metformin has been researched along with aica ribonucleotide in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 37 (27.01) | 29.6817 |
| 2010's | 94 (68.61) | 24.3611 |
| 2020's | 6 (4.38) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Doebber, T; Fenyk-Melody, J; Fujii, N; Goodyear, LJ; Hirshman, MF; Li, Y; Moller, DE; Musi, N; Myers, R; Shen, X; Ventre, J; Wu, M; Zhou, G | 1 |
| Hansen, SH; McCormack, JG | 1 |
| Goodyear, LJ; Musi, N | 1 |
| Buteau, J; Dbaibo, G; El-Assaad, W; Hardy, S; Joly, E; Nolan, C; Peyot, ML; Prentki, M; Roduit, R; Rosenberg, L | 1 |
| Lehrman, MA; Shang, J | 1 |
| Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME | 1 |
| Al-Khalili, L; Forsgren, M; Kannisto, K; Krook, A; Lönnqvist, F; Zierath, JR | 1 |
| Huypens, P; Pipeleers, D; Quartier, E; Van de Casteele, M | 1 |
| Farese, RV; Giudicelli, J; Longnus, SL; Sajan, MP; Ségalen, C; Van Obberghen, E | 1 |
| Capano, M; Crompton, M | 1 |
| Araki, E; Fujisawa, K; Imoto, K; Kukidome, D; Matsumura, T; Motoshima, H; Nishikawa, T; Sonoda, K; Taguchi, T; Yano, M | 1 |
| Andreelli, F; Bertrand, L; Foretz, M; Guigas, B; Hue, L; Taleux, N; Vertommen, D; Viollet, B; Wiernsperger, N | 1 |
| Hattori, S; Hattori, Y; Kasai, K; Suzuki, K | 1 |
| Shakulov, RS | 1 |
| da Silva Xavier, G; Foretz, M; Kaufmann, MR; Leclerc, I; Looser, R; Meyer, UA; Rencurel, F; Rutter, GA; Stroka, D; Viollet, B | 1 |
| Chabrolle, C; Dupont, J; Tosca, L; Uzbekova, S | 1 |
| Frost, RA; Jefferson, LS; Krawiec, BJ; Lang, CH; Nystrom, GJ | 1 |
| Bilodeau-Goeseels, S; Guillemette, C; Richard, FJ; Sasseville, M | 1 |
| Hardie, DG; Towler, MC | 1 |
| Bibee, KP; Chi, MM; Eng, GS; Jungheim, ES; Moley, KH; Sheridan, RA; Wyman, A | 1 |
| Baines, DL; Hardie, DG; Kalsi, KK; Mustard, KJ; Pellatt, LJ; Pucovsky, V; Scott, JW; Sivagnanasundaram, J; Woollhead, AM | 1 |
| Chang, AS; Chi, MM; Moley, KH; Ratchford, AM; Sheridan, R | 1 |
| Carvalheira, JB; de Souza, CT; Faria, MC; Morari, J; Pauli, JR; Ropelle, ER; Saad, MJ; Ueno, M; Velloso, LA; Zecchin, KG | 1 |
| Fang, LP; Feng, LY; Feng, X; Li, J; Nan, FJ; Pang, T; Wen, TQ; Yu, LF; Zang, Y | 1 |
| Baetz, D; Counillon, L; Longnus, SL; Ségalen, C; Van Obberghen, E | 1 |
| Caraty, A; Chabrolle, C; Coyral-Castel, S; Dupont, J; Ferreira, G; Jeanpierre, E; Lomet, D; Monget, P; Rame, C; Tosca, L | 1 |
| Agius, L; Arden, C; Harbottle, A; Khan, S; Lange, AJ; Mukhtar, MH; Payne, VA | 1 |
| Adachi, M; Brenner, DA | 1 |
| Dolovcak, S; Emmett, D; Esser, V; Fitz, JG; Kilic, G; Parameswara, V; Puljak, L; Waldrop, SL | 1 |
| Albert, AP; Baines, DL; Mace, OJ; Woollhead, AM | 1 |
| Howie, J; Lang, CC; Petrie, JR; Wong, AK | 1 |
| Asakura, M; Asanuma, H; Fujita, M; Ito, S; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Mochizuki, N; Ogai, A; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M | 1 |
| Harhaji-Trajkovic, L; Isenovic, E; Janjetovic, K; Micic, D; Misirkic, M; Prica, M; Stevanovic, D; Sudar, E; Sumarac-Dumanovic, M; Trajkovic, V; Vucicevic, L | 1 |
| Bala, M; Buechler, C; Kopp, A; Lieberer, E; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J | 1 |
| Baty, CJ; Fitch, AC; Hallows, KR; King, JD; Kolls, JK; Magill, A; Myerburg, MM; Oyster, NM; Pilewski, JM; Watkins, SC | 1 |
| Brock, B; Li, WH; Pan, QR; Schmitz, O; Sun, Q; Wang, H; Xiao, XH | 1 |
| Bandow, K; Chiba, N; Kakimoto, K; Kasai, T; Kawamoto, S; Matsuguchi, T; Nagaoka, E; Ohnishi, T; Suzuki, H | 1 |
| Bala, M; Buechler, C; Kopp, A; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J; Wurm, S | 1 |
| Adamczyk, J; Gabryel, B; Labuzek, K; Liber, S; Okopień, B | 1 |
| Barnett, D; Burger, C; O'Riordan, KJ; Osting, SM; Potter, WB; Roopra, A; Wagoner, M | 1 |
| Hauton, D | 1 |
| Davidson, SM; Gonçalves, LM; Mocanu, MM; Paiva, MA; Providência, LA; Yellon, DM | 1 |
| Arnett, TR; Bataveljic, A; Chenu, C; Kola, B; Korbonits, M; Saxon, L; Shah, M; Viollet, B | 1 |
| Foretz, M; Lantier, L; Leclerc, J; Mounier, R; Pende, M; Viollet, B | 1 |
| Andersson, CX; Cansby, E; Johansson, A; Mahlapuu, M; Nerstedt, A; Smith, U | 1 |
| Bogachus, LD; Turcotte, LP | 1 |
| Jung, JH; Kim, HS; Kim, JH; Kim, SJ; Lee, JO; Lee, SK; Park, SH; Uhm, KO; You, GY | 1 |
| Banerjee, A; Flynt, L; Ghosh, S; Mellema, M; Panettieri, RA; Shore, SA; Williams, E; Zhu, M | 1 |
| Hay, N; Joshi, S; Platanias, LC; Viollet, B; Woodard, J | 1 |
| Gartenhaus, RB; Schneider, A | 1 |
| Li, L; Tao, HL; Wang, XF; Zhang, JY; Zhang, L; Zhao, XY | 1 |
| Aguer, C; Foretz, M; Hébrard, S; Kitzmann, M; Lantier, L; Mercier, J | 1 |
| Jang, WG; Kim, EJ; Koh, JT; Lee, KN; Son, HJ | 1 |
| Banerjee, S; Ghoshal, S; Porter, TD | 1 |
| Amato, S; Cantley, L; Liu, X; Man, HY; Rakic, P; Zheng, B | 1 |
| Bouscary, D; Chapuis, N; Green, AS; Lacombe, C; Mayeux, P; Tamburini, J | 1 |
| Brookes, P; Chang, C; Chen, LM; Chou, S; Lee, YF; Li, G; Liu, S; Massett, MP; Uno, H; Wu, Q | 1 |
| Craddock, L; Yang, J; Yap, F | 1 |
| Li, L; Wang, XF; Zhang, JY; Zhao, XY | 1 |
| Chesneau, D; Collet, A; Dupont, J; Lomet, D; Malpaux, B; Menassol, JB; Scaramuzzi, RJ; Tautou, C | 1 |
| Bøtker, HE; Jessen, N; Kristiansen, SB; Lund, S; Magnusson, NE; Nielsen, TT; Schmitz, O; Solskov, L | 1 |
| Altman, JK; Donato, NJ; Glaser, H; Platanias, LC; Vakana, E | 1 |
| Deng, SS; Huang, XJ; Li, J; Qian, M; Wu, L; Yang, CH; Zang, Y | 1 |
| Chin, JT; Fischbein, MP; Itoh, S; Kimura, N; Palmer, OP; Robbins, RC; Troke, JJ; Wang, X | 1 |
| Tan, WS; Wu, W; Ye, Z; Zhou, Y | 1 |
| Janjetovic, K; Micic, D; Misirkic, M; Starcevic, V; Stevanovic, D; Sumarac-Dumanovic, M; Trajkovic, V; Vucicevic, L | 1 |
| Atkins, AR; Coulter, S; Downes, M; Evans, RM; Liddle, C; Rao, R; Sherman, MH; Subramaniam, N; Wilson, C | 1 |
| Fuerst, J; Geibel, JP; Hufnagl, C; Jakab, M; Ketterl, N; Langelueddecke, C; Lehner, L; Ritter, M; Schmidt, S | 1 |
| Drouin, O; Gray, A; Green, CJ; Hardie, DG; Hundal, HS; Lantier, L; Marette, A; Ross, F; Stretton, C; Turban, S; Viollet, B; Watson, ML | 1 |
| Li, GH; Liu, J; Sheng, B | 1 |
| Alexandre, M; Diaz de Villalvilla, A; Gorelick, FS; Kolodecik, TR; Shugrue, CA; Thrower, EC; Young, LH | 1 |
| Holst, JJ; Kappe, C; Patrone, C; Sjöholm, A; Zhang, Q | 1 |
| Das, AK; Du, M; Duarte, MS; Fu, X; Liang, JF; Trobridge, GD; Yang, QY; Zhu, MJ | 1 |
| Huang, H; Kang, R; Luo, G; Wang, J; Yang, W; Zhao, Z | 1 |
| Cheng, JT; Chung, HH; Hsu, CT; Ku, PM; Lee, WJ; Yang, TT | 1 |
| Asnafi, V; Bost, F; Hagenbeek, T; Imbert, V; Lounnas, N; Michiels, JF; Nebout, M; Peyron, JF; Pontier-Bres, R; Reverso, J; Rosilio, C; Sahra, IB; Spits, H | 1 |
| Amrutkar, M; Cansby, E; Mahlapuu, M; Nerstedt, A; Smith, U | 1 |
| Geisslinger, G; King, TS; Kynast, KL; Möser, CV; Niederberger, E; Russe, OQ; Stephan, H | 1 |
| Farese, RV; Ivey, RA; Sajan, MP | 1 |
| Jie, S; Kim, HS; Kim, JH; Kim, N; Kim, SJ; Lee, HJ; Lee, JO; Lee, SK; Moon, JW; Park, SH; You, GY | 1 |
| Cai, B; Cai, X; Chen, X; Cheng, J; Hu, H; Hu, X; Huang, J; Jing, X; Li, Y; Tan, X; Wang, Q | 1 |
| Baik, SH; Choi, HY; Choi, KM; Hong, HC; Jung, TW; Lee, SY; Yoo, HJ | 1 |
| Abraham, E; Deshane, J; Gao, Y; Jiang, S; Park, DW; Stigler, WS; Tadie, JM; Zmijewski, JW | 1 |
| Alexeyev, MF; Creighton, JR; Jian, MY; Wolkowicz, PE; Zmijewski, JW | 1 |
| Belyaev, ND; Clarke, NE; Lambert, DW; Turner, AJ | 1 |
| Ardah, MT; Dulovic, M; El-Agnaf, OM; Harhaji-Trajkovic, L; Jovanovic, M; Kostic, V; Kravic-Stevovic, T; Markovic, I; Paunovic, V; Stefanis, L; Trajkovic, V; Xilouri, M | 1 |
| Hofer, A; Kladt, N; Lellek, V; Noe, N; Schauß, A; Tischner, C; Wenz, T | 1 |
| Erpicum, P; Jouret, F; Krzesinski, JM | 1 |
| Buac, D; Dou, QP; Kona, FR; Seth, AK | 1 |
| Alexandre, J; Berthier, A; Bouchaert, E; Colin, S; Dehondt, H; Diemer, H; Gheeraert, C; Groen, AK; Kamilic, J; Lefebvre, P; Lien, F; Lucas, A; Patrice, A; Pattou, F; Ploton, M; Porez, G; Prawitt, J; Rachez, C; Staels, B; Van Dorsselaer, A | 1 |
| Kim, HS; Kim, N; Kim, SJ; Lee, HJ; Lee, JO; Lee, SK; Moon, JW; Park, SH | 1 |
| Chen, W; Cheng, J; Cheng, W; Guo, Y; Huang, J; Huang, T; Jing, X; Li, Y; Tan, X; Wang, Q; Yamamoto, T; Zhang, Y; Zhu, Y | 1 |
| Geisslinger, G; Grösch, S; King, TS; Kynast, KL; Möser, CV; Niederberger, E; Olbrich, K; Russe, OQ | 1 |
| Chen, W; Fang, Y; Gong, L; Han, W; He, C; Hu, H; Jin, W; Li, D; Lou, F; Lou, H; Pan, H; Pan, Q; Sui, X; Wang, K; Wang, X; Xu, Y; Yang, J; Zhang, M; Zheng, Y; Zhou, X | 1 |
| Ahima, RS; Bang, S; Chen, Y; Kim, SF | 1 |
| Amrutkar, M; Cansby, E; Durán, EN; Mahlapuu, M; Nerstedt, A; Smith, U | 1 |
| Asara, JM; German, NJ; Gonzalez-Herrera, KN; Haigis, MC; Janzer, A; Struhl, K | 1 |
| Huang, F; Kou, J; Li, J; Liu, B; Liu, K; Qi, L; Sun, Y; Wang, M; Xiao, N | 1 |
| Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B | 1 |
| Alves, S; Blesbois, E; Froment, P; Grasseau, I; Métayer-Coustard, S; Nguyen, TM; Praud, C | 1 |
| Dyck, JR; Kim, TT | 1 |
| Burgos, RA; Córdova, A; Menarim, B; Ramírez-Reveco, A; Ratto, M; Rodríguez-Gil, JE; Strobel, P; Ulloa, O; Valenzuela, P; Vallejo, A | 1 |
| Bandow, K; Kakimoto, K; Kusuyama, J; Matsuguchi, T; Ohnishi, T | 1 |
| Gao, R; Goswami, R; Li, Q; Liu, L; Lv, Q; Yang, S; Zhen, Q; Zhou, H | 1 |
| Kai, Y; Kawano, Y; Narahara, H; Yamamoto, H | 1 |
| Choi, YK; Jang, SY; Jeon, JH; Jeong, WI; Jung, GS; Kang, YN; Kim, MK; Lee, IK; Park, KG; Park, SY; Shin, EC | 1 |
| Asahara, S; Bartolome, A; Inoue, H; Kanno, A; Kawamoto, T; Kido, Y; Koyanagi-Kimura, M; Matsuda, T; Matsuura, Y; Mieda, Y; Ogawa, W; Seino, S; Shimizu, S; Suzuki, E; Takahashi, H; Takai, T; Yokoi, N | 1 |
| Dong, H; Jiang, SJ; Li, JB; Lu, FE; Wang, KF; Xu, LJ; Yi, P; Zou, X | 1 |
| Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH | 1 |
| Dai, YL; Huang, SL; Leng, Y | 1 |
| Beauloye, C; Bertrand, L; Daskalopoulos, EP; Dufeys, C; Horman, S | 1 |
| Carvajal, K; El Hafidi, M; Moreno-Arriola, E; Ortega-Cuéllar, D | 1 |
| Baines, DL; Baker, EH; Carr, G; Garnett, JP; Patkee, WR | 1 |
| Ka, SO; Kim, JH; Kim, SJ; Park, BH; Park, JH; Shen, C | 1 |
| Ahn, HY; Ha, TS; Park, HY; Seong, SB | 1 |
| Dai, KR; Fan, QM; Han, XG; Qiao, H; Qu, XH; Tang, TT; Wang, L; Wang, YG; Yang, Y | 1 |
| Dash, PK; Hill, JL; Hylin, MJ; Kobori, N; Moore, AN; Rozas, NS; Zhao, J | 1 |
| Sun, A; Wang, P; Xu, L | 1 |
| Ahmad, W; Ebert, PR | 1 |
| Amano, T; Ishikawa, E; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Ma, A; Wang, J; Zhao, M; Zhu, H | 1 |
| Bizjak, M; Dolinar, K; Malavašič, P; Pavlin, M; Pirkmajer, S; Pohar, J | 1 |
| Faggi, L; Giustina, A; Tulipano, G | 1 |
| Boudaba, N; Foretz, M; Huet, C; Marion, A; Pierre, R; Viollet, B | 1 |
| Blendy, JA; Brynildsen, JK; Jin, S; Kim, SF; Lee, BG; Perron, IJ | 1 |
| Hosaka, T; Ishida, H; Kitahara, A; Kondo, T; Morita, N; Murashima, T; Onuma, H; Sumitani, Y; Takahashi, K; Tanaka, T | 1 |
| Bedard, N; Di Marco, S; Ford, RJ; Gallouzi, IE; Griss, T; Hall, DT; Jones, RG; Ma, JF; Mubaid, S; Omer, A; Pause, A; Sadek, J; Sanchez, BJ; Steinberg, GR; Tremblay, AMK; Wing, SS | 1 |
| Allwood, JW; Beall, C; Lees, Z; Logie, L; McDougall, G; Rena, G | 1 |
| Hughey, CC; Hunter, RW; Jessen, N; Lantier, L; Peggie, M; Sakamoto, K; Sicheri, F; Sundelin, EI; Wasserman, DH; Zeqiraj, E | 1 |
| Chen, D; Chen, H; Li, T; Liu, J; Liu, X; Lu, C; Ning, Z; Piao, HL; Qi, H; Tekcham, DS; Wang, W; Wang, Z; Xia, T; Xu, G; Yan, M; Zhao, X | 1 |
| Chen, E; Li, R; Liu, B; Liu, J; Liu, Y; Pan, T; Qu, H; Tang, Y; Tian, R; Zhang, R | 1 |
| Timm, KN; Tyler, DJ | 1 |
| Ganapathy, V; Higuchi, K; Kopel, J; Ramachandran, S; Ristic, B; Sato, T | 1 |
| Chen, BB; Chen, Y; Finkel, T; Huckestein, BR; Jiang, Y; Jurczak, MJ; Kennerdell, JR; Larsen, MB; Lear, TB; Lin, B; Liu, Y; Mallampalli, RK; Monga, SP; Nguyen, MK; O'Donnell, CP; Tuncer, F | 1 |
| Fu, CN; Gao, WS; Qu, YJ; Song, SS; Wei, H; Yue, SW | 1 |
| Cao, XJ; Chen, X; Qian, HY; Sun, YZ; Wu, R; Xu, GY; Zhang, PA; Zhu, HY | 1 |
| Dang, TN; Floyd, ZE; Kuhn, P; Pauli, GF; Poulev, A; Ribnicky, DM; Simmler, C; Vandanmagsar, B; Yu, Y | 1 |
9 review(s) available for metformin and aica ribonucleotide
| Article | Year |
|---|---|
AMP-activated protein kinase and muscle glucose uptake.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Exercise; Glucose; Glycogen; Humans; Hypoglycemic Agents; Insulin; Metformin; Multienzyme Complexes; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Nutritional Status; Protein Serine-Threonine Kinases; Rats; Ribonucleotides | 2003 |
AMP-activated protein kinase in metabolic control and insulin signaling.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adipocytes; Amino Acid Sequence; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carbohydrate Metabolism; Cell Cycle; Consensus Sequence; Diabetes Mellitus; Energy Metabolism; Enzyme Activation; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Lipid Metabolism; Metformin; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Muscle Cells; Neoplasms; Obesity; Oxygen Consumption; Peptide Hormones; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Subunits; Rats; Ribonucleotides; Sequence Alignment; Sequence Homology, Amino Acid | 2007 |
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cardiovascular Diseases; Enzyme Activation; Enzyme Activators; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Syndrome; Metformin; Ribonucleotides; Signal Transduction; Thiazolidinediones | 2009 |
LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Hematologic Neoplasms; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Protein Serine-Threonine Kinases; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases | 2011 |
[Role of AMP-activated protein kinase in renal ischemic preconditioning].
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Enzyme Activation; Epithelial Cells; Graft Survival; Humans; Ischemia; Ischemic Preconditioning; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Metformin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Ribonucleotides; Signal Transduction | 2014 |
Is AMPK the savior of the failing heart?
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Heart; Heart Failure; Humans; Metformin; Myocardium; Ribonucleotides | 2015 |
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.
Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Berberine; Cardiomegaly; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Humans; Metformin; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Resveratrol; Ribonucleotides; Signal Transduction; Stilbenes; Thiazolidinediones; Wound Healing | 2016 |
Energy Remodeling, Mitochondrial Disorder and Heart Failure.
Topics: Aminoimidazole Carboxamide; Animals; Energy Metabolism; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Mitochondrial Diseases; Ribonucleotides; Thiazolidinediones; Trimetazidine | 2016 |
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Caloric Restriction; Cardiotoxicity; Doxorubicin; Enzyme Activation; Enzyme Activators; Exercise; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Mitochondria, Heart; Myocytes, Cardiac; Resveratrol; Ribonucleotides; Signal Transduction; Thiazolidinediones | 2020 |
128 other study(ies) available for metformin and aica ribonucleotide
| Article | Year |
|---|---|
Role of AMP-activated protein kinase in mechanism of metformin action.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Proteins; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Enzyme Activation; Fatty Acids; Gene Expression; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Multienzyme Complexes; Muscle, Skeletal; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2001 |
Application of (13)C-filtered (1)H NMR to evaluate drug action on gluconeogenesis and glycogenolysis simultaneously in isolated rat hepatocytes.
Topics: Aminoimidazole Carboxamide; Animals; Carbon Isotopes; Cells, Cultured; Gluconeogenesis; Glucose; Glycerol; Glycolysis; Hepatocytes; Lactic Acid; Metformin; Nuclear Magnetic Resonance, Biomolecular; Protons; Rats; Rats, Wistar; Reference Values; Ribonucleotides | 2002 |
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.
Topics: Aminoimidazole Carboxamide; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Drug Synergism; Fatty Acids; Glucose; Humans; Hypoglycemic Agents; Islets of Langerhans; Metformin; Mitochondria; Oleic Acid; Oxidation-Reduction; Palmitates; Ribonucleotides; Stearates | 2003 |
Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates.
Topics: Amides; Aminoimidazole Carboxamide; Binding Sites; Caffeine; Catalysis; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic AMP; Cyclic GMP; Enzyme Activation; Fibroblasts; Glycogen; Glycogen Phosphorylase; Humans; Hypoglycemic Agents; Indoles; Lipid Metabolism; Mannose; Metformin; Oligosaccharides; Phosphorylation; Protein Binding; Ribonucleotides; Skin; Time Factors | 2004 |
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Elongation Factor 2 Kinase; Enzyme Activation; Green Fluorescent Proteins; Hypertrophy; Hypoglycemic Agents; Immunoblotting; Luminescent Proteins; Metformin; Microscopy, Fluorescence; Multienzyme Complexes; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Ribose; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Time Factors | 2004 |
Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.
Topics: Adult; Aminoimidazole Carboxamide; Biopsy; Cells, Cultured; Female; Glucose; Glucose Transporter Type 4; Glycogen; Humans; Insulin; Male; Metformin; Middle Aged; Monosaccharide Transport Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Reference Values; Ribonucleotides; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription Factors | 2005 |
Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Northern; Blotting, Western; Chromans; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Glucose; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Metformin; Mice; Multienzyme Complexes; Phenformin; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2005 |
Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; Insulin; Insulin Receptor Substrate Proteins; Male; Metformin; Mitogen-Activated Protein Kinase 3; Multienzyme Complexes; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction | 2005 |
Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; bcl-2-Associated X Protein; Cells, Cultured; Cytosol; Green Fluorescent Proteins; Metformin; Mitochondria, Heart; Multienzyme Complexes; Myocardial Ischemia; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Sprague-Dawley; Ribonucleotides | 2006 |
Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cells, Cultured; DNA-Binding Proteins; DNA, Mitochondrial; Endothelial Cells; Enzyme Activation; Heat-Shock Proteins; Humans; Hyperglycemia; Hypoglycemic Agents; Metformin; Mitochondria; Mitochondrial Proteins; Multienzyme Complexes; NF-E2-Related Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Ribonucleotides; RNA, Messenger; Superoxide Dismutase; Transcription Factors | 2006 |
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.
Topics: Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cattle; Glucokinase; Glucose; Kinetics; Liver; Male; Metformin; Models, Biological; Oligomycins; Phosphofructokinase-2; Protein Transport; Rats; Rats, Wistar; Ribonucleotides | 2006 |
Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cells, Cultured; Chemokine CCL2; Cytokines; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; I-kappa B Kinase; I-kappa B Proteins; Membrane Glycoproteins; Metformin; Multienzyme Complexes; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; Tumor Necrosis Factor-alpha | 2006 |
AMPK or ZMPK?
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Enzyme Activation; Humans; Isopentenyladenosine; Metformin; Models, Biological; Phosphorylation; Protein Kinases; Ribonucleosides; Ribonucleotides | 2006 |
Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Base Sequence; Cells, Cultured; DNA Primers; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Hepatocytes; Humans; Immunohistochemistry; Metformin; Mice; Multienzyme Complexes; Phenobarbital; Protein Serine-Threonine Kinases; Ribonucleotides | 2006 |
Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK).
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cattle; Cell Proliferation; Cell Survival; Cells, Cultured; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Insulin-Like Growth Factor I; Metformin; Multienzyme Complexes; Ovarian Follicle; Ovary; Phosphorylation; Progesterone; Protein Serine-Threonine Kinases; Ribonucleotides; Signal Transduction; Steroids | 2007 |
AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Deoxyglucose; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Energy Metabolism; Enzyme Activators; Glucocorticoids; Homeostasis; Metformin; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2007 |
Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.
Topics: Alanine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Cattle; Cell Nucleus; Colforsin; Cyclic AMP; Enzyme Activation; Female; Hypoglycemic Agents; Meiosis; Metformin; Multienzyme Complexes; Mycophenolic Acid; Oocytes; Protein Serine-Threonine Kinases; Protein Subunits; Ribonucleotides | 2007 |
AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Apoptosis; Enzyme Activation; Female; Glucose; Insulin-Like Growth Factor I; Metformin; Mice; Mice, Inbred Strains; Pregnancy; Pregnancy Outcome; Ribonucleotides; Superovulation | 2007 |
Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Amiloride; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cell Line; Chromatography, High Pressure Liquid; Epithelial Cells; Epithelial Sodium Channels; Fluorescence; Humans; Hypoglycemic Agents; Lung; Metformin; Microscopy, Confocal; Multienzyme Complexes; Ouabain; Phenformin; Protein Serine-Threonine Kinases; Ribonucleotides; Sodium | 2007 |
Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphosphate; Alanine Transaminase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Female; Hypoglycemic Agents; Metformin; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Oocytes; Pregnancy; Pregnancy in Diabetics; Protein Serine-Threonine Kinases; Ribonucleotides; Streptozocin | 2007 |
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anorexia; Deoxyglucose; Drug Administration Routes; Hypothalamus; Male; Metformin; Multienzyme Complexes; Neoplasm Transplantation; Neoplasms; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Survival Analysis; Tumor Cells, Cultured | 2007 |
AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Astrocytes; Cell Differentiation; Cell Line, Transformed; Cerebral Cortex; Embryo, Mammalian; Enzyme Activation; Hippocampus; Humans; Hypoglycemic Agents; Janus Kinases; Metformin; Mice; Multienzyme Complexes; Mutation; Neurons; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; STAT3 Transcription Factor; Stem Cells | 2008 |
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Glucose; Heart Ventricles; Hydrogen-Ion Concentration; Male; Metformin; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers | 2008 |
The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Estrous Cycle; Female; Gonadotropin-Releasing Hormone; Hypoglycemic Agents; Hypothalamus; Metformin; Multienzyme Complexes; Periodicity; Protein Serine-Threonine Kinases; Protein Subunits; Rats; Rats, Wistar; Ribonucleotides; RNA, Messenger | 2008 |
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Carrier Proteins; Cells, Cultured; Diuretics; Enzyme Activation; Glucokinase; Glucose; Hepatocytes; Hypoglycemic Agents; Immunohistochemistry; Male; Metformin; Multienzyme Complexes; Phosphofructokinase-2; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Wistar; Ribonucleotides; Sorbitol | 2008 |
High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.
Topics: Adenylate Kinase; Adiponectin; Aminoimidazole Carboxamide; Animals; Cell Division; Cell Line; Enzyme Activation; Humans; Liver; Metformin; Rats; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Telomerase | 2008 |
Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line.
Topics: Aminoimidazole Carboxamide; Amiodarone; AMP-Activated Protein Kinases; Animals; Apolipoproteins B; Cell Line; Enzyme Inhibitors; Epoxy Compounds; Exocytosis; Fatty Acids; Hepatocytes; Humans; Hypoglycemic Agents; Lipid Metabolism; Lovastatin; Metformin; Multienzyme Complexes; Oxidation-Reduction; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; Triglycerides | 2008 |
AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers.
Topics: Amiloride; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biophysical Phenomena; Cell Line; Cell Membrane; Cyclic Nucleotide-Gated Cation Channels; Epithelial Cells; Epithelial Sodium Channels; Humans; Ion Channel Gating; Lung; Metformin; Patch-Clamp Techniques; Permeability; Ribonucleotides | 2008 |
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Cells, Cultured; Disease Progression; Dogs; Drug Evaluation, Preclinical; Fibrosis; Gene Expression Regulation; Heart Failure; Insulin Resistance; Metformin; Myocytes, Cardiac; Natriuretic Peptides; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides; Transforming Growth Factor beta1; Ultrasonography; Ventricular Dysfunction, Left | 2009 |
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Enzyme Activation; G2 Phase; Glioma; Humans; Metformin; Pheochromocytoma; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides | 2009 |
Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity.
Topics: Adiponectin; Adult; Aminoimidazole Carboxamide; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Diabetes Mellitus, Type 2; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Obesity; Receptors, Cell Surface; Ribonucleotides | 2009 |
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Cell Polarity; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Epithelial Cells; Epithelial Sodium Channels; Humans; Inflammation Mediators; Membrane Potentials; Metformin; Microscopy, Confocal; Pneumonia; Respiratory Mucosa; Ribonucleotides; Sodium; Time Factors; Water-Electrolyte Balance | 2010 |
Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell.
Topics: Aminoimidazole Carboxamide; Animals; Cell Line, Tumor; Gene Expression Regulation; Glucose; Insulin-Secreting Cells; Metformin; Rats; Receptors, G-Protein-Coupled; Ribonucleotides | 2009 |
Osteoblast differentiation is functionally associated with decreased AMP kinase activity.
Topics: 3T3-L1 Cells; Adipocytes; Alkaline Phosphatase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Calcification, Physiologic; Cell Differentiation; Cell Line; Cell Survival; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Gene Expression; Glucose; Hypoglycemic Agents; Integrin-Binding Sialoprotein; Metformin; Mice; Mice, Inbred C57BL; Osteoblasts; Osteocalcin; Osteopontin; Phosphorylation; Ribonucleotides; Sialoglycoproteins; Transfection | 2009 |
Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Aminoimidazole Carboxamide; Body Mass Index; Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Galectin 3; Humans; Immunoblotting; Male; Metformin; Middle Aged; Monocytes; Oleic Acid; Palmitic Acid; Pyrazoles; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; Solubility; Time Factors | 2009 |
Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Cells, Cultured; Endosomes; Enzyme Activation; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lipopolysaccharides; Lysosomes; Metformin; Microglia; Peptide Fragments; Phagocytosis; Phosphoproteins; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides | 2010 |
Metabolic regulation of neuronal plasticity by the energy sensor AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antimetabolites; Blotting, Western; Deoxyglucose; Energy Metabolism; Enzyme Activation; Hippocampus; Hypoglycemic Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Metformin; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neuronal Plasticity; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases; Vidarabine | 2010 |
Does long-term metformin treatment increase cardiac lipoprotein lipase?
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Enzyme Activation; Glucose; Hypoglycemic Agents; Lipid Metabolism; Lipoprotein Lipase; Metformin; Myocardium; Rats; Ribonucleotides; Triglycerides | 2011 |
Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Heart; Hemodynamics; Hypoglycemic Agents; Infarction; Male; Metformin; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides | 2010 |
AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.
Topics: Alkaline Phosphatase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bone and Bones; Cell Differentiation; Cell Proliferation; Enzyme Activation; Enzyme Activators; Gene Expression Regulation, Enzymologic; Metformin; Mice; Mice, Knockout; Neurosecretory Systems; Organ Size; Osteoblasts; Osteogenesis; Phenotype; Protein Subunits; Rats; Ribonucleotides; RNA, Messenger; Tibia | 2010 |
Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Size; Cells, Cultured; Immunoblotting; In Vitro Techniques; Metformin; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphorylation; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa | 2010 |
AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Blotting, Western; Cell Survival; Cells, Cultured; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Interleukin-6; Liver; Metformin; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor | 2010 |
Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; CD36 Antigens; Cell Line; Down-Regulation; Fatty Acids; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Metformin; Muscle, Skeletal; Palmitates; Protein Kinases; Rats; Ribonucleotides; RNA Interference; Sirtuin 1 | 2010 |
Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cell Line; Gene Expression Regulation; Glucose Transporter Type 4; HeLa Cells; Humans; Insulin; Metformin; Mice; Muscle Cells; Muscle, Skeletal; Mutant Proteins; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Protein Transport; rab4 GTP-Binding Proteins; Ribonucleotides; RNA, Messenger; Signal Transduction | 2011 |
Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anilides; Anti-Inflammatory Agents; Antimetabolites; Asthma; Cells, Cultured; Chromans; Cytokines; Enzyme Activators; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Hypoglycemic Agents; Inflammation Mediators; Metformin; Myocytes, Smooth Muscle; PPAR gamma; Pyrazoles; Pyrimidines; Respiratory System; Ribonucleotides; Rosiglitazone; Thiazolidinediones; Troglitazone; Vidarabine | 2011 |
AMPK as a therapeutic target in renal cell carcinoma.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Humans; Kidney Neoplasms; Metformin; Molecular Targeted Therapy; Ribonucleotides; Signal Transduction | 2010 |
AMPK signaling: a targetable tumor suppressor pathway?
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Metformin; Molecular Targeted Therapy; Ribonucleotides; Signal Transduction | 2010 |
Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Echocardiography; Heart Failure; Hypoglycemic Agents; Insulin; Male; Metformin; Myocardium; Natriuretic Peptide, Brain; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Wistar; Ribonucleotides; Ventricular Function, Left; Ventricular Remodeling | 2011 |
Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cells, Cultured; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lipid Metabolism; Metformin; Middle Aged; Mitochondria; Muscle Fibers, Skeletal; Obesity; Oxidation-Reduction; Palmitates; Phosphorylation; Quadriceps Muscle; Ribonucleotides | 2011 |
AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells.
Topics: 3T3 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Homeodomain Proteins; Metformin; Mice; Osteoblasts; Protein Kinases; Ribonucleotides; RNA, Small Interfering; Smad1 Protein; Smad5 Protein; Smad8 Protein; Transcription, Genetic | 2011 |
Activation of AMP-kinase by policosanol requires peroxisomal metabolism.
Topics: Adenylate Kinase; Aldehyde Oxidoreductases; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anticholesteremic Agents; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinoma, Hepatocellular; Cells, Cultured; Enzyme Activation; Fatty Alcohols; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypoglycemic Agents; Liver; Metformin; Mice; Mice, Inbred C57BL; Peroxisomes; Protein Serine-Threonine Kinases; Rats; Ribonucleotides | 2011 |
AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Axons; Cell Polarity; Cells, Cultured; Hippocampus; Kinesins; Metformin; Mice; Microtubule-Associated Proteins; Neurons; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Ribonucleotides; Signal Transduction; Tissue Culture Techniques | 2011 |
Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Electron Transport Complex I; Gene Expression Regulation; Humans; Lactic Acid; Metformin; Mice; Mitochondria; Mitochondrial Myopathies; Muscle Weakness; Muscle, Skeletal; Myoblasts; NADH Dehydrogenase; Physical Conditioning, Animal; Receptors, Steroid; Receptors, Thyroid Hormone; Ribonucleotides | 2011 |
Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Hydrocarbons, Fluorinated; Liver; Liver X Receptors; Metformin; Orphan Nuclear Receptors; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; Sulfonamides; Transcription, Genetic | 2011 |
Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Survival; Cells, Cultured; Hypoglycemic Agents; Metformin; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Ribonucleotides; RNA, Messenger; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2011 |
The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain; Circadian Rhythm; Female; Infusions, Intraventricular; Melatonin; Metformin; Ribonucleotides; Sheep | 2011 |
Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Gene Expression; Gene Expression Profiling; Genes; Genetic Association Studies; Heart Ventricles; Ischemic Preconditioning, Myocardial; Metformin; Oligonucleotide Array Sequence Analysis; Phenotype; Physical Conditioning, Animal; Rats; Rats, Wistar; Ribonucleotides | 2012 |
Antileukemic effects of AMPK activators on BCR-ABL-expressing cells.
Topics: Amino Acid Substitution; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Metformin; Molecular Targeted Therapy; Mutant Proteins; Prodrugs; Protein Kinases; Recombinant Proteins; Ribonucleotides | 2011 |
5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Metformin; Receptors, Progesterone; Ribonucleotides; RNA, Small Interfering; Transcription, Genetic | 2011 |
A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Endothelial Cells; Enzyme Activation; Graft Rejection; Heart Transplantation; Metformin; Mice; Mice, Inbred C57BL; Reperfusion Injury; Ribonucleotides; Signal Transduction; Transplantation, Homologous | 2011 |
AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.
Topics: Adipogenesis; Adult Stem Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Mesenchymal Stem Cells; Metformin; Osteogenesis; Rabbits; Ribonucleotides; Time Factors | 2011 |
Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.
Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Eating; Ghrelin; Hypoglycemic Agents; Hypothalamus; Male; Metformin; Rats; Rats, Wistar; Ribonucleotides; Signal Transduction | 2012 |
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; beta Catenin; Hepatic Stellate Cells; Humans; Hypoglycemic Agents; Inflammation; Lipopolysaccharides; Male; Membrane Proteins; Metformin; Rats; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Wnt Proteins | 2012 |
Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Calcium; Cell Line, Tumor; Cell Proliferation; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulinoma; KATP Channels; Membrane Potentials; Metformin; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Ribonucleotides | 2012 |
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Activators; Glucose; Hypoglycemic Agents; Metformin; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Phenformin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Ribonucleotides; Signal Transduction; Time Factors | 2012 |
Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Transcription Factors; Daphnia; Metformin; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.
Topics: Amino Acid Sequence; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Ceruletide; Cyclic AMP-Dependent Protein Kinases; Enzyme Precursors; Gene Expression Regulation; Male; Metformin; Octoxynol; Pancreas; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium Dodecyl Sulfate | 2012 |
Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Caspase 3; Cytoprotection; Enteroendocrine Cells; Glucagon-Like Peptide 1; Hypoglycemic Agents; MAP Kinase Kinase 4; Metformin; Mice; Palmitic Acid; Phosphorylation; Protein Kinases; Ribonucleotides; Tumor Cells, Cultured | 2013 |
AMP-activated protein kinase stimulates myostatin expression in C2C12 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Enzyme Activation; Metformin; Mice; Mice, Knockout; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Myostatin; Ribonucleotides; RNA, Messenger | 2012 |
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Knockdown Techniques; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Metformin; Models, Biological; Multiprotein Complexes; Phenylbutyrates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Virus Replication | 2013 |
Mediation of AMP kinase in the increase of glucose uptake in L6 cells induced by activation of imidazoline I-2 receptors.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Benzofurans; Cell Line; Glucose; Imidazoles; Imidazoline Receptors; Metformin; Muscle Cells; Phosphorylation; Rats; Ribonucleotides | 2013 |
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.
Topics: Alleles; Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Lymphoma, T-Cell; Metformin; Mice; Mice, Nude; Neoplasm Transplantation; Phenformin; PTEN Phosphohydrolase; Ribonucleotides; Transgenes | 2013 |
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents; Enzyme Activation; Enzyme Activators; Gene Expression; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Interleukin-6; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Processing, Post-Translational; Ribonucleotides; Serum Amyloid A Protein; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2013 |
Activation of the AMP-activated protein kinase reduces inflammatory nociception.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Enzyme Activation; Hyperalgesia; Inflammation; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Skills; Nociception; Pain Measurement; Ribonucleotides; Rotarod Performance Test | 2013 |
Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Hepatocytes; Humans; Isoenzymes; Liver; Male; Metformin; Middle Aged; Protein Kinase C; Ribonucleotides | 2013 |
Tiam-1, a GEF for Rac1, plays a critical role in metformin-mediated glucose uptake in C2C12 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Glucose; Guanine Nucleotide Exchange Factors; Hypoglycemic Agents; Metformin; Mice; Muscle, Skeletal; p21-Activated Kinases; Phosphorylation; rac1 GTP-Binding Protein; Ribonucleotides; RNA, Messenger; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Up-Regulation | 2013 |
Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.
Topics: Aminoimidazole Carboxamide; Animals; Carcinoma, Hepatocellular; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Metformin; Mice; Ribonucleotides; Xenograft Model Antitumor Assays | 2013 |
AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes.
Topics: Adolescent; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carrageenan; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Activators; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Metformin; Ribonucleotides; Salicylates; Selenoprotein P | 2014 |
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing.
Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bacteremia; Chemotaxis, Leukocyte; Enzyme Activation; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Male; Metformin; Mice; Mice, Inbred C57BL; Neutrophils; Peritonitis; Phagocytosis; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Sirolimus | 2013 |
Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Membrane Permeability; Cell Movement; Cells, Cultured; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Gene Knockdown Techniques; In Vitro Techniques; Lipopolysaccharides; Lung; Male; Metformin; Microvessels; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Ribonucleotides; RNA, Small Interfering; Wound Healing | 2013 |
Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress.
Topics: Aminoimidazole Carboxamide; Angiotensin-Converting Enzyme 2; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation; Humans; Metformin; Peptidyl-Dipeptidase A; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Ribonucleotides; Sirtuin 1 | 2014 |
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro.
Topics: alpha-Synuclein; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Cell Death; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; DNA Fragmentation; Embryo, Mammalian; Humans; Hypoglycemic Agents; Metformin; Neuroblastoma; Neurons; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; RNA, Small Interfering; Tretinoin | 2014 |
Defining the action spectrum of potential PGC-1α activators on a mitochondrial and cellular level in vivo.
Topics: Aminoimidazole Carboxamide; Animals; Bezafibrate; HeLa Cells; Humans; Metformin; Mice; Mitochondrial Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Resveratrol; Ribonucleotides; Rosiglitazone; Signal Transduction; Stilbenes; Thiazolidinediones; Transcription Factors | 2014 |
Regulation of metformin response by breast cancer associated gene 2.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Metformin; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Ribonucleotides; Ubiquitin-Protein Ligases | 2013 |
Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.
Topics: Adenylate Kinase; Amino Acid Sequence; Aminoimidazole Carboxamide; Animals; Bile Acids and Salts; Biological Transport; Caco-2 Cells; Cholestasis, Intrahepatic; Hep G2 Cells; Homeostasis; Humans; Hypoglycemic Agents; Intestinal Mucosa; Intestines; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Receptors, Cytoplasmic and Nuclear; Ribonucleotides; Signal Transduction; Trans-Activators; Transcription, Genetic; Transcriptional Activation | 2014 |
AMPKα2 translocates into the nucleus and interacts with hnRNP H: implications in metformin-mediated glucose uptake.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Cell Line; Cell Nucleus; Glucose; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; Metformin; Muscle, Skeletal; Phosphorylation; Rats; Ribonucleotides; RNA Interference; RNA, Small Interfering; Transcytosis | 2014 |
AMP-activated protein kinase suppresses the in vitro and in vivo proliferation of hepatocellular carcinoma.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Hep G2 Cells; Heterografts; Humans; Hypoglycemic Agents; Ki-67 Antigen; Liver Neoplasms; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Neovascularization, Pathologic; Ribonucleotides | 2014 |
LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Cell Line; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Lipopolysaccharides; Macrophages; Metformin; Mice; Ribonucleotides; TOR Serine-Threonine Kinases | 2014 |
Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Synergism; Enzyme Activation; Enzyme Activators; Female; Fluorouracil; Humans; Metformin; Mice; Ribonucleotides; Xenograft Model Antitumor Assays | 2014 |
Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Gene Knockout Techniques; Gluconeogenesis; Glucose; HEK293 Cells; HeLa Cells; Humans; Hypoglycemic Agents; Lipid Metabolism; Liver; Metformin; Mice; Oxidation-Reduction; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Ribonucleotides | 2014 |
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Inflammation; Interleukin-6; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Ribonucleotides | 2014 |
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.
Topics: Aminoimidazole Carboxamide; Biguanides; Cell Line, Transformed; Cell Line, Tumor; Citric Acid Cycle; Endoplasmic Reticulum; Folic Acid; Glycerophosphates; Glycolysis; Humans; Lactates; Metabolome; Metformin; Neoplastic Stem Cells; Nucleotides; Phenformin; Ribonucleotides; src-Family Kinases; Tamoxifen | 2014 |
Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.
Topics: Adipokines; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Culture Media, Conditioned; Diet; Fructose; Metformin; NF-kappa B; Palmitic Acid; Rats; Resveratrol; Ribonucleotides; Sirtuin 1; Sodium Salicylate; Stilbenes; Vasodilation | 2014 |
Differential effects of AMPK agonists on cell growth and metabolism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes | 2015 |
Central role of 5'-AMP-activated protein kinase in chicken sperm functions.
Topics: Acrosome Reaction; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Survival; Chickens; Male; Metformin; Phosphorylation; Pyrazoles; Pyrimidines; Ribonucleotides; Semen Analysis; Spermatozoa | 2014 |
Use of hypometabolic TRIS extenders and high cooling rate refrigeration for cryopreservation of stallion sperm: presence and sensitivity of 5' AMP-activated protein kinase (AMPK).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Survival; Cryopreservation; Cryoprotective Agents; Horses; Hypoglycemic Agents; Male; Metformin; Ribonucleotides; Semen Preservation; Sperm Motility; Spermatozoa; Tromethamine | 2014 |
AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Base Sequence; Cattle; Cell Differentiation; Cells, Cultured; Chondrogenesis; Embryo, Mammalian; Extremities; Gene Knockdown Techniques; Genes, Reporter; Glucose; Humans; Luciferases; Metformin; Mice, Inbred C57BL; Molecular Sequence Data; Phosphorylation; Protein Subunits; Ribonucleotides; RNA, Small Interfering; Sodium Selenite; SOX9 Transcription Factor; Stem Cells; Transcriptional Activation; Transferrin | 2015 |
AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Lipid Metabolism; Liver Neoplasms; Metformin; Phosphorylation; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2015 |
A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells.
Topics: Adaptor Proteins, Signal Transducing; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cell Cycle Proteins; Chemokines; Female; Granulosa Cells; Humans; I-kappa B Proteins; Metformin; Phosphoproteins; Phosphorylation; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cell Line, Tumor; Gluconeogenesis; Hepacivirus; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Metformin; Receptors, Cytoplasmic and Nuclear; Ribonucleotides; Signal Transduction; Transforming Growth Factor beta | 2015 |
Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity.
Topics: Adamantane; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose Tolerance Test; Hypoglycemic Agents; Insulin-Secreting Cells; Islets of Langerhans; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; Phosphorylation; Pyrrolidines; Ribonucleotides; Vildagliptin | 2015 |
Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
Topics: Active Transport, Cell Nucleus; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Berberine; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose-6-Phosphatase; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Lipids; Liver; Male; Metformin; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Protein Serine-Threonine Kinases; Rats, Wistar; Ribonucleotides; Signal Transduction; Streptozocin; Time Factors; Trans-Activators; Up-Regulation | 2015 |
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Breast Neoplasms; Cyclophosphamide; DNA Damage; DNA Repair; Drug Combinations; Drug Synergism; Embryonic Stem Cells; Epirubicin; Female; Fibroblasts; Fluorouracil; Glucose; Humans; Hypoglycemic Agents; Lactic Acid; Lung; Metformin; Neoplastic Stem Cells; Pyrones; Ribonucleotides; Thiophenes | 2015 |
AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Lipid Metabolism; Metformin; Palmitates; Phosphorylation; Rats; Ribonucleotides | 2015 |
AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Respiration; Energy Metabolism; Fatty Acids; Gene Expression Regulation; Glucose; Humans; Lactic Acid; Longevity; Metformin; Mitochondria; Oxygen; Oxygen Consumption; Protein Serine-Threonine Kinases; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Ribonucleotides; Signal Transduction; Transcription Factors; Transcription, Genetic | 2016 |
Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biological Transport; Cell Line, Tumor; Claudin-1; Coculture Techniques; Electric Impedance; Epithelial Cells; Gene Expression; Glucose; Humans; Hypoglycemic Agents; Metformin; Occludin; Permeability; Pseudomonas aeruginosa; Respiratory Mucosa; Ribonucleotides; Tight Junctions | 2016 |
Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hep G2 Cells; Humans; Hypoglycemic Agents; Liver Neoplasms; MAP Kinase Signaling System; Metformin; Nanog Homeobox Protein; Real-Time Polymerase Chain Reaction; Ribonucleotides | 2016 |
Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Cell Line; Cell Nucleus; Crk-Associated Substrate Protein; Cytoplasm; Focal Adhesion Kinase 1; Losartan; Metformin; Mice; Microscopy, Confocal; Podocytes; Protein Kinase Inhibitors; Ribonucleotides; Signal Transduction | 2016 |
AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis.
Topics: 3T3-L1 Cells; Adipogenesis; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomarkers; Bone and Bones; DNA-Binding Proteins; Enzyme Activation; Humans; Metformin; Mice; Mice, Nude; Osteogenesis; Osteopontin; Promoter Regions, Genetic; Ribonucleotides; Signal Transduction; Transcription Factors | 2016 |
Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Injuries, Traumatic; Enzyme Activators; Hippocampus; Male; Maze Learning; Memory Disorders; Metformin; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nootropic Agents; Parietal Lobe; Phosphorylation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Ribonucleotides | 2016 |
Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease.
Topics: Aminoimidazole Carboxamide; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Hypoglycemic Agents; Levamisole; Metformin; Neurons; Receptors, Nicotinic; Ribonucleotides | 2017 |
Anti-diabetic drug metformin dilates retinal blood vessels through activation of AMP-activated protein kinase in rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Hypoglycemic Agents; Male; Metformin; Rats; Rats, Wistar; Retinal Vessels; Ribonucleotides; Vasodilator Agents | 2017 |
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biphenyl Compounds; Cell Line; Cell Migration Inhibition; Chemotaxis; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Genetic Predisposition to Disease; Humans; Macrophages; Metformin; Mice, Knockout; Phenotype; Pyrones; Receptors, CCR2; Ribonucleotides; Signal Transduction; Thiophenes | 2017 |
Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Enzyme Activation; Female; Humans; Metformin; Pyrones; Ribonucleotides; Thiophenes | 2017 |
Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals.
Topics: Adenylate Kinase; Adenylyl Cyclases; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Proliferation; Cell Survival; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Growth Hormone-Releasing Hormone; Humans; Metformin; Phosphorylation; Pituitary Neoplasms; Rats; Ribonucleotides; Ribosomal Protein S6; Signal Transduction; Stress, Physiological; Tumor Cells, Cultured | 2018 |
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cells, Cultured; Down-Regulation; Enzyme Activation; Fatty Acids; Fatty Liver; Gene Expression Regulation; Hepatocytes; Humans; Lipogenesis; Liver; Male; Metformin; Mice, Knockout; Oxidation-Reduction; Protein Serine-Threonine Kinases; Pyrones; Ribonucleotides; Small Molecule Libraries; Thiophenes | 2018 |
Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anxiety Disorders; Drug Evaluation, Preclinical; Enzyme Activation; Feeding Behavior; Gene Knockdown Techniques; Hippocampus; Male; Metformin; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Nerve Tissue Proteins; Nicotine; Ribonucleotides; Signal Transduction; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2018 |
Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Aminoimidazole Carboxamide; Animals; Chemokine CCL2; Inflammation; Metformin; Mice; NF-kappa B; Palmitic Acid; Phosphorylation; Ribonucleotides; Signal Transduction; Triglycerides | 2018 |
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Cachexia; Cell Line; Enzyme Activation; Inflammation; Interferon-gamma; Male; Metformin; Mice, Inbred BALB C; Mitochondria; Muscle, Skeletal; Neoplasms, Experimental; Nitric Oxide Synthase Type II; Protein Kinases; Ribonucleotides; Shock, Septic; Tumor Necrosis Factor-alpha | 2018 |
Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1).
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Equilibrative Nucleoside Transporter 1; Female; Glucose; Hepatocytes; Hypoglycemic Agents; Liver; Metformin; Mice; Phosphorylation; Ribonucleotides; Signal Transduction; Thioinosine | 2018 |
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Base Sequence; Chickens; Disease Models, Animal; Fructose-Bisphosphatase; Glucose; Glucose Intolerance; Homeostasis; Humans; Hypoglycemia; Liver; Metformin; Mice, Inbred C57BL; Mutation; Obesity; Prodrugs; Ribonucleotides | 2018 |
Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Citric Acid Cycle; Energy Metabolism; Enzyme Inhibitors; Fibroblasts; Humans; Hypoglycemic Agents; Lactic Acid; Metabolic Networks and Pathways; Metabolomics; Metformin; Mice; Mice, Knockout; Ribonucleotides | 2019 |
Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Benzamides; Cell Adhesion; Coculture Techniques; Endotoxemia; Gene Expression Regulation; Histone Deacetylases; HL-60 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoglycemic Agents; Kruppel-Like Transcription Factors; Lipopolysaccharides; Male; Metformin; Mice; Mice, Inbred C57BL; Phosphorylation; Ribonucleotides; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2019 |
The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin.
Topics: Aminoimidazole Carboxamide; Carcinoma, Hepatocellular; Citric Acid; Gene Expression Regulation, Neoplastic; Glycolysis; Hep G2 Cells; Humans; Hypoglycemic Agents; Liver Neoplasms; Metformin; Molecular Targeted Therapy; Ribonucleotides; Signal Transduction; Symporters; TOR Serine-Threonine Kinases | 2020 |
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Transformed; Diet, High-Fat; Epithelial Cells; F-Box Proteins; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondrial Dynamics; Obesity; Phosphorylation; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Stability; Proteolysis; Ribonucleotides; Ubiquitin-Protein Ligases; Ubiquitination | 2021 |
Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Butadienes; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Hypoglycemic Agents; Inflammation; Male; MAP Kinase Signaling System; Metformin; NADPH Oxidase 4; Neuralgia; Nitriles; Obesity; Oxidative Stress; Pain Threshold; Phosphorylation; Rats, Wistar; Ribonucleotides; Spinal Cord | 2021 |
Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; MAP Kinase Signaling System; Metformin; Neuralgia; NF-kappa B; Rats; Rats, Sprague-Dawley; Ribonucleotides | 2021 |
Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Artemisia; Cell Line; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts, Skeletal; Phosphorylation; Phytochemicals; Plant Extracts; Ribonucleotides; Signal Transduction | 2021 |