metformin has been researched along with chitosan in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.44) | 29.6817 |
| 2010's | 24 (58.54) | 24.3611 |
| 2020's | 16 (39.02) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, B; Liu, CH; Meng, XM; Wang, XJ; Xia, XK; Yuan, WP; Zhang, MS | 1 |
| Di, LQ; Liu, R; Wang, LC; Wu, H | 1 |
| Diez-Sales, O; Fadda, AM; Manca, ML; Manconi, M; Merino, V; Merino-Sanjuan, M; Mura, C; Mura, S; Nácher, A | 1 |
| Baldursdottir, S; Jacobsen, J; Madsen, KD; Pedersen, AM; Sander, C | 1 |
| Li, L; Mao, S; Ni, R; Shao, Y; Wang, L; Zhang, T | 1 |
| Hyrup, B; Jacobsen, J; Madsen, KD; Nielsen, HM; Rantanen, J; Sander, C | 1 |
| Jacobsen, J; Nielsen, HM; Sander, C | 1 |
| Jayakumar, R; Lakshmanan, VK; Nair, SV; Snima, KS; Unnikrishnan, AG | 1 |
| Jayakumar, R; Lakshmanan, VK; Snima, KS | 1 |
| Cetin, M; Gundogdu, N | 1 |
| Chen, SM; Chou, CK; Lee, JA; Li, YC; Shih, YM | 1 |
| Shen, Q; Xu, Q; Yi, C; Zhu, T | 2 |
| Cho, CS; Cho, MH; Cui, PF; Jiang, HL; Li, P; Qiao, JB; Shi, K; Wang, FZ; Xie, ZS; Xing, L; Xu, X; Zhang, BF; Zhang, JL | 1 |
| Bajaj, L; Jain, UK; Katare, OP; Madan, J; Pandey, RS; Saini, N; Sodhi, RK | 1 |
| Kasacka, I; Lewandowska, A; Sosnowska, K; Szekalska, M; Winnicka, K; Zakrzeska, A | 1 |
| Karasik, D; Khajuria, DK; Patil, ON; Razdan, R | 1 |
| Arafa, K; El-Gazayerly, ON; El-Sherbiny, IM; Shamma, RN | 1 |
| Dai, Q; Huang, H; Liu, Y; Long, R; Wang, S; Wu, K; Xia, Y; Zhou, X | 1 |
| Murtaza, G; Ubaid, M | 2 |
| Khan, SA; Murtaza, G; Shah, SNH; Ubaid, M | 1 |
| Chinnaiyan, SK; Deivasigamani, K; Gadela, VR | 1 |
| Chen, W; Fan, J; Hao, Q; Jin, X; Ju, D; Liu, H; Luan, J; Mei, X; Tang, S; Wu, Z; Zai, W; Zhang, X | 1 |
| De, A; Jaiswal, A; Kuppuswamy, G | 1 |
| Arun, G; Gayathri, N; Kaleshkumar, K; Kandasamy, S; Rajaram, R; Sivasudha, T | 1 |
| Deng, D; Li, J; Wu, Y; Ye, H; Zhu, J | 1 |
| Chan, A; Gupta, V; Parvathaneni, V; Shukla, SK | 1 |
| Ezati, M; Faghihi, S; Hashemi, A; Houshmand, B; Mohammadnejad, J | 1 |
| Alami-Milani, M; Jelvehgari, M; Salatin, S | 1 |
| Chin, D; Chung, EJ; Hallows, KR; Ho, PY; Li, H; Mancino, V; Pham, J; Poon, C; Wang, J | 1 |
| Ghourchian, H; Khatibi, A; Lari, AS; Zahedi, P | 1 |
| Abd El-Hameed, AM; Abd El-Twab, SM; Abdel-Moneim, A; El-Shahawy, AAG; Yousef, AI | 1 |
| Li, C; Tan, W; Wu, K; Xiao, L; Xu, W; Zeng, X | 1 |
| Bi, W; Cai, S; Deng, S; Du, H; Lei, T; Sun, S; Xiao, Z; Yang, Y; Zhang, X | 1 |
| Liu, Y; Shi, K; Sun, D; Sun, H; Wang, F; Zhang, X; Zuo, B | 1 |
| Jiang, X; Liu, Y; Luo, W; Qi, X; Shen, J; Xiang, X; Zheng, C; Zhou, Z | 1 |
| Akbari, I; Gharati, G; Yari, K | 1 |
| Chen, S; Hao, H; Hu, R; Li, M; Liu, S; Lu, W; Wang, L; Wu, Z; Yu, L | 1 |
| Dasuni Wasana, PW; Rojsitthisak, P; Towiwat, P; Vajragupta, O | 1 |
| Chen, X; Deng, J; Hu, X; Li, D; Peng, M; Xiao, D; Xie, L; Xie, Y; Yang, X; Zhang, X | 1 |
41 other study(ies) available for metformin and chitosan
| Article | Year |
|---|---|
Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Cell Line; Chitin; Chitosan; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Insulin-Secreting Cells; Islets of Langerhans; Male; Malondialdehyde; Metformin; Mice; Mice, Inbred NOD; Oligosaccharides; Rats; Rats, Wistar; Streptozocin; Superoxide Dismutase | 2009 |
Characterizations and microsphere formulation of polysaccharide from the marine clam (Mactra veneriformis).
Topics: Administration, Intranasal; Animals; Aquatic Organisms; Bivalvia; Chitosan; Drug Delivery Systems; Metformin; Microspheres; Particle Size; Polysaccharides; X-Ray Diffraction | 2013 |
Improving oral bioavailability and pharmacokinetics of liposomal metformin by glycerolphosphate-chitosan microcomplexation.
Topics: Adhesiveness; Administration, Oral; Animals; Area Under Curve; Biological Availability; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Drug Carriers; Gastric Mucosa; Glycerophosphates; Hypoglycemic Agents; Intestinal Absorption; Intestinal Mucosa; Liposomes; Male; Metformin; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Rats; Rats, Wistar; Rheology; Solubility; Technology, Pharmaceutical; X-Ray Diffraction | 2013 |
Development of an ex vivo retention model simulating bioadhesion in the oral cavity using human saliva and physiologically relevant irrigation media.
Topics: Adhesiveness; Administration, Buccal; Adult; Animals; Chitosan; Drug Carriers; Drug Compounding; Drug Delivery Systems; Female; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Male; Metformin; Microspheres; Mouth Mucosa; Rheology; Saliva; Species Specificity; Surface Tension; Swine; Young Adult | 2013 |
Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film.
Topics: Acetaminophen; Alginates; Cellulose; Chitosan; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Metformin; Osmolar Concentration; Stearic Acids; Tablets; Theophylline; Trimetazidine | 2013 |
Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration.
Topics: Adhesiveness; Animals; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Compounding; Drug Delivery Systems; Hypoglycemic Agents; Metformin; Microspheres; Models, Biological; Molecular Weight; Mouth Mucosa; Particle Size; Rheology; Swine | 2013 |
Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement.
Topics: Adhesives; Cell Culture Techniques; Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Delivery Systems; Epithelium; Humans; Metformin; Mouth Mucosa; Permeability; Solutions | 2013 |
O-carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells.
Topics: Cell Line, Tumor; Chitosan; Drug Carriers; Hemolysis; Humans; Metformin; Microscopy, Electron, Scanning; Nanoparticles; Pancreatic Neoplasms | 2012 |
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Chitosan; Colony-Forming Units Assay; Drug Compounding; Humans; Hypoglycemic Agents; Materials Testing; Metformin; Mice; Pancreatic Neoplasms; RNA, Messenger; Tissue Distribution | 2014 |
Chitosan-poly (lactide-co-glycolide) (CS-PLGA) nanoparticles containing metformin HCl: preparation and in vitro evaluation.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chitosan; Lactic Acid; Metformin; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Spectroscopy, Fourier Transform Infrared | 2014 |
Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway.
Topics: Animals; Blood Urea Nitrogen; Chitosan; Gentamicins; Humans; Kidney; Kidney Diseases; Metabolic Networks and Pathways; Metformin; Oxidative Stress; Pyruvaldehyde; Rats; Renal Dialysis | 2015 |
Characterization and evaluation of metformin-loaded solid lipid nanoparticles for celluar and mitochondrial uptake.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Chitosan; Chromatography, High Pressure Liquid; Drug Carriers; Female; Humans; Lipids; Male; MCF-7 Cells; Metformin; Mitochondria; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Solubility | 2016 |
Characterization and evaluation of metformin-loaded solid lipid nanoparticles for celluar and mitochondrial uptake.
Topics: Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Humans; Kinetics; Lipids; MCF-7 Cells; Metformin; Mitochondria; Nanoparticles; Particle Size; Solubility | 2016 |
Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Chitosan; Diabetes Mellitus, Type 2; Endocytosis; Fatty Liver; Genetic Therapy; Genetic Vectors; Glucose Tolerance Test; Hep G2 Cells; Homeostasis; Humans; Imines; Lipids; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Microscopy, Confocal; Nanostructures; Oxygen; Phenotype; Polymers; Prodrugs; RNA, Messenger; RNA, Small Interfering; Static Electricity; Sterol Regulatory Element Binding Protein 1 | 2015 |
Intravaginal administration of metformin hydrochloride loaded cationic niosomes amalgamated with thermosensitive gel for the treatment of polycystic ovary syndrome: In vitro and in vivo studies.
Topics: Adhesiveness; Administration, Intravaginal; Animals; Cations; Chitosan; Drug Liberation; Female; Gels; Glycerophosphates; Hormones; Liposomes; Metformin; Mucus; Particle Size; Polycystic Ovary Syndrome; Rats, Wistar; Static Electricity; Sus scrofa; Temperature; Viscosity | 2016 |
The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation.
Topics: Alginates; Animals; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Drug Carriers; Drug Compounding; Glucuronic Acid; Hexuronic Acids; Kidney; Liver; Male; Metformin; Pancreas; Particle Size; Rats; Rats, Wistar; Streptozocin | 2017 |
Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model.
Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Chitosan; Disease Models, Animal; Drug Implants; Male; Materials Testing; Metformin; Microscopy, Electron, Scanning; Periodontitis; Porphyromonas gingivalis; Rats; Rats, Wistar; Surface Properties; X-Ray Diffraction | 2018 |
Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy.
Topics: Cell Line, Tumor; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Liberation; Humans; Metformin; Nanoparticles; Particle Size | 2018 |
The influence of spatial distribution on add-on therapy of designed Ca-Alg/CS MEMs system.
Topics: Alginates; Biocompatible Materials; Capsules; Chitosan; Diabetes Mellitus; Drug Carriers; Drug Liberation; Drug Therapy, Combination; Gels; Hypoglycemic Agents; Insulin; Metformin; Microspheres; Particle Size; Surface Properties | 2018 |
In vitro Evaluation of Genipin-crosslinked Na-alginate/Chitosan Hydrogel Films for Delivery of Metformin: Effect of Chitosan Molecular Weight.
Topics: Alginates; Chitosan; Cross-Linking Reagents; Drug Liberation; Gastric Juice; Glucuronic Acid; Hexuronic Acids; Hydrogels; Hypoglycemic Agents; Intestinal Secretions; Iridoids; Metformin | 2018 |
Fabrication and characterization of genipin cross-linked chitosan/gelatin hydrogel for pH-sensitive, oral delivery of metformin with an application of response surface methodology.
Topics: Administration, Oral; Animals; Chitosan; Delayed-Action Preparations; Gelatin; Hydrogen-Ion Concentration; Iridoids; Male; Metformin; Rabbits | 2018 |
Synthesis and Characterization of pH-Sensitive Genipin Cross-Linked Chitosan/Eudragit® L100 Hydrogel for Metformin Release Study Using Response Surface Methodology.
Topics: Acrylates; Animals; Chitosan; Cross-Linking Reagents; Drug Liberation; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogen-Ion Concentration; Iridoids; Male; Metformin; Particle Size; Polymers; Rabbits; Regression Analysis; Surface Properties | 2018 |
Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.
Topics: Animals; Cell Line; Chemical Phenomena; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Drug Compounding; Drug Liberation; Glucose; Humans; Metformin; Muscle Fibers, Skeletal; Nanoparticles; Particle Size; Pectins; Rats | 2019 |
Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease.
Topics: Animals; Cell-Penetrating Peptides; Chitosan; Diet, High-Fat; Disease Models, Animal; Gene Transfer Techniques; Hep G2 Cells; Humans; Interleukin-22; Interleukins; Male; Metformin; Mice; Mice, Inbred C57BL; Nanoparticles; Non-alcoholic Fatty Liver Disease | 2019 |
Implementation of two different experimental designs for screening and optimization of process parameters for metformin-loaded carboxymethyl chitosan formulation.
Topics: Breast Neoplasms; Cell Survival; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Compounding; Drug Liberation; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Metformin; Nanoparticles; Particle Size; Research Design; Toxicity Tests | 2019 |
Synergistic effect of novel chitosan combined metformin drug on streptozotocin-induced diabetes mellitus rat.
Topics: alpha-Amylases; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Synergism; Insulin; Male; Metformin; Rats; Rats, Wistar | 2020 |
Electrospun metformin-loaded polycaprolactone/chitosan nanofibrous membranes as promoting guided bone regeneration membranes: Preparation and characterization of fibers, drug release, and osteogenic activity in vitro.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Bone Regeneration; Cell Proliferation; Chitosan; Cross-Linking Reagents; Drug Delivery Systems; Drug Liberation; Guided Tissue Regeneration; Membranes, Artificial; Metformin; Nanofibers; Osteogenesis; Polyesters; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical | 2020 |
Metformin-loaded chitosomes for treatment of malignant pleural mesothelioma - A rare thoracic cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; Drug Liberation; Humans; Mesothelioma, Malignant; Metformin; Thoracic Cavity; Thoracic Neoplasms; X-Ray Diffraction | 2020 |
Chitosan Coating of TiO2 Nanotube Arrays for Improved Metformin Release and Osteoblast Differentiation.
Topics: Alkaline Phosphatase; Animals; Cell Adhesion; Cell Differentiation; Cell Proliferation; Cell Shape; Chitosan; Drug Liberation; Humans; Mesenchymal Stem Cells; Metformin; Nanotubes; Osteoblasts; Osteogenesis; Rats, Wistar; Titanium; Wettability | 2020 |
Expert design and optimization of a novel buccoadhesive blend film impregnated with metformin nanoparticles.
Topics: Animals; Biological Availability; Chitosan; Drug Carriers; Drug Delivery Systems; Metformin; Nanoparticles; Particle Size; Sheep | 2020 |
Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease.
Topics: Administration, Oral; Animals; Chitosan; Drug Carriers; Drug Delivery Systems; Humans; Metformin; Mice; Nanoparticles; Polycystic Kidney Diseases | 2021 |
Microfluidic-based synthesized carboxymethyl chitosan nanoparticles containing metformin for diabetes therapy: In vitro and in vivo assessments.
Topics: Animals; Blood Glucose; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; Metformin; Microfluidics; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2021 |
Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Glucose; Glucosides; Inflammation; Lipid Peroxidation; Liver; Male; Metformin; Nanoparticles; Niacinamide; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Stilbenes; Streptozocin | 2021 |
Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis.
Topics: Alveolar Process; Animals; Bone Marrow Cells; Bone Regeneration; Calcium Phosphates; Cell Survival; Chitosan; Male; Metformin; Periodontitis; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Stem Cells; Tissue Scaffolds | 2021 |
Chitosan Hydrogel Supplemented with Metformin Promotes Neuron-like Cell Differentiation of Gingival Mesenchymal Stem Cells.
Topics: Cell Differentiation; Cells, Cultured; Chitosan; Gingiva; Humans; Hydrogels; Mesenchymal Stem Cells; Metformin; Neurons | 2022 |
Kidney-Targeted Drug Delivery System Based on Metformin-Grafted Chitosan for Renal Fibrosis Therapy.
Topics: Chitosan; Drug Carriers; Drug Delivery Systems; Fibrosis; Humans; Kidney; Low Density Lipoprotein Receptor-Related Protein-2; Metformin; Nanoparticles | 2022 |
Metformin modified chitosan as a multi-functional adjuvant to enhance cisplatin-based tumor chemotherapy efficacy.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; B7-H1 Antigen; Cell Line, Tumor; Chitosan; Cisplatin; Drug Resistance, Neoplasm; Humans; Metformin; Neoplasms | 2023 |
Evaluating effect of salt leaching method on release and swelling rate of metformin nanoparticles loaded-chitosan/polyvinyl alcohol porous composite.
Topics: Chitosan; Hydrogels; Metformin; Nanoparticles; Polymers; Polyvinyl Alcohol; Porosity; Sodium Chloride; Spectroscopy, Fourier Transform Infrared | 2023 |
Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect.
Topics: Animals; Biological Availability; Chitosan; Diabetes Mellitus, Type 2; Dogs; Hypoglycemic Agents; Intestines; Metformin; Nanoparticles; Rats | 2022 |
Metformin and curcumin co-encapsulated chitosan/alginate nanoparticles as effective oral carriers against pain-like behaviors in mice.
Topics: Alginates; Animals; Caco-2 Cells; Chitosan; Curcumin; Drug Carriers; Humans; Metformin; Mice; Nanoparticles; Particle Size | 2023 |
Metformin-Loaded Chitosan Hydrogels Suppress Bladder Tumor Growth in an Orthotopic Mouse Model via Intravesical Administration.
Topics: Administration, Intravesical; Animals; Chitosan; Disease Models, Animal; Hydrogels; Metformin; Mice; Urinary Bladder; Urinary Bladder Neoplasms | 2023 |