metformin has been researched along with digoxin in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 9 (24.32) | 29.6817 |
| 2010's | 21 (56.76) | 24.3611 |
| 2020's | 6 (16.22) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S | 1 |
| Mjörndal, T; Spigset, O | 1 |
| Giacomini, KM; Leabman, MK | 1 |
| Byrne, S; Gallagher, P; Kennedy, J; O'Mahony, D; Ryan, C | 1 |
| Nogid, A; Pham, DQ; Plakogiannis, R | 1 |
| Bhagra, S; Eurich, DT; Jhund, PS; Lewsey, JD; MacDonald, MR; Majumdar, SR; McAlister, FA; McMurray, JJ; Petrie, JR; Petrie, MC | 1 |
| Chen, WY; Holmes, MD | 1 |
| Johansson, S; Leese, PT; Li, Y; Lisbon, E; Martin, P; Mathews, D; Oliver, S; Read, J; Steinberg, M | 1 |
| Ebner, T; Ishiguro, N; Taub, ME | 1 |
| Fromm, MF; Glaeser, H; Hoier, E; Knop, J; König, J; Misaka, S; Müller, F; Singer, K | 1 |
| Bhattarai, D; Choi, Y; Hyeon Han, S; Jang, Y; Lee, K; Singh, S | 1 |
| Ebner, T; Gansser, D; Giessmann, T; Hohl, K; Ishiguro, N; Müller, F; Sharma, A; Stopfer, P; Taub, ME; Wein, M; Zimdahl-Gelling, H | 1 |
| Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Lasseter, KC; Rammelsberg, D; Townsend, R; Yamazaki, T | 1 |
| Groen-Wijnberg, M; Kerbusch, V; Krauwinkel, W; Meijer, J; Tretter, R; van Dijk, J; van Gelderen, M; Zhang, W | 1 |
| Anderson, TW; Derving Karsbøl, J; Golor, G; Hausner, H; Holst, AG; Jacobsen, JB; Wagner, FD | 1 |
| Ebner, T; Gansser, D; Giessmann, T; Hohl, K; Hutzel, S; Ishiguro, N; Müller, F; Schmidt, S; Sharma, A; Stopfer, P; Taub, ME | 1 |
| Anderson, TW; Borregaard, J; Bækdal, TA; Hansen, CW; Thomsen, M | 1 |
| Brouwer, KLR; Brouwer, KR; Guo, C; Mosley, C; Stewart, PW | 1 |
| Chen, S; Du, B; Guo, XL; Han, QJ; Hao, GX; Kan, M; Nie, AQ; Shi, HY; Tang, BH; Ye, PP; Zhao, W; Zheng, Y; Zhou, Y | 1 |
| Brunicardi, FC; Creeden, JF; Damoiseaux, R; Erhardt, P; Kalinoski, A; Liu, SH; Markowiak, S; Nemunaitis, J; Sanchez, R; Sutton, JM; Yu, J; Zhang, JT | 1 |
| Carayannopoulos, LN; Krishna, G; Liu, L; Liu, M; Ogasawara, K; Palmisano, M; Surapaneni, S; Thomas, M; Wood-Horrall, RN; Xue, Y; Zhou, S | 1 |
| Alsharaa, A; Alwayn, IPJ; de Vries, A; Donkers, JM; Doppenberg, JB; Dubbeld, J; Knibbe, CAJ; Menke, AL; Stevens, LJ; Vaes, WHJ; van de Steeg, E; van Hoek, B | 1 |
| Fukuhara, T; Kubota, R; Kuwata, A; Matsuo, Y; Matsuzaki, T; Oka, R; Shimizu, R; Sonoyama, T | 1 |
5 review(s) available for metformin and digoxin
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Sitagliptin: a novel agent for the management of type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Pyrazines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Thiazolidinediones; Triazoles | 2008 |
Hiding in plain view: the potential for commonly used drugs to reduce breast cancer mortality.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Digoxin; Drug Repositioning; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Off-Label Use | 2012 |
An Insight into Drug Repositioning for the Development of Novel Anti-Cancer Drugs.
Topics: Antineoplastic Agents; Aspirin; Digoxin; Diphosphonates; Drug Approval; Drug Discovery; Drug Repositioning; Humans; Itraconazole; Metformin; Nelfinavir; Thalidomide | 2016 |
6 trial(s) available for metformin and digoxin
| Article | Year |
|---|---|
Pharmacokinetic evaluations of the co-administrations of vandetanib and metformin, digoxin, midazolam, omeprazole or ranitidine.
Topics: Adolescent; Adult; Area Under Curve; Digoxin; Drug Interactions; Female; Humans; Male; Metformin; Midazolam; Middle Aged; Omeprazole; Piperidines; Quinazolines; Ranitidine; Young Adult | 2014 |
Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin.
Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cation Transport Proteins; Cross-Over Studies; Digoxin; Drug Interactions; Furosemide; Humans; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Metformin; Middle Aged; Neoplasm Proteins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2016 |
Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects.
Topics: Adult; Area Under Curve; Atorvastatin; Digoxin; Female; Healthy Volunteers; Humans; Male; Membrane Transport Proteins; Metformin; Methotrexate; Middle Aged; Nitriles; Pyridines; Triazoles; Young Adult | 2017 |
Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects.
Topics: Adolescent; Adult; Atorvastatin; Cross-Over Studies; Digoxin; Drug Interactions; Drug Therapy, Combination; Female; Glucagon-Like Peptides; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Warfarin; Young Adult | 2017 |
Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions.
Topics: Adult; Area Under Curve; Cross-Over Studies; Digoxin; Dose-Response Relationship, Drug; Drug Development; Drug Interactions; Furosemide; Healthy Volunteers; Humans; Male; Membrane Transport Proteins; Metformin; Middle Aged; Renal Elimination; Rosuvastatin Calcium; Young Adult | 2018 |
Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects.
Topics: Administration, Oral; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Caprylates; Cardiotonic Agents; Case-Control Studies; Cross-Over Studies; Digoxin; Drug Interactions; Female; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Healthy Volunteers; Humans; Hypoglycemic Agents; Lisinopril; Male; Metformin; Middle Aged; Warfarin | 2019 |
26 other study(ies) available for metformin and digoxin
| Article | Year |
|---|---|
Exploring the role of different drug transport routes in permeability screening.
Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2022 |
Increased glucose intolerance related to digoxin treatment in patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Type 2; Digoxin; Fatal Outcome; Female; Glucose Intolerance; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin | 1999 |
Estimating the contribution of genes and environment to variation in renal drug clearance.
Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Butylamines; Calcium Channel Blockers; Cardiotonic Agents; Contrast Media; Digoxin; Environment; Genes; Genetic Variation; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Iohexol; Kidney; Metabolic Clearance Rate; Metformin | 2003 |
STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.
Topics: Abbreviations as Topic; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bendroflumethiazide; Clopidogrel; Delphi Technique; Digoxin; Diuretics; Drug Prescriptions; Drug Therapy; Drug Utilization Review; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Health Services for the Aged; Humans; Ireland; Metformin; Practice Patterns, Physicians'; Reproducibility of Results; Risk Factors; Ticlopidine; Time Factors; United Kingdom | 2008 |
Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Case-Control Studies; Diabetes Mellitus, Type 2; Digoxin; Female; Heart Failure; Humans; Hypoglycemic Agents; Male; Metformin; United Kingdom | 2010 |
The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cell Line; Cell Line, Tumor; Digoxin; Drug Interactions; Furosemide; HEK293 Cells; Humans; Metformin; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Rosuvastatin Calcium | 2015 |
Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein.
Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Catechin; Cells, Cultured; Digoxin; HEK293 Cells; Hepatocytes; Humans; Liver-Specific Organic Anion Transporter 1; Metformin; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Solute Carrier Organic Anion Transporter Family Member 1B3; Tea; Tissue Distribution | 2015 |
Pharmacokinetic Interactions Between Mirabegron and Metformin, Warfarin, Digoxin or Combined Oral Contraceptives.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Adult; Area Under Curve; Contraceptives, Oral, Combined; Digoxin; Double-Blind Method; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Metformin; Thiazoles; Urinary Bladder, Overactive; Warfarin | 2017 |
Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes.
Topics: Biological Transport; Cell Culture Techniques; Cells, Cultured; Digoxin; Erythromycin Estolate; Hepatocytes; Humans; Membrane Transport Proteins; Metformin; Molecular Probes; Rosuvastatin Calcium | 2019 |
Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Digoxin; Furosemide; Gene Expression Regulation; Glomerular Filtration Rate; Humans; Kidney; Male; Metformin; Mice, Inbred NOD; Mice, SCID; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Elimination; Tandem Mass Spectrometry | 2020 |
Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Digoxin; Drug Combinations; Drug Repositioning; Drug Synergism; High-Throughput Screening Assays; Homeodomain Proteins; Humans; Male; Metformin; Mice; Molecular Targeted Therapy; Pancreatic Neoplasms; Simvastatin; Survivin; Trans-Activators | 2020 |
Impact of fedratinib on the pharmacokinetics of transporter probe substrates using a cocktail approach.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Cardiotonic Agents; Case-Control Studies; Digoxin; Drug Interactions; Female; Follow-Up Studies; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Neoplasm Proteins; Non-Randomized Controlled Trials as Topic; Organic Anion Transporters; Pyrrolidines; Rosuvastatin Calcium; Sulfonamides; Tissue Distribution; Young Adult | 2021 |
Novel Explanted Human Liver Model to Assess Hepatic Extraction, Biliary Excretion and Transporter Function.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Digoxin; Drug Interactions; Furosemide; Hepatobiliary Elimination; Humans; Liver; Liver Cirrhosis; Membrane Transport Proteins; Metformin; Neoplasm Proteins; Rosuvastatin Calcium | 2023 |
Evaluation of Drug-Drug Interactions of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor, With Transporter Substrates Based on In Vitro and Clinical Studies.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; COVID-19; Digoxin; Drug Interactions; Enzyme Inhibitors; Humans; Membrane Transport Proteins; Metformin; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transporter 1; Protease Inhibitors; Rosuvastatin Calcium; SARS-CoV-2; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2023 |