metformin has been researched along with leucine in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Katsilambros, N; Nierle, C; Pfeiffer, EE; Schatz, H | 1 |
| Bruckbauer, A; Cao, Q; Cui, X; Fu, L; Li, F; Shi, H; Wu, R; Xue, B; Zemel, MB | 2 |
| Carter, RE; Cobelli, C; Esponda, RR; Johnson, ML; Konopka, AR; Lanza, IR; Nair, KS; Robinson, MM; Schiavon, M; Wondisford, FE | 1 |
| Endou, H; Kawada, A; Kimura, T; Ochiai, T; Sakurai, H; Ueno, S; Yamaga, T | 1 |
| A Gutierrez, M; Hsu, Y; J Lopez, A; K Kennedy, B; M Nguyen, S; Mateen, S; N O'Leary, M; P Mitchell, K; Ramanathan, A; S Sonnet, D; Vockley, J | 1 |
| Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H | 1 |
| Alonso, C; Barritt, AS; Chalasani, N; Flores, O; Gil-Redondo, R; Iruarrizaga-Lejarreta, M; Kolterman, O; Middleton, MS; Rinella, M; Siddiqui, MS; Sirlin, CB; Vuppalanchi, R; Zemel, MB | 1 |
| Loomba, R; Noureddin, M | 1 |
| Barritt, AS; Chalasani, N; Flores, O; Kolterman, O; Rinella, M; Siddiqui, M; Vuppalanchi, R; Zemel, MB | 1 |
| de Hart, NM; Drummond, MJ; Eshima, H; Ferrara, PJ; Fix, DK; Funai, K; Kelley, JJ; Mahmassani, ZS; McKenzie, AI; Montgomery, JA; Petrocelli, JJ; Reidy, PT | 1 |
| Chaix, A; de Hart, NMMP; Drummond, MJ; Ferrara, PJ; Fix, DK; Funai, K; Lang, MJ; Petrocelli, JJ; Yee, EM | 1 |
| Baek, HS; Kang, HM; Kim, IR; Kim, YS; Oh, JM; Park, BS | 1 |
4 trial(s) available for metformin and leucine
| Article | Year |
|---|---|
Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.
Topics: Energy Metabolism; Fasting; Glucagon; Glucose; Humans; Insulin; Kinetics; Leucine; Metformin; Prediabetic State; Rest | 2016 |
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine | 2018 |
Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.
Topics: Adult; Alanine Transaminase; Cohort Studies; Double-Blind Method; Drug Combinations; Female; Humans; Leucine; Lipids; Magnetic Resonance Imaging; Male; Metformin; Non-alcoholic Fatty Liver Disease; Sildenafil Citrate | 2018 |
Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters.
Topics: Body Weight; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Leucine; Male; Metformin; Middle Aged; Obesity; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate | 2019 |
10 other study(ies) available for metformin and leucine
| Article | Year |
|---|---|
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats.
Topics: Animals; Biguanides; Drug Interactions; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Metformin; Oxygen Consumption; Phenformin; Rats; Rats, Inbred Strains; Tritium | 1972 |
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.
Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Fasting; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Signal Transduction; Sirtuin 1 | 2015 |
Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice.
Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Humans; Hyperlipidemias; Leucine; Lipid Metabolism; Liver; Metformin; Mice; Obesity | 2015 |
Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoglycemic Agents; Large Neutral Amino Acid-Transporter 1; Leucine; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice, Inbred BALB C; Mice, Nude; Multiprotein Complexes; TOR Serine-Threonine Kinases; Tyrosine | 2016 |
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Liquid; Disease Models, Animal; Female; Fibroblasts; Homeostasis; Homozygote; Keto Acids; Ketoglutaric Acids; Ketosis; Leucine; Male; Maple Syrup Urine Disease; Mass Spectrometry; Metformin; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation | 2016 |
Editorial: role of leucine-metformin-sildenafil combination in the treatment of nonalcoholic fatty liver disease (NAFLD).
Topics: Humans; Hypoglycemic Agents; Leucine; Metformin; Non-alcoholic Fatty Liver Disease; Sildenafil Citrate | 2018 |
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension; Immunoglobulin G; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Muscle Development; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Organ Size; RNA-Seq; Satellite Cells, Skeletal Muscle; Signal Transduction | 2021 |
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.
Topics: Aged; Animals; Cellular Senescence; Humans; Leucine; Metformin; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Proteostasis | 2023 |
Metformin activates AMPK and mTOR to Inhibit RANKL-stimulated osteoclast formation.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Leucine; Metformin; Mice; Osteoclasts; TOR Serine-Threonine Kinases | 2023 |