Compounds > metformin

metformin and insulin, isophane

metformin has been researched along with insulin, isophane in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (10.20)18.2507
2000's23 (46.94)29.6817
2010's19 (38.78)24.3611
2020's2 (4.08)2.80

Authors

AuthorsStudies
Buscema, M; Italia, S; Mazzarino, S; Rabuazzo, AM; Sangiorgio, L; Squatrito, S; Trischitta, V; Vigneri, R1
Clauson, P; Efendic, S; Karlander, S; Steen, L1
Anderson, D; Briscoe, TA; Cooper, GS; Usifo, OS1
Noth, R; Swislocki, AL1
Helling, T; Jungmann, E; Jungmann, G; Mertens, C; Snelting, U1
Aguilar-Salinas, CA; Arita-Melzer, O; Brito, G; Gómez-Pérez, FJ; Guillen, LE; López-Alvarenga, JC; Mercado, V; Rull-Rodrigo, JA; Velasco-Perez, ML; Wong, B1
Moses, R1
Chow, CC; Cockram, CS; Jorgensen, LN; Tong, PC1
Furlong, NJ; Hardy, KJ; Hulme, SA; O'Brien, SV2
Altuntas, Y; Ersoy, O; Karul, S; Ozen, B; Ozturk, B; Sengul, A; Ucak, S1
de Valk, HW; Goudswaard, AN; Rutten, GE; Stolk, RP; Zuithoff, P1
Hilberg, C; Kvapil, M; Shestakova, M; Swatko, A1
Hänninen, J; Hardy, K; Hulme, S; Kauppinen-Mäkelin, R; Lahdenperä, S; Lehtonen, R; Levänen, H; McNulty, S; Nikkilä, K; Ryysy, L; Tiikkainen, M; Tulokas, T; Vähätalo, M; Virtamo, H; Yki-Järvinen, H1
Dib, SA; Guedes, OM; Mourão-Júnior, CA; Sá, JR1
Kann, PH; Medding, J; Moeller, J; Mokan, M; Mrevlje, F; Regulski, M; Szocs, A; Wascher, T; Zackova, V1
Davies, MJ; Howe, J; Jarvis, J; Johnston, V; Kitchener, DL; Lawrence, IG; McNally, PG; Skinner, TC; Thaware, PK; Tringham, JR1
Civera, M; Martínez, I; Merchante, A; Salvador, M; Sanz, J1
Rönnemaa, T; Vähätalo, M; Viikari, J1
Braceras, R; Chaykin, L; Chu, PL; Matfin, G; Raskin, P; Schwartz, SL; Wynne, A1
Ascić-Buturović, B1
Al-Tayar, B; Kazakova, E; Morozova, A; Saifullina, M; Sazonova, O; Shapiro, I; Sokolovskaya, V; Starceva, M; Starkova, N; Tarasov, A; Ushakova, O; Valeeva, F; Zanozina, O; Zhadanova, E1
Halperin, F; Ingelfinger, JR; McMahon, GT1
Hermansen, K; Hermansen, ML; Mortensen, LS1
De Mattia, G; Laurenti, O; Moretti, A1
Bailey, T; Bergenstal, R; Chang, D; Gylvin, T; Lewin, A; Roberts, V1
Almdal, T; Boesgaard, T; Breum, L; Dunn, E; Gade-Rasmussen, B; Gluud, C; Hedetoft, C; Jarloev, A; Jensen, T; Johansen, LB; Krarup, T; Lund, SS; Lundby Christensen, L; Madsbad, S; Mathiesen, E; Moelvig, J; Nielsen, F; Pedersen, O; Perrild, H; Roeder, M; Sneppen, SB; Snorgaard, O; Tarnow, L; Thorsteinsson, B; Vaag, A; Vestergaard, H; Wetterslev, J; Wiinberg, N1
Christiansen, JS; Cucinotta, D; Kanc, K; le Devehat, C; Liebl, A; López de la Torre, M; Smirnova, O; Wojciechowska, M1
Borchert, M; Diessel, S; Forst, S; Forst, T; Hohberg, C; Larbig, M; Pfützner, A; Roth, W1
Christensen, TE; Gundgaard, J; Thomsen, TL1
Hu, M; Luo, Y; Yang, X; Zhang, H; Zhang, L1
Czupryniak, L; Grzeszczak, W; Kolasa, K; Lomon, ID; McEwan, P; Sciborski, C1
Hofland, LJ; Janssen, JA; Lamberts, SW; Vähätalo, M; Varewijck, AJ; Yki-Järvinen, H1
Damci, T; Donnet, JP; Endahl, L; Franek, E; Leiter, LA; Muñoz-Torres, M; Niskanen, L; Skjøth, TV; Vaag, A; Weng, J1
Akbari, S; Alavi, A; Amjadi, N; Moosavi, S; Niromanesh, S; Sharbaf, FR1
Bolli, GB; Candelas, C; Dain, MP; Deerochanawong, C; Home, PD; Landgraf, W; Mathieu, C; Pilorget, V; Riddle, MC1
Fournier, M; Germe, M; Lehmacher, W; Scholz, GH; Theobald, K1
Andersen, H; Hiort, LC; Linjawi, S; Rao, P; Sari, R; Sothiratnam, R1
Andersen, TH; Choi, DS; Chow, F; Christiansen, JS; Gall, MA; Hirao, K; Kaneko, S; Park, Y; Taneda, S1
Chen, L; Chen, R; Liu, Y; Ma, Z; Yu, P1
Gupta, Y; Kalra, S1
Gall, MA; Hirao, K; Hyllested-Winge, J; Kaneko, S; Taneda, S1
Abrahamowicz, M; Behlouli, H; Bernatsky, S; Moura, CS; Pilote, L; Rosenberg, ZB1
Chang, B; Chen, L; Feng, B; Guo, L; Liu, Y; Yang, L1
Barrientos-Perez, M; Liang, B; Lo, FS; Lunsford, A; Thórisdóttir, Ó; Wheeler, MD; Zuckerman-Levin, N1
Burt, MG; Radhakutty, A1
Bilir, SP; Davies, G; Gonzalez, C; Kowal, S; Pawaskar, M; Rajpathak, S1
Al-Azzeh, OY; Khader, YS; Saadeh, NA1
Andrade-Pineda, JE; Camarillo-Nava, VM; Carmona-Aparicio, L; Juárez-Zepeda, TE; Lucho-Gutiérrez, ZM; Pérez-López, D; Pérez-Lozano, DL; Reyes-Pacheco, JA1

Reviews

4 review(s) available for metformin and insulin, isophane

ArticleYear
Combination therapy in type 2 diabetes: the role of repaglinide.
    The Journal of the Association of Physicians of India, 2001, Jan-25, Volume: 49 Spec No

    Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone

2001
Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease.
    Vascular health and risk management, 2008, Volume: 4, Issue:3

    Topics: C-Reactive Protein; Cardiovascular Diseases; Diabetic Angiopathies; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Metformin; Postprandial Period; Risk Assessment; Risk Factors; Thiazolidinediones

2008
Indirect comparison of lixisenatide versus neutral protamine Hagedorn insulin as add-on to metformin and sulphonylurea in patients with type 2 diabetes mellitus.
    German medical science : GMS e-journal, 2014, Volume: 12

    Topics: Adult; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin, Isophane; Metformin; Peptides; Sulfonylurea Compounds; Treatment Outcome

2014
MANAGEMENT OF ENDOCRINE DISEASE: Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia
    European journal of endocrinology, 2018, 10-01, Volume: 179, Issue:4

    Topics: Blood Glucose; Evidence-Based Medicine; Glucocorticoids; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin, Isophane; Metformin; Prednisolone

2018

Trials

33 trial(s) available for metformin and insulin, isophane

ArticleYear
Comparison of combined therapies in treatment of secondary failure to glyburide.
    Diabetes care, 1992, Volume: 15, Issue:4

    Topics: Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Eating; Fasting; Glyburide; Glycated Hemoglobin; Humans; Insulin, Isophane; Metformin; Middle Aged; Obesity

1992
Daytime glibenclamide and bedtime NPH insulin compared to intensive insulin treatment in secondary sulphonylurea failure: a 1-year follow-up.
    Diabetic medicine : a journal of the British Diabetic Association, 1996, Volume: 13, Issue:5

    Topics: Aged; Albuminuria; Analysis of Variance; Blood Glucose; Body Mass Index; C-Peptide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin, Isophane; Insulin, Regular, Pork; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Treatment Failure; Triglycerides

1996
Acarbose vs. bedtime NPH insulin in the treatment of secondary failures to sulphonylurea-metformin therapy in type 2 diabetes mellitus.
    Diabetes, obesity & metabolism, 1999, Volume: 1, Issue:1

    Topics: Acarbose; Blood Glucose; Circadian Rhythm; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Postprandial Period; Retreatment; Sulfonylurea Compounds; Treatment Failure

1999
The contribution of metformin to glycaemic control in patients with Type 2 diabetes mellitus receiving combination therapy with insulin.
    Diabetes research and clinical practice, 2002, Volume: 57, Issue:2

    Topics: Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Postprandial Period; Sulfonylurea Compounds

2002
Repaglinide versus metformin in combination with bedtime NPH insulin in patients with type 2 diabetes established on insulin/metformin combination therapy.
    Diabetes care, 2002, Volume: 25, Issue:10

    Topics: Blood Glucose; Carbamates; Creatinine; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Insulin, Isophane; Male; Metformin; Middle Aged; Piperidines; Time Factors

2002
Comparison of additional metformin or NPH insulin to mealtime insulin lispro therapy with mealtime human insulin therapy in secondary OAD failure.
    Diabetes, obesity & metabolism, 2003, Volume: 5, Issue:6

    Topics: Administration, Oral; Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Lispro; Insulin, Isophane; Metformin; Middle Aged; Postprandial Period; Prospective Studies; Treatment Failure

2003
Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.
    Diabetic medicine : a journal of the British Diabetic Association, 2003, Volume: 20, Issue:11

    Topics: Administration, Oral; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Hemoglobin A; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Patient Satisfaction; Piperidines; Surveys and Questionnaires; Weight Gain

2003
Starting insulin in type 2 diabetes: continue oral hypoglycemic agents? A randomized trial in primary care.
    The Journal of family practice, 2004, Volume: 53, Issue:5

    Topics: Analysis of Variance; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin, Isophane; Male; Metformin; Middle Aged; Sulfonylurea Compounds

2004
Biphasic insulin aspart 30 plus metformin: an effective combination in type 2 diabetes.
    Diabetes, obesity & metabolism, 2006, Volume: 8, Issue:1

    Topics: Biphasic Insulins; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Treatment Outcome

2006
Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.
    Diabetologia, 2006, Volume: 49, Issue:3

    Topics: Adult; Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Insulin; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Lipid Metabolism; Liver; Male; Metformin; Middle Aged

2006
Starting insulin therapy in type 2 diabetes: twice-daily biphasic insulin Aspart 30 plus metformin versus once-daily insulin glargine plus glimepiride.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2006, Volume: 114, Issue:9

    Topics: Aged; Biphasic Insulins; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Treatment Outcome

2006
A randomized controlled trial examining combinations of repaglinide, metformin and NPH insulin.
    Diabetic medicine : a journal of the British Diabetic Association, 2007, Volume: 24, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Piperidines; Treatment Outcome; Weight Gain

2007
Safety and efficacy of repaglinide in combination with metformin and bedtime NPH insulin as an insulin treatment regimen in type 2 diabetes.
    Diabetes research and clinical practice, 2008, Volume: 79, Issue:1

    Topics: Aged; Blood Glucose; Blood Pressure; Body Mass Index; Carbamates; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Insulin, Isophane; Male; Metformin; Middle Aged; Piperidines; Prospective Studies; Safety; Weight Gain

2008
Recognition of fasting or overall hyperglycaemia when starting insulin treatment in patients with type 2 diabetes in general practice.
    Scandinavian journal of primary health care, 2007, Volume: 25, Issue:3

    Topics: Administration, Oral; Adult; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Follow-Up Studies; Glipizide; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin, Isophane; Insulin, Long-Acting; Metformin; Middle Aged

2007
Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).
    Diabetes, obesity & metabolism, 2009, Volume: 11, Issue:1

    Topics: Adult; Aged; Biphasic Insulins; Blood Glucose; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Pioglitazone; Thiazolidinediones; Treatment Outcome; Young Adult

2009
Comparison of biphasic insulin aspart 30 given three times daily or twice daily in combination with metformin versus oral antidiabetic drugs alone in patients with poorly controlled type 2 diabetes: a 16-week, randomized, open-label, parallel-group trial
    Clinical therapeutics, 2007, Volume: 29, Issue:11

    Topics: Biomarkers; Biphasic Insulins; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Endpoint Determination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Quality of Life; Russia; Weight Gain

2007
Comparison of glycaemic control in patients with Type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study.
    Acta diabetologica, 2009, Volume: 46, Issue:1

    Topics: Administration, Oral; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Monitoring, Ambulatory; Pilot Projects

2009
Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea.
    Current medical research and opinion, 2009, Volume: 25, Issue:1

    Topics: Adult; Biphasic Insulins; Blood Glucose; Diabetes Mellitus, Type 2; Exenatide; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Peptides; Sulfonylurea Compounds; Venoms

2009
Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial.
    Diabetes, obesity & metabolism, 2009, Volume: 11, Issue:4

    Topics: Adult; Aged; Biphasic Insulins; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Epidemiologic Methods; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin Detemir; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Research Design; Treatment Outcome; Tunica Intima; Tunica Media; Young Adult

2009
Three different premixed combinations of biphasic insulin aspart - comparison of the efficacy and safety in a randomized controlled clinical trial in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2009, Volume: 11, Issue:7

    Topics: Biphasic Insulins; Blood Glucose; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Treatment Outcome

2009
Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial beta-cell protection in individuals with type 2 diabetes.
    Diabetes, obesity & metabolism, 2010, Volume: 12, Issue:5

    Topics: Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin-Secreting Cells; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Pilot Projects; Postprandial Period

2010
[Comparison on efficacy and safety of two regimens for treatment of type 2 diabetes mellitus: glargine plus metformin versus neutral protamine hagedorn plus metformin].
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2010, Volume: 27, Issue:3

    Topics: Aged; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged

2010
Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.
    Diabetologia, 2012, Volume: 55, Issue:4

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin-Like Growth Factor I; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged

2012
Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial.
    European journal of endocrinology, 2012, Volume: 167, Issue:2

    Topics: Adolescent; Adult; Aged; Biphasic Insulins; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Combinations; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Aspart; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Solubility; Treatment Outcome; Young Adult

2012
Metformin compared with insulin in the management of gestational diabetes mellitus: a randomized clinical trial.
    Diabetes research and clinical practice, 2012, Volume: 98, Issue:3

    Topics: Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Fetal Macrosomia; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin, Isophane; Lost to Follow-Up; Metformin; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Single-Blind Method; Weight Gain

2012
Modulation of insulin dose titration using a hypoglycaemia-sensitive algorithm: insulin glargine versus neutral protamine Hagedorn insulin in insulin-naïve people with type 2 diabetes.
    Diabetes, obesity & metabolism, 2015, Volume: 17, Issue:1

    Topics: Aged; Asia; Blood Glucose Self-Monitoring; Circadian Rhythm; Diabetes Mellitus, Type 2; Drug Dosage Calculations; Drug Resistance; Drug Therapy, Combination; Europe; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Middle East; South Africa; Sulfonylurea Compounds

2015
The study of once- and twice-daily biphasic insulin aspart 30 (BIAsp 30) with sitagliptin, and twice-daily BIAsp 30 without sitagliptin, in patients with type 2 diabetes uncontrolled on sitagliptin and metformin-The Sit2Mix trial.
    Primary care diabetes, 2015, Volume: 9, Issue:5

    Topics: Aged; Asia; Australia; Biomarkers; Biphasic Insulins; Blood Glucose; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Europe; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Sitagliptin Phosphate; South America; Time Factors; Treatment Outcome

2015
Insulin degludec/insulin aspart versus biphasic insulin aspart 30 in Asian patients with type 2 diabetes inadequately controlled on basal or pre-/self-mixed insulin: a 26-week, randomised, treat-to-target trial.
    Diabetes research and clinical practice, 2015, Volume: 107, Issue:1

    Topics: Adult; Aged; Asian People; Biphasic Insulins; Blood Glucose; Diabetes Mellitus, Type 2; Drug Combinations; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Aspart; Insulin Detemir; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Treatment Failure

2015
Effect of liraglutide vs. NPH in combination with metformin on blood glucose fluctuations assessed using continuous glucose monitoring in patients with newly diagnosed type 2 diabetes.
    International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:11

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Body Mass Index; China; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin, Isophane; Liraglutide; Male; Metformin; Middle Aged; Monitoring, Ambulatory; Predictive Value of Tests; Prospective Studies; Time Factors; Treatment Outcome; Waist Circumference

2015
Insulin degludec/insulin aspart versus biphasic insulin aspart 30 twice daily in insulin-experienced Japanese subjects with uncontrolled type 2 diabetes: Subgroup analysis of a Pan-Asian, treat-to-target Phase 3 Trial.
    Journal of diabetes, 2017, Volume: 9, Issue:3

    Topics: Aged; Asian People; Biphasic Insulins; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypertension; Hypoglycemic Agents; Insulin Aspart; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Nasopharyngitis; Treatment Outcome

2017
A randomized, open-label, multicentre, parallel-controlled study comparing the efficacy and safety of biphasic insulin aspart 30 plus metformin with biphasic insulin aspart 30 monotherapy for type 2 diabetes patients inadequately controlled with oral anti
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:12

    Topics: Aged; Biphasic Insulins; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin Aspart; Insulin, Isophane; Male; Metformin; Middle Aged; Prospective Studies; Treatment Outcome; Weight Gain

2018
A 26-week, randomized trial of insulin detemir versus NPH insulin in children and adolescents with type 2 diabetes (iDEAt2).
    European journal of pediatrics, 2018, Volume: 177, Issue:10

    Topics: Adolescent; Blood Glucose; Child; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Detemir; Insulin, Isophane; Life Style; Male; Metformin

2018
Biphasic human insulin 30 thrice daily, is it reasonable?
    BMC research notes, 2020, May-24, Volume: 13, Issue:1

    Topics: Adult; Aged; Biphasic Insulins; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Combinations; Female; Glycated Hemoglobin; Humans; Injections; Insulin; Insulin, Isophane; Male; Metformin; Middle Aged

2020

Other Studies

12 other study(ies) available for metformin and insulin, isophane

ArticleYear
A retrospective analysis of the efficacy and safety of metformin in the African-American patient.
    Journal of the National Medical Association, 1997, Volume: 89, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Black People; Body Weight; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin, Isophane; Male; Metformin; Middle Aged; Prognosis; Retrospective Studies

1997
Case report. Pseudohepatotoxicity of metformin.
    Diabetes care, 1998, Volume: 21, Issue:4

    Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Insulin, Isophane; Liver; Liver Function Tests; Male; Metformin

1998
[Intensified conventional insulin therapy in patients with type 2 diabetes mellitus. Positive long-term effects of insulin lispro on metabolic control and microalbuminuria].
    Fortschritte der Medizin. Originalien, 2001, Jan-11, Volume: 118, Issue:4

    Topics: Aged; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Lispro; Insulin, Isophane; Kidney Function Tests; Male; Metformin; Middle Aged; Treatment Outcome

2001
Effects of metformin on the glycemic control, lipid profile, and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2006, Volume: 39, Issue:4

    Topics: Blood Glucose; Blood Pressure; Body Mass Index; Cohort Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Insulin, Isophane; Lipids; Male; Metabolic Syndrome; Metformin; Middle Aged; Treatment Outcome

2006
Effect of biphasic insulin aspart 30 combined with metformin on glycaemic control in obese people with type 2 diabetes.
    Bosnian journal of basic medical sciences, 2007, Volume: 7, Issue:4

    Topics: Administration, Oral; Aged; Biphasic Insulins; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Insulin; Insulin Aspart; Insulin, Isophane; Insulin, Long-Acting; Male; Metformin; Middle Aged; Obesity; Treatment Outcome

2007
Clinical decisions. Management of type 2 diabetes--polling results.
    The New England journal of medicine, 2008, Feb-14, Volume: 358, Issue:7

    Topics: Body Weight; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Exenatide; Glipizide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Peptides; Pioglitazone; Thiazolidinediones; Venoms

2008
Direct healthcare costs of patients with type 2 diabetes using long-acting insulin analogues or NPH insulin in a basal insulin-only regimen.
    Primary care diabetes, 2010, Volume: 4, Issue:3

    Topics: Adolescent; Adult; Ambulatory Care; Chi-Square Distribution; Child; Child, Preschool; Cost-Benefit Analysis; Denmark; Diabetes Mellitus, Type 2; Drug Costs; Female; General Practice; Health Care Costs; Humans; Hypoglycemic Agents; Infant; Infant, Newborn; Insulin; Insulin Detemir; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Logistic Models; Male; Metformin; Middle Aged; Models, Economic; Odds Ratio; Outcome and Process Assessment, Health Care; Pharmaceutical Services; Primary Health Care; Propensity Score; Referral and Consultation; Registries; Time Factors; Treatment Outcome; Young Adult

2010
The cost-effectiveness of saxagliptin versus NPH insulin when used in combination with other oral antidiabetes agents in the treatment of type 2 diabetes mellitus in Poland.
    Diabetes technology & therapeutics, 2012, Volume: 14, Issue:1

    Topics: Adamantane; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Models, Economic; Poland; Quality-Adjusted Life Years; Sulfonylurea Compounds

2012
A patient centred approach to basal insulin choice for the management of type 2 diabetes mellitus.
    JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:3

    Topics: Checklist; Clinical Decision-Making; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Insulin Detemir; Insulin Glargine; Insulin, Isophane; Insulin, Long-Acting; Metformin; Patient-Centered Care

2016
Treatment Discontinuation and Clinical Events in Type 2 Diabetes Patients Treated with Dipeptidyl Peptidase-4 Inhibitors or NPH Insulin as Third-Line Therapy.
    Journal of diabetes research, 2018, Volume: 2018

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Retrospective Studies; Sulfonylurea Compounds; Withholding Treatment

2018
Cost-effectiveness of intensification with sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes on metformin and sitagliptin vs direct intensification with insulin in the United Kingdom.
    Diabetes, obesity & metabolism, 2019, Volume: 21, Issue:4

    Topics: Adult; Aged; Blood Glucose; Cost-Benefit Analysis; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Costs; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Quality-Adjusted Life Years; Sitagliptin Phosphate; Sodium-Glucose Transporter 2 Inhibitors; United Kingdom

2019
[Cost-effectiveness of treatment of type 2 diabetes mellitus in México].
    Revista medica del Instituto Mexicano del Seguro Social, 2023, Mar-01, Volume: 61, Issue:2

    Topics: Cost-Benefit Analysis; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Mexico

2023