metformin and leucine

metformin has been researched along with leucine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's9 (64.29)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Katsilambros, N; Nierle, C; Pfeiffer, EE; Schatz, H1
Bruckbauer, A; Cao, Q; Cui, X; Fu, L; Li, F; Shi, H; Wu, R; Xue, B; Zemel, MB2
Carter, RE; Cobelli, C; Esponda, RR; Johnson, ML; Konopka, AR; Lanza, IR; Nair, KS; Robinson, MM; Schiavon, M; Wondisford, FE1
Endou, H; Kawada, A; Kimura, T; Ochiai, T; Sakurai, H; Ueno, S; Yamaga, T1
A Gutierrez, M; Hsu, Y; J Lopez, A; K Kennedy, B; M Nguyen, S; Mateen, S; N O'Leary, M; P Mitchell, K; Ramanathan, A; S Sonnet, D; Vockley, J1
Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H1
Alonso, C; Barritt, AS; Chalasani, N; Flores, O; Gil-Redondo, R; Iruarrizaga-Lejarreta, M; Kolterman, O; Middleton, MS; Rinella, M; Siddiqui, MS; Sirlin, CB; Vuppalanchi, R; Zemel, MB1
Loomba, R; Noureddin, M1
Barritt, AS; Chalasani, N; Flores, O; Kolterman, O; Rinella, M; Siddiqui, M; Vuppalanchi, R; Zemel, MB1
de Hart, NM; Drummond, MJ; Eshima, H; Ferrara, PJ; Fix, DK; Funai, K; Kelley, JJ; Mahmassani, ZS; McKenzie, AI; Montgomery, JA; Petrocelli, JJ; Reidy, PT1
Chaix, A; de Hart, NMMP; Drummond, MJ; Ferrara, PJ; Fix, DK; Funai, K; Lang, MJ; Petrocelli, JJ; Yee, EM1
Baek, HS; Kang, HM; Kim, IR; Kim, YS; Oh, JM; Park, BS1

Trials

4 trial(s) available for metformin and leucine

ArticleYear
Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.
    Cell reports, 2016, 05-17, Volume: 15, Issue:7

    Topics: Energy Metabolism; Fasting; Glucagon; Glucose; Humans; Insulin; Kinetics; Leucine; Metformin; Prediabetic State; Rest

2016
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
    Diabetic medicine : a journal of the British Diabetic Association, 2018, Volume: 35, Issue:7

    Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine

2018
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:12

    Topics: Adult; Alanine Transaminase; Cohort Studies; Double-Blind Method; Drug Combinations; Female; Humans; Leucine; Lipids; Magnetic Resonance Imaging; Male; Metformin; Non-alcoholic Fatty Liver Disease; Sildenafil Citrate

2018
Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters.
    Obesity (Silver Spring, Md.), 2019, Volume: 27, Issue:1

    Topics: Body Weight; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Leucine; Male; Metformin; Middle Aged; Obesity; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate

2019

Other Studies

10 other study(ies) available for metformin and leucine

ArticleYear
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats.
    Diabetologia, 1972, Volume: 8, Issue:6

    Topics: Animals; Biguanides; Drug Interactions; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Metformin; Oxygen Consumption; Phenformin; Rats; Rats, Inbred Strains; Tritium

1972
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.
    Metabolism: clinical and experimental, 2015, Volume: 64, Issue:7

    Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Fasting; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Signal Transduction; Sirtuin 1

2015
Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice.
    Metabolism: clinical and experimental, 2015, Volume: 64, Issue:11

    Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Humans; Hyperlipidemias; Leucine; Lipid Metabolism; Liver; Metformin; Mice; Obesity

2015
Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor.
    Journal of pharmacological sciences, 2016, Volume: 131, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoglycemic Agents; Large Neutral Amino Acid-Transporter 1; Leucine; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice, Inbred BALB C; Mice, Nude; Multiprotein Complexes; TOR Serine-Threonine Kinases; Tyrosine

2016
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
    Scientific reports, 2016, 07-04, Volume: 6

    Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Liquid; Disease Models, Animal; Female; Fibroblasts; Homeostasis; Homozygote; Keto Acids; Ketoglutaric Acids; Ketosis; Leucine; Male; Maple Syrup Urine Disease; Mass Spectrometry; Metformin; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation

2016
Editorial: role of leucine-metformin-sildenafil combination in the treatment of nonalcoholic fatty liver disease (NAFLD).
    Alimentary pharmacology & therapeutics, 2018, Volume: 48, Issue:3

    Topics: Humans; Hypoglycemic Agents; Leucine; Metformin; Non-alcoholic Fatty Liver Disease; Sildenafil Citrate

2018
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:9

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension; Immunoglobulin G; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Muscle Development; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Organ Size; RNA-Seq; Satellite Cells, Skeletal Muscle; Signal Transduction

2021
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.
    Aging, 2023, 03-20, Volume: 15, Issue:6

    Topics: Aged; Animals; Cellular Senescence; Humans; Leucine; Metformin; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Proteostasis

2023
Metformin activates AMPK and mTOR to Inhibit RANKL-stimulated osteoclast formation.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:18

    Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Leucine; Metformin; Mice; Osteoclasts; TOR Serine-Threonine Kinases

2023