metformin and berberine

metformin has been researched along with berberine in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.08)	18.2507
2000's	5 (10.42)	29.6817
2010's	28 (58.33)	24.3611
2020's	14 (29.17)	2.80

Authors

Authors	Studies
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Liu, Y; Liu, Z; Peng, D; Wang, X; Xiao, D; Yin, W; Zhang, S; Zhou, M	1
Gao, CR; Huang, QL; Zhang, JQ	1
Chen, J; Chen, M; Hu, R; Li, F; Tang, J; Yang, Y; Yin, J	1
Xing, H; Ye, J; Yin, J	1
Joly, E; Lamontagne, J; Madiraju, SR; Nolan, CJ; Pepin, E; Peyot, ML; Poitout, V; Prentki, M; Ruderman, NB	1
Barroso-Aranda, J; Contreras, F; McCarty, MF	1
Doble, M; Prabhakar, PK	1
Jiang, JD; Kong, WJ; Pan, HN; Song, DQ; Wang, SK; Wang, YM; Wang, ZZ; Wei, J; Wu, JD; Xue, R; Zhang, H; Zhao, W; Zhou, ZX	1
Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Patil, S; Tawari, S; Umathe, S	1
Deng, H; Guan, Y; Liang, K; Ma, Y; Sui, M; Wang, A; Wei, W; Zhang, H; Zhang, Y; Zhao, H	1
Darzynkiewicz, Z; Halicka, HD; Hsieh, TC; Lee, YS; Li, J; Wu, JM; Zhao, H	1
An, Y; Guan, Y; Liu, B; Lu, M; Sun, Z; Zhang, Y	1
Davies, GE; Davies, PS; Droke, EA; Ehli, EA; Hu, Y; Nowotny, D; Soundy, TJ; Young, AJ	1
Finley, J	1
Choi, MK; Choi, YA; Kwon, M; Song, IS	1
Eibl, G; Ming, M; Rozengurt, E; Sinnett-Smith, J; Soares, HP; Wang, J; Young, SH	1
Dong, H; Jiang, SJ; Li, JB; Lu, FE; Wang, KF; Xu, LJ; Yi, P; Zou, X	1
Pang, X; Xu, J; Xue, Z; Zhang, M; Zhang, X; Zhao, L; Zhao, Y	1
Beauloye, C; Bertrand, L; Daskalopoulos, EP; Dufeys, C; Horman, S	1
Hatakeyama, T; Kohno, T; Kojima, T; Konno, T; Saito, T; Satohisa, S; Shimada, H; Takahashi, S; Tsujiwaki, M	1
Darzynkiewicz, Z; Garcia, J; Halicka, HD; Li, J; Zhao, H	1
Lin, Y; Pan, G; Wang, L; Xiao, L; Xue, Y; Zhang, C	1
Hann, SS; Tang, Q; Wu, J; Wu, W; Xiao, Q; Zheng, F	1
Cao, H; Feng, Y; Li, W; Liao, S; Wu, X; Xiao, X; Zhong, W; Zhu, J	1
Alimujiang, M; Bao, Y; Wei, L; Xiao, Y; Xu, M; Yin, J	1
Gao, S; Huang, D; Huang, J; Tong, P; Wang, Y; Wu, X; Yue, Y; Zhao, J	1
Javadipour, M; Keshtzar, E; Khodayar, MJ; Rezaei, M	2
Jin, J; Li, Y; Ma, Y; Shi, R; Wang, T; Xu, X; Xu, Z; Zhao, Y	1
Feng, Y; Gao, Y; Jia, D; Li, W; Li, ZW; Ma, M; Wu, Z; Zhou, X	1
Abrams, SL; Akula, SM; Bueno-Silva, B; Candido, S; Cervello, M; Follo, MY; Gizak, A; Lertpiriyapong, K; Libra, M; Lin, HL; Lombardi, P; Mao, W; Martelli, AM; Matias de Alencar, S; McCubrey, JA; Montalto, G; Murata, RM; Rakus, D; Ramazzotti, G; Ratti, S; Rosalen, PL; Steelman, LS	1
Chan, PKS; Cheung, SCK; Kong, APS; Lin, L; Lyu, Y; Shaw, PC; Yang, M; Yang, X; Zhang, Y; Zuo, Z	1
Chen, QK; Xu, JH; Yu, T; Zhang, W	1
Chen, L; Wei, Y; Yao, Y; Zuo, J	1
Bansal, Y; Bishnoi, M; Kondepudi, KK; Kuhad, A; Medhi, B; Singh, DP; Singh, R; Sodhi, RK	1
Deng, B; Gilbert, RG; Liu, X; Liu, Y; Sullivan, MA; Wang, K; Zhou, J	1
Hu, Q; Lu, FE; Xu, LJ; Xu, XH; Yi, P; Zhou, LS; Zou, X	1
Li, Y; Liu, C; Nie, Z; Xiong, C	1
Bao, Y; Chen, Q; Han, Y; Liu, C; Liu, W; Liu, X; Wang, J; Wu, N; Ye, Y; Yu, Y	1
Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Duda, P; Falzone, L; Gizak, A; Libra, M; Martelli, AM; McCubrey, JA; Meher, AK; Montalto, G; Rakus, D; Ratti, S; Ruvolo, P; Steelman, LS	1
Bai, Y; Deng, L; Feng, CP; Gao, X; Gu, Y; Guo, HX; Jin, C; Song, J; Su, H; Wang, Y; Xu, XY; Zhang, JF; Zhang, JH; Zhen, Z; Zheng, JF	1
Dong, H; Nie, K; Su, H; Tang, Y; Wang, H; Wang, Z; Xu, X	1
He, B; Xing, C; Zhang, J; Zhao, H	1
Sun, G; Sun, X; Zhang, B; Zhang, C; Zhang, X	1
Hedayati, N; Naeini, MB; Oskouei, Z; Tabeshpour, J	1
Kong, APS; Li, D; Li, Z; Lyu, Y; Ming, X; Shaw, PC; Yuan, X; Zhang, C; Zhang, J; Zuo, Z	1
Gao, TL; Guo, HH; Han, YX; Jiang, JD; Luo, ZG; Shen, HR; Wang, LL; Zhang, HJ; Zhang, JL	1

Reviews

4 review(s) available for metformin and berberine

Article	Year
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation. Journal of molecular and cellular cardiology, 2016, Volume: 91 Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Berberine; Cardiomegaly; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Humans; Metformin; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Resveratrol; Ribonucleotides; Signal Transduction; Stilbenes; Thiazolidinediones; Wound Healing	2016
Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells. Advances in biological regulation, 2019, Volume: 73 Topics: AMP-Activated Protein Kinases; Berberine; Cell Proliferation; Humans; Metformin; Neoplasm Proteins; Pancreatic Neoplasms	2019
Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis. Reproductive health, 2021, Aug-18, Volume: 18, Issue:1 Topics: Berberine; Clinical Decision-Making; Female; Humans; Hypoglycemic Agents; Inositol; Insulin; Insulin Resistance; Metabolome; Metformin; Network Meta-Analysis; Polycystic Ovary Syndrome; Thiazolidinediones; Uncertainty	2021
Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review. European journal of pharmacology, 2021, Dec-15, Volume: 913 Topics: Berberine; Biological Availability; Cardiovascular Diseases; Combined Modality Therapy; Diabetes Mellitus; Dietary Supplements; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lycopene; Metformin; Randomized Controlled Trials as Topic; Treatment Outcome	2021

Trials

4 trial(s) available for metformin and berberine

Article	Year
Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism: clinical and experimental, 2008, Volume: 57, Issue:5 Topics: Adult; Aged; Berberine; Cholesterol, HDL; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucose; Glycated Hemoglobin; Humans; Male; Metformin; Middle Aged	2008
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism: clinical and experimental, 2010, Volume: 59, Issue:2 Topics: Aged; Berberine; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Female; Gene Expression; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Liver Diseases; Male; Metformin; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazolidinediones	2010
A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. European journal of endocrinology, 2012, Volume: 166, Issue:1 Topics: Berberine; Cholesterol; Cholesterol, LDL; Female; Humans; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Triglycerides; Waist Circumference; Waist-Hip Ratio	2012
The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. Clinical endocrinology, 2014, Volume: 80, Issue:3 Topics: Adult; Berberine; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Young Adult	2014

Other Studies

40 other study(ies) available for metformin and berberine

Article	Year
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives. Bioorganic & medicinal chemistry letters, 2016, 10-01, Volume: 26, Issue:19 Topics: Berberine; Diabetes Mellitus, Type 2; Hep G2 Cells; Humans; Hypoglycemic Agents; Spectrum Analysis	2016
[Experimental study on berberin raised insulin sensitivity in insulin resistance rat models]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1997, Volume: 17, Issue:3 Topics: Animals; Berberine; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Rats; Rats, Wistar	1997
Effects of berberine on glucose metabolism in vitro. Metabolism: clinical and experimental, 2002, Volume: 51, Issue:11 Topics: Berberine; Cell Line; Chromans; Dose-Response Relationship, Drug; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Metformin; Phenotype; Thiazoles; Thiazolidinediones; Troglitazone	2002
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology, 2009, Volume: 150, Issue:8 Topics: Adenosine Triphosphate; Animals; Berberine; Cell Line; Fatty Acids; Glucose; Hypoglycemic Agents; Immunoblotting; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Lipid Metabolism; Membrane Potential, Mitochondrial; Metformin; Pioglitazone; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Thiazolidinediones	2009
Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease. Medical hypotheses, 2009, Volume: 73, Issue:6 Topics: AMP-Activated Protein Kinases; Animals; Berberine; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Metformin; Polycystic Kidney, Autosomal Dominant; Protein Serine-Threonine Kinases; TOR Serine-Threonine Kinases	2009
Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:12 Topics: Animals; Berberine; Biological Transport; Cells, Cultured; Chlorogenic Acid; Coumaric Acids; Deoxyglucose; Drug Synergism; Drug Therapy, Combination; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Metformin; Muscle Fibers, Skeletal; Muscle, Skeletal; Phenols; Phosphatidylinositol 3-Kinases; Plant Extracts; PPAR gamma; Rats; Thiazolidinediones	2009
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes. Behavioural brain research, 2011, Jun-20, Volume: 220, Issue:1 Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Berberine; Blood Glucose; Body Weight; Brain; Cholinesterase Inhibitors; Cholinesterases; Diabetes Mellitus, Experimental; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Glutathione; Hypoglycemic Agents; Indans; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Metformin; Piperidines; Rats; Rats, Wistar	2011
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging, 2012, Volume: 4, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Aspirin; Ataxia Telangiectasia Mutated Proteins; Berberine; Cell Cycle Proteins; Cell Line, Tumor; Cellular Senescence; Cholecalciferol; Deoxyglucose; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Flow Cytometry; Histones; Humans; Laser Scanning Cytometry; Membrane Potential, Mitochondrial; Metformin; Mitochondria; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins	2012
Metformin and berberine prevent olanzapine-induced weight gain in rats. PloS one, 2014, Volume: 9, Issue:3 Topics: Adipose Tissue, White; Animals; Antipyretics; Benzodiazepines; Berberine; Eating; Female; Ion Channels; Metformin; Mitochondrial Proteins; Olanzapine; Organ Size; Rats; Rats, Sprague-Dawley; Transcriptome; Uncoupling Protein 1; Weight Gain	2014
Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation. Medical hypotheses, 2014, Volume: 83, Issue:5 Topics: Alternative Splicing; AMP-Activated Protein Kinases; Animals; Berberine; DNA, Mitochondrial; Enzyme Activation; Exons; Gene Expression Regulation; Humans; Lamin Type A; Metformin; Models, Biological; Mutation; Nuclear Proteins; Oxidative Phosphorylation; Phosphorylation; Point Mutation; Progeria; Resveratrol; RNA-Binding Proteins; Serine-Arginine Splicing Factors; Stilbenes	2014
Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin. Archives of pharmacal research, 2015, Volume: 38, Issue:5 Topics: Administration, Intravenous; Animals; Berberine; Catecholamine Plasma Membrane Transport Proteins; Drug Interactions; HEK293 Cells; Humans; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats; Rats, Sprague-Dawley	2015
Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. PloS one, 2014, Volume: 9, Issue:12 Topics: Acetyl-CoA Carboxylase; Adenocarcinoma; AMP-Activated Protein Kinases; Animals; Berberine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; DNA Replication; Extracellular Signal-Regulated MAP Kinases; Humans; Hypoglycemic Agents; Insulin; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Nude; Multiprotein Complexes; Neoplasm Transplantation; Neurotensin; Pancreatic Neoplasms; Phosphorylation; RNA Interference; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Transplantation, Heterologous	2014
Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World journal of gastroenterology, 2015, Jul-07, Volume: 21, Issue:25 Topics: Active Transport, Cell Nucleus; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Berberine; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose-6-Phosphatase; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Lipids; Liver; Male; Metformin; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Protein Serine-Threonine Kinases; Rats, Wistar; Ribonucleotides; Signal Transduction; Streptozocin; Time Factors; Trans-Activators; Up-Regulation	2015
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Scientific reports, 2015, Sep-23, Volume: 5 Topics: Animals; Anti-Obesity Agents; Bacteria; Base Sequence; Berberine; Diet, High-Fat; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Gastrointestinal Tract; Male; Metformin; Obesity; Rats; Rats, Wistar; Sequence Analysis, DNA	2015
The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells. Oncotarget, 2016, May-10, Volume: 7, Issue:19 Topics: Adiponectin; Berberine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Endometrial Neoplasms; Endometrium; Epithelial Cells; Female; Gene Knockdown Techniques; Humans; Hypoglycemic Agents; Leptin; MARVEL Domain Containing 2 Protein; Metformin; Neoplasm Invasiveness; Receptors, Lipoprotein; Risk Factors; RNA Interference; RNA, Small Interfering; Tight Junctions; Transcription Factors	2016
Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis. Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:2 Topics: Apoptosis; Autophagy; Berberine; Cell Line; Cell Survival; Deoxyglucose; Drug Synergism; Flow Cytometry; Humans; Lysosomes; Metformin; Proton Pumps; Transglutaminases	2017
The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine. Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:3 Topics: Animals; Berberine; Cells, Cultured; Drug Interactions; HEK293 Cells; Hepatocytes; Humans; Hydrogen-Ion Concentration; Kidney; Male; Metformin; Organic Cation Transport Proteins; Rats, Sprague-Dawley; Tissue Distribution	2018
The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1. Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:1 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Berberine; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Metformin; Neoplasm Invasiveness; Sp1 Transcription Factor	2018
Synthesis, Characterization, and Biological Evaluations of 1,3,5-Triazine Derivatives of Metformin Cyclization with Berberine and Magnolol in the Presence of Sodium Methylate. Molecules (Basel, Switzerland), 2017, Oct-18, Volume: 22, Issue:10 Topics: Anti-Inflammatory Agents; Berberine; Biphenyl Compounds; Cyclization; Humans; Inflammation; Insulin Resistance; Lignans; Metformin; Molecular Structure; Sodium; Structure-Activity Relationship; Triazines	2017
Bidirectional regulation of adenosine 5'-monophosphate-activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration. Journal of cellular biochemistry, 2018, Volume: 119, Issue:12 Topics: AMP-Activated Protein Kinases; Animals; Berberine; Cell Line; Glucose; Glycolysis; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Metformin; Mice; Muscle Fibers, Skeletal	2018
Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling. Molecular medicine reports, 2018, Volume: 18, Issue:5 Topics: Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Aspartate Aminotransferases; Berberine; Chemokine CCL19; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Gene Expression Regulation; Humans; Interleukin-6; Liver; Metformin; Non-alcoholic Fatty Liver Disease; Protein Kinases; Rats; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA; Triglycerides; Tumor Necrosis Factor-alpha	2018
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification. Toxicology letters, 2019, Volume: 301 Topics: Animals; Arsenic; Berberine; Blood Glucose; Diabetes Mellitus, Type 2; Electron Transport Complex II; Gene Expression Regulation; Glutathione; Hepatocytes; Insulin Resistance; Lipid Peroxidation; Male; Malondialdehyde; Metformin; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Sirtuins	2019
Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Jan-15, Volume: 127 Topics: Adipose Tissue; Animals; Antiporters; Berberine; Catecholamine Plasma Membrane Transport Proteins; Dogs; Drug Interactions; Female; Hypoglycemic Agents; Intestinal Mucosa; Kidney; Liver; Madin Darby Canine Kidney Cells; Male; Metformin; Muscle, Skeletal; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats, Sprague-Dawley	2019
A novel berberine-metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats. Clinical and experimental pharmacology & physiology, 2019, Volume: 46, Issue:6 Topics: 3T3 Cells; Adipogenesis; Adipose Tissue, White; Animals; Berberine; Diabetes Mellitus, Type 2; Female; Glucose; Hypoglycemic Agents; Lipid Metabolism; Liver; Male; Metformin; Mice; Obesity; Rats; Rats, Sprague-Dawley	2019
Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway. Journal of biochemical and molecular toxicology, 2019, Volume: 33, Issue:9 Topics: Animals; Arsenic; Berberine; Hypoglycemic Agents; Metformin; Mitochondria; Oxidative Stress; Pancreas; Rats; Sirtuins	2019
Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life sciences, 2019, Oct-15, Volume: 235 Topics: Administration, Oral; Animals; Bacteria; Berberine; Diabetes Mellitus; Drug Administration Schedule; Drug Interactions; Gastrointestinal Microbiome; Humans; Hypoglycemic Agents; Male; Metformin; Rats; Rats, Sprague-Dawley; Tissue Distribution	2019
Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118 Topics: Animals; Berberine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Gastroenteritis; Gastrointestinal Microbiome; Glycated Hemoglobin; Hypoglycemic Agents; Intestinal Mucosa; Metformin; Obesity; Permeability	2019
Combination of metformin and berberine represses the apoptosis of sebocytes in high-fat diet-induced diabetic hamsters and an insulin-treated human cell line. Cell biochemistry and function, 2020, Volume: 38, Issue:5 Topics: Animals; Apoptosis; Berberine; Cells, Cultured; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Therapy, Combination; Glucose; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Injections, Intraperitoneal; Insulin; Mesocricetus; Metformin	2020
Berberine attenuated olanzapine-induced metabolic alterations in mice: Targeting transient receptor potential vanilloid type 1 and 3 channels. Life sciences, 2020, Apr-15, Volume: 247 Topics: Animals; Antipsychotic Agents; Berberine; Body Temperature; Body Weight; Cytokines; Drinking; Female; Gene Expression Regulation; Ghrelin; Hypothalamus; Leptin; Metabolic Diseases; Metformin; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Neuropeptides; Obesity; Olanzapine; RNA, Messenger; Signal Transduction; Treatment Outcome; TRPV Cation Channels	2020
Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice. Carbohydrate polymers, 2020, Sep-01, Volume: 243 Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Glycogenolysis; Hypoglycemic Agents; Liver; Liver Glycogen; Male; Metformin; Mice; Mice, Inbred C57BL; Molecular Structure	2020
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway. Current medical science, 2020, Volume: 40, Issue:3 Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Mellitus, Experimental; Disease Models, Animal; Gluconeogenesis; Glucose Tolerance Test; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Mechanistic Target of Rapamycin Complex 2; Metformin; Muscle, Skeletal; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Streptozocin	2020
Development of capillary-paper spray for small-molecule analysis in complex samples. Analytical and bioanalytical chemistry, 2021, Volume: 413, Issue:4 Topics: Animals; Berberine; Cattle; Equipment Design; Hypoglycemic Agents; Mass Spectrometry; Metformin; Paper; Serum	2021
Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway. BioFactors (Oxford, England), 2021, Volume: 47, Issue:4 Topics: Amyloid beta-Peptides; Animals; Berberine; Cell Line, Tumor; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose; Glucose Transporter Type 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Maze Learning; Metformin; Neurons; Peptide Fragments; Phosphatidylinositol 3-Kinases; Protein Kinase C-epsilon; Rats; Rats, Wistar; Signal Transduction; Streptozocin	2021
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals. Cells, 2021, 04-06, Volume: 10, Issue:4 Topics: Adenocarcinoma; Adenylate Kinase; Antineoplastic Agents; bcl-X Protein; Berberine; Biphenyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Diabetes Mellitus; Dietary Supplements; Disease Progression; Doxorubicin; Female; Fluorouracil; Gemcitabine; Glycogen Synthase Kinase 3 beta; Glycolysis; Humans; Inhibitory Concentration 50; Malaria; MCF-7 Cells; Metformin; Molecular Targeted Therapy; Neoplasm Metastasis; Nitrophenols; Pancreatic Neoplasms; Piperazines; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Thiadiazoles; Tumor Stem Cell Assay	2021
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine, 2021, Volume: 49, Issue:6 Topics: Animals; Apoptosis; Berberine; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Rats; Rats, Sprague-Dawley; Streptozocin; tau Proteins	2021
Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 91 Topics: Animals; Berberine; Endometrium; Female; Metformin; Ovulation; Polycystic Ovary Syndrome; Rats	2021
Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation. Pharmaceutical research, 2021, Volume: 38, Issue:11 Topics: Animals; Berberine; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Drug Synergism; Drug Therapy, Combination; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Male; Metformin; Mice; Nephritis; Protein Serine-Threonine Kinases	2021
Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 101 Topics: Animals; Berberine; Chromatography, Liquid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Mice; RNA, Ribosomal, 16S; Tandem Mass Spectrometry	2022
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 163 Topics: Animals; Berberine; Cricetinae; Hyperlipidemias; Lipids; Metformin; Mice; Obesity	2023