metformin has been researched along with pyruvaldehyde in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 6 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Beisswenger, PJ; Howell, SK; Lal, S; Szwergold, BS; Touchette, AD | 1 |
| Lagarde, M; Lecomte, M; Moinet, G; Patereau, G; Ruggiero-Lopez, D; Wiernsperger, N | 1 |
| Beisswenger, P; Ruggiero-Lopez, D | 1 |
| Hirano, K; Kato, M; Kiho, T; Usui, S | 1 |
| Hamada, Y; Kato, K; Kozakae, M; Li, W; Nakamura, J; Nakamura, N; Nakashima, E; Naruse, K; Oiso, Y; Ota, K; Watabe, K; Watarai, A; Yasuda, Y | 1 |
| Chang, T; Desai, K; Jia, X; Wang, X; Wu, L | 1 |
| Barter, PJ; Brown, BE; Davies, MJ; Nobécourt, E; Rye, KA; Yadav, S; Zeng, J | 1 |
| Lee, JA; Li, YC; Shih, YM | 1 |
| Adeli, K; Ji, J; Jiang, B; Liu, L; Lu, J; Meng, H; Meng, QH; Randell, E; Wang, D | 1 |
| Beisswenger, PJ | 1 |
| Fleming, T; Grolmusz, V; Herzig, S; Kender, Z; Kopf, S; Nawroth, PP; Rácz, K; Reismann, P; Schleicher, E; Torzsa, P | 1 |
| Konovalova, G; Kumskova, E; Lankin, V; Shumaev, K; Tikhaze, A; Viigimaa, M | 1 |
| Chen, SM; Huang, TC; Lee, JA; Li, YC | 1 |
| Poretsky, L; Striker, GE; Vlassara, H; Woodward, M; Yubero-Serrano, EM | 1 |
| Chen, SM; Chou, CK; Lee, JA; Li, YC; Shih, YM | 1 |
| Anumol, T; Dai, J; Hargraves, TL; Jacobsen, NE; Kinsky, OR; Lau, SS; Monks, TJ; Snyder, SA | 1 |
| Adeshara, K; Tupe, R | 1 |
| Kazdová, L; Landa, V; Malínská, H; Mlejnek, P; Oliyarnyk, O; Pravenec, M; Šilhavý, J; Šimáková, M; Škop, V; Strnad, H; Zídek, V | 1 |
| Chang, TJ; Chang, YC; Chuang, LM; Hsieh, ML; Liu, MW; Tseng, HC | 1 |
| Chen, CM; Chen, SM; Huang, YS; Lee, JA; Li, YC; Lin, CE; Tsai, PY | 1 |
| Haluzik, M; Kazdova, L; Malinska, H; Markova, I; Škop, V; Svoboda, P; Trnovska, J | 1 |
| Szwergold, B | 1 |
| Gryciuk, ME; Maciejczyk, M; Mil, KM; Pawlukianiec, C; Zalewska, A; Żendzian-Piotrowska, M; Ładny, JR | 1 |
| Islas-Robles, A; Koh, JY; Li, H; Meda Venkata, SP; Monks, TJ; Nguyen, H; Wang, JM | 1 |
| Antunes, E; de Oliveira, MG; Medeiros, ML; Mónica, FZ; Oliveira, AL | 1 |
| Luo, M; Wang, G; Wang, L; Wang, Y; Wu, J; Xu, C; Yang, Q; Zeng, M; Zheng, Y | 1 |
| Antunes, E; Medeiros, ML; Mello, GC; Oliveira, AL | 1 |
| Chan, CM; Hsiao, G; Hsu, SH; Huang, DY; Lin, WW; Sekar, P | 1 |
3 review(s) available for metformin and pyruvaldehyde
| Article | Year |
|---|---|
Metformin inhibition of glycation processes.
Topics: Azepines; Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Pyruvaldehyde; Randomized Controlled Trials as Topic | 2003 |
Methylglyoxal in diabetes: link to treatment, glycaemic control and biomarkers of complications.
Topics: Animals; Diabetes Complications; Glycation End Products, Advanced; Humans; Mass Spectrometry; Metformin; Pyruvaldehyde | 2014 |
Pleiotropic Properties of Valsartan: Do They Result from the Antiglycooxidant Activity? Literature Review and
Topics: Acetylcysteine; Animals; Antioxidants; Captopril; Chloramines; Chromans; Fructose; Glucose; Glycosylation; Humans; Metformin; Oxidation-Reduction; Pyruvaldehyde; Serum Albumin, Bovine; Thioctic Acid; Tosyl Compounds; Valsartan | 2021 |
3 trial(s) available for metformin and pyruvaldehyde
| Article | Year |
|---|---|
Metformin reduces systemic methylglyoxal levels in type 2 diabetes.
Topics: Adult; Aged; Deoxyglucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Osmolar Concentration; Pyruvaldehyde; Sulfonylurea Compounds; Treatment Outcome | 1999 |
Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactoylglutathione Lyase; Male; Metformin; Middle Aged; Prospective Studies; Pyruvaldehyde | 2014 |
Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.
Topics: Adiponectin; Age Factors; Aged; Albuminuria; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Estrogen Receptor alpha; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Intention to Treat Analysis; Lysine; Male; Metformin; Middle Aged; NF-E2-Related Factor 2; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sevelamer; Sex Factors; Single-Blind Method; Sirtuin 1; White People | 2015 |
22 other study(ies) available for metformin and pyruvaldehyde
| Article | Year |
|---|---|
Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation.
Topics: Animals; Azepines; Cattle; Enzyme Inhibitors; Glycation End Products, Advanced; Glycosylation; Glyoxal; Guanidines; Hypoglycemic Agents; Metformin; Pyruvaldehyde; Serum Albumin | 1999 |
Effect of buformin and metformin on formation of advanced glycation end products by methylglyoxal.
Topics: Animals; Buformin; Cattle; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Guanidines; Metformin; Pyruvaldehyde; Ribonucleases; Serum Albumin, Bovine; Time Factors | 2005 |
Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Glycation End Products, Advanced; Metformin; Mice; Pyruvaldehyde; Reactive Oxygen Species; Schwann Cells | 2007 |
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.
Topics: Animals; Aorta; Dietary Carbohydrates; Fructose; Glutathione; Glycation End Products, Advanced; Hydrogen Peroxide; Hypertension; Hypoglycemic Agents; Lysine; Male; Mesenteric Arteries; Metformin; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Sprague-Dawley | 2008 |
Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.
Topics: Apolipoprotein A-I; Arginine; Cross-Linking Reagents; Glycosylation; Guanidines; Humans; Lipoproteins, HDL; Lysine; Metformin; Phosphatidylcholine-Sterol O-Acyltransferase; Pyridoxamine; Pyruvaldehyde; Thiazoles; Tryptophan | 2008 |
Gentamicin caused renal injury deeply related to methylglyoxal and N(ɛ)-(carboxyethyl)lysine (CEL).
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Gentamicins; Glutathione; Immunohistochemistry; Kidney Diseases; Kidney Function Tests; Lysine; Male; Metformin; Pyruvaldehyde; Rats; Rats, Wistar | 2013 |
The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats.
Topics: Animals; Blood Glucose; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Cells, Cultured; Cholesterol; Fatty Acids, Nonesterified; Fructose; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Protective Agents; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Triglycerides; Vascular Access Devices; Wound Healing | 2013 |
The initiation of free radical peroxidation of low-density lipoproteins by glucose and its metabolite methylglyoxal: a common molecular mechanism of vascular wall injure in atherosclerosis and diabetes.
Topics: Adult; Aged; Coronary Artery Disease; Diabetes Mellitus; Female; Glucose; Humans; Lipid Peroxidation; Lipoproteins, LDL; Male; Metformin; Middle Aged; Probucol; Pyruvaldehyde; Superoxides | 2014 |
Increased renal semicarbazide-sensitive amine oxidase activity and methylglyoxal levels in aristolochic acid-induced nephrotoxicity.
Topics: Amine Oxidase (Copper-Containing); Animals; Aristolochic Acids; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Lysine; Male; Metformin; Mice; Mice, Inbred C57BL; Pyruvaldehyde | 2014 |
Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway.
Topics: Animals; Blood Urea Nitrogen; Chitosan; Gentamicins; Humans; Kidney; Kidney Diseases; Metabolic Networks and Pathways; Metformin; Oxidative Stress; Pyruvaldehyde; Rats; Renal Dialysis | 2015 |
Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Imidazolines; Male; Metformin; Middle Aged; Molecular Conformation; Pyruvaldehyde; Tandem Mass Spectrometry; Young Adult | 2016 |
Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes.
Topics: Antioxidants; Cytoprotection; Diabetes Mellitus; Erythrocytes; Glipizide; Glycated Serum Albumin; Glycation End Products, Advanced; Glycosylation; Humans; Metformin; Monocytes; Native Polyacrylamide Gel Electrophoresis; Oxidative Stress; Pyruvaldehyde; Serum Albumin; Serum Albumin, Bovine | 2016 |
Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein.
Topics: AMP-Activated Protein Kinases; Animals; C-Reactive Protein; Cytokines; Gene Expression; Glucose; Heart Ventricles; Humans; Lipolysis; Male; Metformin; Myocardium; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Inbred SHR; Rats, Transgenic | 2016 |
Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin-Secreting Cells; Metformin; Mitochondria; Phosphatidylinositol 3-Kinases; Pyruvaldehyde; Rats; Signal Transduction | 2016 |
Accumulation of methylglyoxal and d-lactate in Pb-induced nephrotoxicity in rats.
Topics: Animals; Biomarkers; Body Weight; Creatinine; Kidney; Kidney Diseases; L-Lactate Dehydrogenase; Lactates; Lead; Male; Metformin; Pyruvaldehyde; Rats, Wistar; Uric Acid | 2017 |
Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia.
Topics: Animals; Deoxyglucose; Diet; Glutathione; Glyoxal; Hypertriglyceridemia; Hypoglycemic Agents; Lactoylglutathione Lyase; Male; Metformin; Myocardium; Pyruvaldehyde; Rats; Rats, Wistar; Stress, Physiological | 2018 |
Reactions between methylglyoxal and its scavengers in-vivo appear to be catalyzed enzymatically.
Topics: Aldehydes; Carbon; Cardiovascular Agents; Catalysis; Diabetes Complications; Dihydroxyacetone; Fructosamine; Fructose-Bisphosphate Aldolase; Glutathione; Humans; Hydrogen-Ion Concentration; Kinetics; Metformin; Models, Biological; Pentoses; Phenotype; Polyphenols; Pyruvaldehyde | 2017 |
A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.
Topics: Animals; Hindlimb; Hyperglycemia; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazolines; Ischemia; Male; Metformin; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Nitric Oxide Synthase Type III; Pyruvaldehyde | 2021 |
Metformin abrogates the voiding dysfunction induced by prolonged methylglyoxal intake.
Topics: Administration, Oral; Animals; Disease Models, Animal; Glycation End Products, Advanced; Humans; Male; Metformin; Mice; Pyruvaldehyde; Urinary Bladder; Urinary Bladder Diseases; Urination | 2021 |
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Topics: Animals; Apoptosis; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Metformin; Mice; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyruvaldehyde; Reactive Oxygen Species; Signal Transduction; Vascular System Injuries | 2022 |
Metformin Counteracts the Deleterious Effects of Methylglyoxal on Ovalbumin-Induced Airway Eosinophilic Inflammation and Remodeling.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Lung; Magnesium Oxide; Male; Metformin; Mice; Mice, Inbred BALB C; Ovalbumin; Pyruvaldehyde; Reactive Oxygen Species; Receptor for Advanced Glycation End Products | 2023 |
Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: Reversing mitochondrial dysfunction and upregulating glyoxalase 1.
Topics: AMP-Activated Protein Kinases; Animals; Epithelial Cells; Glycation End Products, Advanced; Lactoylglutathione Lyase; Magnesium Oxide; Metformin; Mice; Mitochondria; Pyruvaldehyde; Reactive Oxygen Species; Retinal Diseases; Retinal Pigments | 2023 |