metformin and megestrol acetate

metformin has been researched along with megestrol acetate in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (14.29)29.6817
2010's8 (57.14)24.3611
2020's4 (28.57)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Lin, JF; Shen, ZQ; Zhu, HT1
Kim, MK; Seong, SJ1
Chen, X; Gu, C; Luo, X; Ning, C; Shan, W; Wang, C; Zhang, Z; Zhou, Q1
Bidadi, S; Foroughi, M; Ghojazadeh, M; Melli, MS; Tabrizi, AD1
Atiomo, W; Clement, NS; Mulvaney, CA; Oliver, TR; Sanner, JR; Shiwani, H1
Chen, X; Luo, X; Ning, C; Shan, W; Shi, Y; Xie, B; Xie, L; Xu, Y; Yang, B; Zhang, H; Zhu, Q1
Chen, XJ; Cheng, YL; Du, Y; Guan, J; Gulinazi, Y; Liu, J; Luo, XZ; Ma, FH; Ning, CC; Shan, WW; Sun, L; Yang, BY; Yu, M; Zhang, HW; Zhu, Q1
Atiomo, W1
Aghajani, R; Arab, M; Ghahghaei-Nezamabadi, A; Khalagi, K; Sadeghi, S; Tehranian, A1
Liu, Z; Niu, J; Shi, C; Zhao, X1

Reviews

1 review(s) available for metformin and megestrol acetate

ArticleYear
Metformin for endometrial hyperplasia.
    The Cochrane database of systematic reviews, 2017, Oct-27, Volume: 10

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Disease Progression; Endometrial Hyperplasia; Female; Humans; Hysterectomy; Megestrol Acetate; Metformin; Middle Aged; Precancerous Conditions; Randomized Controlled Trials as Topic; Recurrence; Uterine Hemorrhage; Uterine Neoplasms

2017

Trials

5 trial(s) available for metformin and megestrol acetate

ArticleYear
Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia.
    Journal of gynecologic oncology, 2014, Volume: 25, Issue:3

    Topics: Adult; Antineoplastic Agents, Hormonal; Drug Therapy, Combination; Endometrial Hyperplasia; Female; Humans; Hypoglycemic Agents; Megestrol Acetate; Metabolic Syndrome; Metformin; Pilot Projects; Receptors, Estrogen; Receptors, Progesterone; Single-Blind Method; Treatment Outcome

2014
Antiproliferative effect of metformin on the endometrium--a clinical trial.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:23

    Topics: Adult; Antineoplastic Agents, Hormonal; Atrophy; Carcinoma, Endometrioid; Endometrial Hyperplasia; Endometrial Neoplasms; Endometrium; Female; Humans; Hypoglycemic Agents; Megestrol Acetate; Metformin; Metrorrhagia

2014
Metformin plus megestrol acetate compared with megestrol acetate alone as fertility-sparing treatment in patients with atypical endometrial hyperplasia and well-differentiated endometrial cancer: a randomised controlled trial.
    BJOG : an international journal of obstetrics and gynaecology, 2020, Volume: 127, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Agents, Hormonal; China; Drug Therapy, Combination; Endometrial Hyperplasia; Endometrial Neoplasms; Female; Fertility Preservation; Humans; Megestrol Acetate; Metformin; Middle Aged; Treatment Outcome; Young Adult

2020
The impact of adjunctive metformin to progesterone for the treatment of non-atypical endometrial hyperplasia in a randomized fashion, a placebo-controlled, double blind clinical trial.
    Journal of gynecology obstetrics and human reproduction, 2021, Volume: 50, Issue:6

    Topics: Adult; Antineoplastic Agents, Hormonal; Double-Blind Method; Drug Therapy, Combination; Endometrial Hyperplasia; Endometrial Neoplasms; Female; Humans; Megestrol Acetate; Metformin

2021
Levonorgestrel-releasing intrauterine device plus metformin, or megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and early endometrial carcinoma: a prospective, randomized, blind-endpoint design trial pr
    Reproductive health, 2022, Nov-04, Volume: 19, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Endometrial Hyperplasia; Endometrial Neoplasms; Female; Humans; Intrauterine Devices, Medicated; Levonorgestrel; Megestrol Acetate; Metformin; Obesity; Pregnancy; Prospective Studies; Randomized Controlled Trials as Topic

2022

Other Studies

8 other study(ies) available for metformin and megestrol acetate

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Reverse of progestin-resistant atypical endometrial hyperplasia by metformin and oral contraceptives.
    Obstetrics and gynecology, 2008, Volume: 112, Issue:2 Pt 2

    Topics: Adult; Contraceptives, Oral, Hormonal; Endometrial Hyperplasia; Female; Humans; Hypoglycemic Agents; Megestrol Acetate; Metformin; Progestins

2008
Conservative treatment for atypical endometrial hyperplasia: what is the most effective therapeutic method?
    Journal of gynecologic oncology, 2014, Volume: 25, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Endometrial Hyperplasia; Female; Humans; Hypoglycemic Agents; Megestrol Acetate; Metformin

2014
Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial atypical hyperplasia and endometrial cancer.
    Gynecologic oncology, 2019, Volume: 153, Issue:1

    Topics: Administration, Oral; Adult; Endometrial Hyperplasia; Endometrial Neoplasms; Female; Fertility Preservation; Humans; Hysteroscopy; Megestrol Acetate; Metformin; Middle Aged; Progestins; Retrospective Studies; Treatment Outcome; Young Adult

2019
Is there any move to use metformin for endometrial hyperplasia in routine clinical practice?
    BJOG : an international journal of obstetrics and gynaecology, 2020, Volume: 127, Issue:7

    Topics: Endometrial Hyperplasia; Endometrial Neoplasms; Endometrium; Female; Humans; Hypoglycemic Agents; Megestrol Acetate; Metformin

2020
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