetti, P; Navalesi, R; Villani, G | 1 |
| Jalling, O; Olsen, C | 1 |
| Endoh, M; Kakemi, M; Katayama, K; Koizumi, T; Saeki, K; Sasaki, H | 1 |
| Argaud, D; Leverve, XM; Roth, H; Wiernsperger, N | 1 |
| Beylot, M; Large, V | 1 |
| Dominguez, LJ; Ofenstein, JP; Sarnaik, AP; Sowers, JR | 1 |
| Hiraizumi, M; Seino, H | 1 |
| Ban, T; Kanemoto, N; Nagano, K; Niki, I; Okamoto, T; Sudo, T | 1 |
| Andrikopoulos, S; Connor, T; Cooper, A; de Vries, M; Fahey, R; Foletta, VC; Garcia-Guerra, L; Jones, S; Konstantopoulos, N; Krippner, G; McGee, SL; Molero, JC; Morrison, S; Spolding, B; Swinton, C; Walder, KR; Wanyonyi, S | 1 |
| Acharya, AP; Gardner, AB; Murthy, N; Rafi, M; Woods, EC | 1 |
| Balen, AH; Barth, JH; Campbell, BK; Harris, SE; Maruthini, D; Picton, HM | 1 |
| Drzewoski, J; Sliwinska, A | 1 |
| Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y | 1 |
| Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L | 1 |
| Bassani, G; Ferrero, S; Gattinoni, L; Guenzani, S; Langer, T; Magnoni, S; Properzi, P; Protti, A; Santini, A; Stocchetti, N | 1 |
| Heather, LC; Lewis, AJ; McCallum, C; Miller, JJ; Neubauer, S; Rider, OJ; Tyler, DJ | 1 |
| Bush, LN; Davidson, SM; Freinkman, E; Gitego, N; Gui, DY; Hosios, AM; Luengo, A; Sullivan, LB; Thomas, CJ; Vander Heiden, MG | 1 |
| Flavell, RR; Kurhanewicz, J; Marco-Rius, I; Ohliger, MA; Pearce, D; Vigneron, DB; von Morze, C; Wang, ZJ; Wilson, DM | 1 |
| Butrico, GM; Camporez, JG; Casals, G; Cline, GW; Kemp, BE; Madiraju, AK; Perry, RJ; Petersen, KF; Qiu, Y; Rahimi, Y; Shulman, GI; Steinberg, GR; Vatner, DF; Zhang, D; Zhang, XM | 1 |
| Bizjak, M; Malavašič, P; Pavlin, M; Pirkmajer, S | 1 |
| Tulipano, G | 1 |
| Abiko, Y; Kobayashi, Y; Liu, S; Otani, H; Sasaki, S; Sato, S; Shinohara, Y; Takahashi, N; Wang, X; Washio, J | 1 |
3 review(s) available for metformin and pyruvic acid
| Article | Year |
|---|---|
[Progress in diagnosis of and therapy for diabetic lactic acidosis].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Blood Gas Analysis; Consciousness Disorders; Diabetes Complications; Diagnosis, Differential; Glucose; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Metformin; Pyruvic Acid; Sodium Bicarbonate | 2004 |
Molecular action of metformin in hepatocytes: an updated insight.
Topics: AMP-Activated Protein Kinases; Dihydroxyacetone Phosphate; Electron Transport Complex I; Gluconeogenesis; Glycerolphosphate Dehydrogenase; Hepatocytes; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mitochondria, Liver; Pyruvic Acid | 2015 |
Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area.
Topics: Animals; Antineoplastic Agents; Diabetes Mellitus, Type 2; Female; Gluconeogenesis; Humans; Hypoglycemic Agents; Metformin; Mitochondria; Pharmacogenomic Testing; Polycystic Ovary Syndrome; Pyruvic Acid; Signal Transduction; Tissue Distribution; Weight Loss | 2021 |
19 other study(ies) available for metformin and pyruvic acid
| Article | Year |
|---|---|
Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients.
Topics: Alanine; Blood Glucose; Butyrates; Butyric Acid; Circadian Rhythm; Diabetes Mellitus, Type 2; Glycerol; Humans; Lactates; Lactic Acid; Metformin; Pyruvates; Pyruvic Acid | 1990 |
The effects of metformin compared to the effects of phenformin on the lactate production and the metabolism of isolated parenchymal rat liver cell.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Ethanol; Glycerol; Ketone Bodies; Kinetics; Lactates; Lactic Acid; Liver; Male; Metformin; Oxygen Consumption; Phenformin; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Injections, Intravenous; Intestinal Absorption; Lactates; Lactic Acid; Male; Metformin; Models, Biological; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1983 |
Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Glucagon; Gluconeogenesis; Lactates; Lactic Acid; Liver; Male; Metformin; Perfusion; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1993 |
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.
Topics: Animals; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Lactic Acid; Liver; Male; Metformin; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Starvation; Streptozocin | 1999 |
Effects of insulin and metformin on glucose metabolism in rat vascular smooth muscle.
Topics: Acetyl Coenzyme A; Animals; Glucose; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Mitochondria, Muscle; Muscle, Smooth, Vascular; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1999 |
Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2.
Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Fluorometry; Gluconeogenesis; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Metformin; Pyruvic Acid; Rats; Up-Regulation | 2009 |
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.
Topics: Animals; Blood Glucose; Carbonic Anhydrase Inhibitors; Diabetes Mellitus, Experimental; Glucose Clamp Technique; Glucose-6-Phosphatase; Glycolysis; Homeostasis; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Metformin; Methazolamide; Mice; Mice, Inbred C57BL; Mice, Obese; Oxygen Consumption; Phosphoenolpyruvate Carboxykinase (ATP); Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2012 |
Metabolic engineering of lactate dehydrogenase rescues mice from acidosis.
Topics: Acidosis; Animals; Boronic Acids; Cells, Cultured; Female; Hypoglycemic Agents; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Metabolic Engineering; Metabolic Networks and Pathways; Metformin; Mice; Mice, Inbred C57BL; Pyruvic Acid | 2014 |
The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome.
Topics: Adult; Case-Control Studies; Cell Proliferation; Cells, Cultured; Female; Follicular Fluid; Glucose; Granulosa Cells; Humans; Insulin; Lactic Acid; Metformin; Ovarian Follicle; Polycystic Ovary Syndrome; Progesterone; Pyruvic Acid | 2014 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Disease Susceptibility; DNA Damage; Electron Transport Complex IV; Female; Glycolysis; Humans; Lactic Acid; Lung; Lung Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Monocarboxylic Acid Transporters; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Pyruvic Acid; Reactive Oxygen Species; Stress, Physiological; Symporters; Urethane | 2016 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid | 2016 |
Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis.
Topics: Acidosis, Lactic; Animals; Glycolysis; Hypoglycemic Agents; Infusions, Parenteral; Lactic Acid; Metformin; Microdialysis; Mitochondria, Muscle; Muscle, Skeletal; Pyruvic Acid; Swine; Time Factors | 2016 |
Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Heart; Lactic Acid; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metformin; Myocardium; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Wistar | 2016 |
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex I; Homeostasis; Humans; Metformin; Mice, Nude; Mitochondria; NAD; Neoplasms; Pyruvic Acid; Tumor Microenvironment | 2016 |
Direct assessment of renal mitochondrial redox state using hyperpolarized
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Ketones; Kidney; Lactic Acid; Liver; Magnetic Resonance Imaging; Metformin; Mitochondria; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2018 |
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dihydroxyacetone; Disease Models, Animal; Gluconeogenesis; Injections, Intravenous; Lipid Metabolism; Liver; Male; Metformin; Mice; Oxidation-Reduction; Phosphorylation; Pyruvic Acid; Rats, Sprague-Dawley; Streptozocin | 2018 |
Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations.
Topics: AMP-Activated Protein Kinases; Cell Culture Techniques; Cell Survival; Enzyme Activation; Female; Glucose; Glutamine; Humans; Hypoglycemic Agents; Metformin; Nutrients; Pyruvic Acid; Spheroids, Cellular; Triple Negative Breast Neoplasms; Tumor Microenvironment | 2019 |
Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions.
Topics: Cell Line, Tumor; Cell Proliferation; Culture Media; Glucose; Glutamine; HeLa Cells; Humans; Lactic Acid; Metabolomics; Metformin; NAD; Oxygen; Pyruvic Acid; Tumor Hypoxia | 2022 |