metformin and dacarbazine
metformin has been researched along with dacarbazine in 19 studies
Research
Studies (19)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (10.53) | 29.6817 |
2010's | 13 (68.42) | 24.3611 |
2020's | 4 (21.05) | 2.80 |
Authors
Authors | Studies |
---|---|
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Halatsch, ME; Karpel-Massler, G; Kast, RE | 1 |
Böhmer, FD; Kirches, E; Mawrin, C; Pachow, D; Petermann, A; Wallesch, M; Wilisch-Neumann, A | 1 |
Brem, H; Cohen-Jonathan Moyal, E; Dahan, P; Dang, VT; Lemarié, A; Saland, E; Sarry, JE; Scotland, SJ; Sesen, J; Skuli, N; Toulas, C; Tyler, BM | 1 |
Adeberg, S; Ben Harrabi, S; Bernhardt, D; Bostel, T; Debus, J; Diehl, C; Koelsche, C; Mohr, A; Rieken, S | 1 |
Chen, Y; Li, C; Li, Y; Xie, G; Yu, H; Yu, Z; Zhang, Z; Zhao, G; Zhao, L | 1 |
Kim, DH; Li, S; Liu, Y; Lu, G; Xue, H; Yang, SH; Zhu, JJ | 1 |
Iranshahi, M; Naserian, M; Ramazani, E; Tayarani-Najaran, Z | 1 |
Haghjooy Javanmard, S; Hajimoradi Javarsiani, M; Sajedianfard, J | 1 |
Anisimov, VN; Baldueva, IA; Berstein, LM; Latipova, DK; Novik, AV; Protsenko, SA; Semenova, AI; Semiglazova, TY; Tkachenko, EV; Zhuk, IN | 1 |
Cecchini, AL; Cecchini, R; da Silva Brito, WA; Lopes, NMD; Luiz, RC; Marinello, PC; Sanches, LJ | 1 |
Badgett, T; Crimella, J; Fridley, BL; Gill, J; Gorlick, R; Llosa, N; Metts, JL; Reed, D; Sandler, E; Sansil, S; Smith, T; Thapa, R; Thompson, P; Trucco, M; Weiser, DA | 1 |
Reviews
1 review(s) available for metformin and dacarbazine
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Trials
1 trial(s) available for metformin and dacarbazine
Article | Year |
---|---|
A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Central Nervous System Neoplasms; Child; Child, Preschool; Dacarbazine; Humans; Irinotecan; Maximum Tolerated Dose; Metformin; Neoplasm Recurrence, Local; Neoplasms; Sarcoma, Ewing; Temozolomide; Vincristine | 2023 |
Other Studies
17 other study(ies) available for metformin and dacarbazine
Article | Year |
---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzodiazepines; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Energy Metabolism; Enzyme Activation; Glioblastoma; Humans; Metformin; Olanzapine; Temozolomide | 2011 |
Re-evaluation of cytostatic therapies for meningiomas in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Erlotinib Hydrochloride; Humans; Hydroxyurea; Losartan; Meningeal Neoplasms; Meningioma; Metformin; Mifepristone; Neurofibromin 2; Promoter Regions, Genetic; Quinazolines; Radiation Tolerance; Tamoxifen; Temozolomide; Tumor Suppressor Proteins; Verapamil | 2014 |
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Topics: Adenylate Kinase; Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Division; Cell Line, Tumor; Dacarbazine; Drug Synergism; Glioblastoma; Glycolysis; Humans; Metformin; Mice; Mice, Nude; Mitochondria; Temozolomide; Transcription Factors; Xenograft Model Antitumor Assays | 2015 |
Metformin influences progression in diabetic glioblastoma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood Glucose; Brain; Brain Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Diabetes Complications; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Glioblastoma; Humans; Hyperglycemia; Hypoglycemic Agents; Magnetic Resonance Imaging; Male; Metformin; Middle Aged; Retrospective Studies; Temozolomide; Young Adult | 2015 |
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Glioblastoma; Humans; Male; Metformin; Mice; Mice, SCID; Neoplastic Stem Cells; Random Allocation; Signal Transduction; Temozolomide; Xenograft Model Antitumor Assays | 2015 |
Metformin treatment reduces temozolomide resistance of glioblastoma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; Inhibitory Concentration 50; Metformin; Mice, SCID; Neoplasm Invasiveness; SOXB1 Transcription Factors; Temozolomide; Time Factors; Transcriptome; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
The Role of SAPK/JNK Pathway in the Synergistic Effects of Metformin and Dacarbazine on Apoptosis in Raji and Ramos Lymphoma Cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Humans; Hypoglycemic Agents; Lymphoma; MAP Kinase Signaling System; Metformin | 2018 |
The effects of metformin on the hippo pathway in the proliferation of melanoma cancer cells: a preclinical study.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Cell Proliferation; Dacarbazine; Hippo Signaling Pathway; Humans; Melanoma; Metformin; Signal Transduction; Trans-Activators; YAP-Signaling Proteins | 2022 |
Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Humans; Melanoma; Melatonin; Metformin; Quality of Life | 2021 |
Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Malondialdehyde; Melanoma, Experimental; Metformin; Mice; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Skin Neoplasms; Tumor Suppressor Protein p53 | 2022 |