Compounds > metformin

metformin and irinotecan

metformin has been researched along with irinotecan in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (18.75)29.6817
2010's9 (56.25)24.3611
2020's4 (25.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Berek, JS; Chung, YM; Guan, M; Hu, MC; Hu, T; Ma, J; Ma, M1
Liang, G; Xu, T; Yang, L; Zhang, F1
Celestini, V; Cocco, T; De Rasmo, D; Fasano, C; Forte, G; Gadaleta, RM; Garattini, E; Grossi, V; Lepore Signorile, M; Longo, G; Moschetta, A; Peserico, A; Russo, L; Sanese, P; Scialpi, N; Signorile, A; Simone, C; Terao, M; Tezil, T; Villani, G1
Abd El-Aty, AM; Cetin, M; Galateanu, B; Gundogdu, B; Hacimuftuoglu, A; Jeong, JH; Jung, TW; Mezhuev, Y; Mohammadzadeh, M; Nalci, KA; Okkay, U; Stivaktakis, P; Taghizadehghalehjoughi, A; Taspinar, M; Taspinar, N; Tsatsakis, A; Ugur, AB; Uyanik, A1
Abdalla, KC; Araujo, RLC; Bragagnoli, AC; Cárcano, FM; Carvalheira, JBC; Comar, F; da Silveira Nogueira Lima, JP; Dos Santos, LV; Ferraz, MW; Oliveira, MA; Santos, FA1
Cai, S; Chen, L; Chen, Z; Lu, C; Tong, Y; Wang, M; Wang, Y; Wu, J; Yang, H1
Chen, X; Sun, M; Yang, Z1
Badgett, T; Crimella, J; Fridley, BL; Gill, J; Gorlick, R; Llosa, N; Metts, JL; Reed, D; Sandler, E; Sansil, S; Smith, T; Thapa, R; Thompson, P; Trucco, M; Weiser, DA1

Reviews

2 review(s) available for metformin and irinotecan

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for metformin and irinotecan

ArticleYear
Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial.
    British journal of cancer, 2021, Volume: 124, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Follow-Up Studies; Humans; Irinotecan; Male; Metformin; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Survival Rate; Young Adult

2021
A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation.
    Cancer medicine, 2023, Volume: 12, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Central Nervous System Neoplasms; Child; Child, Preschool; Dacarbazine; Humans; Irinotecan; Maximum Tolerated Dose; Metformin; Neoplasm Recurrence, Local; Neoplasms; Sarcoma, Ewing; Temozolomide; Vincristine

2023

Other Studies

12 other study(ies) available for metformin and irinotecan

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs

2013
Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation.
    Scientific reports, 2014, Jul-24, Volume: 4

    Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Irinotecan; Metformin; Mice, Nude; Neoplastic Stem Cells; Ovarian Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Tumor Burden; Xenograft Model Antitumor Assays

2014
Prognosis of small cell lung cancer patients with diabetes treated with metformin.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2015, Volume: 17, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Case-Control Studies; Chemotherapy, Adjuvant; Cohort Studies; Diabetes Mellitus, Type 2; Etoposide; Female; Humans; Hypoglycemic Agents; Irinotecan; Lung Neoplasms; Male; Metformin; Middle Aged; Multivariate Analysis; Platinum Compounds; Pneumonectomy; Prognosis; Proportional Hazards Models; Retrospective Studies; Small Cell Lung Carcinoma

2015
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
    Cell death & disease, 2018, 02-14, Volume: 9, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cisplatin; CRISPR-Cas Systems; Extracellular Signal-Regulated MAP Kinases; Fluorouracil; Forkhead Box Protein O3; Gene Editing; Gene Expression Regulation, Neoplastic; Genome, Mitochondrial; HEK293 Cells; Humans; Irinotecan; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Inbred C57BL; Mitochondria; NIH 3T3 Cells; Phosphorylation; Signal Transduction; Stress, Physiological

2018
Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies.
    Nanomedicine (London, England), 2018, Volume: 13, Issue:13

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Carriers; Glioblastoma; Humans; Irinotecan; Metformin; Microscopy, Electron, Transmission; Nanoparticles; Neoplasms, Experimental; Neurons; Polylactic Acid-Polyglycolic Acid Copolymer; Rats

2018
Reducing PD-L1 expression with a self-assembled nanodrug: an alternative to PD-L1 antibody for enhanced chemo-immunotherapy.
    Theranostics, 2021, Volume: 11, Issue:4

    Topics: Animals; Apoptosis; B7-H1 Antigen; Breast Neoplasms; Cell Proliferation; Female; Humans; Hypoglycemic Agents; Immunotherapy; Irinotecan; Lung Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Nanoparticles; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2021
Single cell mass spectrometry analysis of drug-resistant cancer cells: Metabolomics studies of synergetic effect of combinational treatment.
    Analytica chimica acta, 2022, Apr-08, Volume: 1201

    Topics: Anti-Infective Agents; Irinotecan; Mass Spectrometry; Metabolomics; Metformin; Neoplasms

2022