metformin and fluoxetine

metformin has been researched along with fluoxetine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (25.00)29.6817
2010's16 (57.14)24.3611
2020's5 (17.86)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Sanders, TA; Taylor, D; Werneke, U1
Bauer, M; Carter, MS; Elman, S; Korenman, SG; Love, M; Rasgon, NL1
Amini, M; Aminorroaya, A; Dastjerdi, MS; Kazemi, F; Mohammady, M; Najafian, A1
Cesarino, EJ; de Almeida, CA; de Carvalho, D; Guimarães, C; Iucif Júnior, N; Pereira, LR; Queiroz, RH1
Al-Zaman, Y; Aylwin, S1
Hashemipour, M; Kelishadi, R; Poursafa, P; Rezvanian, H; Tavakoli, N1
Ayuob, N; Murad, H1
Atkinson, G; Baur, L; Corpeleijn, E; Ells, LJ; Finer, N; Mead, E; Metzendorf, MI; O'Malley, C; Richter, B1
Aswar, M; Aswar, U; Chepurwar, S; Shintre, S1
Abd-Alkhalek, HA; Aboul-Fotouh, S; El-Kharashi, OA; Elmelgy, AA; Khedr, SA; Louka, ML; Sallam, HA1
Alboni, S; Branchi, I; Brunello, N; Golia, MT; Limatola, C; Maggi, L; Matte Bon, G; Milior, G; Poggini, S; Puglisi-Allegra, S; Sciarria, LP; Viglione, A1
Combarnous, Y; Filliatreau, L; Klett, D; Nguyen, TMD1
Chen, X; Dai, X; Fang, W; Hong, L; Huang, W; Ye, Q; Zhang, J1
Costa, BLDSAD; Duarte-Silva, EP; Melo, MG; Mendonça, IP; Oliveira, WH; Paiva, IHR; Peixoto, CA; Silva, RSD1
Agarwal, SM; Ahsan, ZA; Cohn, T; Duncan, MJ; Faulkner, GEJ; Hahn, M; Lockwood, JT; Remington, G; Stogios, N; Takeuchi, H; Taylor, VH1
Boiani, NF; Borrely, SI; Garcia, VSG; Silva, TT; Tominaga, FK1
Feng, JH; Inci, G; Jung, JS; Kang, BG; Kim, JH; Kim, SB; Kim, SC; Lee, JY; Lim, SS; Mo, YW; Park, SH; Seo, JH; Shende, M; Suh, HW1

Reviews

6 review(s) available for metformin and fluoxetine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Options for pharmacological management of obesity in patients treated with atypical antipsychotics.
    International clinical psychopharmacology, 2002, Volume: 17, Issue:4

    Topics: Amantadine; Antipsychotic Agents; Cimetidine; Cyclobutanes; Fluoxetine; Fructose; Humans; Lactones; Metformin; Nizatidine; Obesity; Orlistat; Topiramate; Weight Gain

2002
Common treatment of polycystic ovarian syndrome and major depressive disorder: case report and review.
    Current drug targets. Immune, endocrine and metabolic disorders, 2002, Volume: 2, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Drug Therapy, Combination; Female; Fluoxetine; Humans; Hypoglycemic Agents; Metformin; Mineralocorticoid Receptor Antagonists; Polycystic Ovary Syndrome; Spironolactone

2002
Emerging concepts in the medical and surgical treatment of obesity.
    Frontiers of hormone research, 2008, Volume: 36

    Topics: Adipose Tissue; Amyloid; Anticonvulsants; Antidepressive Agents; Anxiety; Appetite Regulation; Bariatric Surgery; Body Mass Index; Bupropion; Cholecystokinin; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Cyclobutanes; Depression; Diabetes Mellitus, Type 2; Female; Fluoxetine; Fructose; Ghrelin; Humans; Intra-Abdominal Fat; Islet Amyloid Polypeptide; Isoxazoles; Lactones; Leptin; Metabolic Syndrome; Metformin; Obesity; Obesity, Morbid; Orlistat; Oxyntomodulin; Peptide YY; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant; Sertraline; Sleep Apnea, Obstructive; Surgical Procedures, Operative; Topiramate; Zonisamide

2008
Drug interventions for the treatment of obesity in children and adolescents.
    The Cochrane database of systematic reviews, 2016, Nov-29, Volume: 11

    Topics: Adolescent; Anti-Obesity Agents; Body Mass Index; Child; Cyclobutanes; Fluoxetine; Humans; Lactones; Metformin; Orlistat; Pediatric Obesity; Randomized Controlled Trials as Topic

2016
Pharmacological interventions for prevention of weight gain in people with schizophrenia.
    The Cochrane database of systematic reviews, 2022, 10-03, Volume: 10

    Topics: Antipsychotic Agents; Betahistine; Famotidine; Fluoxetine; Humans; Melatonin; Metformin; Nausea; Nizatidine; Ranitidine; Reboxetine; Schizophrenia; Topiramate; Weight Gain

2022

Trials

3 trial(s) available for metformin and fluoxetine

ArticleYear
An open-label pilot study of the combination therapy of metformin and fluoxetine for weight reduction.
    International journal of obesity (2005), 2007, Volume: 31, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Body Mass Index; Drug Therapy, Combination; Female; Fluoxetine; Humans; Hypoglycemic Agents; Metformin; Obesity; Pilot Projects; Prospective Studies; Treatment Outcome; Weight Loss

2007
Tolerability and effectiveness of fluoxetine, metformin and sibutramine in reducing anthropometric and metabolic parameters in obese patients.
    Arquivos brasileiros de endocrinologia e metabologia, 2006, Volume: 50, Issue:6

    Topics: Adolescent; Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Appetite Depressants; Cholesterol; Combined Modality Therapy; Cyclobutanes; Fluoxetine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Multicenter Studies as Topic; Obesity; Placebos; Single-Blind Method

2006
A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity.
    World journal of pediatrics : WJP, 2010, Volume: 6, Issue:4

    Topics: Adolescent; Child; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Metformin; Obesity

2010

Other Studies

19 other study(ies) available for metformin and fluoxetine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats.
    Pain physician, 2015, Volume: 18, Issue:6

    Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Chronic Pain; Constriction, Pathologic; Cytokines; Fluoxetine; Hyperalgesia; Hypoglycemic Agents; Male; Metformin; Neuroprotective Agents; Pioglitazone; Postural Balance; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Swimming; Thiazolidinediones

2015
Telmisartan attenuates diabetes induced depression in rats.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:2

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzimidazoles; Benzoates; Brain; Depression; Depressive Disorder; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Fluoxetine; Hydrocortisone; Interleukin-1beta; Interleukin-6; Male; Metformin; Nitric Oxide; Pilot Projects; Rats; Rats, Wistar; Renin-Angiotensin System; Streptozocin; Swimming; Telmisartan

2017
Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression.
    Naunyn-Schmiedeberg's archives of pharmacology, 2018, Volume: 391, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognition; Diet, High-Fat; Drug Synergism; Fluoxetine; Hippocampus; Hypoglycemic Agents; Male; Metformin; Proto-Oncogene Proteins c-jun; Rats, Wistar; Restraint, Physical; Stress, Psychological

2018
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.
    Neural plasticity, 2019, Volume: 2019

    Topics: Anhedonia; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Hippocampus; Hypoglycemic Agents; Insulin-Like Growth Factor II; Male; Metformin; Mice; Selective Serotonin Reuptake Inhibitors

2019
Inhibition by fluoxetine of LH-stimulated cyclic AMP synthesis in tumor Leydig cells partly involves AMPK activation.
    PloS one, 2019, Volume: 14, Issue:6

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Fluoxetine; Leydig Cells; Luteinizing Hormone; Male; Metformin; Mice

2019
Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation.
    Journal of affective disorders, 2020, 01-01, Volume: 260

    Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Diabetes Mellitus, Type 2; Disease Models, Animal; Fluoxetine; Hippocampus; Histones; Male; Metformin; Mice; Mice, Inbred C57BL; Stress, Psychological; Swimming

2020
Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsońs disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity.
    International immunopharmacology, 2022, Volume: 102

    Topics: Animals; Antidepressive Agents, Second-Generation; Blotting, Western; Depression; Drug Therapy, Combination; Fluorescent Antibody Technique; Fluoxetine; Hindlimb Suspension; Hippocampus; Male; Metformin; Mice; Mice, Inbred C57BL; Neurogenesis; Neuroinflammatory Diseases; Neuronal Plasticity; Parkinsonian Disorders; Prefrontal Cortex; Rotarod Performance Test

2022
Acute and chronic ecotoxicological effects of pharmaceuticals and their mixtures in Daphnia similis.
    Chemosphere, 2022, Volume: 309, Issue:Pt 1

    Topics: Animals; Anti-Bacterial Agents; Aspirin; Ciprofloxacin; Daphnia; Fluoxetine; Hypoglycemic Agents; Metformin; Pharmaceutical Preparations; Water; Water Pollutants, Chemical

2022
Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification.
    Cancer biology & therapy, 2023, 12-31, Volume: 24, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line, Tumor; Fluoxetine; HCT116 Cells; Humans; Metformin; Mice; Mice, Nude; Neoplasms; Reactive Oxygen Species; Signal Transduction

2023