metformin and letrozole

metformin has been researched along with letrozole in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (6.90)	29.6817
2010's	34 (58.62)	24.3611
2020's	20 (34.48)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Ansari, Sh; Bagheri, M; Sohrabvand, F	1
Nader, S	1
Abu Hashim, H; Badawy, A; Shokeir, T	1
Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS	1
Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F	1
Alfazzaman, M; Anwary, SA; Bari, N; Islam, MR	1
Bershteĭn, LM; Boiarkina, MP; Danilova, MA; Gershfel'd, ÉD; Khadzhimba, AS; Kovalevskiĭ, AIu; Maksimov, SIa; Meshkova, IE; Turkevich, EA	1
Legro, RS; Usadi, RS	1
Bates, GW; Propst, AM	2
Abd Elgafor, I	1
Ahn, SH; Chae, BJ; Choi, SY; Han, S; Han, W; Jeong, J; Jeong, SS; Jung, SY; Jung, Y; Kang, E; Kang, HS; Kang, T; Kim, EK; Kim, J; Kim, KS; Kim, LS; Kim, MK; Kim, SI; Kim, SW; Kim, TH; Lee, JE; Lim, W; Moon, HG; Nam, SJ; Noh, DY; Paik, NS; Park, CH; Yoo, YB; Yoon, JH; Yu, JH	1
Nathan, N; Sullivan, SD	1
Diamanti-Kandarakis, E; Motta, AB; Sir-Petermann, T; Spritzer, PM	1
Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D	1
Burke, YZ; Kol, S; Tannus, S	1
Birch Petersen, K; la Cour Freiesleben, N; Lauritsen, MP; Pedersen, AT; Pedersen, NG	1
Mortada, R; Porter, S; Williams, T	1
Balen, AH; Fauser, BC; Franks, S; Legro, RS; Misso, M; Morley, LC; Norman, RJ; Stener-Victorin, E; Teede, H; Wijeyaratne, CN	1
Legro, RS	1
Afsar, T; Ain, QU; Almajwal, A; Jahan, S; Mehboob, A; Munir, F; Razak, S; Shaheen, G; Ullah, H	1
Bhattacharya, S; Costello, MF; Johnson, NP; Kim, BV; Legro, RS; Mol, BW; Ng, EH; Norman, RJ; van Wely, M; Wang, R; Zhang, H	1
Rezk, M; Saif El-Nasr, I; Shaheen, AE	1
Cheong, YC; Jo, J; Lepine, S; Metwally, M	1
Patel, R; Shah, G	1
Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A	1
Bazarganipour, F; Kutenaee, MA; Pourghasem, S; Taghavi, SA	1
Pereira, N; Rosenwaks, Z; Setton, R; Zimmerman, LD	1
AbdelMaksoud, S; El-Bahy, AA; Handoussa, H; Khaled, N; Radwan, R	1
Broaddus, RR; Coleman, RL; Fellman, BM; Iglesias, DA; Lu, KH; Slomovitz, BM; Soliman, PT; Westin, SN; Yates, MS; Yuan, Y; Zhang, Q	1
Amer, SA; Bhattacharya, S; Bordewijk, EM; Falbo, A; Federica, G; Gao, J; Homburg, R; Huang, W; Johnson, NP; Kar, S; König, TE; Legro, RS; Li, W; Lord, J; Mol, BW; Moll, E; Morin-Papunen, L; Nazik, H; Norman, RJ; Özmen, Ü; Palomba, S; Sahin, Y; van Wely, M; Vegetti, W; Wang, R; Williams, CD; Wu, X; Zhang, H	1
Carvalho, MJ; Figueiredo-Dias, M; Oliveira, J; Rodrigues, Â; Subtil, S	1
Goodwin, PJ; Madariaga, A; Oza, AM	1
Cai, H; Chen, A; Ding, Z; Sun, H; Wang, X; Yan, L; Yao, Y	1
Ekramzadeh, M; Golmakani, MT; Koohpeyma, F; Sherafatmanesh, S; Tanideh, N	1
Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S	1
Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L	1
Dehghan, Z; Mirmotalebisohi, SA; Mohammadi-Yeganeh, S; Salehi, M; Sameni, M; Zali, H	1
Li, S; Xiao, L; Xie, Y	1
Ali, T; Amin, F; Ara, R; Bader, GN; Kareem, O; Malik, A; Mir, SA; Rashid, R	1
Jiang, S; Li, R; Sheng, Y; Tang, T; Xu, H	1
Coskun, G; Efendic, F; Erdem, E; Hayretdag, C; Irkorucu, O; Keles, P; Kuras, S; Pence, HH; Polat, S; Saker, D; Sapmaz, E; Sapmaz, T; Sevgin, K; Tekayev, M; Topkaraoglu, S	1
Chen, J; Deng, Y; Dong, H; Feng, Y; Gu, B; Ma, R; Sun, A; Tan, Z; Wang, W; Wang, Y; Zeng, X; Zhao, Y; Zheng, Q; Zou, Y	1
Ibrahim, SF; Kamal, DAM; Mokhtar, MH; Ugusman, A; Zaid, SSM	1
Ibrahim, SF; Kamal, DAM; Mokhtar, MH; Ugusman, A	1
AbdelHameed, SS; Ahmed, AF; Al Sadoun, H; Alhakamy, NA; Anter, AF; Bayoumi, AM; El-Daly, M; El-Moselhy, MA; Mansouri, RA; Moussa, RS; Sharkawi, SS	1
Alhassanin, SA; El-Attar, AA; Essa, ES; Ibrahim, OM; Mostafa, TM	1
Abd El-Khalik, SR; Abdelsattar, AM; AbuoHashish, NA; Eltokhy, AK; Farghal, EE; Khattab, HA; Mariah, RA; Mohamed, DA; Rabah, HM; Raslan, MA	1
AbuoHashish, NA; Ahmed, AS; Alabiad, MA; Alorini, M; Barhoma, RAE; Elgharbawy, N; Elshamy, AM; Eltabaa, EF; Ibrahim, HA; Ibrahim, RR; Safa, MAE; Shalaby, AM; Shatat, D	1
Bader, GN; Gupta, RK; Gupta, S; Jha, RK; Kawale, A; Rashid, R; Sarkar, S; Singh, A; Tripathi, R	1
Anbar, HS; Azam, MM; Dohle, W; El-Gamal, MI; Hersi, F; Islam, T; Omar, HA; Potter, BVL; Shah, HL; Vahora, NY	1

Reviews

17 review(s) available for metformin and letrozole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Ovulation induction in polycystic ovary syndrome. Minerva ginecologica, 2008, Volume: 60, Issue:1 Topics: Adult; Anovulation; Aromatase Inhibitors; Body Mass Index; Clomiphene; Diathermy; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Glucocorticoids; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin Resistance; Laparoscopy; Letrozole; Metformin; Nitriles; Ovulation Induction; Phenotype; Polycystic Ovary Syndrome; Pregnancy; Randomized Controlled Trials as Topic; Time Factors; Triazoles	2008
Reproductive impact of polycystic ovary syndrome. Current opinion in endocrinology, diabetes, and obesity, 2012, Volume: 19, Issue:6 Topics: Abortion, Spontaneous; Clomiphene; Female; Fertilization in Vitro; Humans; Infant, Newborn; Infertility, Female; Laparoscopy; Letrozole; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Triazoles	2012
Polycystic ovarian syndrome management options. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:4 Topics: Clomiphene; Contraceptives, Oral, Hormonal; Estrogen Antagonists; Exercise; Female; Humans; Infertility, Female; Insulin Resistance; Letrozole; Menstruation Disturbances; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Reproductive Techniques, Assisted; Risk Reduction Behavior; Triazoles; Weight Loss	2012
Evaluation and treatment of anovulatory and unexplained infertility. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:4 Topics: Anovulation; Clomiphene; Diet; Evidence-Based Medicine; Exercise; Female; Fertility Agents, Female; Glucocorticoids; Gonadotropins; Humans; Infertility, Female; Laparoscopy; Letrozole; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Risk Reduction Behavior; Triazoles; Weight Loss	2012
The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS). Current pharmaceutical biotechnology, 2014, Volume: 15, Issue:1 Topics: Animals; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Letrozole; Metformin; Nitriles; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications; Triazoles	2014
Novel strategies in the management of polycystic ovary syndrome. Minerva endocrinologica, 2015, Volume: 40, Issue:3 Topics: Adult; Clomiphene; Contraceptives, Oral, Combined; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Hirsutism; Humans; Infertility, Female; Letrozole; Life Style; Menstruation Disturbances; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Precision Medicine; Pregnancy; Selective Estrogen Receptor Modulators; Triazoles; Weight Gain; Weight Loss	2015
Treatment strategies for the infertile polycystic ovary syndrome patient. Women's health (London, England), 2015, Volume: 11, Issue:6 Topics: Anovulation; Antineoplastic Agents; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Infertility, Female; Laparoscopy; Letrozole; Life Style; Metformin; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Triazoles	2015
Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction. Reproductive biomedicine online, 2016, Volume: 32, Issue:6 Topics: Adult; Anovulation; Body Weight; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Life Style; Metformin; Nitriles; Overweight; Ovulation; Ovulation Induction; Patient Safety; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Reproductive Techniques, Assisted; Retrospective Studies; Triazoles	2016
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Human reproduction update, 2016, Volume: 22, Issue:6 Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Consensus; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Healthy Lifestyle; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Obesity; Ovarian Hyperstimulation Syndrome; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Practice Guidelines as Topic; Pregnancy; Receptors, Gonadotropin; Triazoles	2016
Ovulation induction in polycystic ovary syndrome: Current options. Best practice & research. Clinical obstetrics & gynaecology, 2016, Volume: 37 Topics: Anovulation; Anti-Obesity Agents; Aromatase Inhibitors; Bariatric Surgery; Clomiphene; Diet Therapy; Exercise Therapy; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypoglycemic Agents; Infertility, Female; Inositol; Insulin Resistance; Letrozole; Metformin; Nitriles; Obesity; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Selective Estrogen Receptor Modulators; Triazoles	2016
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis BMJ (Clinical research ed.), 2017, 01-31, Volume: 356 Topics: Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Letrozole; Metformin; Network Meta-Analysis; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles	2017
Ovarian surgery for symptom relief in women with polycystic ovary syndrome. The Cochrane database of systematic reviews, 2017, 11-10, Volume: 11 Topics: Acne Vulgaris; Clomiphene; Female; Gonadotropins; Hirsutism; Humans; Laparoscopy; Letrozole; Menstruation Disturbances; Metformin; Nitriles; Ovary; Polycystic Ovary Syndrome; Punctures; Randomized Controlled Trials as Topic; Triazoles	2017
Contemporary Management of Polycystic Ovarian Syndrome. Clinical obstetrics and gynecology, 2019, Volume: 62, Issue:2 Topics: Androgen Antagonists; Aromatase Inhibitors; Biomarkers; Clomiphene; Contraceptives, Oral, Combined; Estrogen Antagonists; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypoglycemic Agents; Letrozole; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Progestins; Sex Hormone-Binding Globulin; Testosterone	2019
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human reproduction update, 2019, 11-05, Volume: 25, Issue:6 Topics: Birth Rate; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Live Birth; Metformin; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Pregnancy, Multiple	2019
Controversial association between polycystic ovary syndrome and breast cancer. European journal of obstetrics, gynecology, and reproductive biology, 2019, Volume: 243 Topics: Androgens; Anovulation; Aromatase Inhibitors; Breast Neoplasms; Clomiphene; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Estrogens; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Letrozole; Metformin; Ovulation Induction; Polycystic Ovary Syndrome; Risk Factors; Sex Hormone-Binding Globulin	2019
Polycystic ovarian syndrome-current pharmacotherapy and clinical implications. Taiwanese journal of obstetrics & gynecology, 2022, Volume: 61, Issue:1 Topics: Acupuncture; Anovulation; Eflornithine; Female; Herbal Medicine; Hirsutism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperandrogenism; Hypoglycemic Agents; Laser Therapy; Letrozole; Metformin; Polycystic Ovary Syndrome; Vitamin D	2022

Trials

7 trial(s) available for metformin and letrozole

Article	Year
Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:6 Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Resistance; Drug Therapy, Combination; Endometrium; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Female; Letrozole; Metformin; Nitriles; Polycystic Ovary Syndrome; Pregnancy; Single-Blind Method; Triazoles	2006
RETRACTED: Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. Fertility and sterility, 2010, Volume: 94, Issue:4 Topics: Adult; Algorithms; Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Female; Letrozole; Metformin; Nitriles; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Treatment Outcome; Triazoles; Young Adult	2010
Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome. Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:1 Topics: Adult; Aromatase Inhibitors; Blood Glucose; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Insulin; Letrozole; Luteinizing Hormone; Metformin; Nitriles; Ovary; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Testosterone; Triazoles; Young Adult	2013
Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR). BMC cancer, 2014, Mar-10, Volume: 14 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Protocols; Female; Humans; Letrozole; Metformin; Neoadjuvant Therapy; Nitriles; Postmenopause; Receptors, Estrogen; Research Design; Triazoles	2014
A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2016, Volume: 132, Issue:2 Topics: Adult; Clomiphene; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Egypt; Female; Fertility Agents, Female; Humans; Infertility, Female; Intention to Treat Analysis; Letrozole; Metformin; Nitriles; Ovulation; Ovulation Induction; Pioglitazone; Polycystic Ovary Syndrome; Prospective Studies; Thiazolidinediones; Triazoles	2016
Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:4 Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Metformin; Nitriles; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Treatment Outcome; Triazoles; Young Adult	2018
The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole. Archives of gynecology and obstetrics, 2019, Volume: 299, Issue:4 Topics: Adult; Female; Folic Acid; Humans; Infertility, Female; Inositol; Letrozole; Metformin; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Single-Blind Method	2019

Other Studies

34 other study(ies) available for metformin and letrozole

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:4 Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Hypoglycemic Agents; Letrozole; Metformin; Nitriles; Omentum; Peritoneal Diseases; Rats; Rats, Wistar; Tissue Adhesions; Triazoles	2010
The effects of metformin and letrozole on endometrium and ovary in a rat model. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:12 Topics: Animals; Aromatase Inhibitors; Cell Count; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Endometrium; Female; Fertility Agents, Female; Hypoglycemic Agents; Letrozole; Metformin; Models, Animal; Nitriles; Organ Size; Ovary; Rats; Rats, Wistar; Triazoles	2011
Outcome of metformin treatment in polycystic ovary syndrome. Mymensingh medical journal : MMJ, 2012, Volume: 21, Issue:1 Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Hypoglycemic Agents; Letrozole; Menstrual Cycle; Metformin; Nitriles; Polycystic Ovary Syndrome; Treatment Outcome; Triazoles; Young Adult	2012
[Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer]. Voprosy onkologii, 2011, Volume: 57, Issue:6 Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Endometrial Neoplasms; Female; Glucose; Humans; Hypoglycemic Agents; Ki-67 Antigen; Letrozole; Metformin; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Nitriles; Treatment Outcome; Triazoles	2011
Diagnosis and Treatment of Polycystic Ovary Syndrome. American family physician, 2016, Jul-15, Volume: 94, Issue:2 Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Infertility, Female; Letrozole; Metformin; Nitriles; Overweight; Polycystic Ovary Syndrome; Triazoles; Weight Loss	2016
Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. Journal of ovarian research, 2016, Dec-07, Volume: 9, Issue:1 Topics: Animals; Antioxidants; Aromatase Inhibitors; Biomarkers; Blood Glucose; Body Weights and Measures; C-Reactive Protein; Disease Models, Animal; Estrous Cycle; Female; Gonadal Hormones; Letrozole; Lipids; Metformin; Nitriles; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Rats; Reactive Oxygen Species; Rutin; Triazoles	2016
Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats. Archives of medical research, 2018, Volume: 49, Issue:3 Topics: Animals; Body Weight; Carboxymethylcellulose Sodium; Diet, High-Fat; Female; Glucose Tolerance Test; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin; Insulin Resistance; Letrozole; Metformin; Pioglitazone; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Receptors, LHRH; RNA, Messenger	2018
Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. Reproductive biology and endocrinology : RB&E, 2018, Sep-14, Volume: 16, Issue:1 Topics: Adult; Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Oocyte Retrieval; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Pilot Projects; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Retrospective Studies; Sperm Injections, Intracytoplasmic; Triazoles	2018
Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin. Life sciences, 2019, Sep-01, Volume: 232 Topics: Aged; Animals; Antioxidants; Aromatase Inhibitors; Blood Glucose; Body Weight; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Estrogens; Estrus; Female; Glycosides; Humans; Hydroxybenzoates; Hypoglycemic Agents; Insulin; Letrozole; Metformin; Ocimum; Organ Size; Ovary; Plant Extracts; Polycystic Ovary Syndrome; Progesterone; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Testosterone; Triglycerides; Uterus	2019
Everolimus, Letrozole, and Metformin in Women with Advanced or Recurrent Endometrioid Endometrial Cancer: A Multi-Center, Single Arm, Phase II Study. Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 02-01, Volume: 26, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Endometrioid; Everolimus; Female; Humans; Letrozole; Metformin; Middle Aged; Progression-Free Survival	2020
Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment? Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 02-01, Volume: 26, Issue:3 Topics: Diabetes Mellitus, Type 2; Everolimus; Female; Genital Neoplasms, Female; Humans; Letrozole; Metformin	2020
Study of the effect of metformin on expression levels of TNF-α and IL-18 in animal models of polycystic ovary syndrome. Minerva medica, 2021, Volume: 112, Issue:5 Topics: Animals; Carboxymethylcellulose Sodium; Disease Models, Animal; Down-Regulation; Estradiol; Estrous Cycle; Female; Follicle Stimulating Hormone; Hypoglycemic Agents; Interleukin-18; Letrozole; Luteinizing Hormone; Metformin; Ovulation; Polycystic Ovary Syndrome; Rats; Testosterone; Tumor Necrosis Factor-alpha	2021
The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. BMC complementary medicine and therapies, 2020, Aug-12, Volume: 20, Issue:1 Topics: Animals; Biomarkers; Carum; Disease Models, Animal; Female; Hypoglycemic Agents; Iran; Letrozole; Metformin; Plant Extracts; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Spinacia oleracea; Thylakoids	2020
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. Journal of ethnopharmacology, 2021, Jun-12, Volume: 273 Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Eucommiaceae; Female; Flavonoids; Gonadal Steroid Hormones; Hypothalamus; Insulin Resistance; Insulin-Like Growth Factor I; Kisspeptins; Letrozole; Metformin; Ovary; Pancreas; Phosphatidylinositol 3-Kinases; Pituitary Gland; Plant Extracts; Plant Leaves; Polycystic Ovary Syndrome; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Androgen; Receptors, Leptin	2021
Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. The Journal of steroid biochemistry and molecular biology, 2021, Volume: 213 Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Blood Glucose; Carboxymethylcellulose Sodium; Catalase; Disease Models, Animal; Estradiol; Female; Flavonols; Gene Expression; Glutathione Peroxidase; Humans; Insulin; Letrozole; Metformin; Ovary; Polycystic Ovary Syndrome; Progesterone; Rats; Rats, Wistar; Sirtuin 1; Steroid 17-alpha-Hydroxylase; Superoxide Dismutase; Testosterone	2021
Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2021, Volume: 29, Issue:2 Topics: Computational Biology; Databases, Protein; Drug Repositioning; Female; Gene Expression Regulation; Humans; Letrozole; Metformin; Phosphatidylinositol 3-Kinases; Pioglitazone; Polycystic Ovary Syndrome; Protein Interaction Maps; Proteomics; Proto-Oncogene Proteins c-akt; Signal Transduction; Spironolactone	2021
Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance. Frontiers in endocrinology, 2021, Volume: 12 Topics: Animals; Animals, Newborn; Antineoplastic Agents; Female; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Letrozole; Metabolic Syndrome; Metformin; Obesity; Polycystic Ovary Syndrome; Rats; Rats, Wistar	2021
The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome. Journal of healthcare engineering, 2022, Volume: 2022 Topics: Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Metformin; Polycystic Ovary Syndrome	2022
Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. Pathology, research and practice, 2022, Volume: 235 Topics: Animals; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Endometriosis; Female; Humans; Inflammation; Interleukin-6; Interleukin-8; Ki-67 Antigen; Letrozole; Metformin; Proto-Oncogene Proteins c-bcl-2; Rats; Tumor Necrosis Factor-alpha	2022
The Disparity in the Management of Polycystic Ovary Syndrome between Obstetrician-Gynecologists in Different-Level Hospitals under the Hierarchical Medical System. BioMed research international, 2022, Volume: 2022 Topics: Androgens; Blood Glucose; Female; Hospitals; Humans; Insulin Resistance; Letrozole; Lipids; Metformin; Polycystic Ovary Syndrome; Pregnancy	2022
Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats. Nutrients, 2022, Oct-18, Volume: 14, Issue:20 Topics: Animals; Aromatase; Clomiphene; Female; Honey; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley	2022
Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model. International journal of molecular sciences, 2022, Nov-25, Volume: 23, Issue:23 Topics: Animals; Clomiphene; Female; Gonadal Steroid Hormones; Honey; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger	2022
Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats. Life sciences, 2023, 01-15, Volume: 313 Topics: Animals; Diet, Ketogenic; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats	2023
Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study. European journal of clinical pharmacology, 2023, Volume: 79, Issue:2 Topics: Biomarkers; Blood Glucose; Breast Neoplasms; Estradiol; Female; Humans; Insulin; Leptin; Letrozole; Metformin; Obesity; Osteocalcin; Overweight; Pilot Projects; Postmenopause; Retrospective Studies	2023
Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue. Redox report : communications in free radical research, 2023, Volume: 28, Issue:1 Topics: Animals; Female; Humans; Insulin Resistance; Letrozole; Lipids; Metformin; Mitochondria; Nanoparticles; Obesity; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Polycystic Ovary Syndrome; Proto-Oncogene Proteins c-akt; Rats; Selenium; Signal Transduction	2023
Ameliorative effect of sesame oil on experimentally induced polycystic ovary syndrome: A cross-link between XBP-1/PPAR-1, regulatory proteins for lipogenesis/steroids. Cell biochemistry and function, 2023, Volume: 41, Issue:2 Topics: Animals; Disease Models, Animal; Female; Humans; Letrozole; Lipogenesis; Metformin; Peroxisome Proliferator-Activated Receptors; Phosphatidylinositol 3-Kinases; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Sesame Oil; Steroids	2023
Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome in the Sprague Dawley rats. Phytotherapy research : PTR, 2023, Volume: 37, Issue:9 Topics: Androgens; Animals; Disease Models, Animal; Female; Follicular Cyst; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley	2023
Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin. European journal of pharmacology, 2023, Dec-05, Volume: 960 Topics: Animals; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats; Rats, Wistar	2023