metformin and clozapine

metformin has been researched along with clozapine in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (25.00)29.6817
2010's20 (62.50)24.3611
2020's4 (12.50)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Balci, H; Eker, E; Ozenoglu, A; Ugurlu, S1
Baptista, T; Carrizo, E; Connell, L; de Baptista, EA; Fernández, I; Fernández, V; Mogollón, J; Prieto, D; Sandia, I; Valbuena, D1
Borgmann-Winter, K; Coffey, BJ; De León, DD; Weaver, LA1
Baptista, T; Carrizo, E; Connell, L; de Baptista, EA; Fernández, E; Fernández, I; Fernández, V; Mogollón, J; Prieto, D; Sandia, I; Valbuena, D1
Khaodhiar, L; Pramyothin, P1
Baptista, T; Carrizo, E; Connell, L; Fernández, E1
Chen, CH; Chiu, CC; Huang, MC; Kao, CF; Kuo, PH; Lin, SK; Lu, ML1
Chen, CH; Chen, PY; Chiu, CC; Huang, MC; Kao, CF; Kuo, PH; Lin, SK; Lu, ML1
Gordon, A; Leong, G; McFadden, M; Scott, JG; Ward, D1
Chen, WH; Hsieh, MH; Huang, WL1
Kisely, S; Leung, J; Russell, AW; Siskind, DJ; Wysoczanski, D1
Chen, CH; Chen, PY; Chiu, CC; Huang, MC; Lin, SK; Lin, YK; Lu, ML1
Baker, A; Flaws, D; Friend, N; Kisely, S; Lim, C; McGrath, JJ; Moudgil, V; Patterson, S; Russell, A; Sardinha, S; Siskind, D; Stedman, T; Suetani, S; Winckel, K1
Corsini, E; Galbiati, V; Iulini, M; Maddalon, A; Marinovich, M1
Adlan, LG; Benyhe, S; Büki, A; Heni, HE; Horvath, G; Kekesi, G; Kis, G; Szűcs, E1
Chen, J; Chen, Y; Fang, T; Huang, G; Li, B; Li, Q; Lin, C; Liu, J; Ma, X; Shao, H; Tian, H; Wang, H; Xu, S; Xu, Y; Yang, A; Yang, W; Yao, C; Yu, X; Zhou, C; Zhuo, C1
Agarwal, SM; Chintoh, AF; Foussias, G; Gerretsen, P; Graff-Guerrero, A; Hahn, MK; Maksyutynska, K; Navagnanavel, J; Powell, V; Remington, G; Sanches, M; Stogios, N1

Reviews

3 review(s) available for metformin and clozapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Metabolic syndrome with the atypical antipsychotics.
    Current opinion in endocrinology, diabetes, and obesity, 2010, Volume: 17, Issue:5

    Topics: Antipsychotic Agents; Benzodiazepines; Cardiovascular Diseases; Clozapine; Humans; Metabolic Syndrome; Metformin; Obesity; Olanzapine; Practice Guidelines as Topic; Psychotic Disorders; Severity of Illness Index; Weight Gain

2010
Metformin for Clozapine Associated Obesity: A Systematic Review and Meta-Analysis.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Antipsychotic Agents; Blood Glucose; Body Mass Index; Body Weight; Clozapine; Fasting; Humans; Hypoglycemic Agents; Metabolic Syndrome; Metformin; Obesity; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome; Triglycerides; Waist Circumference; Weight Gain

2016

Trials

6 trial(s) available for metformin and clozapine

ArticleYear
Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study.
    Schizophrenia research, 2009, Volume: 113, Issue:1

    Topics: Adult; Anthropometry; Antipsychotic Agents; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Cholesterol, HDL; Clozapine; Double-Blind Method; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Insulin Resistance; Leptin; Male; Metformin; Middle Aged; Schizophrenia; Statistics, Nonparametric; Waist Circumference

2009
Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin.
    Schizophrenia research, 2010, Volume: 121, Issue:1-3

    Topics: Adult; Antipsychotic Agents; Blood Glucose; Body Mass Index; Clozapine; Double-Blind Method; Female; Genotype; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin Resistance; Leptin; Male; Metabolic Diseases; Metformin; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Receptors, Leptin; Schizophrenia; Venezuela

2010
Effects of adjunctive metformin on metabolic traits in nondiabetic clozapine-treated patients with schizophrenia and the effect of metformin discontinuation on body weight: a 24-week, randomized, double-blind, placebo-controlled study.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:5

    Topics: Adult; Body Weight; Clozapine; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Metabolic Syndrome; Metformin; Middle Aged; Obesity; Overweight; Psychotic Disorders; Schizophrenia; Time Factors; Treatment Outcome

2013
The Relationships of Obesity-Related Genetic Variants With Metabolic Profiles and Response to Metformin in Clozapine-Treated Patients With Schizophrenia.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aldose-Ketose Isomerases; Alleles; Antipsychotic Agents; Clozapine; Double-Blind Method; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Male; Membrane Proteins; Metabolic Diseases; Metformin; Middle Aged; Obesity; Schizophrenia

2015
Effects of Low Dose Metformin on Metabolic Traits in Clozapine-Treated Schizophrenia Patients: An Exploratory Twelve-Week Randomized, Double-Blind, Placebo-Controlled Study.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Adult; Antipsychotic Agents; Body Mass Index; Body Weight; Clozapine; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Schizophrenia; Treatment Outcome

2016
CoMET: a protocol for a randomised controlled trial of co-commencement of METformin as an adjunctive treatment to attenuate weight gain and metabolic syndrome in patients with schizophrenia newly commenced on clozapine.
    BMJ open, 2018, 03-02, Volume: 8, Issue:3

    Topics: Antipsychotic Agents; Body Mass Index; Body Weight; Clozapine; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Male; Metabolic Syndrome; Metformin; Obesity; Research Design; Schizophrenia; Secondary Prevention; Treatment Outcome; Weight Gain; Weight Loss

2018

Other Studies

23 other study(ies) available for metformin and clozapine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Nutritional approach to metabolic changes arising out of schizophrenia therapy: case report.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:15

    Topics: Adult; Antipsychotic Agents; Behavior Therapy; Clozapine; Female; Humans; Insulin Resistance; Metformin; Obesity; Schizophrenia

2007
Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder.
    Journal of child and adolescent psychopharmacology, 2010, Volume: 20, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Clozapine; Female; Humans; Hypoglycemic Agents; Metformin; Psychotic Disorders; Weight Gain

2010
Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients.
    Schizophrenia research, 2012, Volume: 137, Issue:1-3

    Topics: Adult; Aged; Alanine; Antipsychotic Agents; Blood Glucose; Clozapine; Enzyme-Linked Immunosorbent Assay; Female; Gene Frequency; Genotype; Humans; Hypoglycemic Agents; Insulin; Leptin; Male; Metabolic Diseases; Metformin; Middle Aged; Polymorphism, Genetic; PPAR gamma; Proline

2012
Pancreatitis associated with metformin used for management of clozapine-related weight gain.
    The Australian and New Zealand journal of psychiatry, 2016, Volume: 50, Issue:7

    Topics: Adolescent; Antipsychotic Agents; Clozapine; Disease Management; Humans; Male; Metformin; Pancreatitis; Schizophrenia; Weight Gain

2016
Metformin-induced acute dystonia in a schizophrenic patient treated with sulpiride and clozapine.
    Psychiatry and clinical neurosciences, 2016, Volume: 70, Issue:8

    Topics: Antipsychotic Agents; Clozapine; Drug Interactions; Drug Therapy, Combination; Dystonia; Female; Humans; Hypoglycemic Agents; Metabolic Syndrome; Metformin; Middle Aged; Schizophrenia; Sulpiride

2016
In vitro identification of drugs inducing systemic hypersensitivity reactions known in vivo to be associated with specific HLA genotypes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2020, Volume: 68

    Topics: B7-2 Antigen; Carbamazepine; Cell Survival; Clozapine; Dideoxynucleosides; Drug Hypersensitivity; Genotype; HLA Antigens; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Metformin; THP-1 Cells

2020
Interaction of clozapine with metformin in a schizophrenia rat model.
    Scientific reports, 2021, 08-19, Volume: 11, Issue:1

    Topics: Animals; Behavior, Animal; Body Weight; Clozapine; Disease Models, Animal; Drug Interactions; Feeding Behavior; Metformin; Receptors, Dopamine D1; RNA, Messenger; Schizophrenia; Time Factors

2021
Clozapine induces metformin-resistant prediabetes/diabetes that is associated with poor clinical efficacy in patients with early treatment-resistant schizophrenia.
    Journal of affective disorders, 2021, 12-01, Volume: 295

    Topics: Antipsychotic Agents; Clozapine; Humans; Metformin; Prediabetic State; Prospective Studies; Schizophrenia; Treatment Outcome

2021
Metformin for the prevention of clozapine-induced weight gain: A retrospective naturalistic cohort study.
    Acta psychiatrica Scandinavica, 2022, Volume: 146, Issue:3

    Topics: Adult; Antipsychotic Agents; Clozapine; Cohort Studies; Humans; Male; Metformin; Retrospective Studies; Schizophrenia; Weight Gain

2022