metformin and biguanides

metformin has been researched along with biguanides in 155 studies

Research

Studies (155)

Timeframe	Studies, this research(%)	All Research%
pre-1990	70 (45.16)	18.7374
1990's	13 (8.39)	18.2507
2000's	24 (15.48)	29.6817
2010's	42 (27.10)	24.3611
2020's	6 (3.87)	2.80

Authors

Authors	Studies
Biron, P	1
Schwandt, P; Weisweiler, P	1
Eggstein, M; Luft, D; Schmülling, RM	1
Teijgeler, CA; van Gestel, WJ	1
Goebel, R; Pilger, E; Schmid, P	2
Aro, A; Idänpään-Heikkilä, J; Korhonen, T	1
Kowalik-Borówka, E; Tatoń, J	1
Aro, A	1
Alberti, KG; Nattrass, M	1
Bartosiewicz, W; Czyzyk, A; Lao, B; Orlowska, K; Szczepanik, Z	1
Morgan, DB; Wales, JK; Waters, AK	1
Foltin, E; Irsigler, K; Kritz, H; Regal, H	1
Bartosiewicz, W; Czyzyk, A; Lao, B; Orłowska, K; Szczepanik, Z	1
Kimbel, KH	1
Bolzano, K	1
Bruneder, H; Klein, HJ	1
Agid, R; Estève, B; Marquié, G	1
Caspary, WF; Deuticke, U; Emrich, D; Reimold, W; Willms, B; Zavada, I	1
Isnard, F; Lavieuville, M	1
Botha, JL; Jackson, WP; Vinik, AI	1
Jerums, G	1
Förster, H	1
Berger, W; Heierli, C; Mehnert-Aner, S; Mülly, K; Ritz, R	1
Forshan, PH; Karam, JH; Matin, SB	1
Madhavan, R; Sankaran, JR; Seshasaianam, C; Seshiah, V; Shanker, R; Sundaram, A; Venkataraman, S	1
Aguilar, C; García, JE; Reza, A; Rull, JA	1
Arieff, AI; Barr, J; Gan, SC; Pearl, RG	1
Mehnert, H	2
Saraiva, AM	1
Bowden, CR; Jordan, AD; Marchione, CS; Maryanoff, BE; Reitz, AB; Tuman, RW	1
Liang, JZ; Luo, ZT; Yang, DP	1
Kenworthy, CW	1
Chakrabarti, R; Fearnley, GR; Hocking, ED	1
Katsilambros, N; Nierle, C; Pfeiffer, EE; Schatz, H	1
Jahn, P; Kraaz, W; Loge, O; Losert, W; Schillinger, E	2
Corsini, GU; Muntoni, S; Sirigu, F; Tagliamonte, P	1
Lopis, S; Schneider, T	1
Cucurachi, L; Cucurachi, P; Dell'Anna, A; Strata, A; Zuliani, U	1
Berger, W; Eisner, M	1
Gormsen, J	1
Herbert, V	1
Garrett, ER; Tsau, J	1
Garrett, ER; Hinderling, PH; Tsau, J	1
Fearnley, GR	1
Bianchini, P; Bramanti, G; De Fina, V; Dell'Omodarme, G	1
Lao, B; Okniński, W	1
Chakrabarti, R; Evans, J; Fearnley, GR; Hocking, ED	1
Beckmann, R	1
Laastuen, L; Todd, WR	1
Bewsher, PD; Stowers, JM	1
Dérot, M; Rathery, H; Rathery, M	1
Irsigler, K	1
Tatoń, J	1
Plauchu, M; Thevenon, P	1
Haese, E	1
Berger, W; Constam, GR; Siegenthaler, W	1
Saito, T; Yoshida, S	1
Lunetta, M; Mughini, L; Mughini, MT; Presti, C	1
Adams, JF; Clark, JS; Ireland, JT; Kesson, CM; Watson, WS	1
Angeli, G; Baraldi, B; Carobbio, C; Cocuzza, E; Colloredo Mels, G; D'Amore, V; Maestri, G	1
Goldfine, ID; Pezzino, V; Vigneri, R; Wong, KY	1
Bisesti, V; Giugliano, D; Passariello, N; Saccomanno, F; Sgambato, S	1
Aro, A; Huttunen, JK; Järvinen, R; Juvonen, H; Korhonen, T; Palomäki, P; Ritala, P; Siitonen, O	1
Chen, S; Stucki, JW; Ubl, JJ	1
Bjelajac, A; Carson, DS; Goo, AK	1
Kawamori, R; Yoshii, H	1
Howes, LG; Lykos, D; Sundaresan, P	1
Haupt, E; Panten, U	1
Carmellini, M; Coppelli, A; Del Guerra, S; Giannarelli, R; Lorenzetti, M; Lupi, R; Marchetti, P; Mosca, F; Navalesi, R; Tellini, C	1
Fujimoto, S	2
Detaille, D; Devos, P; Wiernsperger, N	1
McNeill, JH; Orvig, C; Thompson, KH; Woo, LC; Yuen, VG	1
Kuritzky, L; Quillen, DM; Samraj, G	1
André, P; Bard, JM; Charles, MA; Eschwege, E; Fruchart, JC; Juhan-Vague, I; Safar, M; Vague, P	1
Arlt, W; Auchus, RJ; Miller, WL	1
Inzucchi, SE	1
Neye, H	1
Shiba, T	1
Kuroda, A; Yamasaki, Y	1
Kitamura, R; Tanaka, Y	1
Inoue, T; Kira, K; Nagakura, T; Saeki, T; Tanaka, I; Yamazaki, K; Yasuda, N	2
Sakura, H	1
Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS	1
Grimaud, D; Ichai, C; Levraut, J; Samat-Long, C	1
Lockwood, TD; Raymer, ML; Sweeney, D	1
AKAZAWA, Y	1
LEMARCHANT, JM; TEITELBAUM, M	1
JAKSIC, Z; MICULINIC, R; SKRABALO, Z	1
PUCHEGGER, R	1
OKER, C	1
BESSE, J; BILLAUD, L; LESTRADET, H	1
Fonseca, VA; Jawa, AA	1
Ishida, W; Satoh, J	1
Daida, H; Kume, A; Miyazaki, T	1
Chatti, O; Ghaddab, A; Ichai, C; Orban, JC	1
Cai, Y; Finsi, J; Heimberg, H; Hinke, SA; Martens, GA; Pipeleers, D; Van de Casteele, M	1
Miwa, T; Notoya, Y; Odawara, M; Suzuki, T	1
Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI	1
Fisman, EZ; Motro, M; Tenenbaum, A	1
Pollak, M	1
Anisimov, VN	1
Sørensen, LK	1
Kitamura, A; Komuro, S; Sogame, Y; Yabuki, M	1
Beauchamp, MC; Gotlieb, WH; Pollak, M; Rosenblatt, J; Segal, ED; Yasmeen, A	1
Fouladi, RF; Navali, N; Nikpour, MA; Pourabolghasem, S	1
Choi, MG; Jung, JS; Kang, YJ; Kim, CH; Kim, SJ; Kim, SS; Park, SH; Ryu, OH; Sim, YB; Suh, HW	1
Thompson, HJ; Thompson, MD	1
Birnbaum, MJ; Chu, Q; Foretz, M; Miller, RA; Viollet, B; Xie, J	1
Bakris, GL; Flynn, C	1
Kopecky, C	1
Au, C; Cabreiro, F; Cochemé, HM; Gems, D; Greene, ND; Leung, KY; Noori, T; Schuster, E; Vergara-Irigaray, N; Weinkove, D	1
Gong, Y; Inagaki, N; Kagimura, T; Murai, M; Patel, S; Watada, H; Woerle, HJ	1
Sheehan, ME; Wagner, LF	1
Brejchova, J; Cahova, M; Cervinkova, Z; Drahota, Z; Endlicher, R; Kalous, M; Kazdova, L; Milerova, M; Palenickova, E; Svoboda, P; Vosahlikova, M	1
Czlonkowski, A; Filipiak, KJ; Kaplon-Cieslicka, A; Opolski, G; Postula, M; Rosiak, M; Trzepla, E	1
Asara, JM; German, NJ; Gonzalez-Herrera, KN; Haigis, MC; Janzer, A; Struhl, K	1
Bridges, HR; Hirst, J; Jones, AJ; Pollak, MN	1
Fontaine, E	1
Birman, E; Blouin, MJ; Gravel, SP; Hulea, L; Pollak, M; St-Pierre, J; Toban, N; Topisirovic, I; Zakikhani, M; Zhao, Y	1
Emami-Riedmaier, A; Mörike, K; Nies, AT; Schaeffeler, E; Schwab, M	1
Bunting, KD; Cooper, TM; Liu, X; Qu, CK; Yu, WM; Zheng, H	1
Araki, E; Broedl, UC; Kim, G; Koiwai, K; Salsali, A; Tanaka, Y; Taniguchi, A; Tanizawa, Y; Woerle, HJ	1
Cabreiro, F; Pryor, R	1
Alstrup, AK; Busk, M; Frøkiær, J; Jakobsen, S; Jensen, JB; Jessen, N; Munk, OL; Zois, NE	1
Cui, H; Schröder, P	1
Abbas, SY; Abdel-Rahman, RF; Basyouni, WM; El-Bayouki, KA	1
Andreeff, M; Bornmann, W; Duque, JE; Enciso, L; Jaramillo, D; Konopleva, M; Krystal, G; Lee, JT; Lopez, C; Morales, L; Pan, R; Samudio, I; Suarez, M; Velez, J	1
Futatsugi, A; Kato, Y; Kawabata, S; Masuo, Y; Nakamichi, N	1
Langmaier, J; Pižl, M; Samec, Z; Záliš, S	1
Lin, HK; Zhang, X	1
Salehi, R; Samadi, N; Shafiei-Irannejad, V; Yousefi, B; Zarghami, N	1
Abbas, SY; Aly, HF; Arafa, A; Basyouni, WM; El-Bayouk, KAM; Soliman, MS; Tohamy, WM	1
Coutinho, AL; Obianom, ON; Shu, Y; Xue, F; Yang, H; Yang, W	1
Inzucchi, SE; Sanchez-Rangel, E	1
Bailey, CJ	1
Hardie, DG; Pearson, ER; Rena, G	1
Centurión, D; Gutiérrez-Lara, EJ; Navarrete-Vázquez, G; Sánchez-López, A	1
Alan, L; Drahota, Z; Houstek, J; Kovalcikova, J; Kovarova, N; Mracek, T; Pecina, P; Pecinova, A; Zima, M	1
Abbas, SY; Aly, HF; Arafa, A; Basyouni, WM; El Shehry, MF; El-Bayouki, KAM; Soliman, MS	1
Hébrant, M; Herzog, G; Hussin, MH; Jajuli, MN; Rahim, AA; Saad, B	1
Hotta, N	1
Bharatam, PV; Kathuria, D; Raul, AD; Wanjari, P	1
Al-Salami, H; Atlas, MD; Brown, D; Chester, J; Foster, T; Ionescu, CM; Johnston, E; Jones, M; Kovacevic, B; Kuthubutheen, J; Mikov, M; Mooranian, A; Wagle, SR; Walker, D	1
Jimura, F; Kachi, N; Tamaki, H; Tsushima, H	1
Blaza, JN; Bridges, HR; Chung, I; Hirst, J; Pollak, MN; Yin, Z	1
Arredondo-Espinoza, EU; Balderas-Renteria, I; Carranza-Rosales, P; Espinosa-Rodriguez, BA; Mendez-Lopez, LF; Ramirez-Cabrera, MA; Ramirez-Estrada, K; Treviño-Almaguer, D	1
Akai, Y; Higashino, T; Imamura, T; Ishii, H; Kubo, S; Mohri, T; Myojin, T; Nishioka, Y; Noda, T; Okada, S; Okamoto, S	1

Reviews

36 review(s) available for metformin and biguanides

Article	Year
Lactic acidosis in biguanide-treated diabetics: a review of 330 cases. Diabetologia, 1978, Volume: 14, Issue:2 Topics: Acidosis; Biguanides; Buformin; Diabetes Complications; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactates; Metformin; Phenformin	1978
Biguanide-associated lactic acidosis. Case report and review of the literature. Archives of internal medicine, 1992, Volume: 152, Issue:11 Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Emigration and Immigration; Humans; Indonesia; Kidney Failure, Chronic; Male; Metformin; Middle Aged; United States	1992
[Biguanides in the treatment of diabetes mellitus]. Acta medica portuguesa, 1989, Volume: Suppl 1 Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus; Humans; Lipid Metabolism; Metformin	1989
[Pharmacokinetics of blood glucose lowering biguanide derivatives]. Acta diabetologica latina, 1969, Volume: 6 Suppl 1 Topics: Animals; Biguanides; Blood Glucose; Guinea Pigs; Humans; Hypoglycemic Agents; Kinetics; Metformin; Mice; Phenformin; Protein Binding; Rabbits; Rats; Species Specificity; Time Factors; Tritium	1969
[Behavior of lactate and pyruvate in diabetics during ambulatory treatment with biguanides or with a combination of biguanides and sulfonylureas. II]. La Clinica terapeutica, 1980, Jun-30, Volume: 93, Issue:6 Topics: Aged; Ambulatory Care; Biguanides; Diabetes Mellitus; Diabetic Ketoacidosis; Drug Combinations; Female; Glyburide; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Pyruvates; Sulfonylurea Compounds	1980
Metformin: a new treatment option for non-insulin-dependent diabetes mellitus. The Journal of family practice, 1996, Volume: 42, Issue:6 Topics: Biguanides; Diabetes Mellitus, Type 2; Drug Interactions; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Sulfonylurea Compounds	1996
[Drug therapy in subjects with impaired glucose tolerance]. Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:10 Topics: Acarbose; Biguanides; Chromans; Diabetes Mellitus, Type 2; Glucose Intolerance; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Insulin Resistance; Metformin; Pioglitazone; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone	1996
Cardiovascular effects of oral hypoglycaemic drugs. Clinical and experimental pharmacology & physiology, 1996, Volume: 23, Issue:3 Topics: Biguanides; Diabetes Mellitus, Type 2; Glyburide; Heart; Hemodynamics; Humans; Hypoglycemic Agents; Lipoproteins; Metformin; Myocardial Contraction; Potassium Channel Blockers; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide	1996
[Value of biguanide in therapy of diabetes mellitus]. Medizinische Klinik (Munich, Germany : 1983), 1997, Aug-15, Volume: 92, Issue:8 Topics: Biguanides; Blood Glucose; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin	1997
[Therapeutic utility of biguanides in the treatment of NIDDM]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:3 Topics: Biguanides; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin	1999
Improving management of type 2 diabetes mellitus: 2. Biguanides. Hospital practice (1995), 1999, Oct-15, Volume: 34, Issue:11 Topics: Biguanides; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin	1999
Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA, 2002, Jan-16, Volume: 287, Issue:3 Topics: Administration, Oral; Biguanides; Blood Glucose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Diet; Drug Therapy, Combination; Enzyme Inhibitors; Exercise; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	2002
[Therapeutic renaissance. Biguanides in type-2 diabetes: metformin]. Pharmazie in unserer Zeit, 2002, Volume: 31, Issue:3 Topics: Animals; Biguanides; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Liver; Metformin	2002
[Structure and mechanisms of action of biguanides]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Animals; Biguanides; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Intestinal Absorption; Lipid Peroxidation; Liver; Metformin	2002
[Metformin--its regimen and effects]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Acarbose; Biguanides; Clinical Trials as Topic; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Nateglinide; Patient Selection; Phenylalanine; Sulfonylurea Compounds; Treatment Outcome	2002
[Adverse effect of biguanides]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Gastrointestinal Diseases; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Phenformin; Vitamin B 12 Deficiency	2002
[Clinical usefulness of treatment with biguanide and insulin]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Biguanides; Buformin; Clinical Trials as Topic; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Prognosis	2002
[Combination therapy with biguanides]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10 Topics: Acarbose; Biguanides; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone	2002
Role of insulin secretagogues and insulin sensitizing agents in the prevention of cardiovascular disease in patients who have diabetes. Cardiology clinics, 2005, Volume: 23, Issue:2 Topics: Angioplasty, Balloon, Coronary; Animals; Biguanides; Blood Pressure; Chromans; Diabetic Angiopathies; Endothelium, Vascular; Fibrinolysis; Humans; Hypoglycemic Agents; Metformin; Oxidative Stress; Postprandial Period; Risk Factors; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Troglitazone	2005
[Characteristic of metformin for treatment of impaired glucose tolerance]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2 Topics: Arteriosclerosis; Biguanides; Diabetes Mellitus, Type 2; Glucose; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Lipid Metabolism; Metformin; Randomized Controlled Trials as Topic	2005
[Treatment for coronary artery disease patients with impaired glucose tolerance]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2 Topics: Acarbose; Biguanides; Coronary Artery Bypass; Coronary Artery Disease; Glucose Intolerance; Glycoside Hydrolase Inhibitors; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Life Style; Metformin; Risk; Thiazolidinediones	2005
[Metformin-associated lactic acidosis]. Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:10 Topics: Acidosis, Lactic; Biguanides; Humans; Hypoglycemic Agents; Metformin	2006
[Biguanides]. Nihon rinsho. Japanese journal of clinical medicine, 2006, Dec-28, Volume: 64 Suppl 9 Topics: Biguanides; Humans; Hypoglycemic Agents; Metabolic Syndrome; Metformin	2006
Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects. Advances in cardiology, 2008, Volume: 45 Topics: Benzamides; Biguanides; Coronary Disease; Diabetic Angiopathies; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds; Thiazolidinediones	2008
Metformin and other biguanides in oncology: advancing the research agenda. Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:9 Topics: Animals; Antineoplastic Agents; Biguanides; Biomedical Research; Humans; Hypoglycemic Agents; Medical Oncology; Metformin; Neoplasms	2010
Metformin for aging and cancer prevention. Aging, 2010, Volume: 2, Issue:11 Topics: Aging; Animals; Antineoplastic Agents; Biguanides; Caloric Restriction; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin-Like Growth Factor I; Life Expectancy; Longevity; Metformin; Neoplasms	2010
A systems pharmacokinetic and pharmacodynamic approach to identify opportunities and pitfalls in energy stress-mediated chemoprevention: the use of metformin and other biguanides. Current drug targets, 2012, Volume: 13, Issue:14 Topics: Animals; Biguanides; Chemoprevention; Energy Metabolism; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Oxidative Stress	2012
Noninsulin glucose-lowering agents for the treatment of patients on dialysis. Nature reviews. Nephrology, 2013, Volume: 9, Issue:3 Topics: Adamantane; Biguanides; Diabetic Nephropathies; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Glucagon-Like Peptides; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Linagliptin; Meglumine; Metformin; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Renal Dialysis; Renal Insufficiency, Chronic; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome; Triazoles; Uracil; Vildagliptin	2013
Use of noninsulin antidiabetic medications in hospitalized patients. Critical care nursing clinics of North America, 2013, Volume: 25, Issue:1 Topics: Benzamides; Biguanides; Bromocriptine; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Glycoside Hydrolase Inhibitors; Hospitalization; Humans; Hypoglycemia; Hypoglycemic Agents; Incretins; Islet Amyloid Polypeptide; Metformin; Sulfonylurea Compounds; Thiazolidinediones	2013
Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here? Journal of internal medicine, 2015, Volume: 277, Issue:2 Topics: Administration, Oral; Biguanides; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Global Health; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Polymorphism, Genetic; Thiazolidinediones; Treatment Outcome	2015
Repurposing metformin: an old drug with new tricks in its binding pockets. The Biochemical journal, 2015, Nov-01, Volume: 471, Issue:3 Topics: Biguanides; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Metformin; Neoplasms; Proteins	2015
New insights into antidiabetic drugs: Possible applications in cancer treatment. Chemical biology & drug design, 2017, Volume: 90, Issue:6 Topics: AMP-Activated Protein Kinase Kinases; Biguanides; Cell Proliferation; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Protein Serine-Threonine Kinases; Sulfonylurea Compounds; Thiazolidinediones	2017
Metformin: clinical use in type 2 diabetes. Diabetologia, 2017, Volume: 60, Issue:9 Topics: Animals; Biguanides; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin	2017
The mechanisms of action of metformin. Diabetologia, 2017, Volume: 60, Issue:9 Topics: AMP-Activated Protein Kinases; Animals; Biguanides; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin	2017
Biguanides: Species with versatile therapeutic applications. European journal of medicinal chemistry, 2021, Jul-05, Volume: 219 Topics: Anti-Infective Agents; Antineoplastic Agents; Biguanides; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Proguanil	2021
Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions. International journal of molecular sciences, 2022, Jan-13, Volume: 23, Issue:2 Topics: Biguanides; Bile Acids and Salts; Chronic Disease; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Development; Humans; Hypoglycemic Agents; Metformin; Theranostic Nanomedicine	2022

Trials

12 trial(s) available for metformin and biguanides

Article	Year
Diabetic hearts and biguanides. Canadian Medical Association journal, 1975, Aug-09, Volume: 113, Issue:3 Topics: Animals; Biguanides; Canada; Cardiovascular Diseases; Clinical Trials as Topic; Cyclic AMP; Diabetes Mellitus; Female; Humans; Male; Metformin; Phenformin; Placebos; Prospective Studies; Retrospective Studies	1975
[Treatment of primary hyperlipoproteinemias type IV with different biguanides (author's transl)]. Klinische Wochenschrift, 1976, Mar-15, Volume: 54, Issue:6 Topics: Biguanides; Buformin; Cholesterol; Female; Humans; Hyperlipidemias; Lipoproteins, VLDL; Male; Metformin; Middle Aged; Phenformin; Triglycerides	1976
[The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl)]. Wiener klinische Wochenschrift, 1978, May-12, Volume: 90, Issue:10 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Exercise Test; Female; Humans; Lactates; Male; Metformin; Phenformin; Risk	1978
Association of lactic acidosis with biguanide therapy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Aug-13, Volume: 52, Issue:8 Topics: Biguanides; Buformin; Depression, Chemical; Diabetes Mellitus; Humans; Lactates; Metabolic Clearance Rate; Metformin; Phenformin	1977
Fibrinolytic effects of diguanides plus ethyloestrenol in occlusive vascular disease. Lancet (London, England), 1967, Nov-11, Volume: 2, Issue:7524 Topics: Adult; Aged; Angina Pectoris; Biguanides; Blood Coagulation Tests; Cholesterol; Ethylestrenol; Female; Fibrinogen; Humans; Intermittent Claudication; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Placebos; Vascular Diseases	1967
HB419 (glibenclamide) in the treatment of diabetes mellitus. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Aug-09, Volume: 43, Issue:32 Topics: Adult; Age Factors; Aged; Biguanides; Chlorpropamide; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Female; Gallbladder Diseases; Gastrointestinal Diseases; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseases; Male; Metformin; Middle Aged; Phenformin; Sulfonamides; Tolbutamide; Urea; Vascular Diseases	1969
[Biguanides in treatment of obesity. II. Controlled clinical research with placebos, metformin and phenformin in obesity with normal and reduced tolerance to carbohydrates]. La Clinica terapeutica, 1968, Nov-15, Volume: 47, Issue:3 Topics: Adolescent; Adult; Aged; Biguanides; Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Male; Metformin; Middle Aged; Obesity; Phenformin; Placebos	1968
Biguanides and gastric emptying in man. Digestion, 1971, Volume: 4, Issue:5 Topics: Biguanides; Gastrointestinal Motility; Glucose; Humans; Hypoglycemic Agents; Indium; Intestinal Absorption; Intubation, Gastrointestinal; Metformin; Osmolar Concentration; Placebos; Radioisotope Dilution Technique; Radioisotopes; Stomach; Water	1971
[Effect of metformin on glucose utilization and body weight]. Deutsche medizinische Wochenschrift (1946), 1970, Oct-23, Volume: 95, Issue:43 Topics: Biguanides; Blood Glucose; Body Weight; Glucose; Glucose Tolerance Test; Humans; Injections, Intravenous; Lipid Metabolism; Lipids; Metformin; Obesity; Placebos; Time Factors	1970
Therapeutic effects of biguanide vs. statin in polycystic ovary syndrome: a randomized clinical trial. Pakistan journal of biological sciences : PJBS, 2011, Jun-01, Volume: 14, Issue:11 Topics: Adult; Anticholesteremic Agents; Biguanides; Blood Glucose; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Simvastatin; Treatment Outcome; Young Adult	2011
Linagliptin provides effective, well-tolerated add-on therapy to pre-existing oral antidiabetic therapy over 1 year in Japanese patients with type 2 diabetes. Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9 Topics: Asian People; Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Japan; Linagliptin; Male; Metformin; Middle Aged; Purines; Quinazolines; Sulfonylurea Compounds; Thiazolidinediones; Time Factors; Treatment Outcome	2013
Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitus. Diabetes, obesity & metabolism, 2015, Volume: 17, Issue:7 Topics: Adult; Aged; Benzhydryl Compounds; Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Glucosides; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemia; Hypoglycemic Agents; Japan; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome	2015

Other Studies

107 other study(ies) available for metformin and biguanides

Article	Year
[Biguanides, rejection of treatment with buformin and fenformin, and restriction of indications for the use of metformin]. Nederlands tijdschrift voor geneeskunde, 1979, Jun-02, Volume: 123, Issue:22 Topics: Biguanides; Buformin; Drug and Narcotic Control; Humans; Hypoglycemic Agents; Metformin; Netherlands; Phenformin	1979
[Effect of biguanids on the lactate metabolism. Studies in diabetics under submaximal ergometric exercise (author's transl)]. Medizinische Klinik, 1979, Jun-01, Volume: 74, Issue:22 Topics: Biguanides; Blood Glucose; Buformin; Diabetes Mellitus; Humans; Lactates; Male; Membrane Potentials; Metformin; Mitochondria; Phenformin; Physical Exertion; Pyruvates	1979
Biguanide-induced lactic acidosis in Finland. European journal of clinical pharmacology, 1979, Volume: 15, Issue:6 Topics: Acidosis; Aged; Biguanides; Finland; Humans; Hypoglycemic Agents; Lactates; Metformin; Middle Aged; Phenformin	1979
[Indications and contraindications to the diabetes mellitus therapy by biguanide derivatives in the light of the metabolic and epidemiologic studies (author's transl)]. Przeglad lekarski, 1979, Volume: 36, Issue:7 Topics: Adult; Aged; Biguanides; Buformin; Diabetes Mellitus; Humans; Metformin; Middle Aged; Phenformin	1979
[Biguanides and lactic acidosis]. Duodecim; laaketieteellinen aikakauskirja, 1978, Volume: 94, Issue:1 Topics: Acidosis; Biguanides; Buformin; Humans; Lactates; Metformin; Phenformin	1978
Biguanides. Diabetologia, 1978, Volume: 14, Issue:2 Topics: Biguanides; Buformin; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactates; Metformin; Phenformin	1978
The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects. Diabetologia, 1978, Volume: 14, Issue:2 Topics: Adolescent; Adult; Biguanides; Blood Glucose; Buformin; Ethanol; Female; Fructose; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin; Physical Exertion	1978
Blood lactate and pyruvate levels in diabetic patients treated with biguanides with and without sulphonylureas. Diabetologia, 1978, Volume: 14, Issue:2 Topics: Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Lactates; Male; Metformin; Middle Aged; Phenformin; Pyruvates; Sulfonylurea Compounds	1978
[Comparison of the effects of phenformin, buformin and metformin on blood lactate level]. Polskie Archiwum Medycyny Wewnetrznej, 1978, Volume: 59, Issue:3 Topics: Biguanides; Buformin; Female; Humans; Lactates; Male; Metformin; Phenformin	1978
[Biguanides]. Deutsche medizinische Wochenschrift (1946), 1978, Sep-08, Volume: 103, Issue:36 Topics: Acidosis; Biguanides; Buformin; Humans; Metformin; Phenformin	1978
[Biguanides: reasons for withdrawal of drugs and remaining indications]. Acta medica Austriaca, 1978, Volume: 5, Issue:3 Topics: Acidosis; Austria; Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Legislation, Drug; Metformin; Obesity; Phenformin	1978
[Blood lactate and biguanide therapy: comparison between phenformin, metformin and buformin in 408 senile diabetics]. Acta medica Austriaca, 1978, Volume: 5, Issue:3 Topics: Aged; Biguanides; Buformin; Diabetes Mellitus; Female; Humans; Lactates; Male; Metformin; Phenformin	1978
[Effect of biguanide therapy on lactate metabolism during graded submaximal ergometric testing]. Acta medica Austriaca, 1978, Volume: 5, Issue:3 Topics: Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Metformin; Phenformin; Physical Exertion	1978
[NN-dimethylbiguanide attenuates the lipid disorders of rats on an atherogenic diet]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1975, Jun-02, Volume: 280, Issue:21 Topics: Animals; Biguanides; Cholesterol; Cholesterol, Dietary; Depression, Chemical; Diet, Atherogenic; Dietary Fats; Fatty Acids; Hyperlipidemias; Liver; Male; Metformin; Rats; Stimulation, Chemical	1975
Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides. Diabetologia, 1977, Volume: 13, Issue:3 Topics: Biguanides; Buformin; Carbon Dioxide; Cholic Acids; Diabetes Mellitus; Doxycycline; Feces; Female; Glycocholic Acid; Humans; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12	1977
[Lactic acidosis and biguanides: present state of the question in France]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1977 Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Female; France; Humans; Lactates; Male; Metformin; Middle Aged; Phenformin	1977
The biguanides: action and clinical indications. Australian family physician, 1976, Volume: 5, Issue:7 Topics: Biguanides; Diabetes Mellitus; Humans; Hyperglycemia; Metformin; Phenformin	1976
[The importance of lactate acidosis as a side effect of biguanide therapy]. Fortschritte der Medizin, 1976, Dec-16, Volume: 94, Issue:35-36 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug Therapy, Combination; Ethanol; Humans; Kidney; Lactates; Liver; Metformin; Peritoneal Dialysis; Phenformin	1976
[10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)]. Schweizerische medizinische Wochenschrift, 1976, Dec-11, Volume: 106, Issue:50 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Glucagon; Humans; Lactates; Liver; Metformin; Phenformin; Shock, Cardiogenic	1976
Simple elcetron capture gas chromatographic method for the determination of oral hypoglycemic biguanidis in biological fluids. Analytical chemistry, 1975, Volume: 47, Issue:3 Topics: Biguanides; Buformin; Chromatography, Gas; Humans; Metformin; Phenformin	1975
Effect of bed time intermediate acting insulin in NIDDM subjects refractory to a combination of sulphonylureas and biguanides. The Journal of the Association of Physicians of India, 1992, Volume: 40, Issue:10 Topics: Biguanides; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Combinations; Female; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Injections, Subcutaneous; Insulin, Long-Acting; Lipids; Male; Metformin; Middle Aged; Phenformin; Sulfonylurea Compounds; Time Factors	1992
Biguanide related lactic acidosis: incidence and risk factors. Archives of medical research, 1992,Spring, Volume: 23, Issue:1 Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Biguanides; Contraindications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Emergencies; Female; Humans; Incidence; Male; Metformin; Mexico; Middle Aged; Odds Ratio; Phenformin; Prospective Studies; Retrospective Studies; Risk Factors; Sulfonylurea Compounds	1992
[Sulfonylurea compounds or biguanides in the treatment of type 2 diabetes?]. Deutsche medizinische Wochenschrift (1946), 1989, Jul-07, Volume: 114, Issue:27 Topics: Aged; Animals; Biguanides; Cricetinae; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glyburide; Humans; Metformin; Rats; Sulfonylurea Compounds	1989
Carbohydrate biguanides as potential hypoglycemic agents. Journal of medicinal chemistry, 1989, Volume: 32, Issue:9 Topics: Administration, Oral; Animals; Biguanides; Glucose Tolerance Test; Hypoglycemic Agents; Male; Mass Spectrometry; Metformin; Monosaccharides; Phenformin; Rats; Rats, Inbred Strains; Structure-Activity Relationship	1989
[Alteration of blood lactic acid levels in biguanide therapy in diabetics]. Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan, 1985, Volume: 16, Issue:2 Topics: Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Lactates; Lactic Acid; Metformin; Middle Aged; Phenformin	1985
Letter: Coronary care for myocardial infarction in diabetics. Lancet (London, England), 1974, Jun-29, Volume: 1, Issue:7870 Topics: Biguanides; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diet Therapy; Humans; Insulin; Metformin; Myocardial Infarction; Sulfonylurea Compounds	1974
The effect of biguanides on secretion and biosynthesis of insulin in isolated pancreatic islets of rats. Diabetologia, 1972, Volume: 8, Issue:6 Topics: Animals; Biguanides; Drug Interactions; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Metformin; Oxygen Consumption; Phenformin; Rats; Rats, Inbred Strains; Tritium	1972
[Animal experimental studies on the mode of action of biguanides. 1. Studies with hypoglycemia-inducing doses of biguanide]. Arzneimittel-Forschung, 1972, Volume: 22, Issue:7 Topics: Animals; Biguanides; Blood Glucose; Carbon Isotopes; Diaphragm; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Germ-Free Life; Gluconeogenesis; Glucose; Guinea Pigs; Hypoglycemia; Insulin; Insulin Secretion; Liver; Male; Metformin; Oxygen Consumption; Phenformin; Rats	1972
[Animal experimental studies on the mode of action of biguanides. 1. Studies on non hypoglycemically acting biguanide]. Arzneimittel-Forschung, 1972, Volume: 22, Issue:9 Topics: Animals; Biguanides; Butanes; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus; Diaphragm; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glycogen; Guinea Pigs; Hexokinase; Insulin; Lactates; Liver; Metformin; Muscles; Phenformin; Pyruvates; Rats	1972
[Demonstration of the mechanism of action of biguanides (author's transl)]. Acta diabetologica latina, 1973, Volume: 10, Issue:6 Topics: Animals; Biguanides; Fatty Acids; Glucose; Liver; Male; Metformin; Muscles; Oxidation-Reduction; Palmitic Acids; Phenformin; Rats	1973
Fibrinolytic activity and haemagglutination inhibition immunoassays. Scandinavian journal of haematology, 1970, Volume: 7, Issue:4 Topics: Adult; Aged; Biguanides; Clofibrate; Coronary Disease; Ethylestrenol; Female; Fibrin; Fibrinogen; Fibrinolysis; Hemagglutination Inhibition Tests; Hemostasis; Humans; Immunoassay; Immunodiffusion; Immunoelectrophoresis; Liver Cirrhosis; Male; Metformin; Middle Aged; Neoplasm Metastasis; Nicotinic Acids; Physical Exertion; Plasminogen; Prostatic Neoplasms; Stimulation, Chemical; Time Factors; Tolazamide	1970
Metformin and B-12 malabsorption. Annals of internal medicine, 1972, Volume: 76, Issue:1 Topics: Biguanides; Intestinal Absorption; Metformin; Vitamin B 12 Deficiency	1972
Diabetes mellitus--refractory obesity. British medical journal, 1972, Jul-15, Volume: 3, Issue:5819 Topics: Biguanides; Diabetes Mellitus; Diet Therapy; Female; Fetal Death; Glucose Tolerance Test; Glycosuria; Humans; Insulin; Metformin; Middle Aged; Obesity; Phenformin; Pregnancy; Pregnancy in Diabetics; Sulfonylurea Compounds	1972
Application of ion-pair methods to drug extraction from biological fluids. I. Quantitative determination of biguanides in urine. Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:9 Topics: Animals; Biguanides; Chemistry, Pharmaceutical; Coloring Agents; Hydrogen-Ion Concentration; Ions; Mathematics; Metformin; Phenformin; Spectrophotometry; Spectrum Analysis; Ultraviolet Rays	1972
Application of ion-pair methods to drug extraction from biological fluids. II. Quantitative determination of biguanides in biological fluids and comparison of protein binding estimates. Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:9 Topics: Animals; Biguanides; Chemistry, Pharmaceutical; Cresols; Dialysis; Dogs; Erythrocytes; Filtration; Humans; Hydrogen-Ion Concentration; Ions; Mathematics; Metformin; Phenformin; Protein Binding; Solvents; Spectrophotometry	1972
[Physiological and pharmacological aspects of fibrinolysis]. La Clinica terapeutica, 1971, May-15, Volume: 57, Issue:3 Topics: Adrenal Cortex Hormones; Anabolic Agents; Arteriosclerosis Obliterans; Biguanides; Blood Coagulation Tests; Blood Platelets; Clofibrate; Coronary Disease; Diabetes Mellitus; Ethylestrenol; Fibrinolysis; Humans; Insulin; Metformin; Myocardial Infarction; Phenformin; Sulfonylurea Compounds; Testosterone; Thrombosis	1971
[Comparative activity of some biguanides, sulfonylureas and their combinations on blood sugar and lactic acid in the guinea pig. II]. Bollettino chimico farmaceutico, 1971, Volume: 110, Issue:4 Topics: Amantadine; Animals; Biguanides; Blood Glucose; Chlorpropamide; Guinea Pigs; Lactates; Metformin; Phenformin; Sulfonylurea Compounds; Tolbutamide	1971
[Effect of biguanide derivatives on blood lactic acid level in diabetics]. Polskie Archiwum Medycyny Wewnetrznej, 1971, Volume: 47, Issue:6 Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Humans; Lactates; Metformin; Middle Aged; Phenformin	1971
Fibrinolytic effect of biguanides. Annals of the New York Academy of Sciences, 1968, Mar-26, Volume: 148, Issue:3 Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis Obliterans; Biguanides; Chlorpropamide; Coronary Disease; Ethylestrenol; Female; Fibrinolysis; Fibrinolytic Agents; Humans; Male; Metformin; Methenolone; Middle Aged; Phenformin; Tolbutamide	1968
[Absorption, distribution in the organism and elimination of metformin]. Diabetologia, 1969, Volume: 5, Issue:5 Topics: Animals; Biguanides; Carbon Isotopes; Chromatography, Paper; Female; Humans; Hypoglycemic Agents; Intestinal Absorption; Male; Metformin; Mice; Rats; Species Specificity	1969
Rat liver glycogen-lowering activity of fed creatine--a retraction. The Journal of nutrition, 1969, Volume: 99, Issue:4 Topics: Animals; Biguanides; Creatine; Crystallization; Depression, Chemical; Gluconeogenesis; Guanidines; Hypoglycemic Agents; Injections, Intraperitoneal; Liver Glycogen; Male; Metformin; Phenformin; Rats; Time Factors	1969
Studies on the mechanism of weight reduction by phenformin. Postgraduate medical journal, 1969, Volume: 45 Topics: Biguanides; Diabetes Mellitus; Female; Humans; Metformin; Obesity; Phenformin	1969
[The place of biguanides in the treatment of diabetes]. Therapeutique (La Semaine des hopitaux), 1970, Volume: 46, Issue:2 Topics: Biguanides; Diabetes Mellitus; Drug Synergism; Humans; Hypoglycemic Agents; Insulin; Metformin; Phenformin	1970
[Clinical pharmacology of oral hypoglycemic drugs]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1968, Sep-19, Volume: 23, Issue:34 Topics: Biguanides; Humans; Hypoglycemic Agents; Metformin; Phenformin	1968
[A hypoglycemizing sulfamide associated with biguanide in the treatment of type I diabetes in adults]. Lyon medical, 1968, Oct-20, Volume: 220, Issue:42 Topics: Adult; Age Factors; Aged; Biguanides; Diabetes Mellitus; Drug Synergism; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Tolbutamide	1968
[On the clinical use of biguanides]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:4 Topics: Aged; Biguanides; Blood Glucose; Body Weight; Cholesterol; Depression, Chemical; Diabetes Mellitus; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Fatty Liver; Humans; Hypoglycemic Agents; Insulin; Liver Glycogen; Metformin; Phenformin; Stimulation, Chemical	1969
[Therapeutic possibilities in diabetes mellitus with biguanides. Clinical experiences in 122 diabetics with dimethylbiguanide(Glucophage)]. Schweizerische medizinische Wochenschrift, 1966, Oct-08, Volume: 96, Issue:40 Topics: Adolescent; Adult; Biguanides; Body Weight; Chemical Phenomena; Chemistry; Diabetes Mellitus; Diet, Diabetic; Female; Glucose Tolerance Test; Humans; Insulin; Male; Metformin; Phenformin	1966
Effects of biguanides on short-circuit current in frog skin. The American journal of physiology, 1984, Volume: 247, Issue:2 Pt 2 Topics: Amiloride; Animals; Biguanides; Buformin; Galvanic Skin Response; Metformin; Mucous Membrane; Phenformin; Rana pipiens; Serous Membrane; Skin; Sodium; Time Factors	1984
Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia, 1983, Volume: 24, Issue:1 Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12	1983
[Insulin response and lipid and purine metabolic disorders in protodiabetes: evaluation of the changes induced with hypoglycemic drug treatment]. La Clinica terapeutica, 1980, Apr-30, Volume: 93, Issue:2 Topics: Adult; Biguanides; Cholesterol; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Metabolism; Male; Metformin; Middle Aged; Purines; Sulfonylurea Compounds; Triglycerides; Uric Acid	1980
Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells. The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:1 Topics: Animals; Biguanides; Breast Neoplasms; Cell Line; Female; Fibroblasts; Humans; Insulin; Liver Neoplasms, Experimental; Lymphocytes; Metformin; Phenformin; Rats; Receptor, Insulin; Sulfonylurea Compounds	1982
[Effects of some oral hypoglycemia drugs on blood levels of lactic and pyruvic acid in diabetes mellitus]. La Clinica terapeutica, 1980, Apr-30, Volume: 93, Issue:2 Topics: Biguanides; Diabetes Mellitus; Humans; Lactates; Metformin; Pyruvates; Sulfonylurea Compounds	1980
[Biguanides in the treatment of diabetes]. Duodecim; laaketieteellinen aikakauskirja, 1980, Volume: 96, Issue:7 Topics: Biguanides; Diabetes Mellitus; Humans; Metformin; Phenformin	1980
Anti-diabetic biguanides inhibit hormone-induced intracellular Ca2+ concentration oscillations in rat hepatocytes. The Biochemical journal, 1994, Dec-01, Volume: 304 ( Pt 2) Topics: Animals; Biguanides; Bucladesine; Calcium; Chlorides; Colforsin; Cyclic AMP; Glucagon; Inositol 1,4,5-Trisphosphate; Insulin; Liver; Male; Manganese Compounds; Metformin; Phenformin; Phenylephrine; Rats; Rats, Wistar; Second Messenger Systems	1994
The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Adolescent; Adult; Arginine; Biguanides; Cadaver; Dose-Response Relationship, Drug; Female; Glucose; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Metformin; Middle Aged	1999
Cellular and molecular mechanisms involved in insulin's potentiation of glycogen synthase activity by metformin. Biochemical pharmacology, 1999, Nov-01, Volume: 58, Issue:9 Topics: Animals; Biguanides; Enzyme Activation; Glycogen; Glycogen Synthase; Hypoglycemic Agents; Insulin; Metformin; Oocytes; Receptor, Insulin; Signal Transduction; Subcellular Fractions; Xenopus laevis	1999
Vanadyl-biguanide complexes as potential synergistic insulin mimics. Journal of inorganic biochemistry, 1999, Sep-30, Volume: 76, Issue:3-4 Topics: Animals; Biguanides; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Metformin; Phenformin; Rats; Rats, Wistar; Vanadates	1999
Accumulation of triglyceride-rich lipoprotein in subjects with abdominal obesity: the biguanides and the prevention of the risk of obesity (BIGPRO) 1 study. Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:3 Topics: Abdomen; Adult; Aged; Biguanides; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Female; Fibrinolysis; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipoproteins; Male; Metformin; Middle Aged; Obesity; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Statistics as Topic; Triglycerides	2001
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase. The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20 Topics: 3-Hydroxysteroid Dehydrogenases; Biguanides; Chromans; Cloning, Molecular; Humans; Kinetics; Metformin; Pioglitazone; Recombinant Proteins; Saccharomyces cerevisiae; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone	2001
Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. Biochemical and biophysical research communications, 2002, Nov-15, Volume: 298, Issue:5 Topics: Animals; Biguanides; Buformin; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Peptide Fragments; Phenformin; Protease Inhibitors; Protein Precursors; Pyrroles; Rats; Rats, Inbred F344; Valine	2002
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Molecular pharmacology, 2003, Volume: 63, Issue:4 Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Host Cell Factor C1; Hypoglycemic Agents; Lactic Acid; Male; Metformin; Mice; Octamer Transcription Factor-1; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Transcription Factors	2003
[Lactic acidosis and biguanides: coincidence or negligence of prescribing guidelines]. Annales francaises d'anesthesie et de reanimation, 2003, Volume: 22, Issue:5 Topics: Acidosis, Lactic; Biguanides; Drug Prescriptions; Guidelines as Topic; Hypoglycemic Agents; Metformin	2003
Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents. Biochemical pharmacology, 2003, Aug-15, Volume: 66, Issue:4 Topics: Animals; Antimalarials; Biguanides; Catalytic Domain; Cathepsin B; Chloroquine; Homeostasis; Hypoglycemic Agents; Lysosomes; Metals; Metformin; Proguanil; Protease Inhibitors; Rats; Zinc	2003
[Oral treatment of diabetes mellitus. Clinical experience of Metformin or Phenformin alone and combined treatment with these biguanides and P-607]. Naika hokan. Japanese archives of internal medicine, 1962, Volume: 9 Topics: Administration, Oral; Biguanides; Chlorpropamide; Diabetes Mellitus; Humans; Metformin; Phenformin	1962
[BIGUANIDES AND SULFONAMIDES IN SMALL DOSES IN THE INITIAL TREATMENT OF THE DIABETES OF THE OBESE PERSON]. Le Diabete, 1963, Volume: 11 Topics: Biguanides; Chlorpropamide; Diabetes Mellitus; Humans; Metformin; Obesity; Sulfanilamide; Sulfanilamides; Sulfonamides	1963
[ATTEMPTED THERAPY OF SEVERE FORMS OF DIABETES MELLITUS WITH A BIGUANIDE PREPARATION "GLUCOPHAGE" (LA 6023)]. Lijecnicki vjesnik, 1963, Volume: 85 Topics: Biguanides; Diabetes Mellitus; Humans; Insulin; Metformin	1963
[EXPERIENCE WITH THE BIGUANIDE "GLUCOPHAGE"]. Wiener klinische Wochenschrift, 1964, May-08, Volume: 76 Topics: Adolescent; Biguanides; Biomedical Research; Geriatrics; Insulin; Metformin; Pharmacology; Toxicology	1964
[ROLE OF BIGUANIDES IN THE TREATMENT OF DIABETES]. Turk Tip Cemiyeti mecmuasi, 1964, Volume: 30 Topics: Biguanides; Diabetes Mellitus; Humans; Metformin; Phenformin; Toxicology	1964
[Study of the action of a biguanide (N,N-dimethylguanylguanidine) on a group of 235 diabetic children]. La Presse medicale, 1960, Feb-27, Volume: 68 Topics: Amidines; Biguanides; Child; Diabetes Mellitus; Humans; Infant; Metformin	1960
The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight. European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3 Topics: Animals; Antimetabolites; Biguanides; Dipeptidyl Peptidase 4; Enteroendocrine Cells; Fluorouracil; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Hypoglycemic Agents; Intestine, Small; Male; Metformin; Mice; Mice, Inbred BALB C; Organ Size; Peptides; Protease Inhibitors; Pyrroles; Rats; Rats, Inbred F344; Valine	2004
Metformin: preventable lactic acidosis. Prescrire international, 2007, Volume: 16, Issue:87 Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Female; France; Humans; Male; Metformin	2007
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. British journal of pharmacology, 2007, Volume: 150, Issue:8 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biguanides; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Enzyme Activation; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; Metformin; Mice; Mitochondria; Multienzyme Complexes; NADP; Oxidation-Reduction; Phenformin; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Succinates; Tetrazolium Salts; Thiazoles; Time Factors	2007
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium	2007
Sitagliptin + metformin: new combination. Do not use this combination. Sitagliptin provides a slight increase of glucose-lowering effects, but there is a disturbing potential for long-term adverse effects: infections, depression, and cancer. Prescrire international, 2009, Volume: 18, Issue:101 Topics: Biguanides; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Approval; Drug Combinations; Drug Synergism; Europe; Humans; Hypoglycemic Agents; Metformin; Pyrazines; Sitagliptin Phosphate; Sitagliptin Phosphate, Metformin Hydrochloride Drug Combination; Sulfonylurea Compounds; Triazoles	2009
Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography-electrospray tandem mass spectrometry. Biomedical chromatography : BMC, 2012, Volume: 26, Issue:1 Topics: Acetonitriles; Autopsy; Biguanides; Chromatography, Liquid; Forensic Sciences; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Linear Models; Metformin; Methanol; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2012
Liver uptake of biguanides in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2011, Volume: 65, Issue:6 Topics: Animals; Biguanides; Biological Transport, Active; Biotransformation; Cells, Cultured; Hepatocytes; Hypoglycemic Agents; Liver; Male; Metformin; Phenformin; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Tissue Distribution	2011
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides. Biochemical and biophysical research communications, 2011, Nov-04, Volume: 414, Issue:4 Topics: Adenylate Kinase; Antineoplastic Agents; Biguanides; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Metformin; Organic Cation Transporter 1; Ovarian Neoplasms; Phenformin; RNA, Small Interfering	2011
Central anti-diabetic action of biguanide and thizolidinediones in D-glucose fed and streptozotocin-treated mouse models. Neuroscience letters, 2012, Oct-18, Volume: 528, Issue:1 Topics: Animals; Biguanides; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Injections, Intraventricular; Injections, Spinal; Metformin; Mice; Mice, Inbred ICR; Pioglitazone; Rosiglitazone; Streptozocin; Thiazolidinediones	2012
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature, 2013, Feb-14, Volume: 494, Issue:7436 Topics: Adenylyl Cyclases; AMP-Activated Protein Kinases; Animals; Biguanides; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Enzyme Activation; Glucagon; Glucose; Hepatocytes; Hypoglycemic Agents; Liver; Metformin; Mice; Phenformin; Phosphorylation; Signal Transduction	2013
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell, 2013, Mar-28, Volume: 153, Issue:1 Topics: Adenylate Kinase; Aging; Animals; Biguanides; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Caloric Restriction; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Escherichia coli; Folic Acid; Humans; Hypoglycemic Agents; Longevity; Metagenome; Metformin; Methionine; Transcription Factors	2013
Patenting carboxyformin in the United States: how does it work and what does it mean? Journal of diabetes science and technology, 2013, Mar-01, Volume: 7, Issue:2 Topics: Biguanides; Biomedical Research; Diabetes Mellitus, Type 2; Drug Approval; Humans; Hypoglycemic Agents; Intellectual Property; Legislation, Drug; Metformin; Patents as Topic; United States	2013
Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties. Physiological research, 2014, Volume: 63, Issue:1 Topics: Animals; Biguanides; Dose-Response Relationship, Drug; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex IV; Enzyme Inhibitors; Male; Metformin; Mitochondria, Liver; Phenformin; Rats; Rats, Wistar	2014
Metformin treatment may be associated with decreased levels of NT-proBNP in patients with type 2 diabetes. Advances in medical sciences, 2013, Volume: 58, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Atherosclerosis; Biguanides; Cardiovascular Diseases; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diuretics; Female; Heart Failure; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Predictive Value of Tests; Prevalence; Risk Factors	2013
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jul-22, Volume: 111, Issue:29 Topics: Aminoimidazole Carboxamide; Biguanides; Cell Line, Transformed; Cell Line, Tumor; Citric Acid Cycle; Endoplasmic Reticulum; Folic Acid; Glycerophosphates; Glycolysis; Humans; Lactates; Metabolome; Metformin; Neoplastic Stem Cells; Nucleotides; Phenformin; Ribonucleotides; src-Family Kinases; Tamoxifen	2014
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. The Biochemical journal, 2014, Sep-15, Volume: 462, Issue:3 Topics: Animals; Antimalarials; Antineoplastic Agents; Biguanides; Cattle; Diabetes Mellitus, Type 2; Electron Transport Complex I; Hep G2 Cells; Humans; Metformin; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Proton-Translocating ATPases; Oxidative Phosphorylation; Plasmodium; Proguanil; Rats; Reperfusion Injury; Triazines	2014
Metformin and respiratory chain complex I: the last piece of the puzzle? The Biochemical journal, 2014, Nov-01, Volume: 463, Issue:3 Topics: Animals; Biguanides; Electron Transport Complex I; Humans; Metformin; Mitochondria, Heart; Mitochondria, Liver; Oxidative Phosphorylation	2014
Serine deprivation enhances antineoplastic activity of biguanides. Cancer research, 2014, Dec-15, Volume: 74, Issue:24 Topics: Animals; Biguanides; Cell Line, Tumor; Glycolysis; Humans; Metformin; Mice; Neoplasms; Oxidative Phosphorylation; Phenformin; Serine; Xenograft Model Antitumor Assays	2014
Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood, 2015, Mar-05, Volume: 125, Issue:10 Topics: Aerobiosis; AMP-Activated Protein Kinases; Animals; Biguanides; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Enzyme Activation; Enzyme Inhibitors; Glycolysis; Hematopoietic Stem Cells; Hypoglycemic Agents; Metformin; Mice; Oxygen Consumption; PTEN Phosphohydrolase	2015
A PET Tracer for Renal Organic Cation Transporters, ¹¹C-Metformin: Radiosynthesis and Preclinical Proof-of-Concept Studies. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:4 Topics: Animals; Autoradiography; Biguanides; Dose-Response Relationship, Drug; Edetic Acid; Isotope Labeling; Kidney; Liver; LLC-PK1 Cells; Metformin; Methylation; Organic Cation Transport Proteins; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Swine; Tissue Distribution	2016
Uptake, translocation and possible biodegradation of the antidiabetic agent metformin by hydroponically grown Typha latifolia. Journal of hazardous materials, 2016, May-05, Volume: 308 Topics: Biguanides; Biodegradation, Environmental; Hydroponics; Hypoglycemic Agents; Metformin; Plant Leaves; Plant Roots; Rhizome; Typhaceae	2016
Synthesis and Evaluation of 1-Substituted-Biguanide Derivatives as Anti-Diabetic Agents for Type II Diabetes Insulin Resistant. Drug research, 2016, Volume: 66, Issue:7 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biguanides; Blood Glucose; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Metformin; Rats; Rats, Wistar; Triglycerides; Urea	2016
Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget, 2016, Aug-09, Volume: 7, Issue:32 Topics: Apoptosis; Biguanides; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Electron Transport; Humans; Metformin; Mitochondria; Nitrophenols; Phenformin; Piperazines; Rotenone; Sulfonamides; U937 Cells	2016
L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides. The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:9 Topics: Amines; Asian People; Biguanides; Biological Transport, Active; Buformin; Carnitine; Cyclohexanecarboxylic Acids; Ergothioneine; Gabapentin; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Intestinal Absorption; Metformin; Organic Cation Transporter 1; Polymorphism, Single Nucleotide; White People	2016
Extreme Basicity of Biguanide Drugs in Aqueous Solutions: Ion Transfer Voltammetry and DFT Calculations. The journal of physical chemistry. A, 2016, Sep-22, Volume: 120, Issue:37 Topics: Biguanides; Hydrogen-Ion Concentration; Metformin; Models, Molecular; Phenformin; Quantum Theory; Solutions; Water	2016
NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides. Cell cycle (Georgetown, Tex.), 2017, Volume: 16, Issue:3 Topics: Biguanides; Metformin; Phenformin	2017
New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant. Drug research, 2017, Volume: 67, Issue:10 Topics: Animals; Biguanides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin Resistance; Lipids; Liver; Metformin; Nitrous Oxide; Rats	2017
Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2. Molecular pharmaceutics, 2017, 08-07, Volume: 14, Issue:8 Topics: 1-Methyl-4-phenylpyridinium; Biguanides; HEK293 Cells; Humans; Liver; Metformin; Organic Cation Transporter 1; Organic Cation Transporter 2	2017
Metformin: historical overview. Diabetologia, 2017, Volume: 60, Issue:9 Topics: Biguanides; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin	2017
Pharmacological evaluation of metformin and N-benzylbiguanide, a novel analogue of metformin, on the vasopressor responses to adrenergic system stimulation in pithed rats with fructose-induced insulin resistance. European journal of pharmacology, 2017, Nov-05, Volume: 814 Topics: Adrenergic Agonists; Animals; Biguanides; Blood Glucose; Blood Pressure; Fructose; Heart Rate; Hemodynamics; Insulin; Insulin Resistance; Male; Metformin; Rats; Rats, Wistar; Receptors, Adrenergic; Sympathetic Nervous System	2017
Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production. Oxidative medicine and cellular longevity, 2017, Volume: 2017 Topics: Adipose Tissue, Brown; Animals; Biguanides; Glycerolphosphate Dehydrogenase; Hydrogen Peroxide; Hypoglycemic Agents; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidation-Reduction; Phenformin; Rats; Rats, Wistar; Reactive Oxygen Species; Succinic Acid	2017
New Biguanides as Anti-Diabetic Agents, Part II: Synthesis and Anti-Diabetic Properties Evaluation of 1-Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes. Archiv der Pharmazie, 2017, Volume: 350, Issue:11 Topics: Administration, Oral; Animals; Biguanides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin; Lipid Peroxidation; Lipids; Liver Function Tests; Male; Metformin; Nitrous Oxide; Rats	2017
Electrochemically Modulated Liquid-Liquid Extraction for Sample Enrichment. Analytical chemistry, 2019, 06-04, Volume: 91, Issue:11 Topics: Biguanides; Chromatography, High Pressure Liquid; Electrochemical Techniques; Hydrophobic and Hydrophilic Interactions; Liquid-Liquid Extraction; Metformin; Phenformin; Quaternary Ammonium Compounds	2019
A new perspective on the biguanide, metformin therapy in type 2 diabetes and lactic acidosis. Journal of diabetes investigation, 2019, Volume: 10, Issue:4 Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Prognosis	2019
Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. Internal medicine (Tokyo, Japan), 2022, Oct-01, Volume: 61, Issue:19 Topics: Acidosis, Lactic; Beriberi; Biguanides; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis; Thiamine; Thiamine Deficiency	2022
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.), 2023, 01-27, Volume: 379, Issue:6630 Topics: Animals; Biguanides; Cryoelectron Microscopy; Electron Transport Complex I; Metformin; Mitochondria	2023
Metformin May Alter the Metabolic Reprogramming in Cancer Cells by Disrupting the L-Arginine Metabolism: A Preliminary Computational Study. International journal of molecular sciences, 2023, Mar-10, Volume: 24, Issue:6 Topics: AMP-Activated Protein Kinases; Antimalarials; Biguanides; Buformin; Creatine; Humans; Metformin; Molecular Docking Simulation; Neoplasms	2023
Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study. International journal of environmental research and public health, 2023, 03-29, Volume: 20, Issue:7 Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Biguanides; Cohort Studies; Diabetes Mellitus; Female; Humans; Inpatients; Japan; Male; Metformin; Retrospective Studies	2023