Compounds > metformin

metformin and deoxyglucose

metformin has been researched along with deoxyglucose in 74 studies

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.35)18.7374
1990's7 (9.46)18.2507
2000's12 (16.22)29.6817
2010's44 (59.46)24.3611
2020's10 (13.51)2.80

Authors

AuthorsStudies
Hundal, HS; Klip, A; Leiter, LA; Ramlal, T; Reyes, R1
Bilan, PJ; Gumà, A; Klip, A; Lam, L; Leiter, LA; Ramlal, T1
Brunetti, A; Buscema, M; Goldfine, ID; Gullo, D; Italia, S; Purrello, F; Vigneri, R1
Bailey, CJ; Mynett, KJ; Page, T1
Cerasi, E; Gorowits, N; Joost, HG; Kaiser, N; King, GL; Sasson, S1
Bailey, CJ; Jefferson, WH; Thomas, CR; Turner, SL1
Beisswenger, PJ; Howell, SK; Lal, S; Szwergold, BS; Touchette, AD1
Detaille, D; Devos, P; Wiernsperger, N1
Ingram, DK; Lane, MA; Roth, GS1
Dey, CS; Kumar, N1
Beisswenger, P; Ruggiero-Lopez, D1
Lehrman, MA; Shang, J1
Dey, CS; Ishrath, A; Kaul, CL; Kumar, N1
Anson, RM; de Cabo, R; Ingram, DK; Lane, MA; Mamczarz, J; Mattison, J; Roth, GS; Zhu, M1
Ahn, MY; Chae, SH; Chang, TS; Han, HK; Jung, jH; Khil, LY; Kim, YC; Lee, BH; Lee, DO; Lee, YM; Moon, CK1
Donnelly, R; Rea, R1
Frost, RA; Jefferson, LS; Krawiec, BJ; Lang, CH; Nystrom, GJ1
Carvalheira, JB; de Souza, CT; Faria, MC; Morari, J; Pauli, JR; Ropelle, ER; Saad, MJ; Ueno, M; Velloso, LA; Zecchin, KG1
Imaizumi, T; Matsui, J; Matsuki, K; Murakami, H; Satoh, K; Suda, T; Tamasawa, N; Tanabe, J; Yamashita, M1
Doble, M; Prabhakar, PK3
Gu, M; Huang, MW; Li, J; Li, JY; Li, YY; Nan, FJ; Pang, T; Qiu, BY; Turner, N; Wu, F; Ye, JM1
Barnett, D; Burger, C; O'Riordan, KJ; Osting, SM; Potter, WB; Roopra, A; Wagoner, M1
Auberger, P; Ben Sahra, I; Bertolotto, C; Bost, F; Cormont, M; Deckert, M; Giorgetti-Peraldi, S; Giuliano, S; Gounon, P; Larbret, F; Laurent, K; Le Marchand-Brustel, Y; Ponzio, G; Tanti, JF1
Allison, DB; Nagy, TR; Smith, DL1
Ben Sahra, I; Bost, F; Tanti, JF1
Barto, R; Engelen, L; Ferreira, I; Gram, J; Lund, SS; Parving, HH; Pedersen, O; Schalkwijk, CG; Stehouwer, CD; Tarnow, L; Teerlink, T; Vaag, AA; Winther, K1
Carvalheira, JB; Dias, MM; Osório-Costa, F; Rocha, GZ; Ropelle, ER; Rossato, FA; Saad, MJ; Vercesi, AE1
Palmer, HJ; Pittman, DD; Thériault, JR1
Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G1
Alves, DS; Ardito, T; Caplan, MJ; Kashgarian, M; Seo-Mayer, PW; Thulin, G; Zhang, L1
Ajani, J; Cheong, JH; Dennison, JB; Hall, H; Ki Hong, W; Kundra, V; Lee, JS; Liang, J; Lu, Y; Mills, GB; Nguyen-Charles, C; Park, ES; Ravoori, M; Tsavachidou, D; Wa Cheng, K; Zhang, D1
Cerasi, E; Kaiser, N; Ketzinel-Gilad, M; Leibowitz, G; Shaked, M1
Auberger, P; Ben-Sahra, I; Bost, F; Budanov, A; Dirat, B; Laurent, K; Puissant, A; Tanti, JF1
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H1
Lawler, SE; Levesley, J; Sinha, P; Steele, L; Taylor, C1
Ishizuka, Y; Kakiya, N; Nawa, H; Oshiro, N; Shirao, T; Takei, N; Witters, LA1
Borowska, M; Dworacka, M; Dworacki, G; Iskakova, S; Krzyżagórska, E; Wesołowska, A1
Issaq, SH; Monks, A; Teicher, BA1
Cheng, G; Dwinell, MB; Kalyanaraman, B; McAllister, D; Tsai, S; Zielonka, J1
Alacam, H; Bedir, A; Okuyucu, A; Ozdemir, T; Salis, O1
Brusko, TM; Choi, SC; Croker, BP; Morel, L; Perry, DJ; Seay, H; Sobel, ES; Xu, Z; Yin, Y1
Bikas, A; Boyle, L; Burman, KD; Costello, J; Hoperia, V; Jensen, K; Klubo-Gwiezdzinska, J; Larin, O; McDaniel, D; Patel, A; Vasko, V; Wartofsky, L1
Andrade-Oliveira, V; Bowman, CE; Brandacher, G; Cheng, CH; Furtmüller, GJ; Lee, CF; Lo, YC; Oh, B; Powell, JD; Slusher, BS; Thomas, AG; Wolfgang, MJ1
Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y1
Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L1
Huo, X; Liu, K; Liu, Q; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Xue, C1
Dolinar, K; Miš, K; Pavlin, M; Pirkmajer, S; Rajh, M1
Chang, JH; Cheong, JH; Choi, J; Huh, YM; Jeon, JY; Kang, SG; Kim, EH; Kim, KS; Kim, P; Kim, SH; Koh, I; Lee, JH; Oh, Y; Park, J; Shim, JK; Yun, M1
Darzynkiewicz, Z; Garcia, J; Halicka, HD; Li, J; Zhao, H1
Hou, XB; Li, TH; Liu, Y; Ren, ZP1
Cheng, J; Hisatome, I; Hong, L; Hu, Y; Li, Z; Luo, C; Wen, T; Yamamoto, T; Yuan, H; Zhang, X; Zhang, Y; Zhu, Y; Zhuang, W; Zou, J1
Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Sun, P; Sun, Y; Wang, C; Xue, C1
Ao, J; Bergholz, J; Chen, D; Li, X; Sun, S; Wu, M; Xiao, ZX; Yi, Y; Zhang, Y1
Emons, G; Gründker, C; Hellriegel, M; Wokoun, U1
Bizjak, M; Dolinar, K; Malavašič, P; Pavlin, M; Pirkmajer, S; Pohar, J1
Allo, G; Carey, MS; Chhina, J; Dai, J; Giri, S; Llaurado, M; Mert, I; Munkarah, AR; Rattan, R; Seward, S1
Agnetti, L; Álvarez, GM; Arbe, MF; Finocchiaro, LME; Fondello, C; Glikin, GC; Tellado, MN; Villaverde, MS1
Haluzik, M; Kazdova, L; Malinska, H; Markova, I; Škop, V; Svoboda, P; Trnovska, J1
Abboud, G; Choi, SC; Kanda, N; Morel, L; Roopenian, DC; Zeumer-Spataro, L1
Bai, XY; Cai, G; Chen, X; Li, Q; Li, Z; Lian, X; Lin, S; Song, K; Wu, X; Zhang, Y1
Baldwin, EA; Barnstein, BO; Caslin, HL; Haque, T; Pondicherry, N; Ryan, JJ; Taruselli, MT1
Chou, KT; Hsu, HS; Hsu, JW; Hsu, TW; Hung, SC; Lin, JH; Liu, CC; Yen, DH1
Chevet, E; Eldering, E; Favaro, F; Iurlaro, R; Lucendo, E; Majem, B; Marchetti, S; Muñoz-Pinedo, C; Nadal, E; Püschel, F; Redondo-Pedraza, J; Ricci, JE1
Brandacher, G; Cheng, CH; Furtmüller, GJ; Lee, CF; Oh, BC; Patel, CH; Powell, JD1
Hadjipanayis, A; Hall, JP; Kelkar, Y; Shipstone, A; Tan, SY; Wynn, TA1
Bremer, T; Derenda-Hell, A; Sadik, CD; Schilf, P; Schmitz, M; Thieme, M; Vaeth, M; Zillikens, D1
Shan, Z; Shi, X; Teng, W; Wang, S; Wang, X; Wu, Q; Zhao, L1
Hoopes, EM; Major, AS; McNew, KL; Moore, DJ; Rhoads, JP; Stocks, BT; Wilson, CS1
Bizjak, M; Gole, B; Magnes, C; Pavlin, M; Potočnik, U; Repas, J; Zügner, E1
Bak, EJ; Cha, JH; Jang, S; Kim, A; Su, H; Tissera, K1
Berber, E; Rouse, BT1
Büsselberg, D; Samuel, SM; Satheesh, NJ; Triggle, CR; Varghese, E1

Reviews

4 review(s) available for metformin and deoxyglucose

ArticleYear
Caloric restriction in primates and relevance to humans.
    Annals of the New York Academy of Sciences, 2001, Volume: 928

    Topics: Aging; Animals; Biomarkers; Blood Glucose; Body Temperature; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Diet, Reducing; Drug Evaluation, Preclinical; Energy Intake; Energy Metabolism; Food Deprivation; Garcinia; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Longevity; Macaca mulatta; Medicine, Ayurvedic; Metformin; Neoplasms; Phytotherapy; Plant Preparations; Primates; Rats; Rats, Inbred F344; Saimiri; Saponins; Triterpenes

2001
Metformin inhibition of glycation processes.
    Diabetes & metabolism, 2003, Volume: 29, Issue:4 Pt 2

    Topics: Azepines; Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Pyruvaldehyde; Randomized Controlled Trials as Topic

2003
Development of calorie restriction mimetics as a prolongevity strategy.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Temperature; Caloric Restriction; Deoxyglucose; Dopamine; Dopamine Agents; Glycolysis; Humans; Insulin; Longevity; Metformin; Oligonucleotide Array Sequence Analysis; Rats; Time Factors; Up-Regulation

2004
Calorie restriction: what recent results suggest for the future of ageing research.
    European journal of clinical investigation, 2010, Volume: 40, Issue:5

    Topics: Animals; Antimetabolites; Biomedical Research; Biomimetics; Caloric Restriction; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Longevity; Metformin; Primates; Quality of Life; Resveratrol; Sirolimus; Stilbenes

2010

Trials

3 trial(s) available for metformin and deoxyglucose

ArticleYear
Metformin reduces systemic methylglyoxal levels in type 2 diabetes.
    Diabetes, 1999, Volume: 48, Issue:1

    Topics: Adult; Aged; Deoxyglucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Osmolar Concentration; Pyruvaldehyde; Sulfonylurea Compounds; Treatment Outcome

1999
Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.
    European journal of endocrinology, 2011, Volume: 164, Issue:3

    Topics: Carbamates; Confidence Intervals; Deoxyglucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines

2011
Statins in low doses reduce VEGF and bFGF serum levels in patients with type 2 diabetes mellitus.
    Pharmacology, 2014, Volume: 93, Issue:1-2

    Topics: Adult; Aged; Blood Glucose; Cholesterol; Deoxyglucose; Diabetes Mellitus, Type 2; Fibroblast Growth Factor 2; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Middle Aged; Triglycerides; Vascular Endothelial Growth Factor A

2014

Other Studies

67 other study(ies) available for metformin and deoxyglucose

ArticleYear
Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.
    Endocrinology, 1992, Volume: 131, Issue:3

    Topics: Aminoisobutyric Acids; Animals; Biological Transport; Cell Line; Cell Membrane; Cell Membrane Permeability; Cytochalasin B; Deoxyglucose; Dose-Response Relationship, Drug; Insulin; Metformin; Monosaccharide Transport Proteins; Muscles; Subcellular Fractions

1992
Stimulation of hexose transport by metformin in L6 muscle cells in culture.
    Endocrinology, 1992, Volume: 130, Issue:5

    Topics: 3-O-Methylglucose; Animals; Biological Transport; Cell Line; Cells, Cultured; Cycloheximide; Deoxyglucose; Glucose; Insulin; Kinetics; Metformin; Methylglucosides; Monosaccharide Transport Proteins; Muscles

1992
Direct effects of biguanides on glucose utilization in vitro.
    Metabolism: clinical and experimental, 1987, Volume: 36, Issue:8

    Topics: Blood Glucose; Cytochalasin B; Deoxyglucose; Humans; In Vitro Techniques; Lymphocytes; Metformin; Phenformin

1987
Importance of the intestine as a site of metformin-stimulated glucose utilization.
    British journal of pharmacology, 1994, Volume: 112, Issue:2

    Topics: Animals; Deoxyglucose; Glucose; Insulin; Intestinal Mucosa; Intestines; Male; Metformin; Rats; Rats, Wistar; Regional Blood Flow; Stimulation, Chemical

1994
Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells.
    British journal of pharmacology, 1996, Volume: 117, Issue:6

    Topics: Animals; Aorta; Blotting, Western; Cattle; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Monosaccharide Transport Proteins; Muscle, Smooth, Vascular; Time Factors

1996
Prevention of dexamethasone-induced insulin resistance by metformin.
    Biochemical pharmacology, 1998, Nov-01, Volume: 56, Issue:9

    Topics: Animals; Deoxyglucose; Dexamethasone; Glucose Transporter Type 1; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; RNA, Messenger

1998
Metformin interaction with insulin-regulated glucose uptake, using the Xenopus laevis oocyte model expressing the mammalian transporter GLUT4.
    European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1

    Topics: 3-O-Methylglucose; Animals; Cytochalasin D; Deoxyglucose; Dose-Response Relationship, Drug; Gene Expression; Glucose; Glucose Transporter Type 4; Insulin; Metformin; Monosaccharide Transport Proteins; Muscle Proteins; Nucleic Acid Synthesis Inhibitors; Oocytes; Parathyroid Hormone; Rats; Xenopus laevis

1999
Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells.
    British journal of pharmacology, 2002, Volume: 137, Issue:3

    Topics: Animals; Cells, Cultured; Deoxyglucose; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Receptor, Insulin; Signal Transduction; Tyrosine

2002
Metformin-stimulated mannose transport in dermal fibroblasts.
    The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11

    Topics: 3-O-Methylglucose; Biological Transport; Carbohydrate Metabolism, Inborn Errors; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Fibroblasts; Glucose; Glycosylation; Humans; Hypoglycemic Agents; Lipid Metabolism; Mannose; Metformin; Models, Biological; Monosaccharide Transport Proteins; Phloretin; Phlorhizin; Skin; Time Factors; Tunicamycin

2004
Combination of metformin and thiazolidindiones restore insulin signalling in insulin-resistant cultured myotubes.
    Life sciences, 2004, Feb-27, Volume: 74, Issue:15

    Topics: Animals; Blotting, Western; Cells, Cultured; Creatine Kinase; Deoxyglucose; Drug Synergism; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Muscle Fibers, Skeletal; Phosphoproteins; Phosphorylation; Precipitin Tests; Receptor, Insulin; Thiazolidinediones

2004
Effects of KST48 [(2R,5SR)3-(2-chlorobenzoyl)-5-(4-chlorophenoxymethyl)-2(3,4-dichlorophenyl) oxazolidine] on glucose transport in L6 myocytes.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:12

    Topics: Antimetabolites; Cell Line; Cell Survival; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Glucose; Glucose Transporter Type 4; Hydrocarbons, Chlorinated; Hypoglycemic Agents; Immunoblotting; Insulin; Kinetics; Metformin; Monosaccharide Transport Proteins; Muscle Cells; Muscle Proteins; Myoblasts; Oxazoles; Protein Transport; Protein-Tyrosine Kinases; Subcellular Fractions

2004
Effects of metformin and oleic acid on adipocyte expression of resistin.
    Diabetes, obesity & metabolism, 2006, Volume: 8, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Antimetabolites; Cell Differentiation; Cell Line; Deoxyglucose; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypoglycemic Agents; Insulin; Metformin; Mice; Muscle Cells; Muscle, Skeletal; Oleic Acid; Protein Kinase Inhibitors; Resistin; RNA, Messenger; Rosiglitazone; Thiazolidinediones

2006
AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:6

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Deoxyglucose; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Energy Metabolism; Enzyme Activators; Glucocorticoids; Homeostasis; Metformin; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases

2007
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.
    Endocrinology, 2007, Volume: 148, Issue:11

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anorexia; Deoxyglucose; Drug Administration Routes; Hypothalamus; Male; Metformin; Multienzyme Complexes; Neoplasm Transplantation; Neoplasms; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Survival Analysis; Tumor Cells, Cultured

2007
Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.
    Atherosclerosis, 2009, Volume: 206, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cells, Cultured; Cholesterol; Deoxyglucose; Gene Expression; Glycation End Products, Advanced; Glycosylation; Guanidines; Humans; Lipoproteins, HDL; Macrophages; Metformin

2009
Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:12

    Topics: Animals; Berberine; Biological Transport; Cells, Cultured; Chlorogenic Acid; Coumaric Acids; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Metformin; Muscle Fibers, Skeletal; Muscle, Skeletal; Phenols; Phosphatidylinositol 3-Kinases; Plant Extracts; PPAR gamma; Rats; Thiazolidinediones

2009
High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.
    Diabetes, 2010, Volume: 59, Issue:1

    Topics: Adenylate Kinase; Animals; Blotting, Western; Cholesterol; Deoxyglucose; Hep G2 Cells; Humans; Lactates; Male; Membrane Potentials; Metformin; Mice; Mice, Inbred C57BL; Mitochondrial Membranes; Myoblasts; Oxygen Consumption; Triglycerides

2010
Metabolic regulation of neuronal plasticity by the energy sensor AMPK.
    PloS one, 2010, Feb-01, Volume: 5, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antimetabolites; Blotting, Western; Deoxyglucose; Energy Metabolism; Enzyme Activation; Hippocampus; Hypoglycemic Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Metformin; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neuronal Plasticity; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases; Vidarabine

2010
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.
    Cancer research, 2010, Mar-15, Volume: 70, Issue:6

    Topics: Adenosine Triphosphate; Adenylate Kinase; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Deoxyglucose; Drug Synergism; Humans; Male; Metformin; Prostatic Neoplasms; Tumor Suppressor Protein p53

2010
The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells.
    Autophagy, 2010, Volume: 6, Issue:5

    Topics: AMP-Activated Protein Kinases; Antimetabolites; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Deoxyglucose; Drug Synergism; Humans; Hypoglycemic Agents; Male; Membrane Proteins; Metformin; Prostatic Neoplasms

2010
Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Feb-15, Volume: 18, Issue:4

    Topics: Administration, Oral; Animals; Arecoline; Biological Transport; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Eugenol; Glucose; Hypoglycemic Agents; Metformin; Muscle Fibers, Skeletal; Rats; Thiazolidinediones; Vanillic Acid

2011
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jun-15, Volume: 17, Issue:12

    Topics: AMP-Activated Protein Kinases; Animals; Antimetabolites; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Drug Synergism; Enzyme Activation; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Mice, SCID; Neoplasms; Paclitaxel; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2011
Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells.
    Biochemical and biophysical research communications, 2011, Jun-10, Volume: 409, Issue:3

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Deoxyglucose; Epithelial Cells; Glucosamine; Haplorhini; HSP70 Heat-Shock Proteins; Hypoglycemic Agents; Kidney Tubules, Proximal; Membrane Proteins; Metformin; Protein Kinases; Swine; Transcription Factor CHOP; Tunicamycin; Unfolded Protein Response

2011
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
    Cancer, 2011, Jul-01, Volume: 117, Issue:13

    Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Deoxyglucose; Disease Progression; Genes, p53; Glucose; Glutamine; Head and Neck Neoplasms; Humans; Lactic Acid; Mass Spectrometry; Metabolomics; Metformin; Neoplasms, Squamous Cell; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Tumor Suppressor Protein p53

2011
Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.
    American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:6

    Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Antimetabolites; Antimycin A; Cell Line; Cell Polarity; Deoxyglucose; Dogs; Enzyme Activation; Epithelial Cells; Kidney; Metformin; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase

2011
Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.
    Journal of agricultural and food chemistry, 2011, Sep-28, Volume: 59, Issue:18

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Cinnamates; Deoxyglucose; Drug Synergism; Hypoglycemic Agents; Metformin; Mice; Thiazolidinediones

2011
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:12

    Topics: Animals; Deoxyglucose; Down-Regulation; Drug Evaluation, Preclinical; Energy Metabolism; Female; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Nude; Neoplasms; Signal Transduction; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Deoxyglucose; Enzyme Activation; Enzyme Activators; Gene Knockdown Techniques; Glucose; Humans; Insulin-Secreting Cells; Isoenzymes; Metformin; Oleic Acid; Palmitic Acid; Protein Transport; Rats; Rats, Wistar

2011
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
    Cell death and differentiation, 2013, Volume: 20, Issue:4

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Caspases; Cell Line; Deoxyglucose; Humans; Metformin; Nuclear Proteins; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation

2013
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
    Aging, 2012, Volume: 4, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins

2012
ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Aniline Compounds; Apoptosis; Blotting, Western; Caspases; Cell Line, Tumor; Cell Proliferation; Child; Deoxyglucose; Drug Synergism; Flow Cytometry; Glioma; Humans; Immunohistochemistry; Metformin; Statistics, Nonparametric; Sulfonamides

2013
AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.
    Journal of neurochemistry, 2013, Volume: 127, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Electroporation; Fibroblasts; Glucose; Hypoglycemic Agents; Immunohistochemistry; Immunoprecipitation; Mechanistic Target of Rapamycin Complex 1; Metformin; Methionine; Multiprotein Complexes; Neurons; Oncogene Protein v-akt; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases

2013
Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:7

    Topics: Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Deoxyglucose; Electron Transport Complex I; Energy Metabolism; Glycolysis; Humans; Hypoglycemic Agents; Metformin; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oligomycins; Osteosarcoma

2014
Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.
    British journal of cancer, 2014, Jul-08, Volume: 111, Issue:1

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Celecoxib; Cell Culture Techniques; Cell Growth Processes; Cell Line, Tumor; Deoxycytidine; Deoxyglucose; Doxorubicin; Energy Metabolism; Gemcitabine; Glycolysis; Humans; Hydrogen; Metformin; Mitochondria; Oxygen Consumption; Pancreatic Neoplasms; Pyrazoles; Sulfonamides

2014
The relationship between anticancer effect of metformin and the transcriptional regulation of certain genes (CHOP, CAV-1, HO-1, SGK-1 and Par-4) on MCF-7 cell line.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Breast Neoplasms; Caveolin 1; Deoxyglucose; Female; Heme Oxygenase-1; Humans; Immediate-Early Proteins; MCF-7 Cells; Metformin; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factor CHOP

2014
Normalization of CD4+ T cell metabolism reverses lupus.
    Science translational medicine, 2015, Feb-11, Volume: 7, Issue:274

    Topics: Animals; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Lupus Erythematosus, Systemic; Metformin; Mice; Phenotype

2015
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.
    Endocrine-related cancer, 2015, Volume: 22, Issue:6

    Topics: Adenocarcinoma, Follicular; AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Papillary; Carrier Proteins; Caspases; Cell Division; Cell Line, Tumor; Culture Media; Deoxyglucose; Drug Screening Assays, Antitumor; Drug Synergism; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Membrane Proteins; Metformin; Molecular Targeted Therapy; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Thyroid Neoplasms

2015
Preventing Allograft Rejection by Targeting Immune Metabolism.
    Cell reports, 2015, Oct-27, Volume: 13, Issue:4

    Topics: Allografts; Animals; CD8-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Diazooxonorleucine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glutamine; Glycolysis; Graft Rejection; Heart Transplantation; Metformin; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphorylation; T-Lymphocytes, Regulatory

2015
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Disease Susceptibility; DNA Damage; Electron Transport Complex IV; Female; Glycolysis; Humans; Lactic Acid; Lung; Lung Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Monocarboxylic Acid Transporters; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Pyruvic Acid; Reactive Oxygen Species; Stress, Physiological; Symporters; Urethane

2016
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
    Journal of immunology (Baltimore, Md. : 1950), 2016, Jan-01, Volume: 196, Issue:1

    Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid

2016
Targeting P-glycoprotein expression and cancer cell energy metabolism: combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:7

    Topics: Antibiotics, Antineoplastic; Antimetabolites; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Proliferation; Deoxyglucose; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Therapy, Combination; Energy Metabolism; Humans; Hypoglycemic Agents; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Metformin; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2016
Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Female; Humans; Metformin; Signal Transduction

2016
Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin.
    Neuro-oncology, 2017, 02-01, Volume: 19, Issue:2

    Topics: Animals; Antimetabolites; Apoptosis; Brain Neoplasms; Cell Proliferation; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Energy Metabolism; Glioblastoma; Glycolysis; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Nude; Oxidative Phosphorylation; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2017
Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis.
    Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:2

    Topics: Apoptosis; Autophagy; Berberine; Cell Line; Cell Survival; Deoxyglucose; Drug Synergism; Flow Cytometry; Humans; Lysosomes; Metformin; Proton Pumps; Transglutaminases

2017
Combination of 2-deoxy d-glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: A549 Cells; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Survival; Deoxyglucose; DNA Adducts; DNA Damage; Drug Synergism; Humans; Intracellular Space; L-Lactate Dehydrogenase; Lipid Peroxidation; Lung Neoplasms; Membrane Potential, Mitochondrial; Metformin; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species

2016
Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells.
    Molecular and cellular endocrinology, 2017, 03-05, Volume: 443

    Topics: 4-Chloro-7-nitrobenzofurazan; Acetylcysteine; Adenylate Kinase; Animals; Antioxidants; Cell Line; Deoxyglucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Models, Biological; Muscle Cells; Muscle, Skeletal; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Uric Acid

2017
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
    Oncotarget, 2017, Jan-31, Volume: 8, Issue:5

    Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Cycle Proteins; Deoxyglucose; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Energy Metabolism; Female; G2 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Metformin; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Tumor Suppressor Protein p53

2017
Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability.
    The Journal of biological chemistry, 2017, Mar-31, Volume: 292, Issue:13

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Deoxyglucose; Drug Therapy, Combination; Heterografts; Humans; Metformin; Mice; Protein Stability; Transcription Factors; Tumor Suppressor Proteins

2017
Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: Starving tumors.
    Oncology reports, 2017, Volume: 37, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Membrane Potential, Mitochondrial; Metformin; Poly(ADP-ribose) Polymerases; Triple Negative Breast Neoplasms

2017
Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.
    Scientific reports, 2017, 05-11, Volume: 7, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Enzyme Activation; Female; Humans; Metformin; Pyrones; Ribonucleotides; Thiophenes

2017
Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer.
    Gynecologic oncology, 2017, Volume: 146, Issue:2

    Topics: AMP-Activated Protein Kinases; Antimetabolites; Blotting, Western; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Metformin; Neoplasm Grading; Neoplasms, Cystic, Mucinous, and Serous; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; ras Proteins; Signal Transduction

2017
Inhibition of bioenergetic metabolism by the combination of metformin and 2-deoxyglucose highly decreases viability of feline mammary carcinoma cells.
    Research in veterinary science, 2017, Volume: 114

    Topics: Animals; Antineoplastic Agents; Cats; Cell Line, Tumor; Cell Survival; Deoxyglucose; Energy Metabolism; Mammary Neoplasms, Animal; Metformin

2017
Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia.
    Physiological research, 2018, 05-04, Volume: 67, Issue:2

    Topics: Animals; Deoxyglucose; Diet; Glutathione; Glyoxal; Hypertriglyceridemia; Hypoglycemic Agents; Lactoylglutathione Lyase; Male; Metformin; Myocardium; Pyruvaldehyde; Rats; Rats, Wistar; Stress, Physiological

2018
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Disease Progression; Germinal Center; Glucose-6-Phosphate Isomerase; Glycolysis; Humans; Joints; Metformin; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Receptors, Antigen, T-Cell

2018
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
    British journal of pharmacology, 2019, Volume: 176, Issue:5

    Topics: Animals; Deoxyglucose; Disease Models, Animal; Drug Therapy, Combination; Kidney; MAP Kinase Signaling System; Metformin; Polycystic Kidney, Autosomal Dominant; Swine; Swine, Miniature; TOR Serine-Threonine Kinases; TRPP Cation Channels

2019
Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Adenosine Triphosphate; Animals; Antimetabolites; Cells, Cultured; Deoxyglucose; Disease Models, Animal; Female; Glycolysis; Humans; Hypersensitivity; Interleukin-33; Male; Mast Cells; Metformin; Mice; Mice, Inbred C57BL; Oxidative Phosphorylation; Peritonitis; Primary Cell Culture; Treatment Outcome

2018
High metabolic rate and stem cell characteristics of esophageal cancer stem-like cells depend on the Hsp27-AKT-HK2 pathway.
    International journal of cancer, 2019, 10-15, Volume: 145, Issue:8

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Deoxyglucose; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Glycolysis; Heat-Shock Proteins; Hexokinase; Humans; Kaplan-Meier Estimate; Metformin; Molecular Chaperones; Neoplastic Stem Cells; Oxidative Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction

2019
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 05-05, Volume: 117, Issue:18

    Topics: Activating Transcription Factor 4; Antimetabolites; Cell Death; Deoxyglucose; Epithelial Cells; Gene Expression Regulation; Glucose; Glutamine; HeLa Cells; Humans; Inflammation; Interleukin-6; Interleukin-8; Macrophages; Metformin; Neoplasms; NF-kappa B; Promoter Regions, Genetic; Starvation; Stress, Physiological

2020
Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Abatacept; Allografts; Animals; Deoxyglucose; Diazooxonorleucine; Glycolysis; Immunosuppression Therapy; Immunosuppressive Agents; Lymphocyte Activation; Metformin; Mice; T-Lymphocytes; Transplantation Tolerance

2020
Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4
    Journal of immunology (Baltimore, Md. : 1950), 2020, 08-15, Volume: 205, Issue:4

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Deoxyglucose; Glycolysis; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolic Networks and Pathways; Metformin; Mice; Oxidative Phosphorylation; Signal Transduction

2020
Inhibition of Glucose Metabolism Abrogates the Effector Phase of Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:7

    Topics: Animals; Autoantibodies; Deoxyglucose; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Glucose; Glycolysis; Humans; Leukotriene B4; Metformin; Mice; Mitochondria; Neutrophils; Oxidative Phosphorylation; Reactive Oxygen Species; Skin

2021
Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Adult; Aged; Animals; Deoxyglucose; Female; Glucose Transporter Type 1; Glycolysis; Hashimoto Disease; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Metformin; Mice; Middle Aged; Signal Transduction; Th1 Cells; Th17 Cells; Thyroiditis, Subacute; TOR Serine-Threonine Kinases

2021
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
    JCI insight, 2021, 10-08, Volume: 6, Issue:19

    Topics: Animals; Antibodies; Antimetabolites; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Glycolysis; Glycosylation; Hypoglycemic Agents; Immune Tolerance; Kidney; Leukocyte Common Antigens; Lupus Erythematosus, Systemic; Metformin; Mice; Oxidative Phosphorylation; Transplantation Tolerance; Transplantation, Homologous

2021
Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells.
    Scientific reports, 2021, 11-01, Volume: 11, Issue:1

    Topics: Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Female; Humans; Hypoglycemic Agents; Metabolome; Metabolomics; Metformin; Triple Negative Breast Neoplasms

2021
Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin.
    Journal of microbiology (Seoul, Korea), 2022, Volume: 60, Issue:8

    Topics: Animals; Deoxyglucose; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Metformin; Stomach

2022
Controlling Herpes Simplex Virus-Induced Immunoinflammatory Lesions Using Metabolic Therapy: a Comparison of 2-Deoxy-d-Glucose with Metformin.
    Journal of virology, 2022, 07-27, Volume: 96, Issue:14

    Topics: Animals; Cornea; Deoxyglucose; Glucose; Herpes Simplex; Herpesvirus 1, Human; Keratitis, Herpetic; Metformin; Mice; T-Lymphocytes; Trigeminal Ganglion

2022
Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 164

    Topics: Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Female; Glucose; Humans; Metformin; TOR Serine-Threonine Kinases; Triple Negative Breast Neoplasms

2023