metformin has been researched along with 1-methyl-4-phenylpyridinium in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Wang, J; Xia, L; Zhou, M | 1 |
| Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI | 1 |
| Inui, K; Katsura, T; Masuda, S; Sato, T; Tanihara, Y; Yonezawa, A | 1 |
| Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI; Usui, T | 1 |
| Fromm, MF; König, J; Solbach, TF; Zolk, O | 1 |
| Fromm, MF; Hoffmann, C; König, J; Singer, K; Zolk, O | 1 |
| Fromm, MF; Grube, M; Solbach, TF; Zolk, O | 1 |
| Jordan, J; Schroeder, C | 1 |
| Inoue, K; Ito, S; Kusuhara, H; Sugiyama, Y; Toyoshima, J; Yokochi, M; Yuasa, H | 1 |
| Balk, B; Bujok, K; Fromm, MF; Glaeser, H; Mandery, K; Schmidt, I | 1 |
| Choi, MK; Song, IS | 1 |
| Harper, JN; Wright, SH | 1 |
| Belzer, M; Jagadish, B; Mash, EA; Morales, M; Wright, SH | 1 |
| Rodrigues, AD; Shen, H; Yang, Z; Zhang, Y; Zhao, W | 1 |
| Fromm, MF; Hacker, K; Kornhuber, J; Maas, R; Zolk, O | 1 |
| Fukuhara, A; Ishiguro, N; Kusuhara, H; Lechner, C; Nishiyama, K; Ohtsu, N; Shimizu, H; Takatani, M; Washio, I; Yamamura, N | 1 |
| Jung, JA; Kaisar, N; Parvez, MM; Shin, HJ; Shin, JG | 1 |
| Coutinho, AL; Obianom, ON; Shu, Y; Xue, F; Yang, H; Yang, W | 1 |
| Morales, M; Sandoval, PJ; Secomb, TW; Wright, SH | 1 |
| Bister, B; Ishiguro, N; Kusuhara, H; Saito, A; Takatani, M | 1 |
22 other study(ies) available for metformin and 1-methyl-4-phenylpyridinium
| Article | Year |
|---|---|
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line; Dogs; Equilibrative Nucleoside Transport Proteins; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Intestinal Absorption; Intestine, Small; Membrane Potentials; Metformin; RNA, Messenger; Transfection | 2007 |
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium | 2007 |
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Cimetidine; Dogs; Humans; Metformin; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Procainamide; Quinidine; Tetraethylammonium; Transfection | 2008 |
Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Benzamides; Cations; Cell Line; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Isoquinolines; Lidocaine; Metformin; Organic Cation Transport Proteins; Procainamide; Quinidine; Rats | 2008 |
Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).
Topics: 1-Methyl-4-phenylpyridinium; Biological Transport; Cell Line; Drug Interactions; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Metformin; Models, Molecular; Molecular Weight; Organic Cation Transport Proteins; Organic Cation Transporter 2; Pharmaceutical Preparations; Solubility; Solvents; Structure-Activity Relationship; Surface Properties; Transfection | 2009 |
Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Dogs; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Transfection | 2011 |
Organic cation transporter 3: expression in failing and nonfailing human heart and functional characterization.
Topics: 1-Methyl-4-phenylpyridinium; Drug Interactions; Endothelial Cells; Gene Expression Regulation; Heart Failure; Heart Ventricles; HEK293 Cells; Humans; Metformin; Myocardium; Organic Cation Transport Proteins | 2011 |
Norepinephrine uptake mechanisms in cardiovascular disease deserve our attention.
Topics: 1-Methyl-4-phenylpyridinium; Heart Failure; Humans; Metformin; Organic Cation Transport Proteins | 2011 |
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
Topics: 1-Methyl-4-phenylpyridinium; 3-Iodobenzylguanidine; Animals; Binding, Competitive; Biological Transport; Cephalexin; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Humans; Kidney; Kinetics; Liver; Male; Metformin; Mice; Mice, Inbred Strains; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pyridines; Tetraethylammonium; Transfection | 2012 |
Inhibition of hepatic uptake transporters by flavonoids.
Topics: 1-Methyl-4-phenylpyridinium; Apigenin; Atorvastatin; Biological Transport; Flavanones; Flavonoids; Food-Drug Interactions; HEK293 Cells; Hepatocytes; Heptanoic Acids; Humans; Inhibitory Concentration 50; Kaempferols; Liver-Specific Organic Anion Transporter 1; Metformin; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; Pyrroles; Quercetin; Rutin; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfobromophthalein; Tritium | 2012 |
Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Substitution; Asian People; Humans; Lamivudine; Metformin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymorphism, Single Nucleotide; Tetraethylammonium | 2012 |
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.
Topics: 1-Methyl-4-phenylpyridinium; Androstenes; Animals; Benzhydryl Compounds; Carbazoles; Carvedilol; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperidines; Propanolamines; Tetraethylammonium | 2013 |
Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.
Topics: 1-Methyl-4-phenylpyridinium; 4-Chloro-7-nitrobenzofurazan; Animals; Biological Transport; Cations; CHO Cells; Cricetinae; Cricetulus; Fluorescent Dyes; HEK293 Cells; Humans; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Quaternary Ammonium Compounds | 2013 |
Assessment of vandetanib as an inhibitor of various human renal transporters: inhibition of multidrug and toxin extrusion as a possible mechanism leading to decreased cisplatin and creatinine clearance.
Topics: 1-Methyl-4-phenylpyridinium; Cell Line; Cisplatin; Creatinine; HEK293 Cells; Humans; Kidney; Metformin; Organic Cation Transport Proteins; Piperidines; Quinazolines | 2013 |
Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates.
Topics: 1-Methyl-4-phenylpyridinium; Cell Line; Drug Evaluation, Preclinical; Drug Interactions; Humans; In Vitro Techniques; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Pyridinium Compounds; Substrate Specificity | 2015 |
Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.
Topics: 1-Methyl-4-phenylpyridinium; Biological Transport; Buffers; Dose-Response Relationship, Drug; Drug Interactions; Estrone; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Modulators; Metformin; Organic Cation Transport Proteins; Rhodamine 123; Risk Assessment; Thiamine; Transfection | 2016 |
Inhibitory Interaction Potential of 22 Antituberculosis Drugs on Organic Anion and Cation Transporters of the SLC22A Family.
Topics: 1-Methyl-4-phenylpyridinium; Aminosalicylic Acid; Animals; Antitubercular Agents; Ciprofloxacin; HEK293 Cells; Humans; Inhibitory Concentration 50; Ion Transport; Kinetics; Levofloxacin; Linezolid; Metformin; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Pyrazinamide; Rifabutin; Rifampin; Zidovudine | 2016 |
Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2.
Topics: 1-Methyl-4-phenylpyridinium; Biguanides; HEK293 Cells; Humans; Liver; Metformin; Organic Cation Transporter 1; Organic Cation Transporter 2 | 2017 |
Kinetic basis of metformin-MPP interactions with organic cation transporter OCT2.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetulus; Drug Interactions; Kinetics; Metformin; Models, Biological; Models, Molecular; Organic Cation Transporter 2; Protein Binding; Protein Conformation | 2019 |
Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors.
Topics: 1-Methyl-4-phenylpyridinium; Ammonium Chloride; Biological Transport; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Metformin; Organic Cation Transport Proteins; Pharmaceutical Preparations | 2021 |