metformin has been researched along with malondialdehyde in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (11.76) | 29.6817 |
| 2010's | 47 (69.12) | 24.3611 |
| 2020's | 13 (19.12) | 2.80 |
| Authors | Studies |
|---|---|
| Arslan, M; Ayvaz, G; Bukan, N; Cakir, N; Karakoç, A; Törüner, F; Yilmaz, M | 1 |
| Guven, GS; Kanigur, G; Onaran, I; Ozdaş, SB; Vehid, S | 1 |
| Al-Bekari, AM; Al-Majed, A; Al-Rejaie, SS; Al-Shabanah, OA; Al-Yahya, AA; Aleisa, AM; Bakheet, SA; Qureshi, S | 1 |
| Hilgertová, J; Kalousová, M; Kvasnicka, J; Prázný, M; Skrha, J; Zima, T | 1 |
| Diamant, M; Scheffer, PG; Schumm-Draeger, PM; Siegmund, T; von Bibra, H | 1 |
| Liu, B; Liu, CH; Meng, XM; Wang, XJ; Xia, XK; Yuan, WP; Zhang, MS | 1 |
| Ou, XP; Xie, W; Yang, TL; Zhang, SD | 1 |
| Alhaider, AA; Attia, SM; Helal, GK | 1 |
| Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA | 1 |
| Anisimov, VN; Deriabina, ON; Plotnikova, NA | 1 |
| Piro, S; Purrello, F; Rabuazzo, AM; Renis, M | 1 |
| Ikewuchi, CC; Ikewuchi, JC; Onyeike, EN; Uwakwe, AA | 1 |
| Aghamohammadi, V; Aliasgharzadeh, A; Gargari, BP | 1 |
| Abd el-Latif, FF; Khalifa, M; Sayed, AA | 1 |
| Ge, P; Li, H; Li, L; Wan, J; Yuan, H; Zhang, L; Zheng, W | 1 |
| Anisimov, VN; Demidov, DV; Kharitonova, TV; Man'cheva, TA; Pashkevich, IV; Plotnikova, NA | 1 |
| Fang, X; Jia, C; Peng, YF; Xu, QY | 1 |
| Atkin, SL; Coady, AM; Kilpatrick, ES; Sathyapalan, T; Shepherd, J | 1 |
| Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H; Pratchayasakul, W | 1 |
| Chen, H; Hochstetter, D; Wang, Y; Xu, P; Zhou, T | 1 |
| Atamer, A; Atamer, Y; Can, AS; Hekimoğlu, A; Ilhan, N; Koçyiğit, Y; Yenice, N | 1 |
| El Sarha, A; Ismail, MA; Refaat, R; Salman, ZK; Selima, E | 1 |
| Chen, A; Deng, W; Fang, D; Huang, Z; Li, H; Li, Y; Liu, J; Liu, L; Wan, X; Wei, G | 1 |
| Cai, Y; Hu, X; Wen, Z; Yi, B; Zhang, T | 1 |
| Bayram, F; Diri, H; Kocer, D | 1 |
| Cai, H; Chang, J; Chen, W; Qi, Y; Tang, C; Yin, X; Zhang, B; Zhang, G; Zhang, J | 1 |
| Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR | 1 |
| Bułdak, RJ; Bułdak, Ł; Duława-Bułdak, A; Kozłowski, M; Liber, S; Machnik, G; Okopień, B; Suchy, D; Łabuzek, K | 1 |
| Aldea, MD; Bolfa, P; Craciun, L; Filip, AG; Ion, RM; Muresan, A; Nenu, I; Olteanu, D; Popescu, T; Tatomir, C | 1 |
| Ban, N; Kawana, H; Murano, T; Nagayama, D; Nagumo, A; Ohira, M; Saiki, A; Shirai, K; Tatsuno, I; Yamaguchi, T | 1 |
| Abd-Elsameea, AA; Mohamed, AM; Moustaf, AA | 1 |
| Bai, B; Fu, S; Jiang, D; Jiang, J; Shen, S; Sun, X; Tan, D; Wu, Z | 1 |
| Budhram, R; Lau-Cam, CA; Pandya, KG | 1 |
| Belova Kumskova, EM; Grechnikova, MA; Konovalova, GG; Lankin, VZ; Shumaev, KB; Tikhaze, AK; Viigimaa, M | 1 |
| Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H | 1 |
| Balaha, MF; Borg, HM; Kabel, AM; Omar, MS | 1 |
| Chinwuba Okoye, T; Chukwunonso Obi, B; Nonye Igwe, C; Okpashi, VE; Olisah Alumanah, E | 1 |
| Ghareeb, DA; Ismail, CA; Mostafa, DK | 1 |
| Chai, DD; Ren, LW; Yang, HY; Yu, ZW; Zhan, P; Zhou, ZY | 1 |
| Akbari, G; Asghari, A; Meghdadi, A; Mortazavi, P | 1 |
| Ding, H; Du, E; He, Z; Liu, C; Qi, S; Qin, Z; Xu, Y; Yang, K; Yang, T; Yang, X; Zhang, C; Zhang, H; Zhang, Z | 1 |
| Cheung, KWK; Giacomini, KM; Hsueh, CH; Huang, SM; Meyer, TW; Zhang, L; Zhao, P | 1 |
| Du, Y; Fang, F; Tan, H; Wei, X; Zhang, H; Zhang, J | 1 |
| Abdollahi, A; Dehpour, AR; Ghasemnejad-Berenji, H; Ghasemnejad-Berenji, M; Ghazi-Khansari, M; Mohajer Ansari, J; Nobakht, M; Pashapour, S; Yazdani, I | 1 |
| Araújo Júnior, RF; Araújo, AA; Araújo, LS; Brito, GAC; Guedes, PMM; Hiyari, S; Leitão, RFC; Medeiros, CACX; Pereira, ASBF; Pirih, FQ | 1 |
| Abu Bakar, AB; Md Lazin, MRML; Mohamed, M; Nna, VU | 1 |
| Delkhosh-Kasmaie, F; Farshid, AA; Imani, M; Tamaddonfard, E | 1 |
| Askari, VR; Mousavi, SH; Rahimi, VB | 1 |
| Javadipour, M; Keshtzar, E; Khodayar, MJ; Rezaei, M | 1 |
| An, Y; Kato, K; Li, H; Mao, J; Wang, L; Wu, J; Xia, H; Yamanaka, K; Yang, Q; Zhang, J; Zhu, Z | 1 |
| Alencar, MS; Alves, EHP; Araújo, AJ; Araújo, AR; Filho, JDBM; Iles, B; Leal, LKAM; Lopes, ALF; Medeiros, JVR; Nolêto, IRSG; Oliveira, AP; Pacheco, G; Sousa, FBM; Vasconcelos, DFP | 1 |
| Gong, SF; Jiang, K; Jiang, T; Li, QL; Si, W; Wang, TJ; Wang, WJ; Wu, RY; Xiong, ZS | 1 |
| Askari, VR; Baradaran Rahimi, V; Mousavi, SH | 1 |
| Latiff, AA; Mardiana, AA; Sahema, ZCT; Santhana, RL; Syed Ahmad Fuad, SB; Zaidun, NH | 1 |
| Gao, X; Shi, W; SreeHarsha, N; Wang, L; Zhang, D | 1 |
| Atak, M; Balik, G; Mercantepe, T; Topcu, A; Tumkaya, L; Uydu, HA | 1 |
| Abdel-Latif, RG; El-Deen, RM; Heeba, GH; Khalifa, MMA | 1 |
| Cecchini, AL; Cecchini, R; da Silva Brito, WA; Dias Lopes, NM; Lovo-Martins, MI; Luiz, RC; Marinello, PC; Pinge-Filho, P; Sanches, LJ | 1 |
| Ishak, NIM; Lau, S; Mohamed, S; Mustapha, NM; Nahar, N; Umran, NS | 1 |
| Erukainure, OL; Islam, MS; Olofinsan, KA; Salau, VF | 1 |
| Erdem, S; Ergenc, M; Ozacmak, VH; Sayan Özaçmak, H; Turan, I | 1 |
| Akbari, G; Asghari, A; Jahandideh, A; Karimi, H; Mortazavi, P | 1 |
| Bătrînu, MG; Croitoru, MD; Dogaru, MT; Fogarasi, E; Jîtcă, G; Miklos, A; Ősz, BE; Rusz, CM; Tero-Vescan, A; Vari, CE | 1 |
| Cecchini, AL; Cecchini, R; da Silva Brito, WA; Lopes, NMD; Luiz, RC; Marinello, PC; Sanches, LJ | 1 |
| Abdulla, MS; Hosny, EN; Khadrawy, YA; Khoder, NM; Sawie, HG; Sharada, HM | 1 |
| Ali, RH; Ali, SK | 1 |
| Attia, SH; Nageeb, MM; Saadawy, SF | 1 |
| Ayhan, S; Caydere, M; Gozukucuk, M; Guney, G; Guney, SS; Hancerliogullari, N; Tokmak, A; Ustun, Y | 1 |
8 trial(s) available for metformin and malondialdehyde
| Article | Year |
|---|---|
The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.
Topics: Adult; Androgens; Antioxidants; Blood Glucose; Body Mass Index; Body Weight; Female; Homeostasis; Homocysteine; Humans; Hypoglycemic Agents; Insulin Resistance; Lipids; Malondialdehyde; Metformin; Models, Statistical; Oxidative Stress; Polycystic Ovary Syndrome; Risk Factors; Rosiglitazone; Smoking; Thiazolidinediones; Time Factors | 2005 |
Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus.
Topics: Adult; Aged; Cross-Over Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypoglycemic Agents; Male; Malondialdehyde; Metformin; Microcirculation; Middle Aged; Oxidative Stress; Pilot Projects; Skin | 2007 |
Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease.
Topics: Adiponectin; Aged; C-Reactive Protein; Diabetes Mellitus, Type 2; Diastole; Drug Therapy, Combination; Echocardiography, Doppler, Pulsed; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Malondialdehyde; Metformin; Middle Aged; Myocardial Contraction; Myocardium; Oxidative Stress; Pilot Projects; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome | 2008 |
Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus.
Topics: Administration, Oral; Aged; Antioxidants; Diabetes Mellitus, Type 2; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Folic Acid; Homocysteine; Humans; Male; Malondialdehyde; Metformin; Middle Aged; Oxidative Stress; Vitamin B 12 | 2011 |
Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome.
Topics: Adult; Atorvastatin; Double-Blind Method; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin Resistance; Malondialdehyde; Metformin; Oxidative Stress; Polycystic Ovary Syndrome; Pyrroles; Treatment Outcome | 2012 |
Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus.
Topics: Aged; Aryldialkylphosphatase; Biomarkers; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Homocysteine; Humans; Hypoglycemic Agents; Insulin; Male; Malondialdehyde; Metabolome; Metformin; Middle Aged; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Triglycerides | 2013 |
Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant α-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus.
Topics: Adult; Aged; Antioxidants; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Infusion Systems; Insulin-Secreting Cells; Lipids; Male; Malondialdehyde; Metformin; Middle Aged; Rosiglitazone; Thiazolidinediones; Thioctic Acid; Time Factors | 2013 |
Metformin reduces circulating malondialdehyde-modified low-density lipoprotein in type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Male; Malondialdehyde; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles | 2014 |
60 other study(ies) available for metformin and malondialdehyde
| Article | Year |
|---|---|
Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress.
Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Antioxidants; Benzene Derivatives; Cells, Cultured; Comet Assay; DNA Damage; DNA Fragmentation; Female; Humans; Hypoglycemic Agents; Lipid Peroxidation; Lymphocytes; Male; Malondialdehyde; Metformin; Oxidative Stress | 2006 |
Effect of metformin on clastogenic and biochemical changes induced by adriamycin in Swiss albino mice.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Mice; Micronucleus Tests | 2007 |
Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Cell Line; Chitin; Chitosan; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Insulin-Secreting Cells; Islets of Langerhans; Male; Malondialdehyde; Metformin; Mice; Mice, Inbred NOD; Oligosaccharides; Rats; Rats, Wistar; Streptozocin; Superoxide Dismutase | 2009 |
[Protective effects of metformin on low-density lipoprotein-induced endothelial dysfunction in rats].
Topics: Animals; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Lipoproteins, LDL; Male; Malondialdehyde; Metformin; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilation | 2009 |
Assessment of genomic instability in normal and diabetic rats treated with metformin.
Topics: Animals; Chromosome Aberrations; Diabetes Mellitus, Experimental; Drug Administration Schedule; Genomic Instability; Glutathione; Hypoglycemic Agents; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Micronuclei, Chromosome-Defective; Mitosis; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Sperm Motility; Spermatozoa | 2009 |
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric Mucosa; Hypoglycemic Agents; Indomethacin; Male; Malondialdehyde; Metformin; Mucins; Nitric Oxide; Rats; Rats, Wistar; Rosiglitazone; Stomach Ulcer; Thiazolidinediones | 2010 |
[Melatonin and metformin inhibit skin carcinogenesis induced by benz(a)pyrene in mice].
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Squamous Cell; Catalase; Central Nervous System Depressants; Hypoglycemic Agents; Male; Malondialdehyde; Melatonin; Metformin; Mice; Mice, Inbred Strains; Pyrenes; Random Allocation; Skin Neoplasms | 2010 |
Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Cell Survival; Fatty Acids, Nonesterified; Glucose; HSP70 Heat-Shock Proteins; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Malondialdehyde; Metformin; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Biomarkers; Blood Cell Count; Blood Cells; Blood Glucose; Blood Urea Nitrogen; Calcium; Cholesterol, HDL; Cholesterol, VLDL; Chromatography, Gas; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Euphorbiaceae; Eye; Hypoglycemic Agents; Kidney; Liver; Malondialdehyde; Metformin; Oxidative Stress; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Wistar; Solvents; Triglycerides; Urea | 2011 |
Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutathione; Interleukin-6; Kidney; Lipid Peroxidation; Malondialdehyde; Metformin; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rosiglitazone; Superoxide Dismutase; Thiazolidinediones; Trigonella | 2012 |
Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Galactosamine; Hypoglycemic Agents; Lipopolysaccharides; Male; Malondialdehyde; Metformin; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2012 |
Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.
Topics: Animals; Antioxidants; Benzo(a)pyrene; Cell Transformation, Neoplastic; Female; Lipid Peroxidation; Malondialdehyde; Melatonin; Metformin; Mice; Reactive Oxygen Species; Skin; Skin Neoplasms | 2011 |
[Metformin improves epididymal sperm quality and antioxidant function of the testis in diet-induced obesity rats].
Topics: Animals; Epididymis; Glutathione Peroxidase; Male; Malondialdehyde; Metformin; Obesity; Rats; Rats, Sprague-Dawley; Sperm Count; Sperm Motility; Spermatozoa; Superoxide Dismutase; Testis | 2012 |
Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats.
Topics: Animals; Blood Glucose; Brain; Dietary Fats; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Malondialdehyde; Maze Learning; Memory; Metformin; Mitochondria; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant status in alloxan-induced diabetic mice.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Liver; Male; Malondialdehyde; Metformin; Mice; Mice, Inbred ICR; Oxidative Stress; Plant Extracts; Polysaccharides; Superoxide Dismutase; Tea | 2012 |
The combined effect of metformin and L-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats.
Topics: Animals; Body Weight; C-Reactive Protein; Caspase 3; Chemokine CCL2; Cysteine; Cytochromes c; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Interactions; Fatty Acids, Nonesterified; Glutathione; Inflammation; Insulin Resistance; Liver; Male; Malondialdehyde; Metformin; Nitrates; Nitrites; Oxidative Stress; Rats; Rats, Wistar | 2013 |
Metformin protects against hyperglycemia-induced cardiomyocytes injury by inhibiting the expressions of receptor for advanced glycation end products and high mobility group box 1 protein.
Topics: Animals; Antioxidants; Creatine Kinase; Gene Expression Regulation; Glycation End Products, Advanced; HMGB1 Protein; Humans; Hyperglycemia; L-Lactate Dehydrogenase; Malondialdehyde; Metformin; Myocytes, Cardiac; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2014 |
The effects of metformin on endothelial dysfunction, lipid metabolism and oxidative stress in women with polycystic ovary syndrome.
Topics: Adult; Apolipoprotein A-I; Apolipoproteins B; Aryldialkylphosphatase; Case-Control Studies; Cholesterol, LDL; Endothelin-1; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Insulin Resistance; Lipid Metabolism; Luteinizing Hormone; Malondialdehyde; Metformin; Nitric Oxide; Oxidative Stress; Polycystic Ovary Syndrome; Progesterone; Young Adult | 2014 |
Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress.
Topics: Adrenergic beta-Agonists; AMP-Activated Protein Kinases; Animals; Apoptosis; Blotting, Western; Cardiotonic Agents; Endoplasmic Reticulum Stress; Heart Diseases; Hemodynamics; Hypoglycemic Agents; Isoproterenol; L-Lactate Dehydrogenase; Male; Malondialdehyde; Metformin; Myocardium; Rats; Rats, Sprague-Dawley | 2014 |
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.
Topics: Animals; Antioxidants; Brain; Convulsants; Glutathione; Kindling, Neurologic; Learning Disabilities; Male; Malondialdehyde; Maze Learning; Memory Disorders; Metformin; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Seizures | 2014 |
Metformin affects macrophages' phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages.
Topics: AMP-Activated Protein Kinases; Antioxidants; Atherosclerosis; Catalase; Cytokines; Female; Glutathione Peroxidase; Humans; Inflammation; Lipopolysaccharides; Macrophages; Male; Malondialdehyde; Metformin; Monocytes; Oxidative Stress; Phenotype; Reactive Oxygen Species; Superoxide Dismutase | 2014 |
Metformin associated with photodynamic therapy--a novel oncological direction.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclooxygenase 2; Glutathione; Hypoglycemic Agents; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metformin; Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Photochemotherapy; Porphyrins; Radiation-Sensitizing Agents; Radiation, Ionizing; Rats; Rats, Wistar | 2014 |
Modulation of the oxidative stress by metformin in the cerebrum of rats exposed to global cerebral ischemia and ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Catalase; Cerebrum; Glutathione Peroxidase; Male; Malondialdehyde; Metformin; Neuroprotective Agents; Oxidative Stress; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2014 |
Protective effects of grape seed extract fractions with different degrees of polymerisation on blood glucose, lipids and hepatic oxidative stress in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Grape Seed Extract; Lipids; Liver; Malondialdehyde; Metformin; Nitric Oxide; Oxidative Stress; Polymerization; Rats; Rats, Sprague-Dawley | 2015 |
Evaluation of the actions of metformin and taurine, singly and in combination, on metabolic and oxidative alterations caused by diabetes in rat erythrocytes and plasma.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Glycated Hemoglobin; Insulin; Male; Malondialdehyde; Metformin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Taurine | 2015 |
Aldehyde inhibition of antioxidant enzymes in the blood of diabetic patients.
Topics: Aldehydes; Animals; Antioxidants; Case-Control Studies; Cattle; Diabetes Mellitus, Type 2; Erythrocytes; Female; Glyoxal; Humans; Hypoglycemic Agents; Male; Malondialdehyde; Metformin; Middle Aged | 2016 |
Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Activation; Glycation End Products, Advanced; Hyperalgesia; Hypoglycemic Agents; Male; Malondialdehyde; Metformin; Oxidative Stress; Pain Perception; Pain Threshold; Phosphorylation; Rats, Sprague-Dawley; Sciatic Nerve; Streptozocin; Superoxide Dismutase; Time Factors | 2015 |
Effect of metformin and adriamycin on transplantable tumor model.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Disease Models, Animal; Doxorubicin; Hypoglycemic Agents; Malondialdehyde; Metformin; Mice, Inbred BALB C; Neoplasms; Tumor Necrosis Factor-alpha | 2015 |
Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats.
Topics: Alloxan; Animals; Antioxidants; Biomarkers; Blood Glucose; Carbamates; Catalase; Diabetes Complications; Diabetes Mellitus, Experimental; Glutathione; Glyburide; Hypoglycemic Agents; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Oxidative Stress; Piperidines; Rats; Superoxide Dismutase | 2016 |
Differential metformin dose-dependent effects on cognition in rats: role of Akt.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cognition; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Hypoglycemic Agents; Male; Malondialdehyde; Maze Learning; Memory Disorders; Metformin; Oxidative Stress; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Wistar; Scopolamine; Tumor Necrosis Factor-alpha | 2016 |
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Cells, Cultured; Diet, High-Fat; Endotoxemia; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Intestine, Small; Lipopolysaccharides; Liver; Male; Malondialdehyde; Metformin; Mice; Muscles; NF-KappaB Inhibitor alpha; Occludin; Phosphorylation; PTEN Phosphohydrolase | 2016 |
Protective effect of metformin on testicular ischemia/reperfusion injury in rats.
Topics: Animals; Male; Malondialdehyde; Metformin; Models, Animal; Oxidative Stress; Peroxidase; Protective Agents; Random Allocation; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Testis | 2016 |
Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Dogs; Ethylene Glycol; Humans; Kidney Calculi; Kidney Tubules; Madin Darby Canine Kidney Cells; Male; Malondialdehyde; Metformin; Oxalates; Oxidative Stress; Rats, Sprague-Dawley; Superoxide Dismutase | 2016 |
The Effect of Uremic Solutes on the Organic Cation Transporter 2.
Topics: Biological Transport; Dimethylamines; Glomerular Filtration Rate; Glucuronates; Glutathione Disulfide; HEK293 Cells; Homocysteine; Humans; Indoles; Kidney; Malondialdehyde; Metformin; Methylamines; Organic Cation Transporter 2; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2017 |
Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Hypoglycemic Agents; Malondialdehyde; Metformin; Myocytes, Cardiac; Oxygen; Rats; Reactive Oxygen Species; Signal Transduction; Sirtuins; Superoxide Dismutase | 2017 |
Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Catalase; Disease Models, Animal; Enzyme Activators; Epididymis; Humans; In Situ Nick-End Labeling; Male; Malondialdehyde; Metformin; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Sperm Count; Spermatic Cord Torsion; Spermatozoa; Testis | 2018 |
Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Gingiva; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Inflammation; Interleukin-1beta; Male; Malondialdehyde; Matrix Metalloproteinase 9; Metformin; NF-kappa B; Oxidative Stress; Periodontitis; RANK Ligand; Rats; Rats, Wistar; Receptor Activator of Nuclear Factor-kappa B; Tumor Necrosis Factor-alpha; X-Ray Microtomography | 2017 |
Antioxidant, anti-inflammatory and synergistic anti-hyperglycemic effects of Malaysian propolis and metformin in streptozotocin-induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Caspase 3; Diabetes Mellitus, Experimental; Drug Synergism; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Insulin; Interleukin-1; Islets of Langerhans; Malaysia; Male; Malondialdehyde; Metformin; NF-kappa B; Proliferating Cell Nuclear Antigen; Propolis; Rats, Sprague-Dawley; Streptozocin | 2018 |
The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations.
Topics: Animals; Behavior, Animal; Caspase 3; Cell Count; Crocus; Cyclohexenes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hippocampus; Hyperglycemia; Malondialdehyde; Maze Learning; Memory Disorders; Metformin; Neurons; Rats, Wistar; Spatial Learning; Streptozocin; Superoxide Dismutase; Swimming; Task Performance and Analysis; Terpenes; Tumor Necrosis Factor-alpha | 2018 |
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study.
Topics: Aging; Anilides; beta-Galactosidase; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Ellagic Acid; Galactose; Glutathione; Glycation End Products, Advanced; Humans; Malondialdehyde; Mannitol; Metformin; Neuroblastoma; Protoporphyrins; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2018 |
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification.
Topics: Animals; Arsenic; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Electron Transport Complex II; Gene Expression Regulation; Glutathione; Hepatocytes; Insulin Resistance; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Sirtuins | 2019 |
The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells.
Topics: Catalase; Drug Synergism; Fibroins; Glucose; Hep G2 Cells; Humans; Hypoglycemic Agents; Insulin Resistance; Interleukin-6; Malondialdehyde; Metformin; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2019 |
Alendronate-induced gastric damage in normoglycemic and hyperglycemic rats is reversed by metformin.
Topics: Alendronate; Animals; Blood Glucose; Collagen; Cytokines; Cytoprotection; Gastric Mucosa; Hyperglycemia; Malondialdehyde; Metformin; Peroxidase; Rats; Rats, Wistar; Stomach | 2019 |
Effect of metformin on cell proliferation, apoptosis, migration and invasion in A172 glioma cells and its mechanisms.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Malondialdehyde; Metformin; Neuroglia; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Superoxide Dismutase; TOR Serine-Threonine Kinases | 2019 |
Ellagic acid dose and time-dependently abrogates d-galactose-induced animal model of aging: Investigating the role of PPAR-γ.
Topics: Aging; Anilides; Animals; Apoptosis; Brain; Ellagic Acid; Galactose; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Metformin; Mice; Models, Animal; Oxidative Stress; PPAR gamma; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2019 |
Effects of naringenin on vascular changes in prolonged hyperglycaemia in fructose-STZ diabetic rat model.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Flavanones; Fructose; Hyperglycemia; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Metformin; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Streptozocin | 2019 |
Cardioprotective role of metformin against sodium arsenite-induced oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Arsenites; Biomarkers; Cardiotonic Agents; Enzymes; Heart; Inflammation; Male; Malondialdehyde; Metformin; Myocardium; Oxidative Stress; Rats, Sprague-Dawley; Sodium Compounds | 2020 |
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Estradiol; Female; Glutathione; Malondialdehyde; Metformin; NF-kappa B; Ovarian Diseases; Ovary; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2019 |
Combined treatments with metformin and phosphodiesterase inhibitors alleviate nonalcoholic fatty liver disease in high-fat diet fed rats: a comparative study.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Body Composition; Body Weight; Cholesterol; Diet, High-Fat; Drug Synergism; Fasting; Gene Expression Regulation; Glutathione; Insulin; Liver; Male; Malondialdehyde; Metformin; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Triglycerides; Tumor Necrosis Factor-alpha | 2020 |
Patterns of cell death induced by metformin in human MCF-7 breast cancer cells.
Topics: Apoptosis; Ferroptosis; Glutathione; Humans; Hypoglycemic Agents; Malondialdehyde; MCF-7 Cells; Metformin; Necroptosis; Oligopeptides; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Compounds | 2020 |
Metformin attenuated histopathological ocular deteriorations in a streptozotocin-induced hyperglycemic rat model.
Topics: Animals; Claudin-1; Diabetes Complications; Diabetes Mellitus, Experimental; Eye Diseases; Glutathione; Hyperglycemia; Hypoglycemic Agents; Male; Malondialdehyde; Metformin; Rats, Sprague-Dawley; Streptozocin; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2021 |
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Benzaldehydes; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Malondialdehyde; Metformin; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Testicular Diseases | 2021 |
Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress.
Topics: Animals; Anxiety; Blood Glucose; Depression; Female; Glutathione; Hippocampus; Malondialdehyde; Metformin; Ovariectomy; Oxidative Stress; Prefrontal Cortex; Protective Agents; Rats; Rats, Wistar | 2021 |
Effects of Metformin on Experimental Varicocele in Rats.
Topics: Animals; Male; Malondialdehyde; Metformin; Rats; Rats, Wistar; Testis; Varicocele | 2021 |
A Simple HPLC/DAD Method Validation for the Quantification of Malondialdehyde in Rodent's Brain.
Topics: Acetonitriles; Animals; Brain; Chromatography, High Pressure Liquid; Haloperidol; Humans; Malondialdehyde; Metformin; Rats | 2021 |
Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Malondialdehyde; Melanoma, Experimental; Metformin; Mice; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Skin Neoplasms; Tumor Suppressor Protein p53 | 2022 |
The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Brain-Derived Neurotrophic Factor; Dopamine; Glutathione; Hypothyroidism; Malondialdehyde; Metformin; Neuroprotective Agents; Nitric Oxide; Norepinephrine; Propylthiouracil; Rats; Serotonin; Thioctic Acid; Tumor Necrosis Factor-alpha | 2022 |
Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Biomarkers; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Donepezil; Glucose; Glyburide; Glycated Hemoglobin; Hypoglycemic Agents; Insulin Glargine; Male; Malondialdehyde; Metformin; Microtubule-Associated Proteins; Nitric Oxide; Rats; Rats, Wistar; Streptozocin; Triglycerides; Tumor Necrosis Factor-alpha | 2022 |
Breast milk mesenchymal stem cells abate cisplatin-induced cardiotoxicity in adult male albino rats via modulating the AMPK pathway.
Topics: AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cardiotoxicity; Cisplatin; Creatine Kinase, MB Form; Humans; Male; Malondialdehyde; Mesenchymal Stem Cells; Metformin; Milk, Human; Oxidative Stress; Rats; Superoxide Dismutase; Troponin T; Tumor Necrosis Factor-alpha | 2022 |
Does the addition of metformin to carboplatin treatment decreases ovarian reserve damage associated with carboplatin usage?
Topics: Animals; Anti-Mullerian Hormone; Carboplatin; Catalase; Female; Malondialdehyde; Metformin; Ovarian Reserve; Rats | 2023 |