Compounds > metformin

metformin and cyclin d1

metformin has been researched along with cyclin d1 in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (5.41)29.6817
2010's27 (72.97)24.3611
2020's8 (21.62)2.80

Authors

AuthorsStudies
Auberger, P; Ben Sahra, I; Bost, F; Colosetti, P; Giorgetti-Peraldi, S; Laurent, K; Le Marchand-Brustel, Y; Loubat, A; Tanti, JF1
Endo, H; Fujisawa, T; Hosono, K; Nagashima, Y; Nakagama, H; Nakajima, A; Nakajima, N; Sugiyama, M; Takahashi, H; Tomimoto, A; Wada, K1
Sha, JP; Xue, YM; Zhou, XZ; Zhu, B1
Auberger, P; Ben Sahra, I; Bost, F; Giorgetti-Peraldi, S; Laurent, K; Le Marchand-Brustel, Y; Regazzetti, C; Robert, G; Tanti, JF1
Bai, XC; Jia, CH; Li, M; Luo, SQ; Wen, ZH; Zhao, L1
Agarwal, C; Agarwal, R; Deep, G; Kaur, M; Sikka, A1
Cai, B; Cai, X; Chen, X; Cheng, J; Hu, H; Hu, X; Huang, J; Jing, X; Li, Y; Tan, X; Wang, Q1
Benassi, MS; Conti, A; Ferrari, S; Novello, C; Pazzaglia, L; Picci, P; Quattrini, I1
Lu, S; Xu, Y1
Guo, P; He, D; Jin, X; Wang, X; Xiong, H; Xu, S; Yu, X; Zhang, T; Zhang, Y1
Chung, YM; Han, S; Kim, BH; Lee, H; Lee, HG; Park, CH; Shin, K; Ye, SK1
Bansal, N; Bertino, JR; DiPaola, RS; Mishra, PJ; Stein, M1
Carpizo, D; DiPaola, RS; Huang, H; Lin, Y; Tan, XL; Xu, Q; Yang, CS; Yue, W; Zheng, X1
Cai, X; Chen, C; Chen, X; Cheng, W; Guan, Y; Hu, X; Jing, X; Tan, X; Wang, Q1
Aviv, H; Chan, CS; Ganesan, S; Hakimi, AA; Hsieh, JJ; Joshi, S; Tolkunov, D; White, E; Yao, M1
Fujihara, S; Fujimori, T; Iwama, H; Kamada, H; Kato, K; Kobara, H; Kobayashi, K; Masaki, T; Yamashita, T1
Berstein, LM; Krasil'nikov, MA; Prokhorov, NS; Scherbakov, AM; Semina, SE; Sorokin, DV; Tatarskiy, VV1
An, H; Dhanasekaran, DN; Gwak, H; Kim, Y; Song, YS1
Albuquerque, M; Bedossa, P; Bourgoin, P; Cauchy, F; Faivre, S; Lambert, S; Laouirem, S; Leporq, B; Mebarki, M; Paradis, V; Soubrane, O; Van Beers, BE1
Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, DH; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Pak, S; Park, SH; Yang, DH; Yang, SK; Ye, BD1
Ayaki, M; Chiyo, T; Fujihara, S; Fujita, K; Iwama, H; Kato, K; Kobara, H; Kobayashi, N; Masaki, T; Matsunaga, T; Mori, H; Morishita, A; Nishiyama, N; Ohura, K; Samukawa, E; Tadokoro, T; Yachida, T; Yamana, Y1
Abo Mansour, HE; El-Ashmawy, NE; El-Bahrawy, HA; Khedr, NF1
Chen, J; Fei, DD; Hu, CH; Huang, WT; Jin, Y; Liu, N; Lu, YB; Lv, YJ; Pang, DL; Sui, BD; Xuan, K; Zhao, P; Zheng, CX; Zhou, CH1
Chen, Y; Dong, C; Dong, M; Hou, J; Li, L; Mu, N; Qv, L; Wang, Y; Xia, M; Xue, F; Zuo, Y1
Rasouli, S; Zarghami, N1
Asbaghi, N; Chatran, M; Dadashpour, M; Faramarzi, L; Jafari-Gharabaghlou, D; Pilehvar-Soltanahmadi, Y; Rasouli, S; Zarghami, N1
Abdel-Hameed, ND; Abdelaleem, OO; El Amin Ali, AM; Hassouna, A; Khalifa, WA; Mohammed, RA; Sabry, D1
Bass, AJ; Beeson, CC; Beeson, GC; Diehl, JA; Ogretmen, B; Oleinik, N; Parnham, S; Qie, S; Rustgi, AK; Wong, KK; Yoshida, A1
Astuti, I; Indarto, D; Mustofa, M; Muthmainah, M; Yudhani, RD1
Bilodeau, M; Goyal, L; Hatting, M; Liang, J; Luo, C; Perry, EA; Puigserver, P; Sharabi, K; Sicinski, P; Srivastava, A; Tavares, CDJ; Zhu, AX1
Beşli, N; Hocaoğlu Emre, FS; Kanıgür, G; Şenol, K; Yaprak Saraç, E; Yenmiş, G1
Alexandersson, I; Aouadi, M; Arifen, N; Boucher, J; Chen, P; Hagberg, CE; Harms, MJ; Hyvönen, MT; Knibbe, C; Krämer, N; Kutschke, M; Lang, S; Li, Q; Salehzadeh, F; Silva Cascales, H; Spalding, KL; Terezaki, E; Thorell, A1
Chen, W; Chen, Y; Guo, G; Huang, C; Liao, X; Liu, J; Liu, Y; Luo, Y; Wang, X; Wang, Y; Zeng, B1
Dadashpour, M; Hassani, N; Jafari-Gharabaghlou, D; Zarghami, N1
Dong, S; Hu, T; Wang, C; Wu, Q; Yang, J; Zhang, J; Zhao, C1
Bonapace, G; Brunetti, A; Brunetti, FS; Chiefari, E; Crocerossa, F; Di Vito, A; Epstein, AL; Foti, DP; Greco, M; Mirabelli, M; Salatino, A1
Dashti, MR; Ghorbanzadeh, F; Hashemi, M; Jafari-Gharabaghlou, D; Zarghami, N1

Other Studies

37 other study(ies) available for metformin and cyclin d1

ArticleYear
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.
    Oncogene, 2008, Jun-05, Volume: 27, Issue:25

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Male; Metformin; Multienzyme Complexes; Prostate; Prostatic Neoplasms; Protein Serine-Threonine Kinases

2008
Metformin suppresses intestinal polyp growth in ApcMin/+ mice.
    Cancer science, 2008, Volume: 99, Issue:11

    Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Cyclin D1; Gene Expression Regulation, Neoplastic; Genes, APC; Immunohistochemistry; Intestinal Polyps; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins c-myc

2008
[Effects of metformin on proliferation of human colon carcinoma cell line SW-480].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010, Volume: 30, Issue:8

    Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Humans; Metformin; Telomerase

2010
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
    Cancer research, 2011, Jul-01, Volume: 71, Issue:13

    Topics: AMP-Activated Protein Kinases; Animals; Cell Cycle; Cell Line, Tumor; Cyclin D1; Humans; Male; Metformin; Mice; Mice, Transgenic; Prostatic Neoplasms; RNA, Messenger; RNA, Small Interfering; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Tumor Suppressor Protein p53

2011
Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells.
    Anatomical record (Hoboken, N.J. : 2007), 2011, Volume: 294, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Antineoplastic Agents; Carcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; G1 Phase Cell Cycle Checkpoints; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Multiprotein Complexes; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Phosphoproteins; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases

2011
Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.
    Cell cycle (Georgetown, Tex.), 2012, Apr-01, Volume: 11, Issue:7

    Topics: beta-Transducin Repeat-Containing Proteins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase Cell Cycle Checkpoints; Head and Neck Neoplasms; Humans; Metformin; Neoplasm Proteins; Protein Biosynthesis; rho GTP-Binding Proteins; S-Phase Kinase-Associated Proteins; Squamous Cell Carcinoma of Head and Neck

2012
Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.
    Oncology reports, 2013, Volume: 30, Issue:5

    Topics: Aminoimidazole Carboxamide; Animals; Carcinoma, Hepatocellular; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mice; Ribonucleotides; Xenograft Model Antitumor Assays

2013
Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation.
    Oncology reports, 2014, Volume: 31, Issue:1

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Cisplatin; Cyclin D1; Humans; Hypoglycemic Agents; Metformin; Osteosarcoma; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Tumor Suppressor Protein p53

2014
Metformin inhibits esophagus cancer proliferation through upregulation of USP7.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:5

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Esophageal Neoplasms; Humans; Metformin; Protein Stability; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Up-Regulation

2013
The antidiabetic drug metformin inhibits the proliferation of bladder cancer cells in vitro and in vivo.
    International journal of molecular sciences, 2013, Dec-18, Volume: 14, Issue:12

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; G1 Phase Cell Cycle Checkpoints; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Proliferating Cell Nuclear Antigen; Signal Transduction; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Urinary Bladder Neoplasms

2013
Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling.
    Biochemical and biophysical research communications, 2015, Jan-02, Volume: 456, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Atorvastatin; Cell Differentiation; Cell Survival; Cyclin D1; Heptanoic Acids; Homeostasis; Hypoglycemic Agents; Kruppel-Like Transcription Factors; Metformin; Mice; Pyrroles; Signal Transduction; Smad3 Protein; Smad7 Protein; STAT3 Transcription Factor; Transforming Growth Factor beta; Tumor Suppressor Protein p53

2015
Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells.
    Oncotarget, 2015, Jun-20, Volume: 6, Issue:17

    Topics: Adenylate Kinase; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Docetaxel; Drug Resistance, Neoplasm; Enzyme Activation; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Humans; Male; Metformin; Neoplasm Invasiveness; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Taxoids; Triazoles; Up-Regulation

2015
Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2.
    Oncotarget, 2015, Aug-28, Volume: 6, Issue:25

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Aspirin; Bcl-2-Like Protein 11; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Survival; Cyclin D1; Female; Humans; Membrane Proteins; Metformin; Mice; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Wound Healing

2015
Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Esophageal Neoplasms; G1 Phase Cell Cycle Checkpoints; Humans; Hypoglycemic Agents; Male; Metformin; Mice, Nude; Resting Phase, Cell Cycle; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2015
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.
    Cell reports, 2015, Dec-01, Volume: 13, Issue:9

    Topics: Adenoma, Oxyphilic; AMP-Activated Protein Kinases; Autophagy; Carcinoma, Renal Cell; Cathepsins; Cell Transformation, Neoplastic; Cyclin D1; DNA Copy Number Variations; Female; Golgi Apparatus; Humans; Karyotype; Kidney; Kidney Neoplasms; Lysosomal Membrane Proteins; Lysosomes; Male; Metformin; Mitochondria; Sequence Analysis, RNA; Transcriptome; Tumor Suppressor Protein p53

2015
The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin.
    Oncology reports, 2016, Volume: 35, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclin D1; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Metformin; Mice; MicroRNAs; Pancreatic Neoplasms; Phosphorylation; Receptor, IGF Type 1; Retinoblastoma Protein; Xenograft Model Antitumor Assays

2016
The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling.
    IUBMB life, 2016, Volume: 68, Issue:4

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Hormonal; Cadherins; Cell Proliferation; Cyclin D1; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; MCF-7 Cells; Metformin; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Snail Family Transcription Factors; Tamoxifen; TOR Serine-Threonine Kinases

2016
Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:2

    Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Female; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Metformin; Ovarian Neoplasms; Ovary; Proteolysis; Signal Transduction

2017
Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis.
    Clinical science (London, England : 1979), 2017, 01-01, Volume: 131, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carbonic Anhydrase IX; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Drug Evaluation, Preclinical; Humans; Liver Neoplasms; Male; Metformin; Mice; Xenograft Model Antitumor Assays

2017
Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
    European journal of pharmacology, 2017, Jan-05, Volume: 794

    Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Cell Proliferation; Colitis; Colonic Neoplasms; Cyclin D1; Diet, Western; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Macrophages; Male; Metformin; Mice; Probiotics

2017
Therapeutic potential of the antidiabetic drug metformin in small bowel adenocarcinoma.
    International journal of oncology, 2017, Volume: 50, Issue:6

    Topics: Adenocarcinoma; Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Metformin; Mice; Neoplasm Proteins; Phosphorylation; Xenograft Model Antitumor Assays

2017
Metformin augments doxorubicin cytotoxicity in mammary carcinoma through activation of adenosine monophosphate protein kinase pathway.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:5

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cell Proliferation; Cyclin D1; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Metformin; Mice; NF-kappa B; Signal Transduction; Tumor Suppressor Protein p53

2017
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.
    Aging cell, 2017, Volume: 16, Issue:5

    Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; Female; Gene Expression Regulation; Metformin; Mice; Neovascularization, Physiologic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Resveratrol; Ribosomal Protein S6 Kinases; Sirolimus; Skin; Skin Aging; Stilbenes; Tumor Suppressor Protein p53; Wound Healing; Wounds, Nonpenetrating

2017
Synergistic effect of metformin and medroxyprogesterone 17‑acetate on the development of endometrial cancer.
    Oncology reports, 2018, Volume: 39, Issue:4

    Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin E; Drug Synergism; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Medroxyprogesterone Acetate; Metformin

2018
Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
    Asian Pacific journal of cancer prevention : APJCP, 2018, Apr-25, Volume: 19, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Cyclin D1; Drug Combinations; Drug Synergism; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Metformin; Telomerase; Tumor Cells, Cultured

2018
Synergistic Anti-proliferative Effects of Metformin and Silibinin Combination on T47D Breast Cancer Cells via hTERT and Cyclin D1 Inhibition.
    Drug research, 2018, Volume: 68, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Drug Screening Assays, Antitumor; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Metformin; Silybin; Telomerase

2018
Anti-proliferative and anti-apoptotic potential effects of epigallocatechin-3-gallate and/or metformin on hepatocellular carcinoma cells: in vitro study.
    Molecular biology reports, 2019, Volume: 46, Issue:2

    Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Catechin; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Glypicans; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; RNA, Long Noncoding; Signal Transduction; Survivin; Vascular Endothelial Growth Factor A

2019
Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.
    Nature communications, 2019, 03-21, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzeneacetamides; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; F-Box Proteins; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Molecular Targeted Therapy; Phenformin; Protein Kinase Inhibitors; Retinoblastoma Protein; Signal Transduction; Thiadiazoles; Xenograft Model Antitumor Assays

2019
Metformin Modulates Cyclin D1 and P53 Expression to Inhibit Cell Proliferation and to Induce Apoptosis in Cervical Cancer Cell Lines.
    Asian Pacific journal of cancer prevention : APJCP, 2019, 06-01, Volume: 20, Issue:6

    Topics: Apoptosis; Cell Proliferation; Cyclin D1; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Hypoglycemic Agents; Metformin; Signal Transduction; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms

2019
Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.
    Cancer research, 2020, 08-15, Volume: 80, Issue:16

    Topics: Animals; Antineoplastic Agents; Cyclin D1; Cyclin-Dependent Kinase 4; Diabetes Mellitus, Type 2; Hyperinsulinism; Hypoglycemic Agents; Liver Neoplasms, Experimental; Male; Metformin; Mice; Obesity; Piperazines; Protein Kinase Inhibitors; Pyridines; Up-Regulation

2020
Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism
    Turkish journal of medical sciences, 2021, 04-30, Volume: 51, Issue:2

    Topics: AMP-Activated Protein Kinases; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Tumor Suppressor Protein p53; Up-Regulation

2021
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
    Nature medicine, 2021, Volume: 27, Issue:11

    Topics: Adipocytes; Adipose Tissue; Cell Cycle; Cell Differentiation; Cellular Senescence; Cyclin D1; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Obesity

2021
Metformin combats obesity by targeting FTO in an m
    Journal of drug targeting, 2022, Volume: 30, Issue:9

    Topics: 3T3-L1 Cells; Adipocytes; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cyclin D1; Cyclin-Dependent Kinase 2; Metformin; Mice; Obesity; RNA-Binding Proteins; Transcription Factors

2022
The Effect of Dual Bioactive Compounds Artemisinin and Metformin Co-loaded in PLGA-PEG Nano-particles on Breast Cancer Cell lines: Potential Apoptotic and Anti-proliferative Action.
    Applied biochemistry and biotechnology, 2022, Volume: 194, Issue:10

    Topics: Alkylmercury Compounds; Antineoplastic Agents; Apoptosis; Artemisinins; bcl-2-Associated X Protein; Benzalkonium Compounds; Benzoflavones; Breast Neoplasms; Carbanilides; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Ethylmercury Compounds; Female; Heterocyclic Compounds; Humans; Metformin; Methacholine Compounds; Nanoparticles; Oximes; Plasmalogens; Sulfonylurea Compounds; Survivin; Trimethyltin Compounds

2022
The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin.
    Immunopharmacology and immunotoxicology, 2023, Volume: 45, Issue:3

    Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Diethylhexyl Phthalate; Glycogen Synthase Kinase 3 beta; Humans; MCF-7 Cells; Metformin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Vimentin

2023
The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Cell Line, Tumor; Cyclin D1; Humans; Male; Matrix Metalloproteinase 11; Metformin; Transcription Factors

2022
Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression.
    Medical oncology (Northwood, London, England), 2023, Jul-29, Volume: 40, Issue:9

    Topics: bcl-2-Associated X Protein; Caco-2 Cells; Colonic Neoplasms; Cyclin D1; Humans; Liposomes; Metformin; Nanoparticles; Polyethylene Glycols; Receptors, G-Protein-Coupled

2023