metformin has been researched along with methotrexate in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (14.71) | 29.6817 |
| 2010's | 19 (55.88) | 24.3611 |
| 2020's | 10 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Cherian, C; Gangjee, A; Hales, E; Hou, Z; Matherly, LH; Mitchell-Ryan, S; Orr, S; Raghavan, S; Ravindra, MP; Wang, Y | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Marc, J; Mlakar, V | 1 |
| Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Lasseter, KC; Rammelsberg, D; Townsend, R; Yamazaki, T | 1 |
| Darko, KO; He, C; Huang, Y; Liu, Z; Peng, M; Su, Q; Tao, T; Yang, X; Yin, T | 1 |
| Geller, S; Kremer, N; Sprecher, E; Zeeli, T | 1 |
| Boehm, M; Hallenbeck, J; Hollander, MC; Ishii, H; Latour, LL; Lin, PC; Merchant, AS; Min, Y; Munasinghe, J; Ray-Choudhury, A; Xiao, Z; Yang, D; Yang, L | 1 |
| O'Neill, LAJ; Pålsson-McDermott, EM | 1 |
| Camera, M; Castiglioni, L; Gelosa, P; Sironi, L | 1 |
| Chaisawang, P; Pannangrong, W; Prajit, R; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P | 1 |
| Abdelhamid Ibrahim, SS; Ali, MA; El-Sayyad, SM; Kandil, LS; Ragab, GM | 1 |
| Abdallah, MS; Abdelsattar Zaki, S; Abo Mansour, HE; Alarfaj, SJ; El-Naggar, ME; Elsawah, HK; Elsokary, MA; Mosalam, EM; Saif, DS; Wahsh, EA | 1 |
| Chen, X; Feng, J; Gao, P; Jia, W; Li, Z; Lu, H; Shen, S; Sun, L; Suo, C; Wang, Y; Wei, H; Yuan, M; Zhang, H; Zhong, X | 1 |
| Aranarochana, A; Chaisawang, P; Naewla, S; Pannangrong, W; Sirichoat, A; Sritawan, N; Suwannakot, K; Welbat, JU; Wigmore, P | 1 |
| Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almami, IS; Almogbel, YS | 1 |
| Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almogbel, YS; Chigurupati, S; Nemala, RA | 1 |
| Aranarochana, A; Pannangrong, W; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P | 1 |
5 review(s) available for metformin and methotrexate
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms.
Topics: Androgen Antagonists; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Deoxycytidine; Estrogen Receptor Modulators; Fluorouracil; Gemcitabine; Humans; Metformin; Methotrexate; Neoplasms; Paclitaxel; Tubulin Modulators | 2017 |
Targeting immunometabolism as an anti-inflammatory strategy.
Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Dimethyl Fumarate; Glycolysis; Humans; Immunomodulation; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Sirolimus | 2020 |
Drug repurposing in cardiovascular diseases: Opportunity or hopeless dream?
Topics: Antibodies, Monoclonal; Cardiovascular Diseases; Cholinesterase Inhibitors; Colchicine; Cytokines; Drug Repositioning; Glucagon-Like Peptide-1 Receptor; Humans; Interleukin 1 Receptor Antagonist Protein; Metformin; Methotrexate; Phosphodiesterase 5 Inhibitors; Xanthine Oxidase | 2020 |
2 trial(s) available for metformin and methotrexate
| Article | Year |
|---|---|
Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects.
Topics: Adult; Area Under Curve; Atorvastatin; Digoxin; Female; Healthy Volunteers; Humans; Male; Membrane Transport Proteins; Metformin; Methotrexate; Middle Aged; Nitriles; Pyridines; Triazoles; Young Adult | 2017 |
The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial.
Topics: Adjuvants, Immunologic; Adult; AMP-Activated Protein Kinases; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Double-Blind Method; Female; Humans; Male; Metformin; Methotrexate; Middle Aged; Treatment Outcome | 2021 |
27 other study(ies) available for metformin and methotrexate
| Article | Year |
|---|---|
Exploring the role of different drug transport routes in permeability screening.
Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implic
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2013 |
Highlights from the latest pharmacogenomic genome-wide association studies.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Biomedical Research; Breast Neoplasms; Cell Cycle Proteins; Chromosomes, Human, Pair 10; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Drug Industry; Exons; Female; Genetic Loci; Genetic Variation; Genome-Wide Association Study; Humans; Male; Metabolism; Metformin; Methotrexate; Neoplasm Proteins; Organic Anion Transporters; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Tamoxifen; Tumor Suppressor Proteins | 2013 |
Failure of initial disease control in bullous pemphigoid: a retrospective study of hospitalized patients in a single tertiary center.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Diabetes Mellitus; Drug Therapy, Combination; Female; Head; Hospitalization; Humans; Hypertension; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Methotrexate; Middle Aged; Pemphigoid, Bullous; Prednisone; Retrospective Studies; Risk Factors; Tertiary Care Centers; Tetracycline; Treatment Failure | 2017 |
Attenuation of Myeloid-Specific TGFβ Signaling Induces Inflammatory Cerebrovascular Disease and Stroke.
Topics: Animals; Cell Line; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Penetrance; Signal Transduction; Stroke; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2017 |
Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model.
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Doublecortin Protein; Hippocampus; Hypoglycemic Agents; Male; Memory Disorders; Metformin; Methotrexate; Neurogenesis; Random Allocation; Rats; Rats, Sprague-Dawley | 2020 |
Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Experimental; Disease Models, Animal; Drug Therapy, Combination; Fish Oils; Gene Expression Regulation; Hypoglycemic Agents; Interleukin-1beta; Male; Metformin; Methotrexate; MicroRNAs; Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 2021 |
Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase.
Topics: Animals; Cell Count; Drug Resistance, Neoplasm; E2F4 Transcription Factor; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Lysosomes; Male; Metformin; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Organoids; Proteolysis; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Transcription, Genetic | 2021 |
Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Doublecortin Protein; Hippocampus; Male; Memory; Memory Disorders; Metformin; Methotrexate; Neurogenesis; NF-E2-Related Factor 2; Nootropic Agents; Open Field Test; Oxidative Stress; Prefrontal Cortex; Rats, Sprague-Dawley | 2021 |
Elucidating the mechanism underlying cognitive dysfunction by investigating the effects of CMF and MET treatment on hippocampal neurons.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognitive Dysfunction; Cyclophosphamide; Female; Fluorouracil; Hippocampus; Humans; Metformin; Methotrexate; Neurons | 2022 |
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognition; Cyclophosphamide; Diabetes Mellitus, Type 2; Dopamine; Female; Fluorouracil; Glutamic Acid; Humans; Metformin; Methotrexate; Rats | 2022 |
Protective effect of metformin on methotrexate induced reduction of rat hippocampal neural stem cells and neurogenesis.
Topics: Animals; bcl-2-Associated X Protein; Hippocampus; Male; Metformin; Methotrexate; Nestin; Neural Stem Cells; Neurogenesis; Rats; Rats, Sprague-Dawley; Transcription Factors | 2023 |