metformin has been researched along with berberine in 48 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (2.08) | 18.2507 |
2000's | 5 (10.42) | 29.6817 |
2010's | 28 (58.33) | 24.3611 |
2020's | 14 (29.17) | 2.80 |
Authors | Studies |
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Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Liu, Y; Liu, Z; Peng, D; Wang, X; Xiao, D; Yin, W; Zhang, S; Zhou, M | 1 |
Gao, CR; Huang, QL; Zhang, JQ | 1 |
Chen, J; Chen, M; Hu, R; Li, F; Tang, J; Yang, Y; Yin, J | 1 |
Xing, H; Ye, J; Yin, J | 1 |
Joly, E; Lamontagne, J; Madiraju, SR; Nolan, CJ; Pepin, E; Peyot, ML; Poitout, V; Prentki, M; Ruderman, NB | 1 |
Barroso-Aranda, J; Contreras, F; McCarty, MF | 1 |
Doble, M; Prabhakar, PK | 1 |
Jiang, JD; Kong, WJ; Pan, HN; Song, DQ; Wang, SK; Wang, YM; Wang, ZZ; Wei, J; Wu, JD; Xue, R; Zhang, H; Zhao, W; Zhou, ZX | 1 |
Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Patil, S; Tawari, S; Umathe, S | 1 |
Deng, H; Guan, Y; Liang, K; Ma, Y; Sui, M; Wang, A; Wei, W; Zhang, H; Zhang, Y; Zhao, H | 1 |
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H | 1 |
An, Y; Guan, Y; Liu, B; Lu, M; Sun, Z; Zhang, Y | 1 |
Davies, GE; Davies, PS; Droke, EA; Ehli, EA; Hu, Y; Nowotny, D; Soundy, TJ; Young, AJ | 1 |
Finley, J | 1 |
Choi, MK; Choi, YA; Kwon, M; Song, IS | 1 |
Eibl, G; Ming, M; Rozengurt, E; Sinnett-Smith, J; Soares, HP; Wang, J; Young, SH | 1 |
Dong, H; Jiang, SJ; Li, JB; Lu, FE; Wang, KF; Xu, LJ; Yi, P; Zou, X | 1 |
Pang, X; Xu, J; Xue, Z; Zhang, M; Zhang, X; Zhao, L; Zhao, Y | 1 |
Beauloye, C; Bertrand, L; Daskalopoulos, EP; Dufeys, C; Horman, S | 1 |
Hatakeyama, T; Kohno, T; Kojima, T; Konno, T; Saito, T; Satohisa, S; Shimada, H; Takahashi, S; Tsujiwaki, M | 1 |
Darzynkiewicz, Z; Garcia, J; Halicka, HD; Li, J; Zhao, H | 1 |
Lin, Y; Pan, G; Wang, L; Xiao, L; Xue, Y; Zhang, C | 1 |
Hann, SS; Tang, Q; Wu, J; Wu, W; Xiao, Q; Zheng, F | 1 |
Cao, H; Feng, Y; Li, W; Liao, S; Wu, X; Xiao, X; Zhong, W; Zhu, J | 1 |
Alimujiang, M; Bao, Y; Wei, L; Xiao, Y; Xu, M; Yin, J | 1 |
Gao, S; Huang, D; Huang, J; Tong, P; Wang, Y; Wu, X; Yue, Y; Zhao, J | 1 |
Javadipour, M; Keshtzar, E; Khodayar, MJ; Rezaei, M | 2 |
Jin, J; Li, Y; Ma, Y; Shi, R; Wang, T; Xu, X; Xu, Z; Zhao, Y | 1 |
Feng, Y; Gao, Y; Jia, D; Li, W; Li, ZW; Ma, M; Wu, Z; Zhou, X | 1 |
Abrams, SL; Akula, SM; Bueno-Silva, B; Candido, S; Cervello, M; Follo, MY; Gizak, A; Lertpiriyapong, K; Libra, M; Lin, HL; Lombardi, P; Mao, W; Martelli, AM; Matias de Alencar, S; McCubrey, JA; Montalto, G; Murata, RM; Rakus, D; Ramazzotti, G; Ratti, S; Rosalen, PL; Steelman, LS | 1 |
Chan, PKS; Cheung, SCK; Kong, APS; Lin, L; Lyu, Y; Shaw, PC; Yang, M; Yang, X; Zhang, Y; Zuo, Z | 1 |
Chen, QK; Xu, JH; Yu, T; Zhang, W | 1 |
Chen, L; Wei, Y; Yao, Y; Zuo, J | 1 |
Bansal, Y; Bishnoi, M; Kondepudi, KK; Kuhad, A; Medhi, B; Singh, DP; Singh, R; Sodhi, RK | 1 |
Deng, B; Gilbert, RG; Liu, X; Liu, Y; Sullivan, MA; Wang, K; Zhou, J | 1 |
Hu, Q; Lu, FE; Xu, LJ; Xu, XH; Yi, P; Zhou, LS; Zou, X | 1 |
Li, Y; Liu, C; Nie, Z; Xiong, C | 1 |
Bao, Y; Chen, Q; Han, Y; Liu, C; Liu, W; Liu, X; Wang, J; Wu, N; Ye, Y; Yu, Y | 1 |
Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Duda, P; Falzone, L; Gizak, A; Libra, M; Martelli, AM; McCubrey, JA; Meher, AK; Montalto, G; Rakus, D; Ratti, S; Ruvolo, P; Steelman, LS | 1 |
Bai, Y; Deng, L; Feng, CP; Gao, X; Gu, Y; Guo, HX; Jin, C; Song, J; Su, H; Wang, Y; Xu, XY; Zhang, JF; Zhang, JH; Zhen, Z; Zheng, JF | 1 |
Dong, H; Nie, K; Su, H; Tang, Y; Wang, H; Wang, Z; Xu, X | 1 |
He, B; Xing, C; Zhang, J; Zhao, H | 1 |
Sun, G; Sun, X; Zhang, B; Zhang, C; Zhang, X | 1 |
Hedayati, N; Naeini, MB; Oskouei, Z; Tabeshpour, J | 1 |
Kong, APS; Li, D; Li, Z; Lyu, Y; Ming, X; Shaw, PC; Yuan, X; Zhang, C; Zhang, J; Zuo, Z | 1 |
Gao, TL; Guo, HH; Han, YX; Jiang, JD; Luo, ZG; Shen, HR; Wang, LL; Zhang, HJ; Zhang, JL | 1 |
4 review(s) available for metformin and berberine
Article | Year |
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AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.
Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Berberine; Cardiomegaly; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Humans; Metformin; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Resveratrol; Ribonucleotides; Signal Transduction; Stilbenes; Thiazolidinediones; Wound Healing | 2016 |
Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells.
Topics: AMP-Activated Protein Kinases; Berberine; Cell Proliferation; Humans; Metformin; Neoplasm Proteins; Pancreatic Neoplasms | 2019 |
Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis.
Topics: Berberine; Clinical Decision-Making; Female; Humans; Hypoglycemic Agents; Inositol; Insulin; Insulin Resistance; Metabolome; Metformin; Network Meta-Analysis; Polycystic Ovary Syndrome; Thiazolidinediones; Uncertainty | 2021 |
Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review.
Topics: Berberine; Biological Availability; Cardiovascular Diseases; Combined Modality Therapy; Diabetes Mellitus; Dietary Supplements; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lycopene; Metformin; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
4 trial(s) available for metformin and berberine
Article | Year |
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Efficacy of berberine in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Berberine; Cholesterol, HDL; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucose; Glycated Hemoglobin; Humans; Male; Metformin; Middle Aged | 2008 |
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Topics: Aged; Berberine; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Female; Gene Expression; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Liver Diseases; Male; Metformin; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazolidinediones | 2010 |
A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.
Topics: Berberine; Cholesterol; Cholesterol, LDL; Female; Humans; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Triglycerides; Waist Circumference; Waist-Hip Ratio | 2012 |
The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment.
Topics: Adult; Berberine; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Young Adult | 2014 |
40 other study(ies) available for metformin and berberine
Article | Year |
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Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives.
Topics: Berberine; Diabetes Mellitus, Type 2; Hep G2 Cells; Humans; Hypoglycemic Agents; Spectrum Analysis | 2016 |
[Experimental study on berberin raised insulin sensitivity in insulin resistance rat models].
Topics: Animals; Berberine; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Rats; Rats, Wistar | 1997 |
Effects of berberine on glucose metabolism in vitro.
Topics: Berberine; Cell Line; Chromans; Dose-Response Relationship, Drug; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Metformin; Phenotype; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.
Topics: Adenosine Triphosphate; Animals; Berberine; Cell Line; Fatty Acids; Glucose; Hypoglycemic Agents; Immunoblotting; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Lipid Metabolism; Membrane Potential, Mitochondrial; Metformin; Pioglitazone; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Thiazolidinediones | 2009 |
Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Metformin; Polycystic Kidney, Autosomal Dominant; Protein Serine-Threonine Kinases; TOR Serine-Threonine Kinases | 2009 |
Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.
Topics: Animals; Berberine; Biological Transport; Cells, Cultured; Chlorogenic Acid; Coumaric Acids; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Metformin; Muscle Fibers, Skeletal; Muscle, Skeletal; Phenols; Phosphatidylinositol 3-Kinases; Plant Extracts; PPAR gamma; Rats; Thiazolidinediones | 2009 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Berberine; Blood Glucose; Body Weight; Brain; Cholinesterase Inhibitors; Cholinesterases; Diabetes Mellitus, Experimental; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Glutathione; Hypoglycemic Agents; Indans; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Metformin; Piperidines; Rats; Rats, Wistar | 2011 |
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2012 |
Metformin and berberine prevent olanzapine-induced weight gain in rats.
Topics: Adipose Tissue, White; Animals; Antipyretics; Benzodiazepines; Berberine; Eating; Female; Ion Channels; Metformin; Mitochondrial Proteins; Olanzapine; Organ Size; Rats; Rats, Sprague-Dawley; Transcriptome; Uncoupling Protein 1; Weight Gain | 2014 |
Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation.
Topics: Alternative Splicing; AMP-Activated Protein Kinases; Animals; Berberine; DNA, Mitochondrial; Enzyme Activation; Exons; Gene Expression Regulation; Humans; Lamin Type A; Metformin; Models, Biological; Mutation; Nuclear Proteins; Oxidative Phosphorylation; Phosphorylation; Point Mutation; Progeria; Resveratrol; RNA-Binding Proteins; Serine-Arginine Splicing Factors; Stilbenes | 2014 |
Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin.
Topics: Administration, Intravenous; Animals; Berberine; Catecholamine Plasma Membrane Transport Proteins; Drug Interactions; HEK293 Cells; Humans; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats; Rats, Sprague-Dawley | 2015 |
Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.
Topics: Acetyl-CoA Carboxylase; Adenocarcinoma; AMP-Activated Protein Kinases; Animals; Berberine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; DNA Replication; Extracellular Signal-Regulated MAP Kinases; Humans; Hypoglycemic Agents; Insulin; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Nude; Multiprotein Complexes; Neoplasm Transplantation; Neurotensin; Pancreatic Neoplasms; Phosphorylation; RNA Interference; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2014 |
Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
Topics: Active Transport, Cell Nucleus; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Berberine; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose-6-Phosphatase; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Lipids; Liver; Male; Metformin; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Protein Serine-Threonine Kinases; Rats, Wistar; Ribonucleotides; Signal Transduction; Streptozocin; Time Factors; Trans-Activators; Up-Regulation | 2015 |
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats.
Topics: Animals; Anti-Obesity Agents; Bacteria; Base Sequence; Berberine; Diet, High-Fat; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Gastrointestinal Tract; Male; Metformin; Obesity; Rats; Rats, Wistar; Sequence Analysis, DNA | 2015 |
The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells.
Topics: Adiponectin; Berberine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Endometrial Neoplasms; Endometrium; Epithelial Cells; Female; Gene Knockdown Techniques; Humans; Hypoglycemic Agents; Leptin; MARVEL Domain Containing 2 Protein; Metformin; Neoplasm Invasiveness; Receptors, Lipoprotein; Risk Factors; RNA Interference; RNA, Small Interfering; Tight Junctions; Transcription Factors | 2016 |
Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis.
Topics: Apoptosis; Autophagy; Berberine; Cell Line; Cell Survival; Deoxyglucose; Drug Synergism; Flow Cytometry; Humans; Lysosomes; Metformin; Proton Pumps; Transglutaminases | 2017 |
The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine.
Topics: Animals; Berberine; Cells, Cultured; Drug Interactions; HEK293 Cells; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kidney; Male; Metformin; Organic Cation Transport Proteins; Rats, Sprague-Dawley; Tissue Distribution | 2018 |
The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Berberine; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Metformin; Neoplasm Invasiveness; Sp1 Transcription Factor | 2018 |
Synthesis, Characterization, and Biological Evaluations of 1,3,5-Triazine Derivatives of Metformin Cyclization with Berberine and Magnolol in the Presence of Sodium Methylate.
Topics: Anti-Inflammatory Agents; Berberine; Biphenyl Compounds; Cyclization; Humans; Inflammation; Insulin Resistance; Lignans; Metformin; Molecular Structure; Sodium; Structure-Activity Relationship; Triazines | 2017 |
Bidirectional regulation of adenosine 5'-monophosphate-activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Cell Line; Glucose; Glycolysis; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Metformin; Mice; Muscle Fibers, Skeletal | 2018 |
Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling.
Topics: Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Aspartate Aminotransferases; Berberine; Chemokine CCL19; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Gene Expression Regulation; Humans; Interleukin-6; Liver; Metformin; Non-alcoholic Fatty Liver Disease; Protein Kinases; Rats; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA; Triglycerides; Tumor Necrosis Factor-alpha | 2018 |
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification.
Topics: Animals; Arsenic; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Electron Transport Complex II; Gene Expression Regulation; Glutathione; Hepatocytes; Insulin Resistance; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Sirtuins | 2019 |
Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine.
Topics: Adipose Tissue; Animals; Antiporters; Berberine; Catecholamine Plasma Membrane Transport Proteins; Dogs; Drug Interactions; Female; Hypoglycemic Agents; Intestinal Mucosa; Kidney; Liver; Madin Darby Canine Kidney Cells; Male; Metformin; Muscle, Skeletal; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats, Sprague-Dawley | 2019 |
A novel berberine-metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats.
Topics: 3T3 Cells; Adipogenesis; Adipose Tissue, White; Animals; Berberine; Diabetes Mellitus, Type 2; Female; Glucose; Hypoglycemic Agents; Lipid Metabolism; Liver; Male; Metformin; Mice; Obesity; Rats; Rats, Sprague-Dawley | 2019 |
Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway.
Topics: Animals; Arsenic; Berberine; Hypoglycemic Agents; Metformin; Mitochondria; Oxidative Stress; Pancreas; Rats; Sirtuins | 2019 |
Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota.
Topics: Administration, Oral; Animals; Bacteria; Berberine; Diabetes Mellitus; Drug Administration Schedule; Drug Interactions; Gastrointestinal Microbiome; Humans; Hypoglycemic Agents; Male; Metformin; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2019 |
Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice.
Topics: Animals; Berberine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Gastroenteritis; Gastrointestinal Microbiome; Glycated Hemoglobin; Hypoglycemic Agents; Intestinal Mucosa; Metformin; Obesity; Permeability | 2019 |
Combination of metformin and berberine represses the apoptosis of sebocytes in high-fat diet-induced diabetic hamsters and an insulin-treated human cell line.
Topics: Animals; Apoptosis; Berberine; Cells, Cultured; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Therapy, Combination; Glucose; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Injections, Intraperitoneal; Insulin; Mesocricetus; Metformin | 2020 |
Berberine attenuated olanzapine-induced metabolic alterations in mice: Targeting transient receptor potential vanilloid type 1 and 3 channels.
Topics: Animals; Antipsychotic Agents; Berberine; Body Temperature; Body Weight; Cytokines; Drinking; Female; Gene Expression Regulation; Ghrelin; Hypothalamus; Leptin; Metabolic Diseases; Metformin; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Neuropeptides; Obesity; Olanzapine; RNA, Messenger; Signal Transduction; Treatment Outcome; TRPV Cation Channels | 2020 |
Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Glycogenolysis; Hypoglycemic Agents; Liver; Liver Glycogen; Male; Metformin; Mice; Mice, Inbred C57BL; Molecular Structure | 2020 |
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Mellitus, Experimental; Disease Models, Animal; Gluconeogenesis; Glucose Tolerance Test; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Mechanistic Target of Rapamycin Complex 2; Metformin; Muscle, Skeletal; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Streptozocin | 2020 |
Development of capillary-paper spray for small-molecule analysis in complex samples.
Topics: Animals; Berberine; Cattle; Equipment Design; Hypoglycemic Agents; Mass Spectrometry; Metformin; Paper; Serum | 2021 |
Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway.
Topics: Amyloid beta-Peptides; Animals; Berberine; Cell Line, Tumor; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose; Glucose Transporter Type 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Maze Learning; Metformin; Neurons; Peptide Fragments; Phosphatidylinositol 3-Kinases; Protein Kinase C-epsilon; Rats; Rats, Wistar; Signal Transduction; Streptozocin | 2021 |
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Topics: Adenocarcinoma; Adenylate Kinase; Antineoplastic Agents; bcl-X Protein; Berberine; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Diabetes Mellitus; Dietary Supplements; Disease Progression; Doxorubicin; Female; Fluorouracil; Gemcitabine; Glycogen Synthase Kinase 3 beta; Glycolysis; Humans; Inhibitory Concentration 50; Malaria; MCF-7 Cells; Metformin; Molecular Targeted Therapy; Neoplasm Metastasis; Nitrophenols; Pancreatic Neoplasms; Piperazines; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Thiadiazoles; Tumor Stem Cell Assay | 2021 |
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action.
Topics: Animals; Apoptosis; Berberine; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Rats; Rats, Sprague-Dawley; Streptozocin; tau Proteins | 2021 |
Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome.
Topics: Animals; Berberine; Endometrium; Female; Metformin; Ovulation; Polycystic Ovary Syndrome; Rats | 2021 |
Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation.
Topics: Animals; Berberine; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Drug Synergism; Drug Therapy, Combination; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Male; Metformin; Mice; Nephritis; Protein Serine-Threonine Kinases | 2021 |
Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice.
Topics: Animals; Berberine; Chromatography, Liquid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Mice; RNA, Ribosomal, 16S; Tandem Mass Spectrometry | 2022 |
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.
Topics: Animals; Berberine; Cricetinae; Hyperlipidemias; Lipids; Metformin; Mice; Obesity | 2023 |