metformin and methotrexate

metformin has been researched along with methotrexate in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (14.71)29.6817
2010's19 (55.88)24.3611
2020's10 (29.41)2.80

Authors

AuthorsStudies
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Cherian, C; Gangjee, A; Hales, E; Hou, Z; Matherly, LH; Mitchell-Ryan, S; Orr, S; Raghavan, S; Ravindra, MP; Wang, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Marc, J; Mlakar, V1
Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Lasseter, KC; Rammelsberg, D; Townsend, R; Yamazaki, T1
Darko, KO; He, C; Huang, Y; Liu, Z; Peng, M; Su, Q; Tao, T; Yang, X; Yin, T1
Geller, S; Kremer, N; Sprecher, E; Zeeli, T1
Boehm, M; Hallenbeck, J; Hollander, MC; Ishii, H; Latour, LL; Lin, PC; Merchant, AS; Min, Y; Munasinghe, J; Ray-Choudhury, A; Xiao, Z; Yang, D; Yang, L1
O'Neill, LAJ; Pålsson-McDermott, EM1
Camera, M; Castiglioni, L; Gelosa, P; Sironi, L1
Chaisawang, P; Pannangrong, W; Prajit, R; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P1
Abdelhamid Ibrahim, SS; Ali, MA; El-Sayyad, SM; Kandil, LS; Ragab, GM1
Abdallah, MS; Abdelsattar Zaki, S; Abo Mansour, HE; Alarfaj, SJ; El-Naggar, ME; Elsawah, HK; Elsokary, MA; Mosalam, EM; Saif, DS; Wahsh, EA1
Chen, X; Feng, J; Gao, P; Jia, W; Li, Z; Lu, H; Shen, S; Sun, L; Suo, C; Wang, Y; Wei, H; Yuan, M; Zhang, H; Zhong, X1
Aranarochana, A; Chaisawang, P; Naewla, S; Pannangrong, W; Sirichoat, A; Sritawan, N; Suwannakot, K; Welbat, JU; Wigmore, P1
Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almami, IS; Almogbel, YS1
Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almogbel, YS; Chigurupati, S; Nemala, RA1
Aranarochana, A; Pannangrong, W; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P1

Reviews

5 review(s) available for metformin and methotrexate

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms.
    Cancer treatment reviews, 2017, Volume: 54

    Topics: Androgen Antagonists; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Deoxycytidine; Estrogen Receptor Modulators; Fluorouracil; Gemcitabine; Humans; Metformin; Methotrexate; Neoplasms; Paclitaxel; Tubulin Modulators

2017
Targeting immunometabolism as an anti-inflammatory strategy.
    Cell research, 2020, Volume: 30, Issue:4

    Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Dimethyl Fumarate; Glycolysis; Humans; Immunomodulation; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Sirolimus

2020
Drug repurposing in cardiovascular diseases: Opportunity or hopeless dream?
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Antibodies, Monoclonal; Cardiovascular Diseases; Cholinesterase Inhibitors; Colchicine; Cytokines; Drug Repositioning; Glucagon-Like Peptide-1 Receptor; Humans; Interleukin 1 Receptor Antagonist Protein; Metformin; Methotrexate; Phosphodiesterase 5 Inhibitors; Xanthine Oxidase

2020

Trials

2 trial(s) available for metformin and methotrexate

ArticleYear
Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects.
    Clinical pharmacology in drug development, 2017, Volume: 6, Issue:1

    Topics: Adult; Area Under Curve; Atorvastatin; Digoxin; Female; Healthy Volunteers; Humans; Male; Membrane Transport Proteins; Metformin; Methotrexate; Middle Aged; Nitriles; Pyridines; Triazoles; Young Adult

2017
The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial.
    International immunopharmacology, 2021, Volume: 95

    Topics: Adjuvants, Immunologic; Adult; AMP-Activated Protein Kinases; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Double-Blind Method; Female; Humans; Male; Metformin; Methotrexate; Middle Aged; Treatment Outcome

2021

Other Studies

27 other study(ies) available for metformin and methotrexate

ArticleYear
Exploring the role of different drug transport routes in permeability screening.
    Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2

    Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implic
    Journal of medicinal chemistry, 2013, Dec-27, Volume: 56, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship

2013
Highlights from the latest pharmacogenomic genome-wide association studies.
    Pharmacogenomics, 2013, Volume: 14, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Biomedical Research; Breast Neoplasms; Cell Cycle Proteins; Chromosomes, Human, Pair 10; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Drug Industry; Exons; Female; Genetic Loci; Genetic Variation; Genome-Wide Association Study; Humans; Male; Metabolism; Metformin; Methotrexate; Neoplasm Proteins; Organic Anion Transporters; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Tamoxifen; Tumor Suppressor Proteins

2013
Failure of initial disease control in bullous pemphigoid: a retrospective study of hospitalized patients in a single tertiary center.
    International journal of dermatology, 2017, Volume: 56, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Diabetes Mellitus; Drug Therapy, Combination; Female; Head; Hospitalization; Humans; Hypertension; Hypoglycemic Agents; Immunosuppressive Agents; Male; Metformin; Methotrexate; Middle Aged; Pemphigoid, Bullous; Prednisone; Retrospective Studies; Risk Factors; Tertiary Care Centers; Tetracycline; Treatment Failure

2017
Attenuation of Myeloid-Specific TGFβ Signaling Induces Inflammatory Cerebrovascular Disease and Stroke.
    Circulation research, 2017, Dec-08, Volume: 121, Issue:12

    Topics: Animals; Cell Line; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Penetrance; Signal Transduction; Stroke; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2017
Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Doublecortin Protein; Hippocampus; Hypoglycemic Agents; Male; Memory Disorders; Metformin; Methotrexate; Neurogenesis; Random Allocation; Rats; Rats, Sprague-Dawley

2020
Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis.
    International immunopharmacology, 2021, Volume: 92

    Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Experimental; Disease Models, Animal; Drug Therapy, Combination; Fish Oils; Gene Expression Regulation; Hypoglycemic Agents; Interleukin-1beta; Male; Metformin; Methotrexate; MicroRNAs; Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha

2021
Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase.
    Cell death & disease, 2021, 10-02, Volume: 12, Issue:10

    Topics: Animals; Cell Count; Drug Resistance, Neoplasm; E2F4 Transcription Factor; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Lysosomes; Male; Metformin; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Organoids; Proteolysis; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Transcription, Genetic

2021
Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Doublecortin Protein; Hippocampus; Male; Memory; Memory Disorders; Metformin; Methotrexate; Neurogenesis; NF-E2-Related Factor 2; Nootropic Agents; Open Field Test; Oxidative Stress; Prefrontal Cortex; Rats, Sprague-Dawley

2021
Elucidating the mechanism underlying cognitive dysfunction by investigating the effects of CMF and MET treatment on hippocampal neurons.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognitive Dysfunction; Cyclophosphamide; Female; Fluorouracil; Hippocampus; Humans; Metformin; Methotrexate; Neurons

2022
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognition; Cyclophosphamide; Diabetes Mellitus, Type 2; Dopamine; Female; Fluorouracil; Glutamic Acid; Humans; Metformin; Methotrexate; Rats

2022
Protective effect of metformin on methotrexate induced reduction of rat hippocampal neural stem cells and neurogenesis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 162

    Topics: Animals; bcl-2-Associated X Protein; Hippocampus; Male; Metformin; Methotrexate; Nestin; Neural Stem Cells; Neurogenesis; Rats; Rats, Sprague-Dawley; Transcription Factors

2023