metformin and adenine

metformin has been researched along with adenine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (14.29)29.6817
2010's10 (71.43)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Becker, ML; Hofman, A; Stricker, BH; Uitterlinden, AG; van Schaik, RH; Visser, LE1
Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A1
Kazazis, C1
Hidaka, K; Iseki, K; Kobayashi, M; Komazawa, H; Ogura, J; Yamaguchi, H1
Cao, L; Gao, L; Jiang, T; Shi, JQ; Tan, L; Tan, MS; Wang, HF; Yu, JT; Zhang, QQ; Zhang, YD; Zhu, XC1
Cai, N; Chen, D; Feng, Y; Pan, Z; Tang, Q; Tian, N; Wang, C; Wang, Q; Wang, X; Wu, Y; Xia, D; Xu, D; Xu, H; Yan, M; Zhang, JJ; Zhang, X; Zhou, K; Zhou, Y1
Hayakawa, N; Hishiki, T; Kubo, A; Minamishima, S; Minamishima, YA; Morisaki, H; Nakamura, T; Oyaizu-Toramaru, T; Suematsu, M; Suhara, T; Yamaguchi, K1
Brand, K; D'Haese, PC; De Broe, ME; De Maré, A; Gottwald-Hostalek, U; Kamel, S; Lalau, JD; Neven, E; Opdebeeck, B; Verhulst, A; Vervaet, B1
Komori, H; Morokado, F; Nakanishi, T; Nishizawa, K; Tamai, I; Yoda, N1
Adham, SA; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Ali, H; Ashique, M; Manoj, P; Nemmar, A1
Corremans, R; D'Haese, PC; De Broe, ME; Leysen, H; Maudsley, S; Neven, E; Verhulst, A; Vervaet, BA1

Other Studies

14 other study(ies) available for metformin and adenine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.
    Diabetes, 2009, Volume: 58, Issue:3

    Topics: Adenine; Aged; Aged, 80 and over; Bile; Blood Glucose; Cohort Studies; Creatinine; Diabetes Mellitus; Drug Resistance, Multiple; Epithelial Cells; Female; Genetic Variation; Genotype; Glomerular Filtration Rate; Glycated Hemoglobin; Guanine; Hepatocytes; Humans; Kidney; Male; Metformin; Organic Cation Transport Proteins; Polymorphism, Single Nucleotide; White People

2009
Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.
    Journal of renal care, 2011, Volume: 37, Issue:1

    Topics: Acidosis, Lactic; Acute Kidney Injury; Adenine; Aged; Anti-HIV Agents; Diabetes Mellitus, Type 2; Drug Interactions; HIV Infections; Humans; Hypoglycemic Agents; Male; Metformin; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir

2011
A case of lactic acidosis (LA) after administration of tenofovir and metformin in a diabetic patient with recently diagnosed HIV infection.
    Journal of renal care, 2011, Volume: 37, Issue:3

    Topics: Acidosis, Lactic; Adenine; Anti-HIV Agents; Diabetes Mellitus, Type 2; HIV Infections; Humans; Hypoglycemic Agents; Male; Metformin; Organophosphonates; Reverse Transcriptase Inhibitors

2011
Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:3

    Topics: Adenine; Animals; Anti-Bacterial Agents; Body Weight; Gene Expression; Hypoglycemic Agents; Kidney; Kidney Failure, Chronic; Male; Metformin; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Penicillin G; Rats; Rats, Wistar; RNA, Messenger; Serum

2013
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.
    British journal of pharmacology, 2014, Volume: 171, Issue:13

    Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain; Brain Ischemia; Disease Models, Animal; Hypoglycemic Agents; Male; Metformin; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2014
Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.
    Cell death & disease, 2016, 10-27, Volume: 7, Issue:10

    Topics: Adenine; Adenylate Kinase; Animals; Apoptosis; Autophagy; Cellular Senescence; Enzyme Activation; Female; Gene Expression Regulation; Intervertebral Disc Degeneration; Male; Metformin; Neuroprotective Agents; Nucleus Pulposus; Oxidative Stress; Rats, Sprague-Dawley; RNA, Small Interfering; tert-Butylhydroperoxide

2016
Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.
    Molecular and cellular biology, 2017, Aug-15, Volume: 37, Issue:16

    Topics: Acidosis, Lactic; Adenine; Animals; Disease Models, Animal; Enzyme Inhibitors; Gluconeogenesis; Kidney; Liver; Male; Metformin; Mice, Inbred C57BL; Oxygen; Procollagen-Proline Dioxygenase; Renal Insufficiency, Chronic; RNA, Messenger; Survival Analysis; Up-Regulation

2017
Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.
    Kidney international, 2018, Volume: 94, Issue:1

    Topics: Adenine; Animals; Chronic Kidney Disease-Mineral and Bone Disorder; Disease Models, Animal; Humans; Hypoglycemic Agents; Male; Metformin; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Severity of Illness Index; Treatment Outcome; Vascular Calcification; Warfarin

2018
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
    PloS one, 2019, Volume: 14, Issue:4

    Topics: Adenine; Animals; Antiporters; Cephalexin; Creatinine; Disease Models, Animal; Down-Regulation; Humans; Hyperuricemia; Kidney; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Pharmacokinetics; Rats; Rats, Wistar; RNA, Messenger; Uric Acid

2019
The Effect of Metformin in Diabetic and Non-Diabetic Rats with Experimentally-Induced Chronic Kidney Disease.
    Biomolecules, 2021, 05-30, Volume: 11, Issue:6

    Topics: Adenine; Animals; Diabetes Mellitus, Experimental; Kidney; MAP Kinase Signaling System; Metformin; Rats; Rats, Wistar; Renal Insufficiency, Chronic

2021
Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats.
    Kidney international, 2022, Volume: 101, Issue:5

    Topics: Adenine; Animals; Canagliflozin; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Male; Metformin; Proteomics; Rats; Renal Insufficiency, Chronic

2022