metformin has been researched along with deoxyglucose in 74 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.35) | 18.7374 |
1990's | 7 (9.46) | 18.2507 |
2000's | 12 (16.22) | 29.6817 |
2010's | 44 (59.46) | 24.3611 |
2020's | 10 (13.51) | 2.80 |
Authors | Studies |
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Hundal, HS; Klip, A; Leiter, LA; Ramlal, T; Reyes, R | 1 |
Bilan, PJ; Gumà, A; Klip, A; Lam, L; Leiter, LA; Ramlal, T | 1 |
Brunetti, A; Buscema, M; Goldfine, ID; Gullo, D; Italia, S; Purrello, F; Vigneri, R | 1 |
Bailey, CJ; Mynett, KJ; Page, T | 1 |
Cerasi, E; Gorowits, N; Joost, HG; Kaiser, N; King, GL; Sasson, S | 1 |
Bailey, CJ; Jefferson, WH; Thomas, CR; Turner, SL | 1 |
Beisswenger, PJ; Howell, SK; Lal, S; Szwergold, BS; Touchette, AD | 1 |
Detaille, D; Devos, P; Wiernsperger, N | 1 |
Ingram, DK; Lane, MA; Roth, GS | 1 |
Dey, CS; Kumar, N | 1 |
Beisswenger, P; Ruggiero-Lopez, D | 1 |
Lehrman, MA; Shang, J | 1 |
Dey, CS; Ishrath, A; Kaul, CL; Kumar, N | 1 |
Anson, RM; de Cabo, R; Ingram, DK; Lane, MA; Mamczarz, J; Mattison, J; Roth, GS; Zhu, M | 1 |
Ahn, MY; Chae, SH; Chang, TS; Han, HK; Jung, jH; Khil, LY; Kim, YC; Lee, BH; Lee, DO; Lee, YM; Moon, CK | 1 |
Donnelly, R; Rea, R | 1 |
Frost, RA; Jefferson, LS; Krawiec, BJ; Lang, CH; Nystrom, GJ | 1 |
Carvalheira, JB; de Souza, CT; Faria, MC; Morari, J; Pauli, JR; Ropelle, ER; Saad, MJ; Ueno, M; Velloso, LA; Zecchin, KG | 1 |
Imaizumi, T; Matsui, J; Matsuki, K; Murakami, H; Satoh, K; Suda, T; Tamasawa, N; Tanabe, J; Yamashita, M | 1 |
Doble, M; Prabhakar, PK | 3 |
Gu, M; Huang, MW; Li, J; Li, JY; Li, YY; Nan, FJ; Pang, T; Qiu, BY; Turner, N; Wu, F; Ye, JM | 1 |
Barnett, D; Burger, C; O'Riordan, KJ; Osting, SM; Potter, WB; Roopra, A; Wagoner, M | 1 |
Auberger, P; Ben Sahra, I; Bertolotto, C; Bost, F; Cormont, M; Deckert, M; Giorgetti-Peraldi, S; Giuliano, S; Gounon, P; Larbret, F; Laurent, K; Le Marchand-Brustel, Y; Ponzio, G; Tanti, JF | 1 |
Allison, DB; Nagy, TR; Smith, DL | 1 |
Ben Sahra, I; Bost, F; Tanti, JF | 1 |
Barto, R; Engelen, L; Ferreira, I; Gram, J; Lund, SS; Parving, HH; Pedersen, O; Schalkwijk, CG; Stehouwer, CD; Tarnow, L; Teerlink, T; Vaag, AA; Winther, K | 1 |
Carvalheira, JB; Dias, MM; Osório-Costa, F; Rocha, GZ; Ropelle, ER; Rossato, FA; Saad, MJ; Vercesi, AE | 1 |
Palmer, HJ; Pittman, DD; Thériault, JR | 1 |
Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G | 1 |
Alves, DS; Ardito, T; Caplan, MJ; Kashgarian, M; Seo-Mayer, PW; Thulin, G; Zhang, L | 1 |
Ajani, J; Cheong, JH; Dennison, JB; Hall, H; Ki Hong, W; Kundra, V; Lee, JS; Liang, J; Lu, Y; Mills, GB; Nguyen-Charles, C; Park, ES; Ravoori, M; Tsavachidou, D; Wa Cheng, K; Zhang, D | 1 |
Cerasi, E; Kaiser, N; Ketzinel-Gilad, M; Leibowitz, G; Shaked, M | 1 |
Auberger, P; Ben-Sahra, I; Bost, F; Budanov, A; Dirat, B; Laurent, K; Puissant, A; Tanti, JF | 1 |
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H | 1 |
Lawler, SE; Levesley, J; Sinha, P; Steele, L; Taylor, C | 1 |
Ishizuka, Y; Kakiya, N; Nawa, H; Oshiro, N; Shirao, T; Takei, N; Witters, LA | 1 |
Borowska, M; Dworacka, M; Dworacki, G; Iskakova, S; Krzyżagórska, E; Wesołowska, A | 1 |
Issaq, SH; Monks, A; Teicher, BA | 1 |
Cheng, G; Dwinell, MB; Kalyanaraman, B; McAllister, D; Tsai, S; Zielonka, J | 1 |
Alacam, H; Bedir, A; Okuyucu, A; Ozdemir, T; Salis, O | 1 |
Brusko, TM; Choi, SC; Croker, BP; Morel, L; Perry, DJ; Seay, H; Sobel, ES; Xu, Z; Yin, Y | 1 |
Bikas, A; Boyle, L; Burman, KD; Costello, J; Hoperia, V; Jensen, K; Klubo-Gwiezdzinska, J; Larin, O; McDaniel, D; Patel, A; Vasko, V; Wartofsky, L | 1 |
Andrade-Oliveira, V; Bowman, CE; Brandacher, G; Cheng, CH; Furtmüller, GJ; Lee, CF; Lo, YC; Oh, B; Powell, JD; Slusher, BS; Thomas, AG; Wolfgang, MJ | 1 |
Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y | 1 |
Choi, SC; Croker, BP; Kanda, N; Morel, L; Xu, Z; Yin, Y; Zeumer, L | 1 |
Huo, X; Liu, K; Liu, Q; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Xue, C | 1 |
Dolinar, K; Miš, K; Pavlin, M; Pirkmajer, S; Rajh, M | 1 |
Chang, JH; Cheong, JH; Choi, J; Huh, YM; Jeon, JY; Kang, SG; Kim, EH; Kim, KS; Kim, P; Kim, SH; Koh, I; Lee, JH; Oh, Y; Park, J; Shim, JK; Yun, M | 1 |
Darzynkiewicz, Z; Garcia, J; Halicka, HD; Li, J; Zhao, H | 1 |
Hou, XB; Li, TH; Liu, Y; Ren, ZP | 1 |
Cheng, J; Hisatome, I; Hong, L; Hu, Y; Li, Z; Luo, C; Wen, T; Yamamoto, T; Yuan, H; Zhang, X; Zhang, Y; Zhu, Y; Zhuang, W; Zou, J | 1 |
Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Sun, P; Sun, Y; Wang, C; Xue, C | 1 |
Ao, J; Bergholz, J; Chen, D; Li, X; Sun, S; Wu, M; Xiao, ZX; Yi, Y; Zhang, Y | 1 |
Emons, G; Gründker, C; Hellriegel, M; Wokoun, U | 1 |
Bizjak, M; Dolinar, K; Malavašič, P; Pavlin, M; Pirkmajer, S; Pohar, J | 1 |
Allo, G; Carey, MS; Chhina, J; Dai, J; Giri, S; Llaurado, M; Mert, I; Munkarah, AR; Rattan, R; Seward, S | 1 |
Agnetti, L; Álvarez, GM; Arbe, MF; Finocchiaro, LME; Fondello, C; Glikin, GC; Tellado, MN; Villaverde, MS | 1 |
Haluzik, M; Kazdova, L; Malinska, H; Markova, I; Škop, V; Svoboda, P; Trnovska, J | 1 |
Abboud, G; Choi, SC; Kanda, N; Morel, L; Roopenian, DC; Zeumer-Spataro, L | 1 |
Bai, XY; Cai, G; Chen, X; Li, Q; Li, Z; Lian, X; Lin, S; Song, K; Wu, X; Zhang, Y | 1 |
Baldwin, EA; Barnstein, BO; Caslin, HL; Haque, T; Pondicherry, N; Ryan, JJ; Taruselli, MT | 1 |
Chou, KT; Hsu, HS; Hsu, JW; Hsu, TW; Hung, SC; Lin, JH; Liu, CC; Yen, DH | 1 |
Chevet, E; Eldering, E; Favaro, F; Iurlaro, R; Lucendo, E; Majem, B; Marchetti, S; Muñoz-Pinedo, C; Nadal, E; Püschel, F; Redondo-Pedraza, J; Ricci, JE | 1 |
Brandacher, G; Cheng, CH; Furtmüller, GJ; Lee, CF; Oh, BC; Patel, CH; Powell, JD | 1 |
Hadjipanayis, A; Hall, JP; Kelkar, Y; Shipstone, A; Tan, SY; Wynn, TA | 1 |
Bremer, T; Derenda-Hell, A; Sadik, CD; Schilf, P; Schmitz, M; Thieme, M; Vaeth, M; Zillikens, D | 1 |
Shan, Z; Shi, X; Teng, W; Wang, S; Wang, X; Wu, Q; Zhao, L | 1 |
Hoopes, EM; Major, AS; McNew, KL; Moore, DJ; Rhoads, JP; Stocks, BT; Wilson, CS | 1 |
Bizjak, M; Gole, B; Magnes, C; Pavlin, M; Potočnik, U; Repas, J; Zügner, E | 1 |
Bak, EJ; Cha, JH; Jang, S; Kim, A; Su, H; Tissera, K | 1 |
Berber, E; Rouse, BT | 1 |
Büsselberg, D; Samuel, SM; Satheesh, NJ; Triggle, CR; Varghese, E | 1 |
4 review(s) available for metformin and deoxyglucose
Article | Year |
---|---|
Caloric restriction in primates and relevance to humans.
Topics: Aging; Animals; Biomarkers; Blood Glucose; Body Temperature; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Diet, Reducing; Drug Evaluation, Preclinical; Energy Intake; Energy Metabolism; Food Deprivation; Garcinia; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Longevity; Macaca mulatta; Medicine, Ayurvedic; Metformin; Neoplasms; Phytotherapy; Plant Preparations; Primates; Rats; Rats, Inbred F344; Saimiri; Saponins; Triterpenes | 2001 |
Metformin inhibition of glycation processes.
Topics: Azepines; Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Pyruvaldehyde; Randomized Controlled Trials as Topic | 2003 |
Development of calorie restriction mimetics as a prolongevity strategy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Temperature; Caloric Restriction; Deoxyglucose; Dopamine; Dopamine Agents; Glycolysis; Humans; Insulin; Longevity; Metformin; Oligonucleotide Array Sequence Analysis; Rats; Time Factors; Up-Regulation | 2004 |
Calorie restriction: what recent results suggest for the future of ageing research.
Topics: Animals; Antimetabolites; Biomedical Research; Biomimetics; Caloric Restriction; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Longevity; Metformin; Primates; Quality of Life; Resveratrol; Sirolimus; Stilbenes | 2010 |
3 trial(s) available for metformin and deoxyglucose
Article | Year |
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Metformin reduces systemic methylglyoxal levels in type 2 diabetes.
Topics: Adult; Aged; Deoxyglucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Metformin; Middle Aged; Osmolar Concentration; Pyruvaldehyde; Sulfonylurea Compounds; Treatment Outcome | 1999 |
Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.
Topics: Carbamates; Confidence Intervals; Deoxyglucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines | 2011 |
Statins in low doses reduce VEGF and bFGF serum levels in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Cholesterol; Deoxyglucose; Diabetes Mellitus, Type 2; Fibroblast Growth Factor 2; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Middle Aged; Triglycerides; Vascular Endothelial Growth Factor A | 2014 |
67 other study(ies) available for metformin and deoxyglucose
Article | Year |
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Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Cell Line; Cell Membrane; Cell Membrane Permeability; Cytochalasin B; Deoxyglucose; Dose-Response Relationship, Drug; Insulin; Metformin; Monosaccharide Transport Proteins; Muscles; Subcellular Fractions | 1992 |
Stimulation of hexose transport by metformin in L6 muscle cells in culture.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Cell Line; Cells, Cultured; Cycloheximide; Deoxyglucose; Glucose; Insulin; Kinetics; Metformin; Methylglucosides; Monosaccharide Transport Proteins; Muscles | 1992 |
Direct effects of biguanides on glucose utilization in vitro.
Topics: Blood Glucose; Cytochalasin B; Deoxyglucose; Humans; In Vitro Techniques; Lymphocytes; Metformin; Phenformin | 1987 |
Importance of the intestine as a site of metformin-stimulated glucose utilization.
Topics: Animals; Deoxyglucose; Glucose; Insulin; Intestinal Mucosa; Intestines; Male; Metformin; Rats; Rats, Wistar; Regional Blood Flow; Stimulation, Chemical | 1994 |
Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells.
Topics: Animals; Aorta; Blotting, Western; Cattle; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Monosaccharide Transport Proteins; Muscle, Smooth, Vascular; Time Factors | 1996 |
Prevention of dexamethasone-induced insulin resistance by metformin.
Topics: Animals; Deoxyglucose; Dexamethasone; Glucose Transporter Type 1; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; RNA, Messenger | 1998 |
Metformin interaction with insulin-regulated glucose uptake, using the Xenopus laevis oocyte model expressing the mammalian transporter GLUT4.
Topics: 3-O-Methylglucose; Animals; Cytochalasin D; Deoxyglucose; Dose-Response Relationship, Drug; Gene Expression; Glucose; Glucose Transporter Type 4; Insulin; Metformin; Monosaccharide Transport Proteins; Muscle Proteins; Nucleic Acid Synthesis Inhibitors; Oocytes; Parathyroid Hormone; Rats; Xenopus laevis | 1999 |
Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells.
Topics: Animals; Cells, Cultured; Deoxyglucose; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Receptor, Insulin; Signal Transduction; Tyrosine | 2002 |
Metformin-stimulated mannose transport in dermal fibroblasts.
Topics: 3-O-Methylglucose; Biological Transport; Carbohydrate Metabolism, Inborn Errors; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Fibroblasts; Glucose; Glycosylation; Humans; Hypoglycemic Agents; Lipid Metabolism; Mannose; Metformin; Models, Biological; Monosaccharide Transport Proteins; Phloretin; Phlorhizin; Skin; Time Factors; Tunicamycin | 2004 |
Combination of metformin and thiazolidindiones restore insulin signalling in insulin-resistant cultured myotubes.
Topics: Animals; Blotting, Western; Cells, Cultured; Creatine Kinase; Deoxyglucose; Drug Synergism; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Muscle Fibers, Skeletal; Phosphoproteins; Phosphorylation; Precipitin Tests; Receptor, Insulin; Thiazolidinediones | 2004 |
Effects of KST48 [(2R,5SR)3-(2-chlorobenzoyl)-5-(4-chlorophenoxymethyl)-2(3,4-dichlorophenyl) oxazolidine] on glucose transport in L6 myocytes.
Topics: Antimetabolites; Cell Line; Cell Survival; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Glucose; Glucose Transporter Type 4; Hydrocarbons, Chlorinated; Hypoglycemic Agents; Immunoblotting; Insulin; Kinetics; Metformin; Monosaccharide Transport Proteins; Muscle Cells; Muscle Proteins; Myoblasts; Oxazoles; Protein Transport; Protein-Tyrosine Kinases; Subcellular Fractions | 2004 |
Effects of metformin and oleic acid on adipocyte expression of resistin.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Antimetabolites; Cell Differentiation; Cell Line; Deoxyglucose; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypoglycemic Agents; Insulin; Metformin; Mice; Muscle Cells; Muscle, Skeletal; Oleic Acid; Protein Kinase Inhibitors; Resistin; RNA, Messenger; Rosiglitazone; Thiazolidinediones | 2006 |
AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Deoxyglucose; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Energy Metabolism; Enzyme Activators; Glucocorticoids; Homeostasis; Metformin; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2007 |
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anorexia; Deoxyglucose; Drug Administration Routes; Hypothalamus; Male; Metformin; Multienzyme Complexes; Neoplasm Transplantation; Neoplasms; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Survival Analysis; Tumor Cells, Cultured | 2007 |
Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cells, Cultured; Cholesterol; Deoxyglucose; Gene Expression; Glycation End Products, Advanced; Glycosylation; Guanidines; Humans; Lipoproteins, HDL; Macrophages; Metformin | 2009 |
Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.
Topics: Animals; Berberine; Biological Transport; Cells, Cultured; Chlorogenic Acid; Coumaric Acids; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Metformin; Muscle Fibers, Skeletal; Muscle, Skeletal; Phenols; Phosphatidylinositol 3-Kinases; Plant Extracts; PPAR gamma; Rats; Thiazolidinediones | 2009 |
High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.
Topics: Adenylate Kinase; Animals; Blotting, Western; Cholesterol; Deoxyglucose; Hep G2 Cells; Humans; Lactates; Male; Membrane Potentials; Metformin; Mice; Mice, Inbred C57BL; Mitochondrial Membranes; Myoblasts; Oxygen Consumption; Triglycerides | 2010 |
Metabolic regulation of neuronal plasticity by the energy sensor AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antimetabolites; Blotting, Western; Deoxyglucose; Energy Metabolism; Enzyme Activation; Hippocampus; Hypoglycemic Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Metformin; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neuronal Plasticity; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases; Vidarabine | 2010 |
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.
Topics: Adenosine Triphosphate; Adenylate Kinase; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Deoxyglucose; Drug Synergism; Humans; Male; Metformin; Prostatic Neoplasms; Tumor Suppressor Protein p53 | 2010 |
The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells.
Topics: AMP-Activated Protein Kinases; Antimetabolites; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Deoxyglucose; Drug Synergism; Humans; Hypoglycemic Agents; Male; Membrane Proteins; Metformin; Prostatic Neoplasms | 2010 |
Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.
Topics: Administration, Oral; Animals; Arecoline; Biological Transport; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Eugenol; Glucose; Hypoglycemic Agents; Metformin; Muscle Fibers, Skeletal; Rats; Thiazolidinediones; Vanillic Acid | 2011 |
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.
Topics: AMP-Activated Protein Kinases; Animals; Antimetabolites; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Drug Synergism; Enzyme Activation; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Mice, SCID; Neoplasms; Paclitaxel; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2011 |
Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Deoxyglucose; Epithelial Cells; Glucosamine; Haplorhini; HSP70 Heat-Shock Proteins; Hypoglycemic Agents; Kidney Tubules, Proximal; Membrane Proteins; Metformin; Protein Kinases; Swine; Transcription Factor CHOP; Tunicamycin; Unfolded Protein Response | 2011 |
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Deoxyglucose; Disease Progression; Genes, p53; Glucose; Glutamine; Head and Neck Neoplasms; Humans; Lactic Acid; Mass Spectrometry; Metabolomics; Metformin; Neoplasms, Squamous Cell; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Tumor Suppressor Protein p53 | 2011 |
Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Antimetabolites; Antimycin A; Cell Line; Cell Polarity; Deoxyglucose; Dogs; Enzyme Activation; Epithelial Cells; Kidney; Metformin; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase | 2011 |
Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cinnamates; Deoxyglucose; Drug Synergism; Hypoglycemic Agents; Metformin; Mice; Thiazolidinediones | 2011 |
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.
Topics: Animals; Deoxyglucose; Down-Regulation; Drug Evaluation, Preclinical; Energy Metabolism; Female; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Nude; Neoplasms; Signal Transduction; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Deoxyglucose; Enzyme Activation; Enzyme Activators; Gene Knockdown Techniques; Glucose; Humans; Insulin-Secreting Cells; Isoenzymes; Metformin; Oleic Acid; Palmitic Acid; Protein Transport; Rats; Rats, Wistar | 2011 |
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Caspases; Cell Line; Deoxyglucose; Humans; Metformin; Nuclear Proteins; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation | 2013 |
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2012 |
ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Aniline Compounds; Apoptosis; Blotting, Western; Caspases; Cell Line, Tumor; Cell Proliferation; Child; Deoxyglucose; Drug Synergism; Flow Cytometry; Glioma; Humans; Immunohistochemistry; Metformin; Statistics, Nonparametric; Sulfonamides | 2013 |
AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.
Topics: AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Electroporation; Fibroblasts; Glucose; Hypoglycemic Agents; Immunohistochemistry; Immunoprecipitation; Mechanistic Target of Rapamycin Complex 1; Metformin; Methionine; Multiprotein Complexes; Neurons; Oncogene Protein v-akt; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Deoxyglucose; Electron Transport Complex I; Energy Metabolism; Glycolysis; Humans; Hypoglycemic Agents; Metformin; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oligomycins; Osteosarcoma | 2014 |
Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Celecoxib; Cell Culture Techniques; Cell Growth Processes; Cell Line, Tumor; Deoxycytidine; Deoxyglucose; Doxorubicin; Energy Metabolism; Gemcitabine; Glycolysis; Humans; Hydrogen; Metformin; Mitochondria; Oxygen Consumption; Pancreatic Neoplasms; Pyrazoles; Sulfonamides | 2014 |
The relationship between anticancer effect of metformin and the transcriptional regulation of certain genes (CHOP, CAV-1, HO-1, SGK-1 and Par-4) on MCF-7 cell line.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Breast Neoplasms; Caveolin 1; Deoxyglucose; Female; Heme Oxygenase-1; Humans; Immediate-Early Proteins; MCF-7 Cells; Metformin; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factor CHOP | 2014 |
Normalization of CD4+ T cell metabolism reverses lupus.
Topics: Animals; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Lupus Erythematosus, Systemic; Metformin; Mice; Phenotype | 2015 |
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.
Topics: Adenocarcinoma, Follicular; AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Papillary; Carrier Proteins; Caspases; Cell Division; Cell Line, Tumor; Culture Media; Deoxyglucose; Drug Screening Assays, Antitumor; Drug Synergism; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose; Glycolysis; Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Membrane Proteins; Metformin; Molecular Targeted Therapy; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Thyroid Neoplasms | 2015 |
Preventing Allograft Rejection by Targeting Immune Metabolism.
Topics: Allografts; Animals; CD8-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Diazooxonorleucine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glutamine; Glycolysis; Graft Rejection; Heart Transplantation; Metformin; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphorylation; T-Lymphocytes, Regulatory | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Disease Susceptibility; DNA Damage; Electron Transport Complex IV; Female; Glycolysis; Humans; Lactic Acid; Lung; Lung Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Monocarboxylic Acid Transporters; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Pyruvic Acid; Reactive Oxygen Species; Stress, Physiological; Symporters; Urethane | 2016 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Glucose; Interferon-gamma; Interleukin-17; Lactic Acid; Lupus Erythematosus, Systemic; Lymphocyte Activation; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyruvic Acid | 2016 |
Targeting P-glycoprotein expression and cancer cell energy metabolism: combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin.
Topics: Antibiotics, Antineoplastic; Antimetabolites; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Proliferation; Deoxyglucose; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Therapy, Combination; Energy Metabolism; Humans; Hypoglycemic Agents; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Metformin; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2016 |
Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Female; Humans; Metformin; Signal Transduction | 2016 |
Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin.
Topics: Animals; Antimetabolites; Apoptosis; Brain Neoplasms; Cell Proliferation; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Energy Metabolism; Glioblastoma; Glycolysis; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Nude; Oxidative Phosphorylation; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis.
Topics: Apoptosis; Autophagy; Berberine; Cell Line; Cell Survival; Deoxyglucose; Drug Synergism; Flow Cytometry; Humans; Lysosomes; Metformin; Proton Pumps; Transglutaminases | 2017 |
Combination of 2-deoxy d-glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism.
Topics: A549 Cells; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Survival; Deoxyglucose; DNA Adducts; DNA Damage; Drug Synergism; Humans; Intracellular Space; L-Lactate Dehydrogenase; Lipid Peroxidation; Lung Neoplasms; Membrane Potential, Mitochondrial; Metformin; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species | 2016 |
Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells.
Topics: 4-Chloro-7-nitrobenzofurazan; Acetylcysteine; Adenylate Kinase; Animals; Antioxidants; Cell Line; Deoxyglucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Models, Biological; Muscle Cells; Muscle, Skeletal; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Uric Acid | 2017 |
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Cycle Proteins; Deoxyglucose; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Energy Metabolism; Female; G2 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Metformin; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Tumor Suppressor Protein p53 | 2017 |
Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Deoxyglucose; Drug Therapy, Combination; Heterografts; Humans; Metformin; Mice; Protein Stability; Transcription Factors; Tumor Suppressor Proteins | 2017 |
Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: Starving tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Membrane Potential, Mitochondrial; Metformin; Poly(ADP-ribose) Polymerases; Triple Negative Breast Neoplasms | 2017 |
Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Enzyme Activation; Female; Humans; Metformin; Pyrones; Ribonucleotides; Thiophenes | 2017 |
Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer.
Topics: AMP-Activated Protein Kinases; Antimetabolites; Blotting, Western; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Metformin; Neoplasm Grading; Neoplasms, Cystic, Mucinous, and Serous; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; ras Proteins; Signal Transduction | 2017 |
Inhibition of bioenergetic metabolism by the combination of metformin and 2-deoxyglucose highly decreases viability of feline mammary carcinoma cells.
Topics: Animals; Antineoplastic Agents; Cats; Cell Line, Tumor; Cell Survival; Deoxyglucose; Energy Metabolism; Mammary Neoplasms, Animal; Metformin | 2017 |
Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia.
Topics: Animals; Deoxyglucose; Diet; Glutathione; Glyoxal; Hypertriglyceridemia; Hypoglycemic Agents; Lactoylglutathione Lyase; Male; Metformin; Myocardium; Pyruvaldehyde; Rats; Rats, Wistar; Stress, Physiological | 2018 |
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Disease Progression; Germinal Center; Glucose-6-Phosphate Isomerase; Glycolysis; Humans; Joints; Metformin; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Receptors, Antigen, T-Cell | 2018 |
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Topics: Animals; Deoxyglucose; Disease Models, Animal; Drug Therapy, Combination; Kidney; MAP Kinase Signaling System; Metformin; Polycystic Kidney, Autosomal Dominant; Swine; Swine, Miniature; TOR Serine-Threonine Kinases; TRPP Cation Channels | 2019 |
Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; Cells, Cultured; Deoxyglucose; Disease Models, Animal; Female; Glycolysis; Humans; Hypersensitivity; Interleukin-33; Male; Mast Cells; Metformin; Mice; Mice, Inbred C57BL; Oxidative Phosphorylation; Peritonitis; Primary Cell Culture; Treatment Outcome | 2018 |
High metabolic rate and stem cell characteristics of esophageal cancer stem-like cells depend on the Hsp27-AKT-HK2 pathway.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Deoxyglucose; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Glycolysis; Heat-Shock Proteins; Hexokinase; Humans; Kaplan-Meier Estimate; Metformin; Molecular Chaperones; Neoplastic Stem Cells; Oxidative Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2019 |
Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells.
Topics: Activating Transcription Factor 4; Antimetabolites; Cell Death; Deoxyglucose; Epithelial Cells; Gene Expression Regulation; Glucose; Glutamine; HeLa Cells; Humans; Inflammation; Interleukin-6; Interleukin-8; Macrophages; Metformin; Neoplasms; NF-kappa B; Promoter Regions, Genetic; Starvation; Stress, Physiological | 2020 |
Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression.
Topics: Abatacept; Allografts; Animals; Deoxyglucose; Diazooxonorleucine; Glycolysis; Immunosuppression Therapy; Immunosuppressive Agents; Lymphocyte Activation; Metformin; Mice; T-Lymphocytes; Transplantation Tolerance | 2020 |
Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Deoxyglucose; Glycolysis; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolic Networks and Pathways; Metformin; Mice; Oxidative Phosphorylation; Signal Transduction | 2020 |
Inhibition of Glucose Metabolism Abrogates the Effector Phase of Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita.
Topics: Animals; Autoantibodies; Deoxyglucose; Disease Models, Animal; Epidermolysis Bullosa Acquisita; Glucose; Glycolysis; Humans; Leukotriene B4; Metformin; Mice; Mitochondria; Neutrophils; Oxidative Phosphorylation; Reactive Oxygen Species; Skin | 2021 |
Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway.
Topics: Adult; Aged; Animals; Deoxyglucose; Female; Glucose Transporter Type 1; Glycolysis; Hashimoto Disease; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Metformin; Mice; Middle Aged; Signal Transduction; Th1 Cells; Th17 Cells; Thyroiditis, Subacute; TOR Serine-Threonine Kinases | 2021 |
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
Topics: Animals; Antibodies; Antimetabolites; CD4-Positive T-Lymphocytes; Deoxyglucose; Disease Models, Animal; Glycolysis; Glycosylation; Hypoglycemic Agents; Immune Tolerance; Kidney; Leukocyte Common Antigens; Lupus Erythematosus, Systemic; Metformin; Mice; Oxidative Phosphorylation; Transplantation Tolerance; Transplantation, Homologous | 2021 |
Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells.
Topics: Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Female; Humans; Hypoglycemic Agents; Metabolome; Metabolomics; Metformin; Triple Negative Breast Neoplasms | 2021 |
Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin.
Topics: Animals; Deoxyglucose; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Metformin; Stomach | 2022 |
Controlling Herpes Simplex Virus-Induced Immunoinflammatory Lesions Using Metabolic Therapy: a Comparison of 2-Deoxy-d-Glucose with Metformin.
Topics: Animals; Cornea; Deoxyglucose; Glucose; Herpes Simplex; Herpesvirus 1, Human; Keratitis, Herpetic; Metformin; Mice; T-Lymphocytes; Trigeminal Ganglion | 2022 |
Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy.
Topics: Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Female; Glucose; Humans; Metformin; TOR Serine-Threonine Kinases; Triple Negative Breast Neoplasms | 2023 |