metformin has been researched along with phenformin in 235 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 134 (57.02) | 18.7374 |
| 1990's | 13 (5.53) | 18.2507 |
| 2000's | 17 (7.23) | 29.6817 |
| 2010's | 56 (23.83) | 24.3611 |
| 2020's | 15 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Bowden, CR; Jordan, AD; Marchione, CS; Maryanoff, BE; Reitz, AB; Tuman, RW | 1 |
| Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS | 1 |
| Dresser, MJ; Giacomini, KM; Gray, AT; Leabman, MK; Xiao, G | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Blomgren, A; Börjesson, L; Gustavsson, L; Hendrickx, R; Jenvert, RM; Johansson, JG; Lohmann, C | 1 |
| DeRose, EF; Duff, MR; Gabel, SA; Howell, EE; Krahn, JM; London, RE; Pedersen, LC | 1 |
| Castagnolo, D; Kim, SH; Semenya, D | 1 |
| Dai, L; Kyani, A; Neamati, N; Roy, J; Sun, D; Xu, Y; Xue, D | 1 |
| Alexander, WD; Marples, J | 1 |
| Biron, P | 1 |
| Verstraete, M | 1 |
| Schwandt, P; Weisweiler, P | 1 |
| Hazard, J | 1 |
| Eggstein, M; Luft, D; Schmülling, RM | 1 |
| Fowler, LK | 1 |
| Bloom, A; Bulpitt, CJ; Shaw, KM | 1 |
| Alberti, KG; Hinks, L; Lloyd, B; Nattrass, M; Todd, PG | 1 |
| Di Saverio, S; Roncaia, R; Torri, A; Zanni, A | 1 |
| Freund, H; Frick, A; Imler, M; Marbach, J; Schlienger, JL | 1 |
| Teijgeler, CA; van Gestel, WJ | 1 |
| Goebel, R; Pilger, E; Schmid, P | 2 |
| Aro, A; Idänpään-Heikkilä, J; Korhonen, T | 2 |
| Kowalik-Borówka, E; Tatoń, J | 1 |
| Lyngsøe, J; Mortensen, H; Schaffalitzky de Muckadell, OB | 1 |
| Marquie, G | 1 |
| Phillips, PJ | 1 |
| Aro, A | 1 |
| Alberti, KG; Nattrass, M | 1 |
| Bartosiewicz, W; Czyzyk, A; Lao, B; Orlowska, K; Szczepanik, Z | 1 |
| Morgan, DB; Wales, JK; Waters, AK | 1 |
| Foltin, E; Irsigler, K; Kritz, H; Regal, H | 1 |
| Bartosiewicz, W; Czyzyk, A; Lao, B; Orłowska, K; Szczepanik, Z | 1 |
| Bergman, U; Boman, G; Wiholm, BE | 1 |
| Kimbel, KH | 1 |
| Björntorp, P; Carlström, S; Fagerberg, SE; Hermann, LS; Holm, AG; Ostman, J; Scherstén, B | 1 |
| Bolzano, K | 1 |
| Bruneder, H; Klein, HJ | 1 |
| Bennett, MA; Fitzgerald, MG; Malins, JM; Pentecost, BL; Soler, NG | 1 |
| Harding, PE; Phillips, PJ; Thomas, DW | 1 |
| Caspary, WF; Deuticke, U; Emrich, D; Reimold, W; Willms, B; Zavada, I | 1 |
| Isnard, F; Lavieuville, M | 1 |
| Botha, JL; Jackson, WP; Vinik, AI | 1 |
| Catellier, C; Dupre, J; Gardiner, RJ; Hunt, JA; McKendry, JB; Toews, CJ; Yip, CC | 1 |
| Cairns, SA; Hartog, M; Marshall, AJ; Shalet, S | 1 |
| Jerums, G | 1 |
| Förster, H | 1 |
| Berger, W; Heierli, C; Mehnert-Aner, S; Mülly, K; Ritz, R | 1 |
| Forshan, PH; Karam, JH; Matin, SB | 1 |
| Brearley, BF | 1 |
| Chlouverakis, C | 1 |
| Madhavan, R; Sankaran, JR; Seshasaianam, C; Seshiah, V; Shanker, R; Sundaram, A; Venkataraman, S | 1 |
| Aguilar, C; García, JE; Reza, A; Rull, JA | 1 |
| Caffau, C; Cernigoi, AM; Velussi, M; Viezzoli, L | 1 |
| Kühnle, HF; Reiter, R; Schmidt, FH; Wolff, HP | 1 |
| Gill, G | 1 |
| Dembe, K; Janeczko, E; Koneczna, A; Pacuła, P; Stryjek-Kamińska, D; Tomaszczyk, M; Trusiewicz, D | 1 |
| Aluffi, E; Bruno, A; Carta, Q; Cavallo-Perin, P; Estivi, P; Lenti, G; Pagano, G | 1 |
| Brunetti, A; Buscema, M; Goldfine, ID; Gullo, D; Italia, S; Purrello, F; Vigneri, R | 1 |
| Alexander, L; Fletcher, P; Hirji, MR; Kuhn, S; Mucklow, JC | 1 |
| Benzi, L; Boni, C; Cecchetti, P; Ciccarone, AM; Ciociaro, D; Di Cianni, G; Giannarelli, R; Marchetti, P; Navalesi, R; Zappella, A | 1 |
| Basta, G; Calafiore, R; Calcinaro, F; Pietropaolo, M | 1 |
| Schernthaner, G | 1 |
| Liang, JZ; Luo, ZT; Yang, DP | 1 |
| Coupar, IM; McColl, I | 1 |
| Chakrabarti, R; Fearnley, GR; Hocking, ED | 1 |
| Chakrabarti, R; Evans, JF; Fearnley, GR | 1 |
| Dewar, HA; Menon, IS | 1 |
| Uvnäs, B | 1 |
| Beringer, A | 1 |
| Chakrabarti, R; Fearnley, GR | 1 |
| Baggio, G; Baiocchi, MR; Briani, G; Crepaldi, G; Fellin, R | 1 |
| Abdel-Khalek, A; Khayyal, MT; Masri, AM; Saleh, S; Sharat, AA | 1 |
| Sapeika, N | 1 |
| Harding, AP | 1 |
| Anderson, J | 1 |
| Penick, SB; Stunkard, AJ | 1 |
| Edlén, A | 1 |
| Bloom, A | 1 |
| Agid, R; Marquié, G | 3 |
| Katsilambros, N; Nierle, C; Pfeiffer, EE; Schatz, H | 1 |
| Chakrabarti, R | 1 |
| Jahn, P; Kraaz, W; Loge, O; Losert, W; Schillinger, E | 2 |
| Tomkin, GH | 1 |
| Corsini, GU; Muntoni, S; Sirigu, F; Tagliamonte, P | 1 |
| Haste, AR; Ormerod, TP; Skipper, EW | 1 |
| Chhetri, MK | 1 |
| Duncan, LJ; MacCuish, AC; Marshall, A; Munro, JF; Wilson, EM | 1 |
| Weinhaus, RS | 1 |
| Jackson, WP; Vinik, AI | 1 |
| Lopis, S; Schneider, T | 1 |
| Mehnert, H | 1 |
| Cucurachi, L; Cucurachi, P; Dell'Anna, A; Strata, A; Zuliani, U | 1 |
| Bertrand, CM; Cramer, J; Duwoos, H; Husson, A; Tayot, J | 1 |
| Debry, G; Laurent, J | 1 |
| Walker, RS | 1 |
| Jallet, F; Loubatières, A; Mariani, MM | 1 |
| Clarke, BF; Duncan, LJ | 1 |
| Bloom, A; Jones, R; Tomkins, AM | 1 |
| Garrett, ER; Tsau, J | 1 |
| Garrett, ER; Hinderling, PH; Tsau, J | 1 |
| Harris, EL | 1 |
| Fearnley, GR | 2 |
| Bianchini, P; Bramanti, G; De Fina, V; Dell'Omodarme, G | 1 |
| Lao, B; Okniński, W | 1 |
| Chakrabarti, R; Evans, J; Fearnley, GR; Hocking, ED | 1 |
| Laastuen, L; Todd, WR | 1 |
| Bewsher, PD; Stowers, JM | 1 |
| Dérot, M; Rathery, H; Rathery, M | 1 |
| Pyke, DA | 1 |
| Cabezas Cerrato, J; Fernández-Cruz, A | 1 |
| Smith, OA; Stowers, JM | 1 |
| Knapik, Z; Kowal-Gierczak, B; Paczyńska, D | 1 |
| Bergmann, F; Gutman, J; Zerachia, A | 1 |
| Tatoń, J | 1 |
| Bigozzi, U; Conti, C; Guazzelli, R; Montali, E; Salti, F | 1 |
| Haese, E | 1 |
| Clarke, BF; Duncan, LJ; Munro, JF | 1 |
| Berger, W; Constam, GR; Siegenthaler, W | 1 |
| Saito, T; Yoshida, S | 1 |
| Dandona, P; Khokher, NA; Taylor, AM; Woods, RJ | 1 |
| Jalling, O; Olsen, C | 1 |
| Pezzino, V; Purrello, F; Trischitta, V; Vigneri, R | 1 |
| Lunetta, M; Mughini, L; Mughini, MT; Presti, C | 1 |
| Adams, JF; Clark, JS; Ireland, JT; Kesson, CM; Watson, WS | 1 |
| Goldfine, ID; Pezzino, V; Vigneri, R; Wong, KY | 1 |
| Curtis-Prior, PB | 1 |
| Aro, A; Huttunen, JK; Järvinen, R; Juvonen, H; Korhonen, T; Palomäki, P; Ritala, P; Siitonen, O | 1 |
| Chen, S; Stucki, JW; Ubl, JJ | 1 |
| Denno, KM; Sadler, TW | 1 |
| Chatton, JY; Chen, S; Stucki, JW; Ubl, JJ | 1 |
| Halvatsiotis, PG; Raptis, AE; Raptis, SA; Tountas, NB; Yalouris, AG | 1 |
| Lopez-Liuchi, JV; Meier, CA | 1 |
| Butler-Jones, D; Stang, M; Wysowski, DK | 1 |
| Lalau, JD; Race, JM | 2 |
| McNeill, JH; Orvig, C; Thompson, KH; Woo, LC; Yuen, VG | 1 |
| Maier, C; Wulf, H | 1 |
| Kuroda, A; Yamasaki, Y | 1 |
| Inoue, T; Kira, K; Nagakura, T; Saeki, T; Tanaka, I; Yamazaki, K; Yasuda, N | 1 |
| AKAZAWA, Y | 1 |
| NABARRO, JD | 1 |
| POULSEN, JE | 1 |
| GRAUPNER, K; WIEZOREK, WD | 1 |
| SZANTO, S | 1 |
| PADFIELD, CJ | 1 |
| AKANUMA, Y; KOSAKA, K | 1 |
| OKER, C | 1 |
| Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR | 1 |
| Huypens, P; Pipeleers, D; Quartier, E; Van de Casteele, M | 1 |
| Feng, SY; Lai, EP | 1 |
| Cai, Y; Finsi, J; Heimberg, H; Hinke, SA; Martens, GA; Pipeleers, D; Van de Casteele, M | 1 |
| Balschi, JA; He, H; Zhang, L | 1 |
| Baines, DL; Hardie, DG; Kalsi, KK; Mustard, KJ; Pellatt, LJ; Pucovsky, V; Scott, JW; Sivagnanasundaram, J; Woollhead, AM | 1 |
| Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI | 1 |
| Hayashi, K; Heishi, M; Ichihara, J; Ishikawa, H; Kanaoka, M; Kawamura, T; Kimura, T; Taiji, M | 1 |
| Hasinoff, BB; O'Hara, KA; Patel, D | 1 |
| Billis, PA; Dykens, JA; Jamieson, J; Marroquin, L; Nadanaciva, S; Will, Y | 1 |
| Kitamura, A; Komuro, S; Sogame, Y; Yabuki, M | 2 |
| Foti, G; Gattinoni, L; Mistraletti, G; Protti, A; Rossi, A; Rudiger, A; Russo, R; Singer, M; Tagliabue, P; Vecchio, S | 1 |
| Bardeesy, N; Brûlé, S; Dennis, P; Gulati, P; Kalender, A; Kemp, BE; Kim, SY; Kozma, SC; Marette, A; Schlager, JJ; Selvaraj, A; Thomas, G; Viollet, B | 1 |
| Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T | 1 |
| Berstein, LM | 1 |
| Fernandez-Millan, E; Leclerc, I; Morris, C; Nyirenda, M; Rutter, GA; Sun, G | 1 |
| Chen, H; Fromm, M; Jiang, S; Miner, J; Riethoven, JJ; Wang, Z; Xia, Y | 1 |
| Noszál, B; Orgován, G | 1 |
| Asara, JM; Dillin, A; Egan, DF; Fitzpatrick, J; Gelino, S; Gwinn, DM; Hansen, M; Joshi, A; Kohnz, RA; Kundu, M; Mair, W; Mihaylova, MM; Shackelford, DB; Shaw, RJ; Taylor, R; Vasquez, DS; Viollet, B | 1 |
| Chen, L; Ma, A; Shen, M; Zhou, Z | 1 |
| Beauchamp, MC; Gotlieb, WH; Pollak, M; Rosenblatt, J; Segal, ED; Yasmeen, A | 1 |
| Ortiz, MI | 1 |
| Alessi, DR; Appleyard, MV; Bray, SE; Coates, PJ; Fleming, S; Kernohan, NM; Murray, KE; Thompson, AM; Wullschleger, S | 1 |
| Fey, SJ; Wrzesinski, K | 1 |
| Drouin, O; Gray, A; Green, CJ; Hardie, DG; Hundal, HS; Lantier, L; Marette, A; Ross, F; Stretton, C; Turban, S; Viollet, B; Watson, ML | 1 |
| Birnbaum, MJ; Chu, Q; Foretz, M; Miller, RA; Viollet, B; Xie, J | 1 |
| Berglund, ED; Cherrington, AD; Habener, JF; Unger, RH | 1 |
| Kitamura, A; Komuro, S; Sogame, Y; Takano, M; Yabuki, M | 1 |
| Asnafi, V; Bost, F; Hagenbeek, T; Imbert, V; Lounnas, N; Michiels, JF; Nebout, M; Peyron, JF; Pontier-Bres, R; Reverso, J; Rosilio, C; Sahra, IB; Spits, H | 1 |
| Brejchova, J; Cahova, M; Cervinkova, Z; Drahota, Z; Endlicher, R; Kalous, M; Kazdova, L; Milerova, M; Palenickova, E; Svoboda, P; Vosahlikova, M | 1 |
| Hsiao, R; Ikegaki, N; Limpar, MM; Lomahan, S; Maloney, NJ; Tang, XX; Tran, TA; Wang, SS | 1 |
| Asara, JM; German, NJ; Gonzalez-Herrera, KN; Haigis, MC; Janzer, A; Struhl, K | 1 |
| Albini, A; Bertolini, F; Calleri, A; Dallaglio, K; Gregato, G; Labanca, V; Mancuso, P; Noonan, DM; Orecchioni, S; Reggiani, F; Talarico, G | 1 |
| Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B | 1 |
| Birman, E; Blouin, MJ; Gravel, SP; Hulea, L; Pollak, M; St-Pierre, J; Toban, N; Topisirovic, I; Zakikhani, M; Zhao, Y | 1 |
| Humphries, KM; Matsuzaki, S | 1 |
| Echeverria, D; Jiang, W; McGinley, JN; Thompson, HJ; Thompson, MD; Zhu, Z | 1 |
| Lilla, C; Livingstone, E; Roesch, A; Schadendorf, D; Swann, S | 1 |
| Baltazar, F; Granja, S; Le Floch, R; Marchiq, I; Moura, CS; Pouysségur, J | 1 |
| Chi, CW; Hsia, CY; Hsu, CC; Lee, HC; Wu, LC; Yeh, TS; Yin, PH | 1 |
| Eckert, MA; Johnson, A; Lengyel, E; Litchfield, LM; Mills, KA; Mukherjee, A; Pan, S; Romero, IL; Shridhar, V | 1 |
| Andreeff, M; Bornmann, W; Duque, JE; Enciso, L; Jaramillo, D; Konopleva, M; Krystal, G; Lee, JT; Lopez, C; Morales, L; Pan, R; Samudio, I; Suarez, M; Velez, J | 1 |
| Kawanishi, S; Mizutani, H; Ohnishi, S | 1 |
| Langmaier, J; Pižl, M; Samec, Z; Záliš, S | 1 |
| Lin, HK; Zhang, X | 1 |
| Benjamin, D; Betz, C; Colombi, M; El-Shemerly, MY; Hall, MN; Hindupur, SK; Lane, HA; Lu, M; Moes, S; Moroni, C; Quagliata, L; Sharpe, T; Terracciano, L; Wodnar-Filipowicz, A | 1 |
| Albini, A; Argenziano, G; Ciarrocchi, A; Dallaglio, K; Dominici, M; Grisendi, G; Longo, C; Petrachi, T; Romagnani, A | 1 |
| Boros, LG; Collins, TQ; D'Agostino, DP; Hitendra, P; Meuillet, EJ; Somlyai, G | 1 |
| Alan, L; Drahota, Z; Houstek, J; Kovalcikova, J; Kovarova, N; Mracek, T; Pecina, P; Pecinova, A; Zima, M | 1 |
| Cai, H; Chen, R; Guan, Q; Guo, Z; He, J; Li, X; Liu, H; Song, K; Wang, X; Yan, H; Zheng, W | 1 |
| Byun, JW; Han, YE; Hwang, S; Kim, JH; Lee, EJ; Yoon, JS | 1 |
| Castaño, JP; Fuentes-Fayos, AC; Gahete, MD; Kineman, RD; Luque, RM; Vázquez-Borrego, MC | 1 |
| Bass, AJ; Beeson, CC; Beeson, GC; Diehl, JA; Ogretmen, B; Oleinik, N; Parnham, S; Qie, S; Rustgi, AK; Wong, KK; Yoshida, A | 1 |
| Dingli, D; Mishra, AK | 1 |
| Atrih, A; Cantrell, DA; Dandapani, M; Foretz, M; Grzes, KM; Hardie, DG; Lamont, DJ; Russell, FM; Vara-Ciruelos, D; Viollet, B | 1 |
| Hébrant, M; Herzog, G; Hussin, MH; Jajuli, MN; Rahim, AA; Saad, B | 1 |
| Aleidi, SM; Alsalamat, HA; Bardaweel, SK; Bashatwah, RM | 1 |
| Jang, H; Kim, A; Kim, H; Kim, MJ; Kim, YH; Lee, SB; Lee, SJ; Myung, JK; Park, EH; Park, JH; Park, S; Shim, S | 1 |
| Ellinger-Ziegelbauer, H; Freyberger, A; Heinz, S; Lawrenz, B; Schladt, L; Schmuck, G | 1 |
| He, H; Li, P; Lin, D; Yang, L | 1 |
| Fraser-Spears, R; Kim, SS; La-Viola, B; Ramsinghani, S; Sikazwe, D; Witte, AP; Yendapally, R | 1 |
| Davis, R; Ding, D; Hillel, AT; Lina, I; Motz, KM; Tsai, HW | 1 |
| Borutaite, V; Cizas, P; Jekabsone, A; Morkuniene, R; Rekuviene, E; Skemiene, K | 1 |
| Borutaite, V; Pampuscenko, K; Svirskiene, N; Svirskis, G | 1 |
| Honglian, Z; Hongling, L; Huiyu, W; Jikai, S; Li, L; Meijuan, Z; Wei, D | 1 |
| Ang, WH; Babak, MV; Balyasnikova, IV; Casini, A; Chang, MR; Chong, KR; Heffeter, P; Kushnarev, V; Lim, ZC; Meier-Menches, SM; Rapta, P; Reichert, L; Tang, HM; Yap, JY; Zannikou, M | 1 |
| Ansari, IH; Longacre, MJ; MacDonald, MJ; Stoker, SW | 1 |
| Barry, AP; Bonglack, EN; Cable, JM; Ch'ng, J; Christofk, HR; Dave, SS; Luftig, MA; Messinger, JE; Parnell, KM; Reinoso-Vizcaíno, NM; Russell, VS | 1 |
| Akao, Y; Heishima, K; Honda, R; Ito, R; Ito, Y; Kuranaga, Y; Nakagawa, T; Nishikawa, M; Sakai, H; Soga, T; Sugito, N; Ueda, H | 1 |
| Bober-Majnusz, K; Dołowy, M; Jampilek, J | 1 |
| Butrico, GM; Cline, GW; Gaspar, RC; Goedeke, L; Hubbard, BT; Hüttemann, M; Kalpage, HA; LaMoia, TE; Nakahara, K; Shimada, A; Shulman, GI; Vatner, DF; Woo, S; Zhang, XM | 1 |
| Jayabal, D; Jayanthi, S; Shimu, MSS; Thirumalaisamy, R | 1 |
21 review(s) available for metformin and phenformin
| Article | Year |
|---|---|
Antimicrobial drugs bearing guanidine moieties: A review.
Topics: Anti-Infective Agents; Binding Sites; DNA Gyrase; Drug Design; Fungi; Gram-Positive Bacteria; Guanidine; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Structure-Activity Relationship | 2021 |
The position of long-term stimulation of the endogenous fibrinolytic system: present achievements and clinical perspectives.
Topics: Adrenocorticotropic Hormone; Anabolic Agents; Androgens; Clofibrate; Coronary Disease; Deamino Arginine Vasopressin; Drug Therapy, Combination; Female; Fibrinolysis; Fibrinolytic Agents; Glucocorticoids; Humans; Inflammation; Male; Metformin; Phenformin; Plasminogen Activators; Postoperative Complications; Sulfonylurea Compounds; Thromboembolism; Thrombophlebitis; Vascular Diseases | 1975 |
Lactic acidosis in biguanide-treated diabetics: a review of 330 cases.
Topics: Acidosis; Biguanides; Buformin; Diabetes Complications; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactates; Metformin; Phenformin | 1978 |
Practical management of diabetes in the tropics.
Topics: Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Metformin; Phenformin; Pregnancy | 1990 |
Obesity.
Topics: Adolescent; Adult; Appetite Depressants; Child; Diagnosis; Diet, Reducing; Fasting; Female; Humans; Male; Metformin; Methylcellulose; Middle Aged; Obesity; Phenformin | 1972 |
The treatment of obesity.
Topics: Amphetamine; Behavior Therapy; Chorionic Gonadotropin; Dextroamphetamine; Exercise Therapy; Hospitalization; Humans; Metformin; Obesity; Phenformin; Psychotherapy, Group; Triiodothyronine; Voluntary Health Agencies | 1972 |
[Differences between 2 antidiabetic biguanides: metformin and phenformin].
Topics: Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus; Fatty Acids; Humans; Insulin; Insulin Secretion; Lactates; Lipid Metabolism; Liver; Metformin; Oxygen Consumption; Phenformin | 1972 |
Current therapeutics. CCXLVI.--Metformin.
Topics: Diabetes Mellitus; Humans; Metformin; Phenformin | 1968 |
Oral treatment of diabetes mellitus.
Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Phenformin; Sulfonamides; Tolbutamide | 1968 |
The management of obesity: some recent concepts.
Topics: Adaptation, Psychological; Adipose Tissue; Appetite Depressants; Attitude; Chlorphentermine; Defense Mechanisms; Diet Therapy; Diet, Reducing; Diethylpropion; Exercise Therapy; Humans; Metformin; Nervous System; Obesity; Phenformin; Thyroid Hormones; Thyroxine; Triiodothyronine | 1969 |
[Pharmacokinetics of blood glucose lowering biguanide derivatives].
Topics: Animals; Biguanides; Blood Glucose; Guinea Pigs; Humans; Hypoglycemic Agents; Kinetics; Metformin; Mice; Phenformin; Protein Binding; Rabbits; Rats; Species Specificity; Time Factors; Tritium | 1969 |
Advances in the treatment of diabetes mellitus.
Topics: Blood Glucose; Chlorpropamide; Clofibrate; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Diabetic Retinopathy; Diet Therapy; Humans; Hypoglycemia; Insulin; Kidney Transplantation; Lactates; Light Coagulation; Metformin; Methods; Pancreas Transplantation; Phenformin; Pituitary Gland; Renal Dialysis; Sulfonylurea Compounds; Tolbutamide | 1971 |
[Behavior of lactate and pyruvate in diabetics during ambulatory treatment with biguanides or with a combination of biguanides and sulfonylureas. II].
Topics: Aged; Ambulatory Care; Biguanides; Diabetes Mellitus; Diabetic Ketoacidosis; Drug Combinations; Female; Glyburide; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Pyruvates; Sulfonylurea Compounds | 1980 |
Therapy for type 2 diabetes: where do we stand after the UK prospective diabetes study?
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diet Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Prospective Studies; Randomized Controlled Trials as Topic; Tolbutamide | 1999 |
Metformin and lactic acidosis in diabetic humans.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Hypoglycemic Agents; Metformin; Phenformin; Prognosis | 2000 |
[Adverse effect of biguanides].
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Gastrointestinal Diseases; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Phenformin; Vitamin B 12 Deficiency | 2002 |
ADVANCES IN THE TREATMENT OF DIABETES MELLITUS.
Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Tolbutamide | 1963 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Phenformin; Risk Assessment | 2003 |
Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond.
Topics: Diet Therapy; Exercise Therapy; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Phenformin | 2010 |
Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma.
Topics: Atorvastatin; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Metformin; Phenformin | 2017 |
A review of phenformin, metformin, and imeglimin.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Phenformin; Triazines | 2020 |
13 trial(s) available for metformin and phenformin
| Article | Year |
|---|---|
Diabetic hearts and biguanides.
Topics: Animals; Biguanides; Canada; Cardiovascular Diseases; Clinical Trials as Topic; Cyclic AMP; Diabetes Mellitus; Female; Humans; Male; Metformin; Phenformin; Placebos; Prospective Studies; Retrospective Studies | 1975 |
[Treatment of primary hyperlipoproteinemias type IV with different biguanides (author's transl)].
Topics: Biguanides; Buformin; Cholesterol; Female; Humans; Hyperlipidemias; Lipoproteins, VLDL; Male; Metformin; Middle Aged; Phenformin; Triglycerides | 1976 |
Glipizide in the treatment of maturity-onset diabetes: a multi-centre, out-patient study.
Topics: Adult; Aged; Blood Glucose; Body Weight; Clinical Trials as Topic; Diabetes Mellitus; Female; Glipizide; Glycosuria; Humans; Male; Metformin; Middle Aged; Phenformin; Sulfonylurea Compounds; Time Factors | 1978 |
Metabolic effects of glucocorticoid and ethanol administration in phenformin- and metformin-treated obese diabetics.
Topics: Aged; Blood Glucose; Diabetes Mellitus; Drug Synergism; Ethanol; Humans; Hydrocortisone; Lactates; Metformin; Middle Aged; Obesity; Phenformin; Pyruvates | 1979 |
[The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Exercise Test; Female; Humans; Lactates; Male; Metformin; Phenformin; Risk | 1978 |
Association of lactic acidosis with biguanide therapy.
Topics: Biguanides; Buformin; Depression, Chemical; Diabetes Mellitus; Humans; Lactates; Metabolic Clearance Rate; Metformin; Phenformin | 1977 |
The hyperlactatemic effect of biguanides: a comparison between phenformin and metformin during a 6-month treatment.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; Phenformin; Time Factors | 1989 |
Fibrinolytic effects of diguanides plus ethyloestrenol in occlusive vascular disease.
Topics: Adult; Aged; Angina Pectoris; Biguanides; Blood Coagulation Tests; Cholesterol; Ethylestrenol; Female; Fibrinogen; Humans; Intermittent Claudication; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Placebos; Vascular Diseases | 1967 |
Weight-reducing effect of diguanides in obese non-diabetic women.
Topics: Adult; Appetite; Bicarbonates; Body Weight; Clinical Trials as Topic; Female; Glucose Tolerance Test; Humans; Metformin; Middle Aged; Nausea; Obesity; Phenformin; Placebos; Time Factors | 1969 |
Preliminary trial of a powerful new sulphonylurea in maturity-onset diabetes--HB419 (glibenclamide).
Topics: Adult; Age Factors; Aged; Blood Chemical Analysis; Chlorpropamide; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Sulfonamides; Tolbutamide | 1969 |
HB419 (glibenclamide) in the treatment of diabetes mellitus.
Topics: Adult; Age Factors; Aged; Biguanides; Chlorpropamide; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Female; Gallbladder Diseases; Gastrointestinal Diseases; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseases; Male; Metformin; Middle Aged; Phenformin; Sulfonamides; Tolbutamide; Urea; Vascular Diseases | 1969 |
[Biguanides in treatment of obesity. II. Controlled clinical research with placebos, metformin and phenformin in obesity with normal and reduced tolerance to carbohydrates].
Topics: Adolescent; Adult; Aged; Biguanides; Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Male; Metformin; Middle Aged; Obesity; Phenformin; Placebos | 1968 |
Therapeutic effect of glibenclamide in a fixed combination with metformin or phenformin in NIDDM patients.
Topics: Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipids; Male; Metformin; Middle Aged; Phenformin; Prospective Studies | 1996 |
201 other study(ies) available for metformin and phenformin
| Article | Year |
|---|---|
Carbohydrate biguanides as potential hypoglycemic agents.
Topics: Administration, Oral; Animals; Biguanides; Glucose Tolerance Test; Hypoglycemic Agents; Male; Mass Spectrometry; Metformin; Monosaccharides; Phenformin; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
Topics: Animals; Biological Transport; CHO Cells; Cimetidine; Cricetinae; Intestinal Absorption; Kinetics; Liver; Metformin; Mice; Mice, Knockout; Organic Cation Transporter 1; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Distribution; Transfection | 2002 |
Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).
Topics: Animals; Biguanides; Female; Humans; Organic Cation Transport Proteins; Organic Cation Transporter 2; Quaternary Ammonium Compounds; Xenopus laevis | 2002 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2.
Topics: Biological Transport; Chemical Phenomena; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pharmaceutical Preparations; Reproducibility of Results; Structure-Activity Relationship; Substrate Specificity | 2013 |
The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallography, X-Ray; Drug Design; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Tetrahydrofolate Dehydrogenase | 2020 |
Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Discovery; Female; Humans; Mice; Mice, Inbred C57BL; Oxidative Phosphorylation; Pancreatic Neoplasms; Structure-Activity Relationship; Sulfonamides; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2022 |
Biguanides and lacticacidosis.
Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Diet, Diabetic; Humans; Lactates; Metformin; Phenformin | 1977 |
[What is the role of the biguanides in the treatment of diabetes mellitus?].
Topics: Acidosis; Diabetes Mellitus; Drug Evaluation; Gastrointestinal Diseases; Humans; Lactates; Metformin; Phenformin | 1978 |
Side effects of therapy in diabetes evaluated by a self-administered questionnaire.
Topics: Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Patient Acceptance of Health Care; Phenformin; Surveys and Questionnaires; Tolbutamide | 1977 |
Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.
Topics: Aged; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Female; Gluconeogenesis; Glyburide; Humans; Insulin; Ketone Bodies; Lactates; Lipids; Male; Metformin; Middle Aged; Phenformin; Pyruvates | 1977 |
[Clinico-statistical studies of the use of oral hypoglycemic agents in the therapy of diabetes: critical evaluation of their effectiveness and tolerance].
Topics: Adult; Aged; Chlorpropamide; Diabetes Mellitus; Drug Evaluation; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Tolbutamide | 1977 |
Effects of biguanides on the intermediate metabolism of glucose in normal and portal-strictured rats.
Topics: Alanine; Ammonia; Animals; Blood Glucose; Constriction; Glutamine; Lactates; Liver Circulation; Male; Metformin; Phenformin; Portal Vein; Pyruvates; Rats; Urea | 1979 |
[Biguanides, rejection of treatment with buformin and fenformin, and restriction of indications for the use of metformin].
Topics: Biguanides; Buformin; Drug and Narcotic Control; Humans; Hypoglycemic Agents; Metformin; Netherlands; Phenformin | 1979 |
[Effect of biguanids on the lactate metabolism. Studies in diabetics under submaximal ergometric exercise (author's transl)].
Topics: Biguanides; Blood Glucose; Buformin; Diabetes Mellitus; Humans; Lactates; Male; Membrane Potentials; Metformin; Mitochondria; Phenformin; Physical Exertion; Pyruvates | 1979 |
Biguanide-induced lactic acidosis in Finland.
Topics: Acidosis; Aged; Biguanides; Finland; Humans; Hypoglycemic Agents; Lactates; Metformin; Middle Aged; Phenformin | 1979 |
[Indications and contraindications to the diabetes mellitus therapy by biguanide derivatives in the light of the metabolic and epidemiologic studies (author's transl)].
Topics: Adult; Aged; Biguanides; Buformin; Diabetes Mellitus; Humans; Metformin; Middle Aged; Phenformin | 1979 |
Comparative effects of metformin and phenformin on the progression and regression of cholesterol induced athreosclerosis in rabbits.
Topics: Animals; Arteriosclerosis; Cholesterol, Dietary; Fatty Liver; Lipid Metabolism; Liver; Male; Metformin; Phenformin; Rabbits | 1979 |
Biguanides and lactic acidosis in diabetics.
Topics: Acidosis; Diabetes Mellitus; Humans; Lactates; Metformin; Phenformin | 1977 |
Biguanides and lactic acidosis in diabetics.
Topics: Acidosis; Humans; Lactates; Metformin; Phenformin | 1978 |
[Biguanides and lactic acidosis].
Topics: Acidosis; Biguanides; Buformin; Humans; Lactates; Metformin; Phenformin | 1978 |
Biguanides.
Topics: Biguanides; Buformin; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactates; Metformin; Phenformin | 1978 |
The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects.
Topics: Adolescent; Adult; Biguanides; Blood Glucose; Buformin; Ethanol; Female; Fructose; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Physical Exertion | 1978 |
Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas.
Topics: Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Lactates; Male; Metformin; Middle Aged; Phenformin; Pyruvates; Sulfonylurea Compounds | 1978 |
[Comparison of the effects of phenformin, buformin and metformin on blood lactate level].
Topics: Biguanides; Buformin; Female; Humans; Lactates; Male; Metformin; Phenformin | 1978 |
Epidemiology of adverse drug reactions to phenformin and metformin.
Topics: Acidosis; Adolescent; Adult; Aged; Drug Prescriptions; Epidemiologic Methods; Female; Humans; Male; Metformin; Middle Aged; Phenformin; Sweden | 1978 |
[Biguanides].
Topics: Acidosis; Biguanides; Buformin; Humans; Metformin; Phenformin | 1978 |
Influence of phenformin and metformin on exercise induced lactataemia in patients with diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Female; Glycosuria; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Physical Exertion | 1978 |
[Lactic acidosis associated with biguanide therapy in Finland 1974-1977].
Topics: Acidosis; Adult; Aged; Female; Humans; Lactates; Male; Metformin; Phenformin | 1978 |
[Biguanides: reasons for withdrawal of drugs and remaining indications].
Topics: Acidosis; Austria; Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Legislation, Drug; Metformin; Obesity; Phenformin | 1978 |
[Blood lactate and biguanide therapy: comparison between phenformin, metformin and buformin in 408 senile diabetics].
Topics: Aged; Biguanides; Buformin; Diabetes Mellitus; Female; Humans; Lactates; Male; Metformin; Phenformin | 1978 |
[Effect of biguanide therapy on lactate metabolism during graded submaximal ergometric testing].
Topics: Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Metformin; Phenformin; Physical Exertion | 1978 |
Myocardial infarction in diabetics.
Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Coronary Care Units; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Sex Factors; Sulfonylurea Compounds; Tolbutamide | 1975 |
Oral hypoglycaemic agents--dangers and contraindications.
Topics: Acidosis; Humans; Lactates; Metformin; Phenformin | 1977 |
Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides.
Topics: Biguanides; Buformin; Carbon Dioxide; Cholic Acids; Diabetes Mellitus; Doxycycline; Feces; Female; Glycocholic Acid; Humans; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12 | 1977 |
[Lactic acidosis and biguanides: present state of the question in France].
Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Female; France; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin | 1977 |
The use of phenformin and metformin.
Topics: Acidosis; Humans; Metformin; Phenformin; Risk | 1977 |
A comparison of phenformin and metformin in the treatment of maturity onset diabetes.
Topics: Adult; Aged; Blood Glucose; Body Weight; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Humans; Male; Metformin; Middle Aged; Phenformin; Triglycerides | 1977 |
The biguanides: action and clinical indications.
Topics: Biguanides; Diabetes Mellitus; Humans; Hyperglycemia; Metformin; Phenformin | 1976 |
[The importance of lactate acidosis as a side effect of biguanide therapy].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug Therapy, Combination; Ethanol; Humans; Kidney; Lactates; Liver; Metformin; Peritoneal Dialysis; Phenformin | 1976 |
[10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Glucagon; Humans; Lactates; Liver; Metformin; Phenformin; Shock, Cardiogenic | 1976 |
Simple elcetron capture gas chromatographic method for the determination of oral hypoglycemic biguanidis in biological fluids.
Topics: Biguanides; Buformin; Chromatography, Gas; Humans; Metformin; Phenformin | 1975 |
The management of pregnancy in diabetes mellitus.
Topics: Birth Weight; Blood Glucose; Chlorpropamide; Delivery, Obstetric; Diet, Diabetic; Female; Fetal Death; Humans; Infant, Newborn; Insulin; Ketosis; Maternal Age; Metformin; Phenformin; Pregnancy; Pregnancy in Diabetics; Time Factors; Tolbutamide | 1975 |
Dietary and medical treatments of obesity: an evaluative review.
Topics: Amphetamines; Appetite Depressants; Behavior Therapy; Chorionic Gonadotropin; Diet, Reducing; Evaluation Studies as Topic; Exercise Therapy; Fenfluramine; Group Processes; Hospitalization; Humans; Hypnosis; Metformin; Nutritional Requirements; Obesity; Phenformin; Psychotherapy; Thyroid Hormones | 1975 |
Effect of bed time intermediate acting insulin in NIDDM subjects refractory to a combination of sulphonylureas and biguanides.
Topics: Biguanides; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Combinations; Female; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Injections, Subcutaneous; Insulin, Long-Acting; Lipids; Male; Metformin; Middle Aged; Phenformin; Sulfonylurea Compounds; Time Factors | 1992 |
Biguanide related lactic acidosis: incidence and risk factors.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Biguanides; Contraindications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Emergencies; Female; Humans; Incidence; Male; Metformin; Mexico; Middle Aged; Odds Ratio; Phenformin; Prospective Studies; Retrospective Studies; Risk Factors; Sulfonylurea Compounds | 1992 |
[Median-term (4 months) treatment with glibenclamide + metformin substituting for glibenclamide + fenformin lowers the lacticemia levels in type-2 diabetics (NIDDM)].
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Glyburide; Glycated Hemoglobin; Glycosuria; Humans; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Phenformin | 1992 |
Blood-glucose-lowering activity of 2-(3-phenylpropoxyimido)-butyrate (BM 13.677).
Topics: Animals; Cells, Cultured; Fasting; Gluconeogenesis; Guinea Pigs; Hypoglycemic Agents; Imino Acids; Liver; Male; Metformin; Mice; Phenformin; Rabbits; Rats | 1990 |
[Evaluation of the late ineffectiveness of sulfonylurea derivatives in patients with diabetes mellitus hospitalized at the Gastroenterology and Metabolic Disease Clinic, Medical Academy, in Warsaw 1976-1987].
Topics: Adult; Age Factors; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Resistance; Drug Therapy, Combination; Female; Hospitalization; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Time Factors | 1989 |
Direct effects of biguanides on glucose utilization in vitro.
Topics: Blood Glucose; Cytochalasin B; Deoxyglucose; Humans; In Vitro Techniques; Lymphocytes; Metformin; Phenformin | 1987 |
The effects of diabetes mellitus, exercise, and single doses of biguanides upon lactate metabolism in man.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Exercise Test; Fasting; Female; Humans; Lactates; Male; Metformin; Middle Aged; Oxidation-Reduction; Phenformin; Phenotype; Pyruvates | 1986 |
Plasma biguanide levels are correlated with metabolic effects in diabetic patients.
Topics: Aged; Blood Glucose; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus, Type 2; Female; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Pyruvates; Triglycerides | 1987 |
[Biguanides and glucidic homeostasis: effects of metformin and phenformin on the intermediate metabolism and insulin receptors of normal subjects].
Topics: Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Lactates; Metformin; Phenformin; Receptor, Insulin | 1985 |
Improvement of insulin action is an important part of the antidiabetic effect of metformin.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Erythrocytes; Humans; Insulin; Metformin; Phenformin; Receptor, Insulin | 1985 |
[Alteration of blood lactic acid levels in biguanide therapy in diabetics].
Topics: Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Lactates; Lactic Acid; Metformin; Middle Aged; Phenformin | 1985 |
Glucose absorption from the rat jejunum during acute exposure to metformin and phenformin.
Topics: Animals; Depression, Chemical; Glucose; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Metformin; Phenformin; Phlorhizin; Rats | 1974 |
Effect of ethyloestrenol combined with phenformin or with metformin on platelet stickiness and serum-cholesterol in patients with occlusive vascular disease.
Topics: Aged; Anticholesteremic Agents; Blood Coagulation Tests; Blood Platelets; Butyrates; Cholesterol; Coronary Disease; Ethylestrenol; Female; Fibrinolysis; Humans; Intracranial Embolism and Thrombosis; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Vascular Diseases | 1968 |
Increased blood-urea during phenformin therapy.
Topics: Adult; Female; Fibrinolytic Agents; Humans; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Phlebitis; Stanozolol; Urea | 1970 |
[Biguanides and lactic acid acidosis].
Topics: Adult; Diabetic Ketoacidosis; Humans; Lactates; Metformin; Middle Aged; Phenformin; Sweden | 1973 |
[Oral antidiabetic therapy with delayed-action glibenclamide and phenformin in fixed combination].
Topics: Adult; Aged; Blood Glucose; Carbutamide; Cholesterol; Delayed-Action Preparations; Diabetes Mellitus; Drug Combinations; Evaluation Studies as Topic; Fatty Acids, Nonesterified; Female; Glyburide; Glycosuria; Humans; Lipids; Male; Metformin; Middle Aged; Phenformin; Tolbutamide; Triglycerides | 1974 |
Pharmacological fibrinolysis.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Clofibrate; Delayed-Action Preparations; Drug Resistance; Drug Therapy, Combination; Ethylestrenol; Female; Fibrin; Fibrinolysis; Humans; Male; Metformin; Methadone; Nandrolone; Phenformin; Stimulation, Chemical; Sulfonylurea Compounds; Testosterone; Time Factors | 1972 |
[Treatment of hyperlipoproteinemias (author's transl)].
Topics: Adolescent; Adult; Anticholesteremic Agents; Child; Cholestyramine Resin; Clofibrate; Dextrothyroxine; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Ion Exchange Resins; Lipoproteins; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Metformin; Middle Aged; Nicotinic Acids; Phenformin | 1974 |
Studies on the effect of oral hypoglycaemic agents on hepatic glycogenolysis.
Topics: Acetohexamide; Animals; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Experimental; Glucose-6-Phosphatase; Hypoglycemic Agents; In Vitro Techniques; Liver; Liver Glycogen; Male; Metformin; Phenformin; Phosphorylases; Rats; Sulfonamides; Tolbutamide | 1974 |
Drugs in obesity.
Topics: Amphetamine; Appetite Depressants; Diet, Reducing; Diuretics; Ephedrine; Fenfluramine; Health Education; Humans; Legislation, Drug; Metformin; Methylcellulose; Motivation; Obesity; Phenformin; Physical Exertion; South Africa; Thyroxine | 1974 |
Letter: Lactic acidosis and biguanides.
Topics: Acidosis; Humans; Lactates; Metformin; Phenformin | 1974 |
[Glibenclamide, a new oral antidiabetic].
Topics: Administration, Oral; Adult; Aged; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Female; Glyburide; Humans; Insulin; Male; Metformin; Middle Aged; Phenformin; Sulfonylurea Compounds | 1972 |
Oral therapy in diabetes.
Topics: Acetohexamide; Administration, Oral; Animals; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Evaluation Studies as Topic; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Obesity; Phenformin; Pyrimidines; Sulfonamides; Time Factors; Tolbutamide | 1972 |
[Inhibitory effects of the certain antidiabetic biguanides upon the intestinal absorption of lipids].
Topics: Animals; Cholesterol; Diet, Atherogenic; Dietary Proteins; Fatty Liver; Feces; Glycerides; Intestinal Absorption; Male; Metformin; Oils; Phenformin; Rabbits | 1972 |
The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats.
Topics: Animals; Biguanides; Drug Interactions; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Metformin; Oxygen Consumption; Phenformin; Rats; Rats, Inbred Strains; Tritium | 1972 |
Comparative effects of platelet adhesiveness by phenformin combined with ethylestrenol or stanozolol.
Topics: Administration, Oral; Arterial Occlusive Diseases; Cholesterol; Drug Therapy, Combination; Ethylestrenol; Fibrinogen; Fibrinolysis; Follow-Up Studies; Glass; Humans; Metformin; Methods; Phenformin; Platelet Adhesiveness; Stanozolol; Time Factors | 1972 |
[Animal experimental studies on the mode of action of biguanides. 1. Studies with hypoglycemia-inducing doses of biguanide].
Topics: Animals; Biguanides; Blood Glucose; Carbon Isotopes; Diaphragm; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Germ-Free Life; Gluconeogenesis; Glucose; Guinea Pigs; Hypoglycemia; Insulin; Insulin Secretion; Liver; Male; Metformin; Oxygen Consumption; Phenformin; Rats | 1972 |
[Animal experimental studies on the mode of action of biguanides. 1. Studies on non hypoglycemically acting biguanide].
Topics: Animals; Biguanides; Butanes; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus; Diaphragm; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glycogen; Guinea Pigs; Hexokinase; Insulin; Lactates; Liver; Metformin; Muscles; Phenformin; Pyruvates; Rats | 1972 |
The effects of metformin on lipid-induced atherosclerosis.
Topics: Animals; Arteries; Arteriosclerosis; Blood Glucose; Cholesterol; Diet, Atherogenic; Fatty Acids, Nonesterified; Fatty Liver; Glycogen; Hyperlipidemias; Intestinal Absorption; Lipoproteins; Liver; Male; Metformin; Phenformin; Phospholipids; Rabbits | 1973 |
Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin.
Topics: Cobalt Isotopes; Diabetes Mellitus; Female; Folic Acid; Hemoglobinometry; Humans; Intestinal Absorption; Male; Metformin; Middle Aged; Phenformin; Schilling Test; Time Factors; Vitamin B 12 | 1973 |
[Effects of antidiabetic biguanides on various types of lipid mobilization in the rabbit].
Topics: Adrenalectomy; Anemia; Animals; Bloodletting; Cholesterol; Ethyl Ethers; Fatty Acids; Fatty Acids, Nonesterified; Hypoglycemic Agents; Intestinal Absorption; Lipid Mobilization; Liver; Metformin; Phenformin; Rabbits | 1973 |
[Demonstration of the mechanism of action of biguanides (author's transl)].
Topics: Animals; Biguanides; Fatty Acids; Glucose; Liver; Male; Metformin; Muscles; Oxidation-Reduction; Palmitic Acids; Phenformin; Rats | 1973 |
[Reversible hyperlactatemia induced by phenformin with muscular asthenia and cardio-respiratory signs].
Topics: Aged; Animals; Asthenia; Diabetes Complications; Diabetic Ketoacidosis; Dyspnea; Heart Diseases; Hepatomegaly; Humans; Hypoxia; Lactates; Leg; Male; Metformin; Muscular Diseases; Phenformin; Rats | 1970 |
[Lactic acidosis and sugar diabetics].
Topics: Alcoholism; Diabetic Ketoacidosis; Humans; Hypoxia; Lactates; Metformin; Phenformin; Starvation | 1970 |
Lactic acidosis through medicaments.
Topics: Acetates; Acidosis; Animals; Culture Techniques; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Glucose; Humans; Insulin; Lactates; Male; Metformin; Myocardium; Phenformin; Pyruvates; Rats; Starvation | 1970 |
[Experimental demonstration of the simulating action of biguanides (phenformin, metformin) on insulin secretion].
Topics: Animals; Autoanalysis; Blood Glucose; Dogs; Hypoglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Metformin; Pancreas; Perfusion; Phenformin; Radioimmunoassay; Rats | 1971 |
Lactic acidosis occurring during phenformin therapy.
Topics: Acidosis; Diabetes Mellitus; Female; Humans; Lactates; Metformin; Middle Aged; Phenformin | 1972 |
Diabetes mellitus--refractory obesity.
Topics: Biguanides; Diabetes Mellitus; Diet Therapy; Female; Fetal Death; Glucose Tolerance Test; Glycosuria; Humans; Insulin; Metformin; Middle Aged; Obesity; Phenformin; Pregnancy; Pregnancy in Diabetics; Sulfonylurea Compounds | 1972 |
Application of ion-pair methods to drug extraction from biological fluids. I. Quantitative determination of biguanides in urine.
Topics: Animals; Biguanides; Chemistry, Pharmaceutical; Coloring Agents; Hydrogen-Ion Concentration; Ions; Mathematics; Metformin; Phenformin; Spectrophotometry; Spectrum Analysis; Ultraviolet Rays | 1972 |
Application of ion-pair methods to drug extraction from biological fluids. II. Quantitative determination of biguanides in biological fluids and comparison of protein binding estimates.
Topics: Animals; Biguanides; Chemistry, Pharmaceutical; Cresols; Dialysis; Dogs; Erythrocytes; Filtration; Humans; Hydrogen-Ion Concentration; Ions; Mathematics; Metformin; Phenformin; Protein Binding; Solvents; Spectrophotometry | 1972 |
Adverse reactions to oral antidiabetic agents.
Topics: Acetohexamide; Acidosis; Administration, Oral; Anemia; Chlorpropamide; Drug Antagonism; Drug Synergism; England; Ethanol; Female; Fetus; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Metformin; Phenformin; Pregnancy; Scotland; Skin Diseases; Skin Manifestations; Tolazamide; Tolbutamide; Wales | 1971 |
[Physiological and pharmacological aspects of fibrinolysis].
Topics: Adrenal Cortex Hormones; Anabolic Agents; Arteriosclerosis Obliterans; Biguanides; Blood Coagulation Tests; Blood Platelets; Clofibrate; Coronary Disease; Diabetes Mellitus; Ethylestrenol; Fibrinolysis; Humans; Insulin; Metformin; Myocardial Infarction; Phenformin; Sulfonylurea Compounds; Testosterone; Thrombosis | 1971 |
[Comparative activity of some biguanides, sulfonylureas and their combinations on blood sugar and lactic acid in the guinea pig. II].
Topics: Amantadine; Animals; Biguanides; Blood Glucose; Chlorpropamide; Guinea Pigs; Lactates; Metformin; Phenformin; Sulfonylurea Compounds; Tolbutamide | 1971 |
[Effect of biguanide derivatives on blood lactic acid level in diabetics].
Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Humans; Lactates; Metformin; Middle Aged; Phenformin | 1971 |
Fibrinolytic effect of biguanides.
Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis Obliterans; Biguanides; Chlorpropamide; Coronary Disease; Ethylestrenol; Female; Fibrinolysis; Fibrinolytic Agents; Humans; Male; Metformin; Methenolone; Middle Aged; Phenformin; Tolbutamide | 1968 |
Rat liver glycogen-lowering activity of fed creatine--a retraction.
Topics: Animals; Biguanides; Creatine; Crystallization; Depression, Chemical; Gluconeogenesis; Guanidines; Hypoglycemic Agents; Injections, Intraperitoneal; Liver Glycogen; Male; Metformin; Phenformin; Rats; Time Factors | 1969 |
Studies on the mechanism of weight reduction by phenformin.
Topics: Biguanides; Diabetes Mellitus; Female; Humans; Metformin; Obesity; Phenformin | 1969 |
[The place of biguanides in the treatment of diabetes].
Topics: Biguanides; Diabetes Mellitus; Drug Synergism; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin | 1970 |
General treatment of diabetes.
Topics: Acidosis; Diabetes Mellitus; Diabetic Coma; Diabetic Nephropathies; Diabetic Retinopathy; Diet, Diabetic; Humans; Hypoglycemic Agents; Infusions, Parenteral; Insulin, Long-Acting; Lactates; Light Coagulation; Metformin; Phenformin; Renal Dialysis | 1970 |
[Glybenclamide and its place among sulfanylureas in the treatment of diabetes mellitus].
Topics: Adolescent; Adult; Aged; Carbutamide; Child; Cyclohexanes; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Sulfones; Tolbutamide; Urea | 1970 |
Vitamin B 12 and metformin.
Topics: Acidosis; Diabetes Mellitus; Folic Acid; Humans; Intestinal Absorption; Lactates; Metformin; Phenformin; Vitamin B 12; Vitamin B 12 Deficiency | 1971 |
[Effect of 1-butyl-biguanidine on serum glycoproteins in patients with adult onset diabetes].
Topics: Administration, Oral; Aged; Diabetes Mellitus; Female; Glycoproteins; Humans; Male; Metformin; Middle Aged; Phenformin; Time Factors | 1971 |
The effect of antihyperglycaemic biguanides, implanted into the hypothalamus, on the water consumption of rats.
Topics: Animals; Drinking; Hypothalamus; Metformin; Phenformin; Rats; Thirst | 1968 |
[Clinical pharmacology of oral hypoglycemic drugs].
Topics: Biguanides; Humans; Hypoglycemic Agents; Metformin; Phenformin | 1968 |
[Effect of dimethylbiguanide on plasmatic NEFA after carbohydrate administration in obese subjects].
Topics: Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose; Glucose Tolerance Test; Humans; Metformin; Obesity; Phenformin | 1968 |
Biguanides reassessed.
Topics: Animals; Humans; Metformin; Phenformin | 1969 |
Oral hypoglycaemic drugs.
Topics: Acetohexamide; Animals; Chlorpropamide; Guinea Pigs; Humans; Hypoglycemic Agents; Metformin; Phenformin; Tolbutamide | 1969 |
[On the clinical use of biguanides].
Topics: Aged; Biguanides; Blood Glucose; Body Weight; Cholesterol; Depression, Chemical; Diabetes Mellitus; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Fatty Liver; Humans; Hypoglycemic Agents; Insulin; Liver Glycogen; Metformin; Phenformin; Stimulation, Chemical | 1969 |
Pharmacological fibrinolysis.
Topics: Aged; Androsterone; Anticholesteremic Agents; Butyrates; Chlorpropamide; Coronary Disease; Ethylestrenol; Female; Fibrinogen; Fibrinolysis; Humans; Intermittent Claudication; Male; Metformin; Middle Aged; Phenformin; Platelet Adhesiveness; Tolbutamide | 1969 |
The treatment of diabetes mellitus with oral hypoglycaemic drugs.
Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Phenformin; Tolbutamide | 1965 |
[Therapeutic possibilities in diabetes mellitus with biguanides. Clinical experiences in 122 diabetics with dimethylbiguanide(Glucophage)].
Topics: Adolescent; Adult; Biguanides; Body Weight; Chemical Phenomena; Chemistry; Diabetes Mellitus; Diet, Diabetic; Female; Glucose Tolerance Test; Humans; Insulin; Male; Metformin; Phenformin | 1966 |
Effects of biguanides on short-circuit current in frog skin.
Topics: Amiloride; Animals; Biguanides; Buformin; Galvanic Skin Response; Metformin; Mucous Membrane; Phenformin; Rana pipiens; Serous Membrane; Skin; Sodium; Time Factors | 1984 |
Effect of metformin on insulin receptor binding and diabetic control.
Topics: Animals; Drug Synergism; Humans; Metformin; Phenformin; Rats; Receptor, Insulin | 1983 |
The effects of metformin compared to the effects of phenformin on the lactate production and the metabolism of isolated parenchymal rat liver cell.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Ethanol; Glycerol; Ketone Bodies; Kinetics; Lactates; Lactic Acid; Liver; Male; Metformin; Oxygen Consumption; Phenformin; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
Effect of metformin on insulin binding to receptors in cultured human lymphocytes and cancer cells.
Topics: Breast Neoplasms; Cells, Cultured; Cycloheximide; Humans; Insulin; Lymphocytes; Metformin; Phenformin; Receptor, Insulin | 1982 |
Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy.
Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12 | 1983 |
Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells.
Topics: Animals; Biguanides; Breast Neoplasms; Cell Line; Female; Fibroblasts; Humans; Insulin; Liver Neoplasms, Experimental; Lymphocytes; Metformin; Phenformin; Rats; Receptor, Insulin; Sulfonylurea Compounds | 1982 |
Reduction of the absorption of the fatty acid and glycerol moieties of ingested triglycerides by biguanides: a possible contribution to their anti-obesity, anti-hypertriglyceridaemic and anti-diabetes properties.
Topics: Adipose Tissue; Animals; Carbon Radioisotopes; Fatty Acids; Glycerol; Hypoglycemic Agents; Intestinal Absorption; Liver; Male; Metformin; Obesity; Phenformin; Rats; Rats, Inbred Strains; Time Factors; Triglycerides; Triolein; Tritium | 1982 |
[Biguanides in the treatment of diabetes].
Topics: Biguanides; Diabetes Mellitus; Humans; Metformin; Phenformin | 1980 |
Anti-diabetic biguanides inhibit hormone-induced intracellular Ca2+ concentration oscillations in rat hepatocytes.
Topics: Animals; Biguanides; Bucladesine; Calcium; Chlorides; Colforsin; Cyclic AMP; Glucagon; Inositol 1,4,5-Trisphosphate; Insulin; Liver; Male; Manganese Compounds; Metformin; Phenformin; Phenylephrine; Rats; Rats, Wistar; Second Messenger Systems | 1994 |
Effects of the biguanide class of oral hypoglycemic agents on mouse embryogenesis.
Topics: Animals; Culture Techniques; Embryonic and Fetal Development; Female; Hypoglycemic Agents; Metformin; Mice; Mice, Inbred ICR; Phenformin; Pregnancy | 1994 |
A critical evaluation of in situ measurement of mitochondrial electrical potentials in single hepatocytes.
Topics: Adrenergic alpha-Agonists; Animals; Cytophotometry; Evaluation Studies as Topic; Fluorescent Dyes; Hypoglycemic Agents; Liver; Membrane Potentials; Metformin; Mitochondria, Liver; Models, Theoretical; Phenformin; Phenylephrine; Rats; Reproducibility of Results; Rhodamine 123; Rhodamines | 1996 |
Incidence of lactic acidosis in metformin users.
Topics: Acidosis, Lactic; Cohort Studies; Databases as Topic; Death Certificates; Humans; Hypoglycemic Agents; Incidence; Lactates; Metformin; Phenformin; Registries; Saskatchewan; United States; United States Food and Drug Administration | 1999 |
Lactic acidosis in metformin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Middle Aged; Phenformin; Retrospective Studies; Risk Factors | 1999 |
Vanadyl-biguanide complexes as potential synergistic insulin mimics.
Topics: Animals; Biguanides; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Metformin; Phenformin; Rats; Rats, Wistar; Vanadates | 1999 |
[Recommendations for perioperative interruption of metformin medication].
Topics: Acidosis, Lactic; Contraindications; Humans; Hypoglycemic Agents; Metformin; Perioperative Care; Phenformin; Risk Factors | 2001 |
Enhanced secretion of glucagon-like peptide 1 by biguanide compounds.
Topics: Animals; Biguanides; Buformin; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Peptide Fragments; Phenformin; Protease Inhibitors; Protein Precursors; Pyrroles; Rats; Rats, Inbred F344; Valine | 2002 |
[Oral treatment of diabetes mellitus. Clinical experience of Metformin or Phenformin alone and combined treatment with these biguanides and P-607].
Topics: Administration, Oral; Biguanides; Chlorpropamide; Diabetes Mellitus; Humans; Metformin; Phenformin | 1962 |
[ORAL DIABETIC DRUGS].
Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Female; Humans; Metformin; Phenformin; Pregnancy; Pregnancy in Diabetics; Tolbutamide | 1964 |
[THE INFLUENCE OF THE CONSTITUENTS OF THE LYTIC COCKTAIL ON THE ACTION OF HYPOGLYCEMIC AGENTS].
Topics: Alcoholic Beverages; Cardiovascular Agents; Chlorpromazine; Ergot Alkaloids; Guinea Pigs; Hypoglycemic Agents; Insulin; Meperidine; Metformin; Oxytocics; Pharmacology; Phenformin; Promethazine; Research; Tolbutamide | 1963 |
COMBINED TRIAL OF ACETOHEXAMIDE AND TWO DIGUANIDE PREPARATIONS.
Topics: Acetohexamide; Chlorpropamide; Diabetes Mellitus; Geriatrics; Hypoglycemic Agents; Insulin; Metformin; Pharmacology; Phenformin; Tolbutamide; Toxicology | 1964 |
A REVIEW OF THE HISTORY OF THE TREATMENT OF DIABETES MELLITUS AND THE SEARCH FOR ORAL HYPOGLYCAEMIC AGENTS.
Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Guanidine; Guanidines; History; Humans; Hypoglycemic Agents; Metformin; Phenformin; Sulfonylurea Compounds; Tolbutamide | 1964 |
[MEDICAL TREATMENT OF DIABETES MELLITUS, INCLUDING DIET THERAPY].
Topics: Diabetes Mellitus; Diet, Diabetic; Humans; Hypoglycemic Agents; Insulin; Insulin Antibodies; Metformin; Phenformin; Prognosis | 1964 |
[ROLE OF BIGUANIDES IN THE TREATMENT OF DIABETES].
Topics: Biguanides; Diabetes Mellitus; Humans; Metformin; Phenformin; Toxicology | 1964 |
Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Northern; Blotting, Western; Chromans; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Glucose; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Metformin; Mice; Multienzyme Complexes; Phenformin; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2005 |
Solid phase extraction--non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma.
Topics: Electrophoresis, Capillary; Glyburide; Humans; Hypoglycemic Agents; Metformin; Phenformin; Reference Standards; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2006 |
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biguanides; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Enzyme Activation; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; Metformin; Mice; Mitochondria; Multienzyme Complexes; NADP; Oxidation-Reduction; Phenformin; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Succinates; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.
Topics: Adenosine Monophosphate; Adenylate Kinase; Animals; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Hypoglycemic Agents; Male; Metformin; Myocardium; Phenformin; Rats; Rats, Sprague-Dawley; Signal Transduction | 2007 |
Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Amiloride; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cell Line; Chromatography, High Pressure Liquid; Epithelial Cells; Epithelial Sodium Channels; Fluorescence; Humans; Hypoglycemic Agents; Lung; Metformin; Microscopy, Confocal; Multienzyme Complexes; Ouabain; Phenformin; Protein Serine-Threonine Kinases; Ribonucleotides; Sodium | 2007 |
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium | 2007 |
Comparison of gene expression changes induced by biguanides in db/db mice liver.
Topics: Animals; Blood Glucose; Computational Biology; Dose-Response Relationship, Drug; Gene Expression Profiling; Hypoglycemic Agents; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Oligonucleotide Array Sequence Analysis; Phenformin | 2008 |
Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib.
Topics: Acetyl-CoA Carboxylase; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antineoplastic Agents; Apoptosis; Cells, Cultured; Hypoglycemic Agents; Indoles; L-Lactate Dehydrogenase; Metformin; Muscle Cells; Oxidative Stress; Phenformin; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sunitinib | 2008 |
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Buformin; Cell Line; Cell Respiration; Cell Survival; Culture Media; Glutathione; Glycolysis; Hepatocytes; Humans; Hypoglycemic Agents; Lactic Acid; Male; Membrane Potential, Mitochondrial; Metformin; Mitochondria, Liver; Oxidation-Reduction; Phenformin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2008 |
A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes.
Topics: Alanine Transaminase; Animals; Bile Acids and Salts; Biological Transport; CHO Cells; Cricetinae; Cricetulus; Hepatocytes; Humans; Hypoglycemic Agents; Liver; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 1; Phenformin; Rats; Rats, Sprague-Dawley | 2009 |
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication.
Topics: Acidosis, Lactic; Aged; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Oxygen Consumption; Phenformin; Retrospective Studies | 2010 |
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Topics: Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Cell Line; Drosophila; Glucose; Hypoglycemic Agents; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Phenformin; Proteins; Sequence Alignment; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2010 |
Comparison of potential risks of lactic acidosis induction by biguanides in rats.
Topics: Acidosis, Lactic; Animals; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Phenformin; Rats; Rats, Inbred F344 | 2010 |
AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.
Topics: Acetyltransferases; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Blotting, Western; Calcium; Cell Line; Enzyme Activation; Female; Glucagon; Glucagon-Secreting Cells; Glucose; Hypoglycemic Agents; Immunohistochemistry; Metformin; Mice; Phenformin; Phosphorylation; Pyrones; Thiophenes | 2011 |
Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Inflammation; Linoleic Acids, Conjugated; Metformin; Mice; Phenformin; Prostaglandin Antagonists; Prostaglandins; Triglycerides; Tumor Necrosis Factor-alpha | 2011 |
Electrodeless, accurate pH determination in highly basic media using a new set of (1)H NMR pH indicators.
Topics: Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Metformin; Molecular Structure; Osmolar Concentration; Pharmaceutical Preparations; Phenformin; Potentiometry; Protons; Reproducibility of Results; Solutions; Technology, Pharmaceutical | 2011 |
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Line; Cell Line, Tumor; Cell Survival; Energy Metabolism; Hepatocytes; Humans; Insulin; Intracellular Signaling Peptides and Proteins; Liver; Metformin; Mice; Mitochondria, Liver; Phenformin; Phosphorylation; Protein Serine-Threonine Kinases; Sequestosome-1 Protein; Signal Transduction; Transcription Factor TFIIH; Transcription Factors | 2011 |
Simultaneous determination and pharmacokinetic study of metformin and rosiglitazone in human plasma by HPLC-ESI-MS.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Least-Squares Analysis; Male; Metformin; Phenformin; Reproducibility of Results; Rosiglitazone; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Thiazolidinediones | 2011 |
Liver uptake of biguanides in rats.
Topics: Animals; Biguanides; Biological Transport, Active; Biotransformation; Cells, Cultured; Hepatocytes; Hypoglycemic Agents; Liver; Male; Metformin; Phenformin; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Tissue Distribution | 2011 |
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides.
Topics: Adenylate Kinase; Antineoplastic Agents; Biguanides; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Metformin; Organic Cation Transporter 1; Ovarian Neoplasms; Phenformin; RNA, Small Interfering | 2011 |
Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.
Topics: Animals; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; KATP Channels; Male; Metformin; Pain Measurement; Phenformin; Rats; Rats, Wistar | 2012 |
Phenformin as prophylaxis and therapy in breast cancer xenografts.
Topics: Adenylate Kinase; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Female; Histones; Humans; Ki-67 Antigen; Liver; Metformin; Mice; Mice, Nude; Phenformin; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Spleen; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.
Topics: Acetaminophen; Adenosine Triphosphate; Amiodarone; Bioreactors; Diclofenac; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lethal Dose 50; Metformin; Phenformin; Proteins; Reproducibility of Results; Risk Assessment; Spheroids, Cellular; Toxicity Tests; Valproic Acid | 2012 |
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Activators; Glucose; Hypoglycemic Agents; Metformin; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Phenformin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Ribonucleotides; Signal Transduction; Time Factors | 2012 |
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Topics: Adenylyl Cyclases; AMP-Activated Protein Kinases; Animals; Biguanides; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Enzyme Activation; Glucagon; Glucose; Hepatocytes; Hypoglycemic Agents; Liver; Metformin; Mice; Phenformin; Phosphorylation; Signal Transduction | 2013 |
Dissecting the actions of widely used diabetes drugs.
Topics: Animals; Cyclic AMP; Diabetes Mellitus; Glucagon; Gluconeogenesis; Humans; Hypoglycemic Agents; Liver; Metformin; Phenformin | 2013 |
Transport of biguanides by human organic cation transporter OCT2.
Topics: Biological Transport; Female; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 2; Phenformin | 2013 |
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.
Topics: Alleles; Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Lymphoma, T-Cell; Metformin; Mice; Mice, Nude; Neoplasm Transplantation; Phenformin; PTEN Phosphohydrolase; Ribonucleotides; Transgenes | 2013 |
Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties.
Topics: Animals; Biguanides; Dose-Response Relationship, Drug; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex IV; Enzyme Inhibitors; Male; Metformin; Mitochondria, Liver; Phenformin; Rats; Rats, Wistar | 2014 |
Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin.
Topics: 3-Iodobenzylguanidine; Acetylation; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Metformin; Mitochondria; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Phenformin; Proto-Oncogene Proteins c-myc; Up-Regulation | 2014 |
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.
Topics: Aminoimidazole Carboxamide; Biguanides; Cell Line, Transformed; Cell Line, Tumor; Citric Acid Cycle; Endoplasmic Reticulum; Folic Acid; Glycerophosphates; Glycolysis; Humans; Lactates; Metabolome; Metformin; Neoplastic Stem Cells; Nucleotides; Phenformin; Ribonucleotides; src-Family Kinases; Tamoxifen | 2014 |
The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Electron Transport Complex I; Female; Humans; Metformin; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Phenformin; Phosphorylation; TOR Serine-Threonine Kinases; Tumor Microenvironment | 2015 |
Differential effects of AMPK agonists on cell growth and metabolism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes | 2015 |
Serine deprivation enhances antineoplastic activity of biguanides.
Topics: Animals; Biguanides; Cell Line, Tumor; Glycolysis; Humans; Metformin; Mice; Neoplasms; Oxidative Phosphorylation; Phenformin; Serine; Xenograft Model Antitumor Assays | 2014 |
Selective inhibition of deactivated mitochondrial complex I by biguanides.
Topics: Animals; Electron Spin Resonance Spectroscopy; Electron Transport Complex I; Enzyme Inhibitors; Heart; Hydrogen-Ion Concentration; Hypoglycemic Agents; In Vitro Techniques; Ischemia; Kinetics; Magnesium Chloride; Male; Metformin; Mitochondria, Heart; Models, Molecular; Myocardium; Phenformin; Rats, Sprague-Dawley; Submitochondrial Particles; Superoxides | 2015 |
Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat.
Topics: Animals; Apoptosis; Blotting, Western; Buformin; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Female; Hypoglycemic Agents; Mammary Neoplasms, Experimental; Metformin; Phenformin; Rats; Rats, Sprague-Dawley | 2015 |
Combining BRAF(V) (600E) inhibition with modulators of the mitochondrial bioenergy metabolism to overcome drug resistance in metastatic melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzodiazepines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrazines; Imidazoles; Indoles; Melanoma; Metformin; Mitochondria; Oxidative Phosphorylation; Oximes; Phenformin; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Vemurafenib | 2015 |
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Basigin; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Female; Gene Knockdown Techniques; Glycolysis; Humans; Lactic Acid; Lung Neoplasms; Metformin; Mice, Nude; Monocarboxylic Acid Transporters; Muscle Proteins; Phenformin; Protein Serine-Threonine Kinases; Protein Transport; Symporters; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs.
Topics: Adenosine Triphosphate; Apoptosis; Carcinoma, Hepatocellular; Energy Metabolism; Glycolysis; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mitochondria; Oligomycins; Oxygen Consumption; Phenformin; Rotenone | 2015 |
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Topics: Animals; Antineoplastic Agents; Ascites; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; Humans; Hyperglycemia; Hypoglycemic Agents; Lactic Acid; MAP Kinase Signaling System; Metformin; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Pentose Phosphate Pathway; Phenformin; Proto-Oncogene Proteins c-myc | 2015 |
Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.
Topics: Apoptosis; Biguanides; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Electron Transport; Humans; Metformin; Mitochondria; Nitrophenols; Phenformin; Piperazines; Rotenone; Sulfonamides; U937 Cells | 2016 |
The enhancement of oxidative DNA damage by anti-diabetic metformin, buformin, and phenformin, via nitrogen-centered radicals.
Topics: Animals; Buformin; Cattle; DNA Damage; Humans; Hypoglycemic Agents; Metformin; Oxidation-Reduction; Phenformin; Reactive Oxygen Species | 2016 |
Extreme Basicity of Biguanide Drugs in Aqueous Solutions: Ion Transfer Voltammetry and DFT Calculations.
Topics: Biguanides; Hydrogen-Ion Concentration; Metformin; Models, Molecular; Phenformin; Quantum Theory; Solutions; Water | 2016 |
NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides.
Topics: Biguanides; Metformin; Phenformin | 2017 |
Syrosingopine sensitizes cancer cells to killing by metformin.
Topics: Animals; Cell Line, Tumor; Drug Synergism; Glycolysis; Humans; Metformin; Mice; Mice, Knockout; Phenformin; Phosphopyruvate Hydratase; Reserpine | 2016 |
Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma.
Topics: Aldehyde Dehydrogenase; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Energy Metabolism; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Metformin; Microphthalmia-Associated Transcription Factor; Neoplasm Invasiveness; Neoplastic Stem Cells; Phenformin; Phenotype; Skin Neoplasms; Spheroids, Cellular; Time Factors; Transfection | 2017 |
Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.
Topics: Adipose Tissue, Brown; Animals; Biguanides; Glycerolphosphate Dehydrogenase; Hydrogen Peroxide; Hypoglycemic Agents; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidation-Reduction; Phenformin; Rats; Rats, Wistar; Reactive Oxygen Species; Succinic Acid | 2017 |
Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line; Databases, Genetic; Drug Repositioning; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Metformin; Phenformin; Protein Interaction Maps; Sample Size; Statistics as Topic; Transcriptome | 2017 |
Biguanides Metformin and Phenformin Generate Therapeutic Effects via AMP-Activated Protein Kinase/Extracellular-Regulated Kinase Pathways in an In Vitro Model of Graves' Orbitopathy.
Topics: Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Fibroblasts; Graves Ophthalmopathy; Humans; Hyaluronic Acid; MAP Kinase Signaling System; Metformin; Phenformin; Phosphorylation; Signal Transduction | 2018 |
The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cell Survival; Cells, Cultured; Female; Follicle Stimulating Hormone; Ghrelin; Macaca; Metformin; Papio; Phenformin; Phosphatidylinositol 3-Kinases; Pituitary Gland; Receptors, Leptin; Receptors, Somatostatin; Signal Transduction; Thyrotropin; TOR Serine-Threonine Kinases; Up-Regulation | 2018 |
Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; F-Box Proteins; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Molecular Targeted Therapy; Phenformin; Protein Kinase Inhibitors; Retinoblastoma Protein; Signal Transduction; Thiadiazoles; Xenograft Model Antitumor Assays | 2019 |
Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells.
Topics: Antibodies, Monoclonal; Biomarkers, Tumor; Bortezomib; Cell Line, Tumor; Dexamethasone; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Interleukin-6; Metformin; Multiple Myeloma; Phenformin; Plasma Cells; Receptors, Interleukin-6; Sequence Analysis, RNA; Signal Transduction; Syndecan-1; Thalidomide | 2019 |
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Disease Models, Animal; Disease-Free Survival; Female; Glycolysis; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenformin; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; PTEN Phosphohydrolase; Signal Transduction; Sirolimus | 2019 |
Electrochemically Modulated Liquid-Liquid Extraction for Sample Enrichment.
Topics: Biguanides; Chromatography, High Pressure Liquid; Electrochemical Techniques; Hydrophobic and Hydrophilic Interactions; Liquid-Liquid Extraction; Metformin; Phenformin; Quaternary Ammonium Compounds | 2019 |
Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study.
Topics: Administration, Oral; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Glucose; Humans; Hypoglycemic Agents; Metformin; Phenformin | 2018 |
Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemoradiotherapy; Colon; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Fluorouracil; Humans; Male; Metformin; Mice; Mice, Nude; Neoplasm Recurrence, Local; Phenformin; Rectal Neoplasms; Signal Transduction; Smad Proteins; STAT3 Transcription Factor; Transforming Growth Factor beta; Xenograft Model Antitumor Assays | 2019 |
Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Energy Metabolism; Gluconeogenesis; Heart; Lactic Acid; Liver; Male; Metformin; Mitochondria; Oxidative Phosphorylation; Phenformin; Rats, Wistar; Rotenone; Transcriptome | 2019 |
Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy.
Topics: Atenolol; Chloroform; Colloids; Drug Contamination; Hypoglycemic Agents; Limit of Detection; Liquid Phase Microextraction; Metal Nanoparticles; Metformin; Methanol; Phenformin; Reproducibility of Results; Silver; Solvents; Spectrum Analysis, Raman | 2019 |
Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type II Diabetes Mellitus.
Topics: Adult; Aged; Amobarbital; Biopsy; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cicatrix; Constriction, Pathologic; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Glottis; Glycolysis; Humans; Hypoglycemic Agents; Iatrogenic Disease; Intubation, Intratracheal; Laryngostenosis; Male; Metformin; Middle Aged; Muscle Contraction; Myofibroblasts; Oxidative Phosphorylation; Phenformin; Primary Cell Culture; Trachea; Tracheal Stenosis; Tracheostomy; Young Adult | 2021 |
Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury.
Topics: Animals; Brain; Brain Injuries; Electron Transport Complex I; Humans; Male; Metformin; Mitochondria; Mitochondrial Permeability Transition Pore; Mitochondrial Transmembrane Permeability-Driven Necrosis; Necrosis; Neurons; Neuroprotective Agents; Oxidative Phosphorylation; Phenformin; Rats | 2020 |
Different effects of metformin and phenformin on hypoxia-induced Ca
Topics: Animals; Calcium; Cytosol; Hypoxia; Male; Metformin; Neurons; Phenformin; Primary Cell Culture; Rats; Rats, Wistar | 2021 |
Rapid detection of the metformin illegally added of in TCM and health food by TLC-IR.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dietary Supplements; Drug Contamination; Drugs, Chinese Herbal; Food Contamination; Humans; Metformin; Phenformin; Reproducibility of Results; Spectrophotometry, Infrared; Time Factors; Workflow | 2020 |
Interfering with Metabolic Profile of Triple-Negative Breast Cancers Using Rationally Designed Metformin Prodrugs.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Coordination Complexes; Drug Evaluation, Preclinical; Energy Metabolism; Gold; Humans; Metformin; Mice; Molecular Conformation; Phenformin; Prodrugs; Transplantation, Heterologous; Triple Negative Breast Neoplasms | 2021 |
Metformin's Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glycerolphosphate Dehydrogenase; Humans; Male; Metformin; Mice; Mice, Inbred BALB C; Mitochondria; NAD; Oxidation-Reduction; Phenformin; Rats | 2021 |
Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.
Topics: B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Epstein-Barr Virus Infections; Glucose; Glutathione; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Lactic Acid; Lymphoma; Metformin; Monocarboxylic Acid Transporters; NAD; Oxygen Consumption; Phenformin; Reactive Oxygen Species; Up-Regulation | 2021 |
Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Electron Transport Complex I; Endoplasmic Reticulum Stress; Female; Humans; Lung Neoplasms; Metabolome; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasm Metastasis; Neoplasms, Experimental; Petasites; Phenformin; Sesquiterpenes; Unfolded Protein Response; Xenograft Model Antitumor Assays | 2021 |
A Comparative Study of the Lipophilicity of Metformin and Phenformin.
Topics: Chromatography, Reverse-Phase; Chromatography, Thin Layer; Hydrophobic and Hydrophilic Interactions; Metformin; Molecular Structure; Phenformin | 2021 |
Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.
Topics: Animals; Electron Transport Complex IV; Gluconeogenesis; Glucose; Glycerol; Glycerolphosphate Dehydrogenase; Guanidines; Hypoglycemic Agents; Liver; Metformin; Oxidation-Reduction; Phenformin; Pyridines | 2022 |
Molecular insights of anti-diabetic compounds and its hyaluronic acid conjugates against aldose reductase enzyme through molecular modeling and simulations study-a novel treatment option for inflammatory diabetes.
Topics: Aldehyde Reductase; Diabetes Mellitus, Type 2; Humans; Hyaluronic Acid; Inflammation; Insulin Resistance; Ligands; Metformin; Molecular Docking Simulation; Molecular Dynamics Simulation; Phenformin; Sitagliptin Phosphate | 2023 |