metformin and 17-alpha-hydroxyprogesterone

metformin has been researched along with 17-alpha-hydroxyprogesterone in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (33.33)18.2507
2000's8 (44.44)29.6817
2010's4 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jakubowicz, DJ; Nestler, JE1
Utiger, RD1
Koivunen, RM; Martikainen, HK; Morin-Papunen, LC; Ruokonen, A1
Bayram, F; Keleştimur, F; Sahin, Y; Unlühizarci, K1
Arslanian, S; Witchel, SF1
Bayram, F; Keleştimur, F; Sahin, Y; Tutuş, A; Unlühizarci, K1
Cianci, A; Ciani, A; De Leo, V; Egbe, TO; la Marca, A; Morgante, G; Paglia, T1
Caputo, M; Castello, R; Moghetti, P; Muggeo, M; Negri, C; Perrone, F; Tosi, F; Zanolin, E1
Attia, GR; Carr, BR; Rainey, WE1
Koivunen, RM; Martikainen, HK; Morin-Papunen, LC; Ruokonen, A; Tapanainen, JS1
Bendlová, B; Cibula, D; Hill, M; Snajderová, M; Stárka, L; Sulcová, J; Vondra, K; Vrbíková, J1
Battaglia, C; Gamba, O; Genazzani, AD; Malavasi, B; Strucchi, C; Tortolani, F1
Berker, B; Corapcioglu, D; Demirel, C; Emral, R; Kose, K; Unlu, C1
Bahtiyar, G; Sacerdote, AS; Weiss, K1
De Cicco, S; Guido, M; Lanzone, A; Proto, C; Romualdi, D; Tagliaferri, V1
Ferriani, RA; Japur de Sá Rosa-e-Silva, AC; Nascimento, AD; Reis, RM; Silva Lara, LA1
Asenjo, S; Cassorla, F; Codner, E; Eyzaguirre, FC; Iñíguez, G; López, P; Mujica, V; Torrealba, I1
Krysiak, R; Okopien, B1

Trials

7 trial(s) available for metformin and 17-alpha-hydroxyprogesterone

ArticleYear
Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome.
    The New England journal of medicine, 1996, Aug-29, Volume: 335, Issue:9

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Blood Glucose; Female; Humans; Hydroxyprogesterones; Hyperandrogenism; Hypoglycemic Agents; Insulin; Leuprolide; Luteinizing Hormone; Metformin; Obesity; Polycystic Ovary Syndrome; Steroid 17-alpha-Hydroxylase; Testosterone

1996
Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.
    Fertility and sterility, 1998, Volume: 69, Issue:4

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Androstenedione; Blood Glucose; Cohort Studies; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Menstruation; Metformin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Sex Hormone-Binding Globulin; Testosterone; Time Factors

1998
Metformin treatment reduces ovarian cytochrome P-450c17alpha response to human chorionic gonadotrophin in women with insulin resistance-related polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2000, Volume: 15, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Chorionic Gonadotropin; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Ovary; Polycystic Ovary Syndrome; Steroid 17-alpha-Hydroxylase; Testosterone

2000
Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Blood Glucose; Buserelin; Cholesterol; Double-Blind Method; Endocrine Glands; Female; Glucose Clamp Technique; Glucose Tolerance Test; Gonadotropin-Releasing Hormone; Humans; Hypoglycemic Agents; Insulin Resistance; Menstruation Disturbances; Metformin; Polycystic Ovary Syndrome; Triglycerides

2000
Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.
    Fertility and sterility, 2004, Volume: 81, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Androstenedione; Area Under Curve; Blood Glucose; C-Peptide; Estradiol; Female; Follicle Stimulating Hormone; Humans; Insulin; Luteinizing Hormone; Menstrual Cycle; Metformin; Obesity; Ovary; Polycystic Ovary Syndrome; Testosterone

2004
Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2004, Volume: 19, Issue:3

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Body Mass Index; Dehydroepiandrosterone Sulfate; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Luteinizing Hormone; Menstrual Cycle; Metformin; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Testosterone

2004
Metformin for the treatment of hyperandrogenism in adolescents with type 1 diabetes mellitus.
    Hormone research in paediatrics, 2013, Volume: 80, Issue:5

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androsterone; Diabetes Complications; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Gonadotropins; Humans; Hyperandrogenism; Hypoglycemic Agents; Metformin; Ovulation

2013

Other Studies

11 other study(ies) available for metformin and 17-alpha-hydroxyprogesterone

ArticleYear
Insulin and the polycystic ovary syndrome.
    The New England journal of medicine, 1996, Aug-29, Volume: 335, Issue:9

    Topics: 17-alpha-Hydroxyprogesterone; Female; Humans; Hydroxyprogesterones; Hyperandrogenism; Insulin; Luteinizing Hormone; Metformin; Obesity; Polycystic Ovary Syndrome; Steroid 17-alpha-Hydroxylase; Testosterone

1996
The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome.
    European journal of endocrinology, 1999, Volume: 140, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androstenedione; Blood Glucose; Cytochrome P-450 Enzyme System; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Isoenzymes; Metformin; Polycystic Ovary Syndrome

1999
Ovarian responses to hCG stimulation: insulin resistance/hyperinsulinaemia vs. insulin deficiency.
    Clinical endocrinology, 1999, Volume: 51, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenocorticotropic Hormone; Blood Glucose; Chorionic Gonadotropin; Drug Therapy, Combination; Female; Follicle Stimulating Hormone; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Luteinizing Hormone; Metformin; Ovary; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Stimulation, Chemical; Testosterone; Time Factors

1999
The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome.
    Clinical endocrinology, 1999, Volume: 51, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Androstenedione; Buserelin; Case-Control Studies; Female; Follicle Stimulating Hormone; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Statistics, Nonparametric

1999
Metformin directly inhibits androgen production in human thecal cells.
    Fertility and sterility, 2001, Volume: 76, Issue:3

    Topics: 17-alpha-Hydroxyprogesterone; 3-Hydroxysteroid Dehydrogenases; Androgens; Androstenedione; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Colforsin; Female; Gene Expression Regulation, Enzymologic; Humans; Metformin; Phosphoproteins; Progesterone; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Testosterone; Theca Cells; Transcription, Genetic

2001
Ovarian steroidogenic response to human chorionic gonadotrophin in obese women with polycystic ovary syndrome: effect of metformin.
    Human reproduction (Oxford, England), 2001, Volume: 16, Issue:12

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Androstenedione; Blood Glucose; Chorionic Gonadotropin; Estradiol; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Obesity; Ovary; Polycystic Ovary Syndrome; Steroids; Testosterone

2001
[Effect of long-term treatment with metformin on steroid levels and parameters of insulin resistance in women with polycystic ovary syndrome].
    Casopis lekaru ceskych, 2001, Nov-08, Volume: 140, Issue:22

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adult; Androgens; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Menstrual Cycle; Metformin; Polycystic Ovary Syndrome

2001
Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2007, Volume: 13, Issue:6

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adult; Aged; Antipsychotic Agents; Cortodoxone; Dehydroepiandrosterone; Endocrine Disruptors; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Male; Metformin; Middle Aged; Radioimmunoassay; Rosiglitazone; Testosterone; Thiazolidinediones; Valproic Acid

2007
The metabolic status modulates the effect of metformin on the antimullerian hormone-androgens-insulin interplay in obese women with polycystic ovary syndrome.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:5

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Androgens; Androstenedione; Anti-Mullerian Hormone; Body Mass Index; Female; Follicular Phase; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Metformin; Obesity; Polycystic Ovary Syndrome; Testosterone; Waist-Hip Ratio; Young Adult

2011
Effects of metformin on serum insulin and anti-Mullerian hormone levels and on hyperandrogenism in patients with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:3

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Anti-Mullerian Hormone; Female; Follicular Phase; Humans; Hyperandrogenism; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Longitudinal Studies; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Prospective Studies; Testosterone; Up-Regulation; Young Adult

2013
The effect of metformin on androgen production in diabetic women with non-classic congenital adrenal hyperplasia.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2014, Volume: 122, Issue:10

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adult; Androgens; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Metformin; Middle Aged; Testosterone; Treatment Outcome

2014