metformin and fluorouracil

metformin has been researched along with fluorouracil in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (12.96)	29.6817
2010's	35 (64.81)	24.3611
2020's	12 (22.22)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Inoue, T; Kira, K; Nagakura, T; Saeki, T; Tanaka, I; Yamazaki, K; Yasuda, N	1
Xu, W; Yang, Y	3
Chang, JG; Feng, LY; Feng, YH; Huang, WT; Lee, JC; Lu, PJ; Shiau, AL; Tsao, CJ; Tung, CL; Wu, CL	1
Aldea, M; Berindan, I; Cristea, V; Irimie, A; Kacso, G; Petrushev, B; Pop, T; Soritau, O; Susman, S; Tomuleasa, C	1
Flaherty, AM	1
Gao, F; Guan, M; Xue, Y; Zhang, Q; Zhang, Y; Zheng, Z	1
Farhana, L; Levi, E; Majumdar, AP; Nangia-Makker, P; Rajendra, SG; Vasudevan, A; Yu, Y	1
Chen, W; Fang, Y; Gong, L; Han, W; He, C; Hu, H; Jin, W; Li, D; Lou, F; Lou, H; Pan, H; Pan, Q; Sui, X; Wang, K; Wang, X; Xu, Y; Yang, J; Zhang, M; Zheng, Y; Zhou, X	1
Ajani, JA; Chen, Q; Honjo, S; Johnson, RL; Scott, AW; Skinner, HD; Song, S; Stroehlein, J	1
Kaddis, N; Saif, MW	1
Feng, T; Gao, Z; Hou, Z; Jia, K; Li, Y; Ling, S; Sun, D; Tian, Y; Wang, L; Xu, F; Zhang, H	1
Chai, Z; Li, L; Liu, C; Shen, X; Wang, L; Zhang, X; Zhang, Z	1
Berbée, M; Buijsen, J; Houben, R; Janssen, L; Lambin, P; Larue, R; Schraepen, MC; Sosef, M; Van De Voorde, L; Vanneste, B	1
Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH	1
Chen, X; He, C; Wu, X; Wu, Y	1
Ferdous, T; Harada, K; Harada, T; Ueyama, Y	1
Alex, A; Bariani, G; Bezerra Neto, JE; Braghiroli, MI; Capareli, FC; Faria, LD; Hoff, PM; Lobo Dos Santos, JF; Miranda, VC; Riechelmann, RP; Sabbaga, J	1
Gao, Z; Han, Z; Liang, R; Luo, N; Sun, D; Tang, B; Tian, Y; Wang, C; Wang, L; Zhang, R	1
Darko, KO; He, C; Huang, Y; Liu, Z; Peng, M; Su, Q; Tao, T; Yang, X; Yin, T	1
Damelin, LH; Jivan, R; Mavri-Damelin, D; Mynhardt, C; Peres, J; Prince, S; Veale, RB	1
Celestini, V; Cocco, T; De Rasmo, D; Fasano, C; Forte, G; Gadaleta, RM; Garattini, E; Grossi, V; Lepore Signorile, M; Longo, G; Moschetta, A; Peserico, A; Russo, L; Sanese, P; Scialpi, N; Signorile, A; Simone, C; Terao, M; Tezil, T; Villani, G	1
Huang, ZL; Jia, LF; Li, XM; Shan, S; Zhou, CY	1
El-Fatatry, BM; Hussien, FZ; Ibrahim, OM; Mostafa, TM	1
Adamo, V; Aglietta, M; Antista, M; Banzi, M; Barni, S; Bidoli, P; Buonadonna, A; Cavanna, L; Ciarlo, A; Cinieri, S; Clerico, M; Damiani, A; De Placido, S; Di Bartolomeo, M; Dotti, KF; Faedi, M; Ferrari, D; Ferrari, L; Ferrario, S; Frassineti, GL; Galli, F; Giordani, P; Gori, S; Iaffaioli, RV; Labianca, RF; Leonardi, F; Lonardi, S; Maiello, E; Marchetti, P; Nicolini, M; Pavesi, L; Re, GL; Rosati, G; Tamburini, E; Tronconi, MC; Vernieri, C; Zampino, MG; Zaniboni, A	1
Chen, D; Liu, Y; Wen, Y; Yan, D; Zhang, H; Zhao, Y; Zou, M	1
Asano, A; Kobayashi, M; Maehara, O; Nakagawa, K; Natsuizaka, M; Ohnishi, S; Sakamoto, N; Suda, G; Takeda, H	1
Jang, H; Kim, A; Kim, H; Kim, MJ; Kim, YH; Lee, SB; Lee, SJ; Myung, JK; Park, EH; Park, JH; Park, S; Shim, S	1
Cruz-Gil, S; Pape, K; Ramírez de Molina, A; Sánchez-Martínez, R; Schölch, S; Stange, D; Wagner-Reguero, S	1
Asprino, PF; Camargo, AA; Costa, ÉT; Fernandes, JM; Jandrey, EHF; Koyama, FC; Leite, KRM; Perez, RO	1
Sang, J; Sun, Q; Tang, R; Yang, M	1
Fatehi-Agdam, M; Jeddi, F; Najafzadeh, N; Panahizadeh, R; Vatankhah, MA	1
Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Duda, P; Falzone, L; Gizak, A; Libra, M; Martelli, AM; McCubrey, JA; Meher, AK; Montalto, G; Rakus, D; Ratti, S; Ruvolo, P; Steelman, LS	1
Goebel, S; Hoelzer, D; Leovsky, C; Meyer, FB; Spangel, SB; Thierbach, R	1
Ala, M	1
Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almami, IS; Almogbel, YS	1
Islam, MK; Lian, HK; Lim, JCW; Sagineedu, SR; Selvarajoo, N; Stanslas, J	1
Chen, Y; Li, X; Ma, R; Shan, E; Shan, J; Sun, H; Zhang, J; Zhou, Y	1
Deng, H; He, Z; Li, G; Mou, T; Shi, J; Sui, C; Sun, K; Wang, T; Wang, Y; Xu, Z; Yang, J; Zhang, P; Zhuang, B	1
Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almogbel, YS; Chigurupati, S; Nemala, RA	1
Chen, J; Dai, Q; Ge, Y; He, S; Shi, YL; Vashisth, MK; Wang, XB; Xia, J	1

Reviews

4 review(s) available for metformin and fluorouracil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Management of diabetes and pancreatic cancer. Oncology nursing forum, 2012, Volume: 39, Issue:5 Topics: Adenocarcinoma; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dexamethasone; Diabetes Mellitus, Type 2; Disease Management; Drug Resistance; Drug Therapy, Combination; Exenatide; Fluorouracil; Humans; Hyperglycemia; Hyperglycemic Hyperosmolar Nonketotic Coma; Hypoglycemic Agents; Insulin; Leucovorin; Male; Malnutrition; Metformin; Middle Aged; Nausea; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Pancreatectomy; Pancreatic Neoplasms; Peptides; Sulfonylurea Compounds; Venoms	2012
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms. Cancer treatment reviews, 2017, Volume: 54 Topics: Androgen Antagonists; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Deoxycytidine; Estrogen Receptor Modulators; Fluorouracil; Gemcitabine; Humans; Metformin; Methotrexate; Neoplasms; Paclitaxel; Tubulin Modulators	2017
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment. Mini reviews in medicinal chemistry, 2022, Volume: 22, Issue:20 Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Fluorouracil; Humans; Metformin; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Sirolimus; TOR Serine-Threonine Kinases	2022

Trials

3 trial(s) available for metformin and fluorouracil

Article	Year
Phase 2 Trial of Metformin Combined With 5-Fluorouracil in Patients With Refractory Metastatic Colorectal Cancer. Clinical colorectal cancer, 2016, Volume: 15, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Metformin; Middle Aged	2016
Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study. International journal of colorectal disease, 2018, Volume: 33, Issue:12 Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Egypt; Fluorouracil; Humans; Leucovorin; Metformin; Neoplasm Staging; Neuroprotective Agents; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; Prospective Studies; Risk Factors; Time Factors; Treatment Outcome	2018
Impact of Metformin Use and Diabetic Status During Adjuvant Fluoropyrimidine-Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis. The oncologist, 2019, Volume: 24, Issue:3 Topics: Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Diabetes Mellitus, Type 2; Female; Fluorouracil; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Oxaliplatin; Risk Factors	2019

Other Studies

47 other study(ies) available for metformin and fluorouracil

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight. European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3 Topics: Animals; Antimetabolites; Biguanides; Dipeptidyl Peptidase 4; Enteroendocrine Cells; Fluorouracil; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Hypoglycemic Agents; Intestine, Small; Male; Metformin; Mice; Mice, Inbred BALB C; Organ Size; Peptides; Protease Inhibitors; Pyrroles; Rats; Rats, Inbred F344; Valine	2004
Drug sorption onto and release from soy protein fibers. Journal of materials science. Materials in medicine, 2009, Volume: 20, Issue:12 Topics: Biocompatible Materials; Diclofenac; Fluorouracil; Metformin; Pharmacokinetics; Soybean Proteins; Thermodynamics	2009
Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto starch acetate fibers. Biotechnology and bioengineering, 2010, Mar-01, Volume: 105, Issue:4 Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Diclofenac; Diffusion; Fluorouracil; Hypoglycemic Agents; Kinetics; Metformin; Pharmaceutical Preparations; Starch; Thermodynamics	2010
Relationship between drug release and some physical parameters of drug sorption onto PLA fibers. Journal of biomaterials science. Polymer edition, 2010, Volume: 21, Issue:4 Topics: Diclofenac; Diffusion; Fluorouracil; Lactic Acid; Metformin; Models, Chemical; Pharmaceutical Preparations; Polyesters; Polymers; Solvents; Temperature; Thermodynamics	2010
MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. International journal of molecular medicine, 2012, Volume: 29, Issue:5 Topics: Antimetabolites, Antineoplastic; Cell Movement; Cell Proliferation; Colonic Neoplasms; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Hypoglycemic Agents; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Metformin; MicroRNAs; PTEN Phosphohydrolase; Up-Regulation	2012
Metformin plus PIAF combination chemotherapy for hepatocellular carcinoma. Experimental oncology, 2012, Volume: 34, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Fluorouracil; Glutathione; Humans; Interferon-alpha; Liver Neoplasms; Metformin	2012
Effects of metformin on CD133+ colorectal cancer cells in diabetic patients. PloS one, 2013, Volume: 8, Issue:11 Topics: AC133 Antigen; Adult; Aged; Aged, 80 and over; Antigens, CD; Antineoplastic Agents; Apoptosis; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Female; Fluorouracil; Glycoproteins; Humans; Hypoglycemic Agents; Immunohistochemistry; Male; Metformin; Middle Aged; Peptides	2013
Metformin: a potential therapeutic agent for recurrent colon cancer. PloS one, 2014, Volume: 9, Issue:1 Topics: Animals; Cell Movement; Colonic Neoplasms; Female; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Metformin; Mice; Mice, SCID; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin	2014
Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. PloS one, 2014, Volume: 9, Issue:5 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Synergism; Enzyme Activation; Enzyme Activators; Female; Fluorouracil; Humans; Metformin; Mice; Ribonucleotides; Xenograft Model Antitumor Assays	2014
Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. International journal of oncology, 2014, Volume: 45, Issue:2 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Separation; Drug Synergism; Esophageal Neoplasms; Flow Cytometry; Fluorescent Antibody Technique; Fluorouracil; Heterografts; Humans; Immunoblotting; Metformin; Mice; Mice, Nude; Neoplastic Stem Cells; Signal Transduction; TOR Serine-Threonine Kinases; Transfection	2014
Second-line treatment for pancreatic cancer. JOP : Journal of the pancreas, 2014, Jul-28, Volume: 15, Issue:4 Topics: Albumins; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Docetaxel; Drug Resistance, Neoplasm; Fluorouracil; Gemcitabine; Humans; Leucovorin; Metformin; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pancreatic Neoplasms; Survival Analysis; Taxoids; Treatment Outcome	2014
Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cells. Molecular medicine reports, 2014, Volume: 10, Issue:6 Topics: AMP-Activated Protein Kinases; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Metformin; Multidrug Resistance-Associated Proteins; TOR Serine-Threonine Kinases	2014
A toxicology study to evaluate the embryotoxicity of metformin compared with the hypoglycemic drugs, the anticancer drug, the anti-epileptic drug, the antibiotic, and the cyclo-oxygenase (COX)-2 inhibitor. Journal of diabetes, 2015, Volume: 7, Issue:6 Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Anticonvulsants; Antineoplastic Agents; Cell Differentiation; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Embryonic Stem Cells; Fibroblasts; Fluorouracil; Gene Expression Regulation, Developmental; Hypoglycemic Agents; Metformin; Mice; Penicillins; Phenytoin; Risk Assessment; Rosiglitazone; Sulfonamides; Sulfonylurea Compounds; Thiazolidinediones	2015
Can metformin improve 'the tomorrow' of patients treated for oesophageal cancer? European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2015, Volume: 41, Issue:10 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Case-Control Studies; Chemoradiotherapy; Cisplatin; Cohort Studies; Diabetes Mellitus, Type 2; Esophageal Neoplasms; Esophagectomy; Female; Fluorouracil; Humans; Hypoglycemic Agents; Logistic Models; Male; Metformin; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Staging; Paclitaxel; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome	2015
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells. Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:10 Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cyclophosphamide; DNA Damage; DNA Repair; Drug Combinations; Drug Synergism; Embryonic Stem Cells; Epirubicin; Female; Fibroblasts; Fluorouracil; Glucose; Humans; Hypoglycemic Agents; Lactic Acid; Lung; Metformin; Neoplastic Stem Cells; Pyrones; Ribonucleotides; Thiophenes	2015
Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials, 2016, Volume: 75 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cross-Linking Reagents; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Drug Synergism; Flow Cytometry; Fluorouracil; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Injections; Metformin; Mice, Inbred BALB C; Models, Biological; Polyethylene Glycols; Polylysine; Proton Magnetic Resonance Spectroscopy; Rheology; Schiff Bases; Survival Analysis; Xenograft Model Antitumor Assays	2016
Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. International journal of oncology, 2016, Volume: 49, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Metformin; Mice; Mouth Neoplasms; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2016
Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP. Oncotarget, 2016, Jul-19, Volume: 7, Issue:29 Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Diabetes Mellitus, Type 2; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Hypoglycemic Agents; Liver Neoplasms; Male; Metformin; Mice; Mice, Nude; Middle Aged; Phosphoproteins; Prognosis; Transcription Factors; Xenograft Model Antitumor Assays; YAP-Signaling Proteins	2016
Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma. Journal of cellular biochemistry, 2018, Volume: 119, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Synergism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Thymidine Kinase; Thymidylate Synthase; Thymine Nucleotides; Up-Regulation; Xenograft Model Antitumor Assays	2018
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell death & disease, 2018, 02-14, Volume: 9, Issue:2 Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cisplatin; CRISPR-Cas Systems; Extracellular Signal-Regulated MAP Kinases; Fluorouracil; Forkhead Box Protein O3; Gene Editing; Gene Expression Regulation, Neoplastic; Genome, Mitochondrial; HEK293 Cells; Humans; Irinotecan; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Inbred C57BL; Mitochondria; NIH 3T3 Cells; Phosphorylation; Signal Transduction; Stress, Physiological	2018
[Metformin's effect on 5-fluorouracil,cisplatin,paclitaxel in laryngocarcinoma Hep-2 cells]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2017, Apr-05, Volume: 31, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Fluorouracil; Humans; Hypoglycemic Agents; Laryngeal Neoplasms; Metformin; Paclitaxel	2017
A responsive porous hydrogel particle-based delivery system for oncotherapy. Nanoscale, 2019, Feb-07, Volume: 11, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Drug Carriers; Fluorouracil; Hep G2 Cells; Humans; Hydrogels; Male; Metformin; Mice; Mice, Nude; Nanoparticles; Porosity	2019
Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines. Neoplasia (New York, N.Y.), 2019, Volume: 21, Issue:6 Topics: AC133 Antigen; AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-beta; Cell Proliferation; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mice; Protein Kinases; Signal Transduction; Xenograft Model Antitumor Assays	2019
Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer. Cancer science, 2019, Volume: 110, Issue:9 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemoradiotherapy; Colon; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Fluorouracil; Humans; Male; Metformin; Mice; Mice, Nude; Neoplasm Recurrence, Local; Phenformin; Rectal Neoplasms; Signal Transduction; Smad Proteins; STAT3 Transcription Factor; Transforming Growth Factor beta; Xenograft Model Antitumor Assays	2019
A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment. PloS one, 2019, Volume: 14, Issue:7 Topics: Animals; Antineoplastic Agents; Coenzyme A Ligases; Colorectal Neoplasms; Down-Regulation; Fluorouracil; Glycolysis; Hypoglycemic Agents; Intestinal Mucosa; Lipid Metabolism; Metformin; Mice; Organoids	2019
Metformin as an Alternative Radiosensitizing Agent to 5-Fluorouracil During Neoadjuvant Treatment for Rectal Cancer. Diseases of the colon and rectum, 2020, Volume: 63, Issue:7 Topics: Animals; Case-Control Studies; Chemoradiotherapy; Combined Modality Therapy; Female; Fluorouracil; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Nude; Models, Animal; Neoadjuvant Therapy; Radiation-Sensitizing Agents; Rectal Neoplasms; Signal Transduction	2020
Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU. BioMed research international, 2020, Volume: 2020 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Xenograft Model Antitumor Assays	2020
Efficacy of Metformin and Chemotherapeutic Agents on the Inhibition of Colony Formation and Shh/Gli1 Pathway: Metformin/Docetaxel Versus Metformin/5-Fluorouracil. Drug research, 2021, Volume: 71, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Docetaxel; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Metformin; Signal Transduction; Stomach Neoplasms; Tumor Stem Cell Assay; Zinc Finger Protein GLI1	2021
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals. Cells, 2021, 04-06, Volume: 10, Issue:4 Topics: Adenocarcinoma; Adenylate Kinase; Antineoplastic Agents; bcl-X Protein; Berberine; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Diabetes Mellitus; Dietary Supplements; Disease Progression; Doxorubicin; Female; Fluorouracil; Gemcitabine; Glycogen Synthase Kinase 3 beta; Glycolysis; Humans; Inhibitory Concentration 50; Malaria; MCF-7 Cells; Metformin; Molecular Targeted Therapy; Neoplasm Metastasis; Nitrophenols; Pancreatic Neoplasms; Piperazines; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Thiadiazoles; Tumor Stem Cell Assay	2021
Metformin alters therapeutic effects in the BALB/c tumor therapy model. BMC cancer, 2021, May-28, Volume: 21, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BALB 3T3 Cells; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Culture Media; Docetaxel; Doxorubicin; Drug Evaluation, Preclinical; Drug Interactions; Fluorouracil; Glucose; Humans; Metformin; Methylcholanthrene; Mice; Mitomycin; Neoplasms	2021
The Emerging Role of Metformin in the Prevention and Treatment of Colorectal Cancer: A Game Changer for the Management of Colorectal Cancer. Current diabetes reviews, 2022, Volume: 18, Issue:8 Topics: Adenoma; Colorectal Neoplasms; Fluorouracil; Humans; Hypoglycemic Agents; Incidence; Metformin	2022
Elucidating the mechanism underlying cognitive dysfunction by investigating the effects of CMF and MET treatment on hippocampal neurons. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognitive Dysfunction; Cyclophosphamide; Female; Fluorouracil; Hippocampus; Humans; Metformin; Methotrexate; Neurons	2022
Metformin protects 5-Fu-induced chemotherapy oral mucositis by reducing endoplasmic reticulum stress in mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2022, Jun-01, Volume: 173 Topics: Animals; Antineoplastic Agents; Apoptosis; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Fluorouracil; Metformin; Mice; Mice, Inbred C57BL; NF-kappa B; Stomatitis	2022
FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis. Archives of biochemistry and biophysics, 2022, 06-15, Volume: 722 Topics: Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm; Ferroptosis; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Metformin; Proteins	2022
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:7 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognition; Cyclophosphamide; Diabetes Mellitus, Type 2; Dopamine; Female; Fluorouracil; Glutamic Acid; Humans; Metformin; Methotrexate; Rats	2022
Metformin ameliorates 5-fluorouracil-induced intestinalinjury by inhibiting cellular senescence, inflammation, and oxidative stress. International immunopharmacology, 2022, Volume: 113, Issue:Pt A Topics: Animals; Cellular Senescence; Fluorouracil; Inflammation; Male; Metformin; Mice; Mice, Inbred BALB C; Oxidative Stress	2022