metformin has been researched along with cyclosporine in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 20 (74.07) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Almeida, A; Attia, S; Delgado-Esteban, M; Detaille, D; El-Mir, MY; Fontaine, E; Guigas, B; Leverve, X; R-Villanueva, G | 1 |
| Benhamou, PY; Cottet-Rousselle, C; Fontaine, E; Halimi, S; Lablanche, S; Lamarche, F; Leverve, X | 1 |
| Hokari, A | 1 |
| Bernardi, P; Chauvin, C; De Oliveira, F; De Paulis, D; Fontaine, E; Gharib, A; Lablanche, S; Leverve, X; Li, B; Ovize, M; Vial, G | 1 |
| Arnon, R; Goldis, M; Regelmann, MO | 1 |
| Gulliver, WP; van der Zee, HH | 1 |
| Afonso-Pereira, F; Basit, AW; Mai, Y; Murdan, S | 1 |
| Ahn, SW; Hong, SK; Kim, H; Kim, HS; Lee, KW; Mussin, N; Oh, DK; Oh, SC; Park, MY; Seo, S; Suh, KS; Yi, NJ; Yoon, KC | 1 |
| Abdelwahed, R; Arakawa, H; Ellawatty, WEA; Fujita, KI; Ishida, H; Kato, Y; Masuo, Y; Nakamichi, N; Sasaki, Y; Yamazaki, E | 1 |
| Huang, YX; Li, Y; Liang, S; Lin, CX; Liu, SY; Su, YF; Tao, J; Zhang, LS; Zhao, ZK; Zheng, JM | 1 |
| Chen, W; Gan, J; Marathe, P; Panfen, E; Shen, H; Sinz, M; Zhang, Y | 1 |
| Das, P; Kumar, VL; Vangaveti, S | 1 |
| Aliazadeh, S; Alizadeh, AM; Amiriani, T; Dehpour, A; Enayati, A; Ensan, PS; Jafarzadeh, F; Jand, Y; Khori, V; Mazaheri, Z; Moheimani, HR; Pourabouk, M; Pourkhani, AH; Rajaei, M; Shakiba, D; Zeyghami, MA | 1 |
| Borutaite, V; Jankeviciute, S; Svirskiene, N; Svirskis, G | 1 |
5 review(s) available for metformin and cyclosporine
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
Topics: Antiviral Agents; Cyclosporine; Diterpenes; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fatty Alcohols; Female; Fluvastatin; Hepatitis C, Chronic; Humans; Indoles; Interferon-alpha; Male; Metformin; Nitro Compounds; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Silybin; Silymarin; Thiazoles | 2011 |
New-onset diabetes mellitus after pediatric liver transplantation.
Topics: Albuminuria; Child; Cyclosporine; Diabetes Mellitus; Diabetic Retinopathy; Glucocorticoids; Humans; Hyperlipidemias; Hypertension; Immunosuppressive Agents; Insulin; Liver Failure; Liver Transplantation; Metformin; Pediatrics; Risk Factors; Sirolimus; Tacrolimus | 2015 |
Medical Treatments of Hidradenitis Suppurativa: More Options, Less Evidence.
Topics: Acitretin; Adrenal Cortex Hormones; Anti-Infective Agents; Cyclosporine; Dapsone; Dermatologic Agents; Gluconates; Hidradenitis Suppurativa; Hormones; Humans; Hypoglycemic Agents; Injections, Intralesional; Keratolytic Agents; Metformin; Ustekinumab | 2016 |
22 other study(ies) available for metformin and cyclosporine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclosporine; Cytochromes c; Diabetic Neuropathies; Enzyme Inhibitors; Etoposide; Hypoglycemic Agents; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2008 |
Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.
Topics: Animals; Apoptosis; Biological Transport; Calcium; Cell Death; Cell Line; Cell Survival; Cyclosporine; Fructose; Glucose; Insulin-Secreting Cells; Metformin; Mitochondria; Permeability; Protective Agents; Rats | 2011 |
Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D.
Topics: Animals; Cyclophilins; Cyclosporine; Electron Transport Complex I; Humans; Metformin; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Peptidyl-Prolyl Isomerase F; Rotenone | 2012 |
Excipient-mediated alteration in drug bioavailability in the rat depends on the sex of the animal.
Topics: Ampicillin; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cyclosporine; Excipients; Female; Male; Metformin; Polyethylene Glycols; Ranitidine; Rats, Wistar; Sex Factors | 2017 |
Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; HCT116 Cells; HT29 Cells; Humans; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Smad3 Protein; Tacrolimus; Transplantation, Heterologous | 2017 |
Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib.
Topics: Administration, Intravenous; Animals; Cyclosporine; HEK293 Cells; Hepatocytes; Humans; Indazoles; Inhibitory Concentration 50; Liver; Male; Metformin; Mice; Mice, Inbred ICR; Octamer Transcription Factor-1; Protein Kinase Inhibitors; Pyrimidines; Quaternary Ammonium Compounds; Sulfonamides; Tissue Distribution; Transfection | 2018 |
Metformin Attenuates Cyclosporine A-induced Renal Fibrosis in Rats.
Topics: Animals; Creatinine; Cyclosporine; Disease Models, Animal; Fibrosis; Humans; Immunosuppressive Agents; Kidney; Male; MAP Kinase Signaling System; Metformin; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Renal Elimination | 2019 |
Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.
Topics: Cyclosporine; Drug Interactions; HEK293 Cells; Hepatocytes; Humans; Male; Metformin; Organic Cation Transporter 1 | 2019 |
Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Inflammation; Kidney Diseases; Male; Metformin; Oxidation-Reduction; Rats; Rats, Wistar; Silymarin | 2021 |
Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bile Ducts; Cardiomyopathies; Cyclosporine; Cytoprotection; Enzyme Activation; Hemodynamics; Ischemic Preconditioning, Myocardial; Isolated Heart Preparation; Ligation; Liver Cirrhosis, Experimental; Male; Metformin; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats, Wistar; Signal Transduction | 2021 |
Effects of Metformin on Spontaneous Ca
Topics: Animals; Caffeine; Calcium Signaling; Chromans; Cyclosporine; Electron Transport Complex I; Female; Hypoxia; Male; Metformin; Microglia; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Primary Cell Culture; Rats; Reactive Oxygen Species; Rotenone | 2021 |