metformin has been researched along with palmitic acid in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Bruce, CR; Collier, CA; Dyck, DJ; Lopaschuk, G; Smith, AC | 1 |
| Abrahani, A; An, D; Chan, JK; Ghosh, S; Innis, SM; Kewalramani, G; Pulinilkunnil, T; Qi, D; Rodrigues, B | 1 |
| Bellin, C; de Wiza, DH; Rösen, P; Wiernsperger, NF | 1 |
| Bala, M; Buechler, C; Kopp, A; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J; Wurm, S | 1 |
| Chae, HJ; Chae, SW; Jeong, SK; Kim, DS; Kim, HR | 1 |
| Chen, L; Ren, P; Shen, YH; Song, J; Wang, XL; Zhang, L | 1 |
| Chen, L; Hou, X; Li, XN; Shen, YH; Song, J; Wang, X; Zhang, L | 1 |
| Bailey, CJ; Flatt, PR; Irwin, N; McClenaghan, NH; McKiney, JM | 1 |
| Cerasi, E; Kaiser, N; Ketzinel-Gilad, M; Leibowitz, G; Shaked, M | 1 |
| Holst, JJ; Kappe, C; Patrone, C; Sjöholm, A; Zhang, Q | 1 |
| He, J; Huang, W; Jiang, Y; Lin, X; Wang, J; Xu, Z; Zhang, J; Zhou, Z | 1 |
| Csala, M; Kéri, G; Kokas, M; Mandl, J; Simon-Szabó, L | 1 |
| Huang, F; Kou, J; Li, J; Liu, B; Liu, K; Qi, L; Sun, Y; Wang, M; Xiao, N | 1 |
| Bi, Y; Bu, R; Cao, S; Shi, J; Tang, S; Wu, W; Yin, W; Zhu, D | 1 |
| Cha, BS; Kang, ES; Lee, BW; Lee, WK; Lee, YH; Song, YM | 1 |
| Hong, T; Hou, W; Ke, J; Liu, Y; Lu, R; Tian, Q; Wang, G; Wei, R; Yang, J | 1 |
| Bi, Y; Ge, Z; Hong, T; Tang, S; Tang, W; Wang, H; Wu, W; Zhu, D | 1 |
| Bosque, BP; da Silva, CV; de Jesus, MM; Góes, RM; Landim, BC; Ribeiro, DL; Zanon, RG | 1 |
| Hosaka, T; Ishida, H; Kitahara, A; Kondo, T; Morita, N; Murashima, T; Onuma, H; Sumitani, Y; Takahashi, K; Tanaka, T | 1 |
| Fan, SY; Gu, X; Liang, H; Lin, MJ; Liu, W; Shen, FX; Wang, L; Wang, XQ; Yan, X | 1 |
| Comas, F; Fernández-Real, JM; Höring, M; Latorre, J; Liebisch, G; Liñares-Pose, L; Lluch, A; López, M; Moreno-Navarrete, JM; Nidhina Haridas, PA; Oliveras-Cañellas, N; Olkkonen, VM; Ortega, FJ; Ricart, W; Zhou, Y | 1 |
| Hu, Z; Zhang, W | 1 |
1 trial(s) available for metformin and palmitic acid
| Article | Year |
|---|---|
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Topics: Animals; Anthracenes; Apoptosis; Autophagy; Blood Glucose; Diabetes Mellitus; Drinking Water; Drugs, Chinese Herbal; Endoplasmic Reticulum Stress; Glucose; Glycolipids; Islets of Langerhans; Metformin; Mice; Mice, Inbred C57BL; Palmitic Acid; Tablets | 2022 |
21 other study(ies) available for metformin and palmitic acid
| Article | Year |
|---|---|
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Drug Interactions; Female; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Malonyl Coenzyme A; Metformin; Multienzyme Complexes; Muscle, Skeletal; Palmitic Acid; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Triglycerides | 2006 |
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.
Topics: Acetyl-CoA Carboxylase; Animals; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Fatty Acids; Glycolysis; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lactic Acid; Male; Metformin; Models, Biological; Myocytes, Cardiac; Palmitic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors | 2006 |
Generation of reactive oxygen species by endothelial and smooth muscle cells: influence of hyperglycemia and metformin.
Topics: Animals; Antioxidants; Endothelium, Vascular; Glucose; Glycation End Products, Advanced; Hyperglycemia; Hypoglycemic Agents; In Vitro Techniques; Metformin; Mitochondria; Muscle, Smooth, Vascular; NADPH Oxidases; Palmitic Acid; Rats; Reactive Oxygen Species | 2006 |
Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Aminoimidazole Carboxamide; Body Mass Index; Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Galectin 3; Humans; Immunoblotting; Male; Metformin; Middle Aged; Monocytes; Oleic Acid; Palmitic Acid; Pyrazoles; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; Solubility; Time Factors | 2009 |
Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Cell Culture Techniques; Cell Survival; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Hep G2 Cells; Humans; Hypoglycemic Agents; Immunoprecipitation; Insulin; Insulin Resistance; Liver; Metformin; Microscopy, Fluorescence; Oxidative Stress; Palmitic Acid; Phosphorylation | 2010 |
Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4.
Topics: Atherosclerosis; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Down-Regulation; Fatty Acid-Binding Proteins; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Hypoglycemic Agents; Lipid Metabolism; Macrophages; Metformin; Palmitic Acid; Transcription, Genetic; Up-Regulation | 2010 |
Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway.
Topics: AMP-Activated Protein Kinase Kinases; Cells, Cultured; Endothelium, Vascular; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Hypoglycemic Agents; Metformin; Palmitic Acid; Protein Kinases; Reactive Oxygen Species; Thioredoxins; Up-Regulation | 2010 |
Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Metformin; Palmitic Acid; Rats; Time Factors | 2010 |
AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Deoxyglucose; Enzyme Activation; Enzyme Activators; Gene Knockdown Techniques; Glucose; Humans; Insulin-Secreting Cells; Isoenzymes; Metformin; Oleic Acid; Palmitic Acid; Protein Transport; Rats; Rats, Wistar | 2011 |
Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Caspase 3; Cytoprotection; Enteroendocrine Cells; Glucagon-Like Peptide 1; Hypoglycemic Agents; MAP Kinase Kinase 4; Metformin; Mice; Palmitic Acid; Phosphorylation; Protein Kinases; Ribonucleotides; Tumor Cells, Cultured | 2013 |
Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Proliferation; Cell Survival; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Metformin; Mice; Mice, Inbred C57BL; Palmitic Acid; Signal Transduction | 2014 |
Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Hypoglycemic Agents; Insulin Receptor Substrate Proteins; Insulin-Secreting Cells; Insulinoma; JNK Mitogen-Activated Protein Kinases; Metformin; Palmitic Acid; Pancreatic Neoplasms; Phosphorylation; Rats; Transcription Factor CHOP | 2014 |
Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.
Topics: Adipokines; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Culture Media, Conditioned; Diet; Fructose; Metformin; NF-kappa B; Palmitic Acid; Rats; Resveratrol; Ribonucleotides; Sirtuin 1; Sodium Salicylate; Stilbenes; Vasodilation | 2014 |
Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway.
Topics: AMP-Activated Protein Kinases; Animals; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Muscle, Skeletal; Palmitic Acid; Sterol Regulatory Element Binding Protein 1 | 2015 |
Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53.
Topics: Animals; Benzothiazoles; Caloric Restriction; Cell Survival; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Gene Expression Regulation; Glucose; Hep G2 Cells; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Obese; Mitochondria; Mitophagy; Palmitic Acid; Signal Transduction; Sirtuin 1; Toluene; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2016 |
Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Cyclic AMP-Dependent Protein Kinases; Diet, High-Fat; Drug Synergism; Glucagon-Like Peptide-1 Receptor; Human Umbilical Vein Endothelial Cells; Humans; Liraglutide; Male; Metformin; Mice; Mice, Knockout; Nitric Oxide Synthase Type III; Palmitic Acid; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction | 2017 |
Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK/SREBP-1c pathway in skeletal muscle cells exposed to palmitate.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Insulin; Male; Metformin; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Palmitic Acid; rho-Associated Kinases; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2017 |
Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Insulin; Male; Metformin; Obesity; Palmitic Acid; Prostate | 2018 |
Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Aminoimidazole Carboxamide; Animals; Chemokine CCL2; Inflammation; Metformin; Mice; NF-kappa B; Palmitic Acid; Phosphorylation; Ribonucleotides; Signal Transduction; Triglycerides | 2018 |
Molecular interplay between microRNA-130a and PTEN in palmitic acid-mediated impaired function of endothelial progenitor cells: Effects of metformin.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytoprotection; Down-Regulation; Endothelial Progenitor Cells; Male; Metformin; MicroRNAs; Neovascularization, Physiologic; Palmitic Acid; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats, Sprague-Dawley | 2019 |
Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cells, Cultured; Ceramides; DEAD-box RNA Helicases; Energy Metabolism; Hep G2 Cells; Hepatocytes; Homeostasis; Humans; Hypoglycemic Agents; Lipid Droplets; Lipid Metabolism; Metformin; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Palmitic Acid; Protein Kinases; Ribonuclease III | 2020 |