metformin and curcumin

metformin has been researched along with curcumin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's13 (54.17)24.3611
2020's11 (45.83)2.80

Authors

AuthorsStudies
Darvesh, AS; Geldenhuys, WJ; Leeper, TC; Morris, DL; Sullivan, PG; Yonutas, HM1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Steinman, TI1
Chen, J; Hann, SS; Wang, Z; Wu, J; Zhao, S; Zheng, F1
Ben, Q; Du, Y; Gao, J; Gong, Y; He, X; Huang, L; Jin, J; Li, Z; Man, X; Ning, X; Wu, H; Xu, M1
Babica, P; Čtveráčková, L; Lenčešová, Z; Trosko, JE; Upham, BL1
Antony, B; Benny, M; Hicks, W; Jacob, T; Kulsum, S; Kumar, VV; Kuriakose, MA; Kuruvilla, BT; Lakshminarayan, P; Raghavan, N; Raju, N; Ravindra, DR; Seshadri, M; Sharma, A; Siddappa, G; Sudheendra, HV; Sunny, SP; Suresh, A1
Dadashpour, M; Farajzadeh, R; Javidfar, S; Lotfi-Attari, J; Pilehvar-Soltanahmadi, Y; Sadeghzadeh, H; Shafiei-Irannejad, V; Zarghami, N1
Cao, ZQ; Cheng, YN; Gong, FL; Guo, XL; Yu, LG; Zhang, HH; Zhang, Y1
Chudhuri, A; Dehghan, E; Dehghani, M; Goodarzi, M; Hakimi, A; Lin, R; Mirzaei, H; Robertson, S; Saremi, B; Tu, X; Yadavali, S; Zhang, Y1
Abdel Baky, NA; Abdelsamia, EM; Balah, A; Khaleel, SA1
Biron, VL; Conrad, D; Harris, J; Kostiuk, M; Lindsay, C; O'Connell, DA; Seikaly, H1
Cao, L; Han, J; Kumar Sah, S; Xie, Y; Zhi, D1
Bahador, A; Chiniforush, N; Plotino, G; Pourhajibagher, M1
Cao, H; Lu, J; Tang, H; Xu, P; Yan, X; Zheng, Y; Zhou, L1
Eslami, SS; Jafari, D; Montazeri, H; Sadeghizadeh, M; Tarighi, P1
Cordero-Martínez, E; León-Ramírez, C; Ruiz-Herrera, J; Sánchez-Segura, L; Soberanes-Gutiérrez, CV; Vega-Arreguín, JC1
Atkin, SL; Azarpazhooh, MR; Heydari, B; Karimi-Zarchi, M; Sahebkar, A; Simental-Mendía, LE; Sohrevardi, SM; Teymourzadeh, M1
Chai, HC; Chua, KH; Lim, SK; Mahendran, R; Ong, KC1
Abdulmalek, S; Awad, D; Balbaa, M; Eldala, A1
Dasuni Wasana, PW; Muangnoi, C; Rojsitthisak, P; Towiwat, P; Vajragupta, O1
Chen, M; Duan, P; Gao, H; Gong, Y; Li, J; Lu, A; Xie, J; Xu, H1
Dasuni Wasana, PW; Rojsitthisak, P; Towiwat, P; Vajragupta, O1
Apte, K; Kumbhare, K; Mishra, S; Patil, D; Patwardhan, B; Shengule, S1

Reviews

3 review(s) available for metformin and curcumin

ArticleYear
Polycystic kidney disease: a 2011 update.
    Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:2

    Topics: Antineoplastic Agents; Benzazepines; Curcumin; Everolimus; Gastrointestinal Agents; Glomerular Filtration Rate; Humans; Hypertension; Hypoglycemic Agents; Immunosuppressive Agents; Indazoles; Kidney; Metformin; Octreotide; Organ Size; Polycystic Kidney, Autosomal Dominant; Sirolimus; Sodium; Tolvaptan

2012
Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment.
    Clinical and experimental nephrology, 2021, Volume: 25, Issue:11

    Topics: Antioxidants; Chalcones; Curcumin; Diterpenes; Diterpenes, Kaurane; Emodin; Epoxy Compounds; Estrogen Antagonists; Flavanones; Humans; Hypoglycemic Agents; Metformin; Phenanthrenes; Plant Extracts; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Quercetin; Resveratrol

2021
Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review.
    European journal of pharmacology, 2022, Nov-05, Volume: 934

    Topics: Bibliometrics; Cataract; Curcumin; Humans; Lanosterol; Metformin; Oxysterols; Resveratrol

2022

Trials

1 trial(s) available for metformin and curcumin

ArticleYear
Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial.
    Advances in experimental medicine and biology, 2021, Volume: 1308

    Topics: Blood Glucose; Curcumin; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycystic Ovary Syndrome

2021

Other Studies

20 other study(ies) available for metformin and curcumin

ArticleYear
Identification of small molecules that bind to the mitochondrial protein mitoNEET.
    Bioorganic & medicinal chemistry letters, 2016, 11-01, Volume: 26, Issue:21

    Topics: Hypoglycemic Agents; Ligands; Mitochondrial Proteins; Protein Binding; Small Molecule Libraries; Thiazolidinediones

2016
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling: the role of PGC-1α and Sp1.
    Cellular signalling, 2013, Volume: 25, Issue:12

    Topics: Adenylate Kinase; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Curcumin; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Metformin; Molecular Targeted Therapy; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; Transcription Factors

2013
Bulk pancreatic cancer cells can convert into cancer stem cells(CSCs) in vitro and 2 compounds can target these CSCs.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; beta Catenin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Humans; Ki-67 Antigen; Metformin; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Octamer Transcription Factor-3; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcr; Receptor, Notch1; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1

2016
Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants.
    Nutrition and cancer, 2016, Volume: 68, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Caprylates; Carcinogens; Cell Communication; Cell Survival; Cells, Cultured; Curcumin; DDT; Epithelial Cells; Fluorenes; Fluorocarbons; Gap Junctions; Hexachlorocyclohexane; Liver; Metformin; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate

2016
Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:11

    Topics: 4-Nitroquinoline-1-oxide; AC133 Antigen; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Chemoprevention; Curcumin; Female; Hyaluronan Receptors; Hypoglycemic Agents; Metformin; Mice, Inbred C57BL; Mouth; Mouth Neoplasms; Neoplastic Stem Cells

2017
Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells.
    Artificial cells, nanomedicine, and biotechnology, 2018, Volume: 46, Issue:5

    Topics: Breast Neoplasms; Capsules; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug Carriers; Drug Liberation; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Metformin; Nanoparticles; Particle Size; Polyesters; Polyethylene Glycols; Telomerase

2018
Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo.
    Molecular carcinogenesis, 2018, Volume: 57, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Cells, Cultured; Curcumin; Female; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2018
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway.
    Nature communications, 2017, 12-20, Volume: 8, Issue:1

    Topics: Animals; Antihypertensive Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Line, Tumor; Curcumin; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Hydralazine; Hypoglycemic Agents; In Vitro Techniques; Longevity; Metformin; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Stress, Physiological; Tauopathies; Transcription Factors

2017
Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiotonic Agents; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Synergism; Heart; Heme Oxygenase-1; Janus Kinases; Male; Membrane Proteins; Metformin; Myocardium; NF-E2-Related Factor 2; Rats; Rats, Wistar; STAT Transcription Factors; Treatment Outcome

2019
Antitumour effects of metformin and curcumin in human papillomavirus positive and negative head and neck cancer cells.
    Molecular carcinogenesis, 2019, Volume: 58, Issue:11

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Metformin; Papillomaviridae; Papillomavirus Infections; Squamous Cell Carcinoma of Head and Neck

2019
Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway.
    Journal of food biochemistry, 2019, Volume: 43, Issue:7

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Curcumin; Drug Combinations; Gentamicins; Kidney; Metformin; Oxidative Stress; Rats; Rats, Wistar

2019
Dual wavelength irradiation antimicrobial photodynamic therapy using indocyanine green and metformin doped with nano-curcumin as an efficient adjunctive endodontic treatment modality.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 29

    Topics: Anti-Bacterial Agents; Bacterial Load; Bicuspid; Biofilms; Curcumin; Disinfection; Enterococcus faecalis; In Vitro Techniques; Indocyanine Green; Lasers, Semiconductor; Metformin; Photochemotherapy; Photosensitizing Agents; Tooth Root

2020
Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro.
    IUBMB life, 2020, Volume: 72, Issue:5

    Topics: Animals; Cardiotonic Agents; Caspase 1; Cell Line; Cell Survival; Curcumin; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Electrocardiography; Gene Expression Regulation; Glucose; Glucose Tolerance Test; HMGB1 Protein; Hypoglycemic Agents; Interleukin-1beta; Male; Metformin; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction

2020
Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line.
    Nutrition and cancer, 2021, Volume: 73, Issue:6

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Curcumin; Humans; Male; Metformin; Prostatic Neoplasms

2021
Cell death in Ustilago maydis: comparison with other fungi and the effect of metformin and curcumin on its chronological lifespan.
    FEMS yeast research, 2020, 10-15, Volume: 20, Issue:7

    Topics: Basidiomycota; Cell Death; Culture Media; Curcumin; Metformin; Microbial Viability; Reactive Oxygen Species; Saccharomyces cerevisiae; Yarrowia

2020
Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes.
    Scientific reports, 2021, 10-19, Volume: 11, Issue:1

    Topics: Animals; Antioxidants; Blood Glucose; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Hypoglycemic Agents; Inflammation; Insulin; Insulin Resistance; Liver; Male; Metformin; Nanoparticles; Obesity; Oxidative Stress; Rats; Streptozocin; Zinc Oxide

2021
Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain.
    Scientific reports, 2022, 06-11, Volume: 12, Issue:1

    Topics: Analgesics; Anti-Inflammatory Agents; Curcumin; Humans; Metformin; Pain

2022
Metformin and curcumin co-encapsulated chitosan/alginate nanoparticles as effective oral carriers against pain-like behaviors in mice.
    International journal of pharmaceutics, 2023, Jun-10, Volume: 640

    Topics: Alginates; Animals; Caco-2 Cells; Chitosan; Curcumin; Drug Carriers; Humans; Metformin; Mice; Nanoparticles; Particle Size

2023
Herb-drug interaction of Nisha Amalaki and Curcuminoids with metformin in normal and diabetic condition: A disease system approach.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 101

    Topics: Animals; Curcuma; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Herb-Drug Interactions; Hypoglycemic Agents; Male; Metformin; Phyllanthus emblica; Plant Extracts; Rats; Rats, Wistar

2018