metformin and cimetidine

metformin has been researched along with cimetidine in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.72)	18.7374
1990's	1 (1.72)	18.2507
2000's	17 (29.31)	29.6817
2010's	35 (60.34)	24.3611
2020's	4 (6.90)	2.80

Authors

Authors	Studies
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Blomgren, A; Börjesson, L; Gustavsson, L; Hendrickx, R; Jenvert, RM; Johansson, JG; Lohmann, C	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW	1
Bochner, F; Keal, J; Rolan, P; Somogyi, A; Stockley, C	1
Guanci, R; Lilley, LL	1
Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS	1
Sanders, TA; Taylor, D; Werneke, U	1
Conlon, C; Dawson, D	1
Ahmed, N; Arayne, MS; Sultana, N	1
Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI	2
Chow, MS; Tomlinson, B; Wang, ZJ; Yin, OQ	1
Begg, EJ; Gardiner, SJ; Kirkpatrick, CM; Zhang, M	1
Inui, K; Katsura, T; Masuda, S; Sato, T; Tanihara, Y; Yonezawa, A	1
Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI; Usui, T	1
Inui, K; Katsura, T; Masuda, S; Sato, T; Terada, T; Tsuda, M; Ueba, M	1
Ekblad, U; Heikkinen, T; Laine, K; Rahi, M; Rönnemaa, T; Tertti, K	1
Christopher, R; Covington, P; Davenport, M; Fleck, P; Karim, A; Li, X; Mekki, Q; Wann, E	1
Boehm, KM; Gunaga, S	1
Arayne, MS; Siddiqui, FA; Sultana, N; Zuberi, MH	1
Inoue, K; Ito, S; Kusuhara, H; Sugiyama, Y; Toyoshima, J; Yokochi, M; Yuasa, H	1
Harper, JN; Wright, SH	1
Ahn, KS; Hong, CW; Kang, GW; Lee, DY; Lee, IH; Seo, JH	1
Egawa, T; Hayashi, T; Kurogi, E; Ma, X; Ogino, Y; Oshima, R; Serizawa, Y; Tsuda, S; Yamada, M	1
Jiang, HD; Lei, HM; Li, LP; Sun, SY; Tu, MJ; Zeng, S; Zhou, H	1
Almond, L; Burt, HJ; Gaohua, L; Harwood, MD; Jamei, M; Neuhoff, S; Rostami-Hodjegan, A; Rowland-Yeo, K; Tucker, GT	1
Duan, H; Wang, J; Yin, J	1
Derdau, V; Fromm, MF; König, J; Mertsch, K; Müller, F; Sandvoss, M; Weitz, D	1
Baviera, AM; Benzi, JRL; de Moraes, NV; Stevens, JH; Yamamoto, PA	1
Breining, P; Bross, P; Busk, M; Fernandez-Guerra, P; Gormsen, LC; Hansen, JB; Jakobsen, S; Jensen, JB; Jessen, N; Markussen, LK; Pedersen, SB; Rasmussen, NE; Richelsen, B; Rolighed, L; Sundelin, EI	1
Clark, AM; Ekins, S; Sandoval, PJ; Wright, SH; Zorn, KM	1
Fromm, MF; König, J; Mertsch, K; Müller, F; Weitz, D	1
Ceckova, M; Deutsch, B; Fromm, MF; Reznicek, J; Staud, F	1
Caldwell, DJ; D'Aco, V; Davidson, T; Kappler, K; Robinson, PF; Simon-Hettich, B; Straub, JO; Tell, J	1
Bister, B; Ishiguro, N; Lee, W; Nishiyama, K; Sugiyama, Y; Toshimoto, K	1
Ebner, T; Hanke, N; Ishiguro, N; Lehr, T; Müller, F; Nock, V; Selzer, D; Stopfer, P; Türk, D; Wiebe, S	1
Contreras, D; García, MA; González, PM	1
Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z	1
Hoshi, M; Imaoka, T; Itokawa, KI; Yamada, M; Yamamura, N	1

Reviews

3 review(s) available for metformin and cimetidine

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Options for pharmacological management of obesity in patients treated with atypical antipsychotics. International clinical psychopharmacology, 2002, Volume: 17, Issue:4 Topics: Amantadine; Antipsychotic Agents; Cimetidine; Cyclobutanes; Fluoxetine; Fructose; Humans; Lactones; Metformin; Nizatidine; Obesity; Orlistat; Topiramate; Weight Gain	2002

Trials

1 trial(s) available for metformin and cimetidine

Article	Year
Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects. International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:1 Topics: Administration, Oral; Adult; Area Under Curve; Cimetidine; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Food-Drug Interactions; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Uracil; Young Adult	2010

Article

Year

Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.

International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:1

Topics: Administration, Oral; Adult; Area Under Curve; Cimetidine; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Food-Drug Interactions; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Uracil; Young Adult

2010

Other Studies

54 other study(ies) available for metformin and cimetidine

Article	Year
Exploring the role of different drug transport routes in permeability screening. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. Journal of medicinal chemistry, 2013, Sep-26, Volume: 56, Issue:18 Topics: Biological Transport; Chemical Phenomena; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pharmaceutical Preparations; Reproducibility of Results; Structure-Activity Relationship; Substrate Specificity	2013
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries	2017
Reduction of metformin renal tubular secretion by cimetidine in man. British journal of clinical pharmacology, 1987, Volume: 23, Issue:5 Topics: Adult; Cimetidine; Female; Humans; Kidney Tubules; Kinetics; Lactates; Male; Metformin; Pyruvates	1987
Dangers of new drugs. Does your facility or team have a system for incorporating new agents? The American journal of nursing, 1996, Volume: 96, Issue:2 Topics: Aged; Cimetidine; Diabetes Mellitus, Type 2; Drug Information Services; Drug Interactions; Female; Humans; Medication Systems, Hospital; Metformin	1996
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Animals; Biological Transport; CHO Cells; Cimetidine; Cricetinae; Intestinal Absorption; Kinetics; Liver; Metformin; Mice; Mice, Knockout; Organic Cation Transporter 1; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Distribution; Transfection	2002
Case study: metformin-associated lactic acidosis: could orlistat be relevant? Diabetes care, 2003, Volume: 26, Issue:8 Topics: Acidosis, Lactic; Anti-Obesity Agents; Anti-Ulcer Agents; Cimetidine; Drug Interactions; Female; Humans; Hypoglycemic Agents; Lactones; Metformin; Middle Aged; Orlistat	2003
In vitro availability of metformin in presence of h(2) receptor antagonists. Pakistan journal of pharmaceutical sciences, 2006, Volume: 19, Issue:1 Topics: Cimetidine; Famotidine; Gastric Juice; Histamine H2 Antagonists; Hydrogen-Ion Concentration; Intestinal Secretions; Metformin; Ranitidine	2006
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium	2007
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:8 Topics: Animals; Carbon Radioisotopes; Cell Line; Cimetidine; Cryopreservation; DNA, Complementary; Hepatocytes; Humans; Metformin; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; Pyridinium Compounds; Rats; Tetraethylammonium; Transfection; Tritium	2007
OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenetics and genomics, 2008, Volume: 18, Issue:7 Topics: Adult; China; Cimetidine; DNA Mutational Analysis; Drug Interactions; Gene Frequency; Humans; Hypoglycemic Agents; Kidney; Male; Metabolic Clearance Rate; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Polymorphism, Single Nucleotide	2008
Cimetidine does not appear to influence the distribution of metformin into human milk. British journal of clinical pharmacology, 2008, Volume: 66, Issue:4 Topics: Adult; Biological Transport, Active; Breast Feeding; Cimetidine; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Infant; Infant, Newborn; Male; Metformin; Milk, Human; Organic Cation Transport Proteins; Pregnancy	2008
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochemical pharmacology, 2008, Oct-01, Volume: 76, Issue:7 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Cimetidine; Dogs; Humans; Metformin; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Procainamide; Quinidine; Tetraethylammonium; Transfection	2008
Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:9 Topics: 1-Methyl-4-phenylpyridinium; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Benzamides; Cations; Cell Line; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Isoquinolines; Lidocaine; Metformin; Organic Cation Transport Proteins; Procainamide; Quinidine; Rats	2008
Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1 Topics: Animals; Cell Line; Cell Membrane; Cell Size; Cimetidine; Cytoplasmic Vesicles; Dogs; Epithelial Cells; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Kidney; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Transfection	2009
The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010, Jan-31, Volume: 39, Issue:1-3 Topics: Antipyrine; Biological Transport, Active; Cimetidine; Female; Humans; Maternal-Fetal Exchange; Metformin; Organic Cation Transport Proteins; Perfusion; Placenta; Pregnancy	2010
Cimetidine-induced lactic acidosis and acute pancreatitis. Southern medical journal, 2010, Volume: 103, Issue:8 Topics: Acidosis, Lactic; Acute Disease; Cimetidine; Diabetes Mellitus, Type 2; Drug Interactions; Female; Gastroesophageal Reflux; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Pancreatitis; Recurrence	2010
Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection. Journal of chromatographic science, 2010, Volume: 48, Issue:9 Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Ethylamines; Famotidine; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Linear Models; Metformin; Methanol; Ranitidine; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tablets; Young Adult	2010
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; 3-Iodobenzylguanidine; Animals; Binding, Competitive; Biological Transport; Cephalexin; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Humans; Kidney; Kinetics; Liver; Male; Metformin; Mice; Mice, Inbred Strains; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pyridines; Tetraethylammonium; Transfection	2012
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2. American journal of physiology. Renal physiology, 2013, Jan-01, Volume: 304, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Androstenes; Animals; Benzhydryl Compounds; Carbazoles; Carvedilol; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperidines; Propanolamines; Tetraethylammonium	2013
Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin. Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:19 Topics: Acidosis, Lactic; Aged, 80 and over; Cimetidine; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Metformin; Pancreatitis; Severity of Illness Index	2013
Evidence for organic cation transporter-mediated metformin transport and 5'-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles. Metabolism: clinical and experimental, 2015, Volume: 64, Issue:2 Topics: 3-O-Methylglucose; AMP-Activated Protein Kinases; Animals; Biological Transport; Cimetidine; Energy Metabolism; Enzyme Activation; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Transport Modulators; Metformin; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Organic Cation Transport Proteins; Phosphorylation; Protein Processing, Post-Translational; Random Allocation; Rats, Wistar	2015
[Establishment of MDCK cell models expressing human MATE1 or co-expressing with human OCT1 or OCT2]. Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:7 Topics: Animals; Biological Transport; Cimetidine; DNA, Complementary; Dogs; Drug Interactions; Humans; Madin Darby Canine Kidney Cells; Metformin; Organic Cation Transport Proteins; Transfection	2015
Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Jun-10, Volume: 88 Topics: Anti-Ulcer Agents; Cimetidine; Computer Simulation; Drug Carriers; Drug Interactions; Electrochemistry; Hypoglycemic Agents; Kidney; Liver; Metformin; Models, Biological; Organic Cation Transport Proteins	2016
Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 359, Issue:3 Topics: Animals; Atenolol; Biological Transport; Cimetidine; Dogs; Drug Interactions; HEK293 Cells; Humans; Intracellular Space; Kidney; Madin Darby Canine Kidney Cells; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Pharmaceutical Preparations	2016
Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine. Molecular pharmaceutics, 2017, 09-05, Volume: 14, Issue:9 Topics: Animals; Biological Transport; Cell Line; Cimetidine; Dogs; HEK293 Cells; Humans; Kidney; Madin Darby Canine Kidney Cells; Memantine; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Receptors, N-Methyl-D-Aspartate	2017
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats. Life sciences, 2018, May-01, Volume: 200 Topics: Amines; Animals; Cimetidine; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Gabapentin; gamma-Aminobutyric Acid; Male; Metformin; Organic Cation Transporter 2; Rats; Rats, Wistar	2018
Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro. Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:9 Topics: Adipose Tissue, Brown; Animals; Cimetidine; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Metformin; Mice; Octamer Transcription Factor-3; Organic Cation Transport Proteins; Oxygen Consumption; Positron Emission Tomography Computed Tomography; Transcriptome	2018
Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates. Molecular pharmacology, 2018, Volume: 94, Issue:3 Topics: Animals; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Hypoglycemic Agents; Ligands; Metformin; Models, Chemical; Organic Cation Transporter 2; Protein Binding; Substrate Specificity	2018
Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition. Molecular pharmaceutics, 2018, 08-06, Volume: 15, Issue:8 Topics: Animals; Cimetidine; Dogs; Drug Interactions; HEK293 Cells; Humans; Kidney Tubules; Madin Darby Canine Kidney Cells; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Renal Elimination	2018
Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate). PloS one, 2018, Volume: 13, Issue:8 Topics: Alkynes; Animals; Area Under Curve; Benzoxazines; Cimetidine; Cyclopropanes; Dogs; Half-Life; HEK293 Cells; Humans; Kidney; Lamivudine; Madin Darby Canine Kidney Cells; Male; Metformin; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Cation Transport Proteins; Rats; Rats, Wistar; Renal Elimination; Reverse Transcriptase Inhibitors; ROC Curve	2018
Environmental risk assessment of metformin and its transformation product guanylurea. I. Environmental fate. Chemosphere, 2019, Volume: 216 Topics: Animals; Biodegradation, Environmental; Cimetidine; Humans; Hypoglycemic Agents; Metformin; Risk Assessment; Water Pollutants, Chemical	2019
Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine. CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:6 Topics: Algorithms; Biological Transport; Cimetidine; Drug Interactions; Humans; Kidney; Metabolic Clearance Rate; Metformin; Models, Biological	2019
A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals. Clinical pharmacokinetics, 2020, Volume: 59, Issue:11 Topics: Adult; Cimetidine; Drug Interactions; Humans; Hypoglycemic Agents; Metformin; Pharmacogenetics; Renal Insufficiency, Chronic	2020
Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability. Pharmaceutical research, 2020, Jun-08, Volume: 37, Issue:7 Topics: Animals; Biofilms; Biological Transport; Cell Adhesion; Cells, Cultured; Cimetidine; Diffusion; Dogs; Humans; Hydrogen-Ion Concentration; Lopinavir; Madin Darby Canine Kidney Cells; Metformin; Pyrimethamine; Quinidine	2020
Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. Iranian journal of allergy, asthma, and immunology, 2021, Sep-28, Volume: 20, Issue:5 Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cimetidine; Disease Models, Animal; Female; Humans; Ibuprofen; Immunomodulation; Metformin; Mice; T-Lymphocyte Subsets; T-Lymphocytes	2021
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2023, Volume: 53, Issue:2 Topics: Animals; Cimetidine; Humans; Kidney; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats	2023