metformin has been researched along with dichloroacetic acid in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Choi, YW; Lim, IK | 1 |
| Coppock, JD; Haugrud, AB; Miskimins, WK; Zhuang, Y | 1 |
| Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L | 1 |
| Choe, TB; Hong, SE; Jin, HO; Kim, EK; Kim, HA; Kim, JI; Lee, JK; Noh, WC; Park, IC; Seong, MK; Ye, SK | 1 |
| Bertolasi, V; Casciano, F; Gilli, P; Melloni, E; Rigolin, GM; Rimondi, E; Secchiero, P; Voltan, R; Zauli, G | 1 |
| He, F; He, J; Huang, Y; Li, B; Li, X; Lyu, X; Ni, Z; Wang, Y; Wu, Y; Yan, X; Zeng, Y; Zhang, Y; Zheng, Y | 1 |
| An, S; Hong, J; Hong, SE; Hwang, SG; Jin, HO; Kim, CS; Kim, HA; Kim, JI; Lee, JK; Noh, WC; Park, IC; Song, JY | 1 |
| D'Agostino, DP; Koutnik, AP; Poff, AM; Ward, NP | 1 |
| Amoroso, R; Arduini, A; Cama, A; Cataldi, A; De Lellis, L; di Giacomo, V; Florio, R; Gallorini, M; Mariani-Costantini, R; Natale, A; Perconti, S; Sanna, M; Verginelli, F; Veschi, S | 1 |
| Kolesnik, DL; Prokhorova, IV; Pyaskovskaya, ON; Solyanik, GI | 1 |
| Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI; Yakshibaeva, YR | 1 |
| Gorbach, O; Kolesnik, DL; Pyaskovskaya, ON; Solyanik, GI | 1 |
| Albayrak, G; Dere, UA; Emmez, H; Konac, E | 1 |
| Goericke-Pesch, S; Granados-Soler, JL; Kietzmann, M; Klose, K; Müller, P; Murua Escobar, H; Nolte, I; Packeiser, EM; Schille, JT | 1 |
| Cho, Y; Choi, DH; Kim, SY; Kim, TS; Lee, CY; Lee, M; Park, M; Shim, MS | 1 |
16 other study(ies) available for metformin and dichloroacetic acid
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Respiration; Dichloroacetic Acid; Drug Synergism; Female; Glucose; HeLa Cells; Humans; MCF-7 Cells; Metformin; Mitochondria; Oxidative Stress; Pyruvate Dehydrogenase Complex | 2014 |
Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dichloroacetic Acid; Drug Synergism; Female; Humans; Lactates; MCF-7 Cells; Metformin; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species | 2014 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid | 2016 |
Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Survival; Dichloroacetic Acid; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Metformin; Neoplasms, Experimental; Treatment Outcome | 2016 |
Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; Cell Line, Tumor; Dichloroacetic Acid; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Metformin; Myeloid Cell Leukemia Sequence 1 Protein | 2016 |
Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Dichloroacetic Acid; Drug Synergism; Drug Therapy, Combination; Female; Growth Inhibitors; Humans; Lactic Acid; Metformin; Mice; Mice, Nude; Ovarian Neoplasms; Xenograft Model Antitumor Assays | 2016 |
TRAIL restores DCA/metformin-mediated cell death in hypoxia.
Topics: Breast Neoplasms; Cell Death; Cell Hypoxia; Dichloroacetic Acid; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Metformin; Receptors, Death Domain; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2016 |
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Electron Transport Complex I; Glioblastoma; Membrane Potential, Mitochondrial; Metformin; Mice; Oxidative Stress; Rotenone; Superoxides | 2017 |
Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Humans; Metformin; Oxazoles; Paraganglioma; Tyrosine | 2018 |
Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dichloroacetic Acid; Female; Glioma; Hematology; Humans; Metformin; Rats | 2018 |
Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Metformin | 2019 |
Metformin enhances cytotoxic action of dichloroacetate against Lewis lung carcinoma cells in vitro.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Synergism; Glucose; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Metformin | 2020 |
Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM).
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Dopamine Agents; Dose-Response Relationship, Drug; Glioblastoma; Humans; Hypoglycemic Agents; Memantine; Metformin; Proto-Oncogene Proteins c-bcl-2 | 2021 |
Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line.
Topics: Animals; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Dogs; Fibroblasts; Male; Metformin; Mitochondria; Muscle Cells; Oxidative Phosphorylation; Prostatic Neoplasms; Reactive Oxygen Species; Urinary Bladder Neoplasms | 2021 |
Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Flow Cytometry; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Phosphatidylinositol 3-Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Transcription Factors | 2021 |