metformin has been researched along with niacinamide in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 10 (34.48) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Pari, L; Saravanan, R | 1 |
| Davey, AK; Li, HT; Wang, J; Wu, XD | 1 |
| Brockmöller, J; Tzvetkov, MV | 1 |
| Asatiani, E; Chen, HX; Doyle, LA; Fu, S; Hess, KR; Hong, DS; Kurzrock, R; Liu, X; Lorusso, P; McQuinn, L; Mita, M; Naing, A; Piha-Paul, S | 1 |
| Bernards, R; Groenendijk, FH; Hauptmann, M; Horlings, HM; Jonkers, J; Mellema, WW; Schut, E; Smit, EF; van den Heuvel, MM; van der Burg, E; Willems, SM | 1 |
| Hsieh, SC; Hsieh, YH; Tang, MJ; Tsai, JP; Yang, SF | 1 |
| Auge, D; Fromm, MF; Hoier, E; Maas, R; Mieth, M; Müller, F; Pontones, CA; Renner, B; Zolk, O | 1 |
| Chen, G; Derwahl, M; Nicula, D; Renko, K | 1 |
| Côté, CD; Duca, FA; Filippi, BM; Lam, TK; Rasmussen, BA; Rutter, GA; Zadeh-Tahmasebi, M | 1 |
| Chen, T; Cheng, X; Jia, Y; Jiang, T; Li, J; Liu, T; Liu, Z; Wang, F; Zeng, J; Zhang, C; Zhang, L; Zhu, H | 1 |
| Brunetti, O; Casadei Gardini, A; Cascinu, S; Faloppi, L; Foschi, FG; Frassineti, GL; Marisi, G; Masi, G; Nanni, O; Ricca Rosellini, S; Scarpi, E; Scartozzi, M; Silvestris, N; Tamberi, S; Tamburini, E; Tenti, E; Ulivi, P; Vivaldi, C | 1 |
| Bianco, R; Castellone, MD; Ciaramella, V; Ciardiello, F; De Vita, F; Della Corte, CM; Di Mauro, C; Fasano, M; Martinelli, E; Morgillo, F; Orditura, M; Papaccio, F; Sasso, FC; Troiani, T | 1 |
| Cao, M; Cui, Y; Fang, F; Gao, J; Guo, Z; Li, H; Li, Q; Song, T; Sun, H; You, A; Zhang, T; Zhang, W; Zhou, H; Zhu, X | 1 |
| Cao, M; Cui, Y; Fang, F; Gao, J; Guo, Z; Li, H; Li, Q; Song, T; Sun, H; Yin, H; You, A; Zhang, T; Zhang, W; Zhou, H; Zhu, X; Zuo, B | 1 |
| Alarcón-Aguilar, FJ; Almanza-Pérez, JC; Cruz, M; Estrada-Soto, S; García-Díaz, JA; García-Jiménez, S; Gómez-Zamudio, J; Hidalgo-Figueroa, S; Ibarra-Barajas, M; Navarrete-Vázquez, G | 1 |
| Fan, N; Feng, T; Hou, Z; Huang, Q; Li, Y; Ling, S; Liu, L; Liu, Y; Shi, L; Song, L; Tian, Y; Wang, M; Xu, F; Yang, X; Zhao, F | 1 |
| Aprile, G; Brunetti, O; Casadei Gardini, A; Cascinu, S; De Matteis, S; Ercolani, G; Faloppi, L; Foschi, FG; Frassineti, GL; Granato, AM; Marisi, G; Negrini, G; Palmieri, V; Passardi, A; Perrone, G; Santini, D; Scartozzi, M; Silvestris, N; Tamburini, E; Tovoli, F; Valgiusti, M; Vespasiani-Gentilucci, U | 1 |
| Antoniewicz, MR; Au, J; DeWaal, D; Guzman, G; Hay, N; Jeon, SM; Long, CP; Nogueira, V; Patra, KC; Terry, AR | 1 |
| Bahrami-Asl, Z; Fattahi, A; Latifi, Z; Mihanfar, A; Nejabati, HR; Nouri, M; Roshangar, L; Samadi, N; Shahnazi, V | 1 |
| Acheampong, DO; Addo, JK; Asiamah, EA; Ayiku, PJ; Boye, A; Brah, AS; Gyamerah, EO; Mensah, DA | 1 |
| Ardakani, YH; Foroumadi, A; Lavasani, H; Neyshaburinezhad, N; Rouini, M; Seidabadi, M | 1 |
| Kaneko, Y; Nishimura, T; Oda, K; Shibata, M; Toyoshima, J | 1 |
| Feng, B; Mathialagan, S; Rodrigues, AD; Varma, MVS | 1 |
| Abd El-Hameed, AM; Abd El-Twab, SM; Abdel-Moneim, A; El-Shahawy, AAG; Yousef, AI | 1 |
| Ankathi, SK; Banavali, SD; Bhargava, PG; Daddi, A; Goel, M; Gota, V; Jadhav, S; Mandavkar, S; Nashikkar, C; Naughane, D; Ostwal, V; Patkar, S; Ramaswamy, A; Shetty, N; Shriyan, B; Srinivas, S | 1 |
| Boone, K; Ezike, T; Omizu, B; Omoaghe, A; Oyesola, O | 1 |
| Kuppusamy, P; Nagalingam, A; Saxena, NK; Sharma, D; Siddharth, S; Wu, Q | 1 |
| Chellappan, DK; Chellian, J; Krishnappa, P; Mak, KK; Pichika, MR | 1 |
5 trial(s) available for metformin and niacinamide
| Article | Year |
|---|---|
Incidence of mucositis in patients treated with temsirolimus-based regimens and correlation to treatment response.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Metformin; Middle Aged; Mucositis; Niacinamide; Protein Kinase Inhibitors; Retrospective Studies; Sirolimus; TOR Serine-Threonine Kinases; Treatment Outcome; Young Adult | 2014 |
Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Synergism; Female; Humans; Lung Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mutation; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Reactive Oxygen Species; Signal Transduction; Sorafenib; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2015 |
N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.
Topics: Adult; Blood Glucose; Creatinine; Cross-Over Studies; Drug Interactions; Female; HEK293 Cells; Humans; Hypoglycemic Agents; Kidney; Male; Metformin; Niacinamide; Organic Cation Transport Proteins; Trimethoprim; Young Adult | 2015 |
A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers.
Topics: Adamantane; Adult; Biological Transport; Drug Interactions; Healthy Volunteers; HEK293 Cells; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Niacinamide; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Protein Kinase Inhibitors; Young Adult | 2020 |
Phase I Study Evaluating Dose De-escalation of Sorafenib with Metformin and Atorvastatin in Hepatocellular Carcinoma (SMASH).
Topics: Antineoplastic Agents; Atorvastatin; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Metformin; Niacinamide; Phenylurea Compounds; Sorafenib; Treatment Outcome | 2022 |
24 other study(ies) available for metformin and niacinamide
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effect of succinic acid monoethyl ester on hemoglobin glycation and tail tendon collagen properties in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Hypoglycemic Agents; Injections, Intraperitoneal; Insulin; Male; Metformin; Niacinamide; Rats; Rats, Wistar; Streptozocin; Succinates; Tail; Tendons | 2008 |
Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats.
Topics: Adiponectin; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flavonoids; Glycogen; Hexokinase; Hypoglycemic Agents; Insulin; Interleukin-6; Liver; Male; Metformin; Niacinamide; Pancreas; Rats; Rats, Wistar; Streptozocin; Tumor Necrosis Factor-alpha | 2011 |
Polymorphic OCT1: a valid biomarker, but for which drugs?
Topics: Biomarkers, Pharmacological; Cations; Humans; Metformin; Morphine; Niacinamide; Organic Cation Transporter 1; Pharmacogenetics; Phenylurea Compounds; Sorafenib | 2013 |
Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Matrix Metalloproteinase 9; Metformin; Neoplasm Invasiveness; NF-kappa B; Niacinamide; Phenylurea Compounds; Signal Transduction; Sorafenib; Urokinase-Type Plasminogen Activator | 2014 |
Synergistic anti-proliferative effect of metformin and sorafenib on growth of anaplastic thyroid cancer cells and their stem cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Cycle Checkpoints; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Metformin; Neoplasm Proteins; Neoplastic Stem Cells; Niacinamide; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Sorafenib; Spheroids, Cellular; Thyroid Neoplasms; Tumor Stem Cell Assay | 2015 |
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Duodenum; Gene Expression Regulation, Enzymologic; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Clamp Technique; HEK293 Cells; Humans; Insulin; Insulin Resistance; Liver; Male; Metformin; Niacinamide; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Signal Transduction | 2015 |
Metformin synergistically sensitizes FLT3-ITD-positive acute myeloid leukemia to sorafenib by promoting mTOR-mediated apoptosis and autophagy.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Drug Synergism; Enzyme Activation; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Metformin; Microtubule-Associated Proteins; Molecular Targeted Therapy; Mutation; Neoplasm Proteins; Neoplastic Stem Cells; Niacinamide; Phenylurea Compounds; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sorafenib; Tandem Repeat Sequences; TOR Serine-Threonine Kinases | 2015 |
Effects of metformin on clinical outcome in diabetic patients with advanced HCC receiving sorafenib.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Drug Resistance, Neoplasm; Humans; Hypoglycemic Agents; Liver Neoplasms; Metformin; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Retrospective Studies; Sorafenib; Survival Analysis; Treatment Outcome | 2015 |
Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Chromatin Immunoprecipitation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Immunoenzyme Techniques; Lung Neoplasms; MAP Kinase Kinase 1; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2016 |
Metformin inhibits the prometastatic effect of sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Lung Neoplasms; Metformin; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Niacinamide; Phenylurea Compounds; Signal Transduction; Sorafenib; Thioredoxins; Transcription Factors; Xenograft Model Antitumor Assays | 2016 |
Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models.
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Epithelial-Mesenchymal Transition; Humans; Hypoglycemic Agents; Liver Neoplasms; Male; Metformin; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Recurrence, Local; Niacinamide; Phenylurea Compounds; Sorafenib; Transcription Factors; Xenograft Model Antitumor Assays | 2016 |
Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Anti-Inflammatory Agents; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Glycosides; Hypoglycemic Agents; Hypolipidemic Agents; Lipogenesis; Male; Metformin; Mice; Molecular Docking Simulation; Niacinamide; Oxidation-Reduction; Rats, Wistar; Streptozocin | 2016 |
Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Metformin; Multiprotein Complexes; Niacinamide; Phenylurea Compounds; Signal Transduction; Sorafenib; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2017 |
Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Databases, Factual; Diabetes Mellitus, Type 2; Disease-Free Survival; Drug Interactions; Drug Resistance, Neoplasm; Female; Humans; Hypoglycemic Agents; Immunohistochemistry; Insulin; Italy; Kaplan-Meier Estimate; Liver Neoplasms; Male; Metformin; Middle Aged; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Retrospective Studies; Sirtuin 3; Sorafenib; Time Factors; Treatment Outcome | 2017 |
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Glycolysis; Hep G2 Cells; Hexokinase; Humans; Hypoglycemic Agents; Liver Neoplasms; Male; Mechanistic Target of Rapamycin Complex 1; Metabolic Flux Analysis; Metformin; Mice, Nude; Molecular Targeted Therapy; Niacinamide; Oxidative Phosphorylation; Phenylurea Compounds; Sorafenib; Xenograft Model Antitumor Assays | 2018 |
Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Cytokines; Estrous Cycle; Female; Gene Expression; Glucose Transporter Type 4; Hyperandrogenism; Luteinizing Hormone; Metformin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Ovary; Polycystic Ovary Syndrome; Rats, Wistar; Resistin; Steroid 17-alpha-Hydroxylase; Testosterone | 2020 |
Glucose lowering and pancreato-protective effects of Abrus Precatorius (L.) leaf extract in normoglycemic and STZ/Nicotinamide - Induced diabetic rats.
Topics: Abrus; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Ghana; Glucose Tolerance Test; Hypoglycemic Agents; Male; Medicine, African Traditional; Metformin; Niacinamide; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Streptozocin | 2020 |
Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin.
Topics: Animals; Cytochrome P450 Family 2; Dextromethorphan; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Expression Regulation; Hepatobiliary Elimination; Hypoglycemic Agents; Insulin; Male; Metformin; Niacinamide; Rats; Rats, Wistar; Streptozocin | 2020 |
Drug-Drug Interactions Involving Renal OCT2/MATE Transporters: Clinical Risk Assessment May Require Endogenous Biomarker-Informed Approach.
Topics: Acidosis, Lactic; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antiviral Agents; Area Under Curve; Biomarkers; Creatinine; Drug Interactions; HEK293 Cells; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; In Vitro Techniques; Metformin; Niacinamide; Organic Cation Transport Proteins; Organic Cation Transporter 2; Proton Pump Inhibitors; Renal Elimination | 2021 |
Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Glucose; Glucosides; Inflammation; Lipid Peroxidation; Liver; Male; Metformin; Nanoparticles; Niacinamide; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Stilbenes; Streptozocin | 2021 |
Effects of Combined
Topics: Animals; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Garcinia kola; Glyburide; Hypoglycemic Agents; Insulin; Male; Metformin; Niacinamide; Plant Extracts; Rats; Rats, Wistar; Streptozocin | 2022 |
Metformin Enhances the Anti-Cancer Efficacy of Sorafenib via Suppressing MAPK/ERK/Stat3 Axis in Hepatocellular Carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Liver Neoplasms; Metformin; Mice; Niacinamide; Phenylurea Compounds; Sorafenib; Xenograft Model Antitumor Assays | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Niacinamide; Quercetin; Rats; Streptozocin; Vascular Diseases | 2022 |