metformin has been researched along with dorsomorphin in 32 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 7 (21.88) | 29.6817 |
2010's | 25 (78.13) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
Blowers, EC; Natarajan, A; Rana, S | 1 |
Chen, Y; Doebber, T; Fenyk-Melody, J; Fujii, N; Goodyear, LJ; Hirshman, MF; Li, Y; Moller, DE; Musi, N; Myers, R; Shen, X; Ventre, J; Wu, M; Zhou, G | 1 |
Chabrolle, C; Dupont, J; Tosca, L; Uzbekova, S | 1 |
Beauchamp, MC; Bruchim, I; Gotlieb, WH; Gu, J; Lau, S; Pollak, MN; Saumet, J | 1 |
Joly, E; Lamontagne, J; Madiraju, SR; Nolan, CJ; Pepin, E; Peyot, ML; Poitout, V; Prentki, M; Ruderman, NB | 1 |
Asakura, M; Asanuma, H; Fujita, M; Ito, S; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Mochizuki, N; Ogai, A; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M | 1 |
Harhaji-Trajkovic, L; Isenovic, E; Janjetovic, K; Micic, D; Misirkic, M; Prica, M; Stevanovic, D; Sudar, E; Sumarac-Dumanovic, M; Trajkovic, V; Vucicevic, L | 1 |
Bala, M; Buechler, C; Kopp, A; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J; Wurm, S | 1 |
Adamczyk, J; Gabryel, B; Labuzek, K; Liber, S; Okopień, B | 1 |
Barnett, D; Burger, C; O'Riordan, KJ; Osting, SM; Potter, WB; Roopra, A; Wagoner, M | 1 |
Davidson, SM; Gonçalves, LM; Mocanu, MM; Paiva, MA; Providência, LA; Yellon, DM | 1 |
Bado, A; Cherrah, Y; Ducroc, R; Faouzi, MA; Meddah, B; Sakar, Y | 1 |
Bristow, RG; Cutz, JC; Harding, S; Liu, C; Rashid, A; Sanli, T; Singh, G; Tsakiridis, T; Wright, J | 1 |
Kim, BJ; Kim, GH; Kim, GS; Kim, SW; Kim, YS; Koh, JM; Lee, KU; Lee, SH; Lee, SY; Lee, YS | 1 |
Banerjee, A; Flynt, L; Ghosh, S; Mellema, M; Panettieri, RA; Shore, SA; Williams, E; Zhu, M | 1 |
Dupont, J; Froment, P; Maillard, V; McNeilly, AS; McNeilly, JR; Rame, C; Tosca, L | 1 |
Chang, KC; Jang, HJ; Kim, HJ; Kim, YM; Lee, JH; Lee, YS; Nizamutdinova, IT; Seo, HG; Tsoyi, K | 1 |
Esfahanian, N; Garjani, A; Ghazi-Khansari, M; Maleki-Dizaji, N; Nikbin, B; Shakiba, Y; Soraya, H | 1 |
Fuerst, J; Geibel, JP; Hufnagl, C; Jakab, M; Ketterl, N; Langelueddecke, C; Lehner, L; Ritter, M; Schmidt, S | 1 |
Alexandre, M; Diaz de Villalvilla, A; Gorelick, FS; Kolodecik, TR; Shugrue, CA; Thrower, EC; Young, LH | 1 |
Afolayan, AJ; Du, J; Eis, A; Konduri, GG; Shi, Y; Teng, RJ | 1 |
Andersen, B; Hansen, HS; Nygaard, EB; Vienberg, SG; Ørskov, C | 1 |
Chang, JW; Kim, JH; Kim, JS; Kim, SB; Lee, JH; Lee, SK; Park, JS | 1 |
Gong, M; Liu, JH; Ma, AQ; Ni, YJ; Song, P; Wang, TZ; Wang, XH; Wei, F; Wu, Y; Yuan, Z; Zhuo, XZ | 1 |
Abdulrahman, RM; Boon, MR; Guigas, B; Hovens, GC; Rensen, PC; Sips, HC; Smit, JW | 1 |
Alexeyev, MF; Creighton, JR; Jian, MY; Wolkowicz, PE; Zmijewski, JW | 1 |
Ashabi, G; Goudarzvand, M; Khalaj, L; Khodagholi, F; Nasiri, M | 1 |
Alves, S; Blesbois, E; Froment, P; Grasseau, I; Métayer-Coustard, S; Nguyen, TM; Praud, C | 1 |
Chen, X; Fu, W; Lan, C; Li, L; Liao, Q; Liao, X; Wang, WE; Xia, X; Yang, D; Yue, R; Zeng, C | 1 |
Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K | 1 |
Dehpour, AR; Esmaeili, J; Sahebgharani, M; Shirooie, S | 1 |
1 review(s) available for metformin and dorsomorphin
Article | Year |
---|---|
Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases.
Topics: Adenine Nucleotides; Allosteric Regulation; AMP-Activated Protein Kinases; Humans; Intracellular Signaling Peptides and Proteins; Metabolic Diseases; Molecular Structure; Neoplasms; Protein Structure, Tertiary; Small Molecule Libraries | 2015 |
31 other study(ies) available for metformin and dorsomorphin
Article | Year |
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Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Role of AMP-activated protein kinase in mechanism of metformin action.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Proteins; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Enzyme Activation; Fatty Acids; Gene Expression; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Multienzyme Complexes; Muscle, Skeletal; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2001 |
Possible role of 5'AMP-activated protein kinase in the metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation.
Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Butadienes; Cattle; Cell Cycle; Enzyme Activation; Enzyme Inhibitors; Female; Immunohistochemistry; In Vitro Techniques; Metformin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multienzyme Complexes; Nitriles; Oocytes; Phosphorylation; Progesterone; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines | 2007 |
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.
Topics: Adenylate Kinase; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Metformin; Ovarian Neoplasms; Phosphorylation; Pyrazoles; Pyrimidines; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa | 2008 |
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.
Topics: Adenosine Triphosphate; Animals; Berberine; Cell Line; Fatty Acids; Glucose; Hypoglycemic Agents; Immunoblotting; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Lipid Metabolism; Membrane Potential, Mitochondrial; Metformin; Pioglitazone; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Thiazolidinediones | 2009 |
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Cells, Cultured; Disease Progression; Dogs; Drug Evaluation, Preclinical; Fibrosis; Gene Expression Regulation; Heart Failure; Insulin Resistance; Metformin; Myocytes, Cardiac; Natriuretic Peptides; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides; Transforming Growth Factor beta1; Ultrasonography; Ventricular Dysfunction, Left | 2009 |
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Enzyme Activation; G2 Phase; Glioma; Humans; Metformin; Pheochromocytoma; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides | 2009 |
Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Aminoimidazole Carboxamide; Body Mass Index; Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Galectin 3; Humans; Immunoblotting; Male; Metformin; Middle Aged; Monocytes; Oleic Acid; Palmitic Acid; Pyrazoles; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; Solubility; Time Factors | 2009 |
Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Cells, Cultured; Endosomes; Enzyme Activation; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lipopolysaccharides; Lysosomes; Metformin; Microglia; Peptide Fragments; Phagocytosis; Phosphoproteins; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides | 2010 |
Metabolic regulation of neuronal plasticity by the energy sensor AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antimetabolites; Blotting, Western; Deoxyglucose; Energy Metabolism; Enzyme Activation; Hippocampus; Hypoglycemic Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Metformin; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neuronal Plasticity; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases; Vidarabine | 2010 |
Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Heart; Hemodynamics; Hypoglycemic Agents; Infarction; Male; Metformin; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides | 2010 |
Metformin-induced regulation of the intestinal D-glucose transporters.
Topics: AMP-Activated Protein Kinases; Animals; Biological Transport, Active; Glucose; Glucose Tolerance Test; Glucose Transporter Type 2; Hypoglycemic Agents; Intestinal Mucosa; Male; Metformin; Microvilli; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Sodium-Glucose Transporter 1 | 2010 |
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Topics: AMP-Activated Protein Kinases; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Enzyme Activation; Female; G2 Phase; Humans; Lung Neoplasms; Male; Metformin; Morpholines; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyrones; Radiation Tolerance; RNA, Small Interfering; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2010 |
AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.
Topics: Adenylate Kinase; Animals; Apoptosis; Blotting, Western; Bone Resorption; Catechin; Cell Differentiation; Cell Survival; Cells, Cultured; Macrophage Colony-Stimulating Factor; MAP Kinase Kinase Kinases; Metformin; Mice; Mice, Inbred ICR; Osteoclasts; Osteogenesis; Pyrazoles; Pyrimidines; RANK Ligand; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stilbenes | 2010 |
Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anilides; Anti-Inflammatory Agents; Antimetabolites; Asthma; Cells, Cultured; Chromans; Cytokines; Enzyme Activators; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Hypoglycemic Agents; Inflammation Mediators; Metformin; Myocytes, Smooth Muscle; PPAR gamma; Pyrazoles; Pyrimidines; Respiratory System; Ribonucleotides; Rosiglitazone; Thiazolidinediones; Troglitazone; Vidarabine | 2011 |
Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA).
Topics: Acetyl-CoA Carboxylase; Activins; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Isoenzymes; Luteinizing Hormone; Metformin; Phosphorylation; Pituitary Gland; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Signal Transduction | 2011 |
Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Cytokines; Endotoxemia; HMGB1 Protein; Interleukin-1beta; Lipopolysaccharides; Macrophages; Male; Metformin; Mice; Mice, Inbred BALB C; Peroxidase; Pyrazoles; Pyrimidines; Survival Rate; Tumor Necrosis Factor-alpha | 2011 |
Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells.
Topics: AMP-Activated Protein Kinases; Cell Movement; Cell Proliferation; Gene Expression Regulation, Enzymologic; Human Umbilical Vein Endothelial Cells; Humans; Hypoglycemic Agents; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metformin; Pyrazoles; Pyrimidines | 2012 |
Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Calcium; Cell Line, Tumor; Cell Proliferation; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulinoma; KATP Channels; Membrane Potentials; Metformin; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Ribonucleotides | 2012 |
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.
Topics: Amino Acid Sequence; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Ceruletide; Cyclic AMP-Dependent Protein Kinases; Enzyme Precursors; Gene Expression Regulation; Male; Metformin; Octoxynol; Pancreas; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium Dodecyl Sulfate | 2012 |
AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension.
Topics: AMP-Activated Protein Kinases; Animals; Caveolin 1; Cells, Cultured; Endothelial Cells; Enzyme Activation; Hypertension, Pulmonary; Metformin; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Phosphorylation; Platelet-Derived Growth Factor; Pulmonary Artery; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Sheep, Domestic; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2013 |
Metformin stimulates FGF21 expression in primary hepatocytes.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Fibroblast Growth Factors; Hepatocytes; Humans; Hypoglycemic Agents; Liver Glycogen; Male; Metformin; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Subunits; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2012 |
AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition.
Topics: Albumins; Aldosterone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Cell Line; Epithelial-Mesenchymal Transition; Glucose; Heme Oxygenase-1; Humans; Metformin; NADPH Oxidase 4; NADPH Oxidases; Nephrosclerosis; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Ribonucleosides; Thioredoxins; Transforming Growth Factor beta | 2013 |
Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; Heart Failure; Isoproterenol; Male; Metformin; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2013 |
Impact of Metformin and compound C on NIS expression and iodine uptake in vitro and in vivo: a role for CRE in AMPK modulation of thyroid function.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Cyclic AMP Response Element Modulator; Iodides; Male; Metformin; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrimidines; Rats; Symporters; Thyroid Gland | 2014 |
Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Membrane Permeability; Cell Movement; Cells, Cultured; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Gene Knockdown Techniques; In Vitro Techniques; Lipopolysaccharides; Lung; Male; Metformin; Microvessels; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Ribonucleotides; RNA, Small Interfering; Wound Healing | 2013 |
Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway.
Topics: Adenylate Kinase; Animals; Apoptosis; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Hippocampus; Male; Metformin; Mitochondrial Turnover; Neuroprotective Agents; NF-E2-Related Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Premedication; Pyrazoles; Pyrimidines; Rats; Reperfusion Injury; Signal Transduction; Transcription Factors | 2014 |
Central role of 5'-AMP-activated protein kinase in chicken sperm functions.
Topics: Acrosome Reaction; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Survival; Chickens; Male; Metformin; Phosphorylation; Pyrazoles; Pyrimidines; Ribonucleotides; Semen Analysis; Spermatozoa | 2014 |
Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction.
Topics: AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cell Survival; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Humans; Hypoglycemic Agents; Injections, Intralesional; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Phosphorylation; Pyrazoles; Pyrimidines; Spheroids, Cellular | 2017 |
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagonists; Evans Blue; Hyperalgesia; Hypoglycemic Agents; Intestinal Mucosa; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Metformin; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nociception; Permeability; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Stress, Physiological; Sulpiride | 2019 |
In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway.
Topics: AMP-Activated Protein Kinase Kinases; Analgesics, Opioid; Animals; Cell Line, Tumor; Cyclic AMP; Drug Tolerance; Eukaryotic Initiation Factors; Glioblastoma; Humans; Metformin; Methadone; Morphine; Opioid-Related Disorders; Phosphorylation; Protein Kinases; Pyrazoles; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |