Compounds > metformin

metformin and 2-piperidone

metformin has been researched along with 2-piperidone in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (77.78)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Chung, CH; Jang, HC; Kim, JA; Kim, SW; Lee, WY; Min, KW; Nam-Goong, IS; Rhee, EJ; Shivane, VK; Sosale, AR1
Kim, SH; Lee, SH; Yim, HJ1
Bae, KS; Choi, HY; Kim, B; Kim, JA; Kim, MJ; Kim, YH; Lee, SH; Lim, HS; Noh, YH1
Ahn, JY; Cho, JY; Cho, YM; Jang, IJ; Kim, JA; Lee, H; Lee, S; Lim, KS; Shin, D; Yu, KS1
Jang, IJ; Jung, JH; Kim, JA; Lee, H; Lim, KS; Oh, J; Park, SI; Yu, KS1
Chung, BH; Jin, J; Jin, L; Lim, SW; Yang, CW1
Chamnan, P; Han, KA; Kim, DJ; Kim, ES; Kim, EY; Kim, M; Kim, SH; Kwon, S; Lee, KW; Lee, MK; Lim, S; Moon, MK; Wongtanate, M; Yoon, KH; Yu, J1
Ahn, CH; Ahn, KJ; Chung, CH; Han, KA; Jang, HC; Kim, BJ; Kim, CH; Kim, J; Kim, SW; Ko, KP; Lee, DH; Lee, H; Lee, HW; Lee, KJ; Nam, JY; Oh, TK; Park, HK; Park, JH; Park, KS; Park, SW; Park, TS; Yu, JM1
Cho, JH; Hur, GC; Jang, YH; Jung, CH; Kim, JH; Kim, SH; Lee, BW; Lee, SH; Lee, WJ; Park, CY; Park, SE; Suh, S1
Choi, MG; Ihm, SH; Kang, JG; Kim, CS; Kim, SH; Lee, SJ; Yoo, HJ1
Chung, CH; Jang, HC; Jung, CH; Lee, WY; Min, KW; Nam-Goong, IS; Rhee, EJ; Shivane, VK; Sosale, AR1
Conde-Carmona, I; García-Medina, S; Jiménez-Vargas, JM; Lee, SH; Martínez-Muñoz, A1
Bae, KS; Cho, YS; Lee, SH; Lim, HS1
Chung, JY; Lee, S; Lee, SW; Park, SI; Yu, KS1
Benjachareonwong, S; Chamnan, P; Cho, YM; Choi, S; Deerochanawong, C; Kang, ES; Kim, S; Kosachunhanun, N; Kwon, S; Lee, MK; Lee, WJ; Oh, T; Pratipanawatr, T; Sattanon, S; Seekaew, S; Sirirak, T; Suraamornkul, S; Suwanwalaikorn, S1
Bae, JC; Hwang, YC; Kim, HJ; Kim, JH; Kim, SY; Kwak, SH; Lee, EY; Lee, S; Suh, S; Won, JC1
Ahn, BR; Kim, MS; Nguyen, HD; Oh, H; Yoon, IM1
Chung, SM; Hong, JH; Hwang, IC; Lim, S; Moon, JS1

Reviews

1 review(s) available for metformin and 2-piperidone

ArticleYear
Antidiabetic effect of gemigliptin: a systematic review and meta-analysis of randomized controlled trials with Bayesian inference through a quality management system.
    Scientific reports, 2021, 10-22, Volume: 11, Issue:1

    Topics: Animals; Bayes Theorem; Humans; Hypoglycemic Agents; Metformin; Piperidones; Pyrimidines; Randomized Controlled Trials as Topic

2021

Trials

14 trial(s) available for metformin and 2-piperidone

ArticleYear
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor gemigliptin compared with sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Aged; Asian People; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Fasting; Female; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidones; Pyrazines; Pyrimidines; Republic of Korea; Risk Reduction Behavior; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2013
Effects of food on the pharmacokinetics of gemigliptin/metformin sustained-release 50/1,000 mg (25/500 mg x 2 tablets) fixeddose combination tablet in healthy male volunteers.
    International journal of clinical pharmacology and therapeutics, 2014, Volume: 52, Issue:5

    Topics: Administration, Oral; Adult; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Food-Drug Interactions; Half-Life; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metabolic Clearance Rate; Metformin; Piperidones; Postprandial Period; Pyrimidines; Republic of Korea; Sex Factors; Tablets; Young Adult

2014
Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects.
    Clinical drug investigation, 2014, Volume: 34, Issue:6

    Topics: Adult; Blood Glucose; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidones; Pyrimidines; Young Adult

2014
A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Drug Therapy, Combination; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Organization and Administration; Piperidones; Pyrimidines; Republic of Korea; Tablets; Therapeutic Equivalency; Young Adult

2015
Efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes: A double-blind randomized controlled trial (INICOM study).
    Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:1

    Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Piperidones; Proinsulin; Pyrimidines; Republic of Korea; Thailand; Treatment Outcome

2017
Efficacy and safety of gemigliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus inadequately controlled with combination treatment of metformin and sulphonylurea: a 24-week, multicentre, randomized, double-blind, placebo-
    Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:5

    Topics: Aged; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Monitoring; Drug Resistance; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Incidence; Male; Metformin; Middle Aged; Piperidones; Pyrimidines; Republic of Korea; Risk; Sulfonylurea Compounds

2017
Effect of gemigliptin on glycaemic variability in patients with type 2 diabetes (STABLE study).
    Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:6

    Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidones; Pyrimidines; Sitagliptin Phosphate; Sulfonylurea Compounds; Treatment Outcome; Young Adult

2017
A 52-week extension study of switching from gemigliptin vs sitagliptin to gemigliptin only as add-on therapy for patients with type 2 diabetes who are inadequately controlled with metformin alone.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:6

    Topics: Aged; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidones; Pyrimidines; Sitagliptin Phosphate; Treatment Outcome

2018
Pharmacokinetic Interactions Between Gemigliptin and Metformin, and Potential Differences in the Pharmacokinetic Profile of Gemigliptin Between the Mexican and Korean Populations: A Randomized, Open-label Study in Healthy Mexican Volunteers.
    Clinical therapeutics, 2018, Volume: 40, Issue:10

    Topics: Adult; Area Under Curve; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Humans; Hypoglycemic Agents; Male; Metformin; Mexico; Piperidones; Pyrimidines; Republic of Korea; Young Adult

2018
Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects.
    Journal of Korean medical science, 2018, Oct-08, Volume: 33, Issue:41

    Topics: Adult; Area Under Curve; Cross-Over Studies; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Combinations; Healthy Volunteers; Humans; Male; Metformin; Middle Aged; Patient Safety; Piperidones; Pyrimidines; Tablets; Young Adult

2018
Pharmacokinetic comparison of gemigliptin 50 mg and metformin 500 mg as a fixed-dose combination and loose combination
.
    International journal of clinical pharmacology and therapeutics, 2019, Volume: 57, Issue:2

    Topics: Area Under Curve; Chromatography, Liquid; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Healthy Volunteers; Humans; Metformin; Piperidones; Pyrimidines; Tandem Mass Spectrometry

2019
Efficacy and safety of gemigliptin as add-on therapy to insulin, with or without metformin, in patients with type 2 diabetes mellitus (ZEUS II study).
    Diabetes, obesity & metabolism, 2020, Volume: 22, Issue:1

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Metformin; Piperidones; Pyrimidines; Treatment Outcome; Weight Gain

2020
Comparison of the effects of gemigliptin and dapagliflozin on glycaemic variability in type 2 diabetes: A randomized, open-label, active-controlled, 12-week study (STABLE II study).
    Diabetes, obesity & metabolism, 2020, Volume: 22, Issue:2

    Topics: Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 2; Fasting; Female; Glucosides; Glycemic Control; Humans; Male; Metformin; Middle Aged; Piperidones; Pyrimidines; Republic of Korea; Young Adult

2020
Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi-heart study.
    Diabetes, obesity & metabolism, 2023, Volume: 25, Issue:8

    Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Heart; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidones; Prospective Studies; Pyrimidines; Sulfonylurea Compounds

2023

Other Studies

3 other study(ies) available for metformin and 2-piperidone

ArticleYear
Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry.
    Archives of pharmacal research, 2013, Volume: 36, Issue:10

    Topics: Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Industry; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Piperidones; Pyrimidines; Republic of Korea

2013
Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus.
    Translational research : the journal of laboratory and clinical medicine, 2016, Volume: 174

    Topics: Animals; Apoptosis; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Exenatide; Hyperglycemia; Islets of Langerhans; Male; Metformin; Mitochondria; Oxidative Stress; Peptides; Piperidones; Pyrimidines; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Venoms

2016
Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells.
    Endocrine, 2018, Volume: 59, Issue:2

    Topics: AMP-Activated Protein Kinases; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Humans; Hypoglycemic Agents; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Metformin; Phosphorylation; Piperidones; Pyrimidines; Signal Transduction; Thyroid Neoplasms; Vascular Cell Adhesion Molecule-1

2018