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metergoline and 1-(3-chlorophenyl)piperazine

metergoline has been researched along with 1-(3-chlorophenyl)piperazine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199017 (62.96)18.7374
1990's8 (29.63)18.2507
2000's2 (7.41)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hamblin, MW; Metcalf, MA1
Glennon, RA1
Hamblin, MW; Monsma, FJ; Shen, Y; Sibley, DR; Ward, RP1
Hamblin, MW; Jose, PA; Metcalf, MA; Monsma, FJ; Shen, Y; Sibley, DR1
Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB1
Bai, F; Johnstone, EM; Little, SP; Nelson, DL; Su, C; Varga, G; Yin, T1
Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D1
Bendotti, C; Borsini, F; Ferraris, A; Garattini, S; Mennini, T; Samanin, R1
Aulakh, CS; Hill, JL; Murphy, DL1
Bernstein, SE; Grover, GN; Hill, JL; Murphy, DL; Pigott, TA; Zohar, J; Zohar-Kadouch, RC1
Asnis, GM; Cahn, W; Kahn, RS; Kalus, O; van Praag, HM; Wetzler, S1
Kesslick, JM; Martin, GE; Mathiasen, JR1
Brazell, C; Dourish, CT; King, BH; Middlemiss, DN1
Chojnacka-Wójcik, E; Jaros, T; Kłodzińska, A; Maj, J1
Barrett, JE; Brady, LS1
Wielosz, M1
Mueller, EA; Murphy, DL; Sunderland, T1
Insel, TR; Zohar, J1
Bagdy, G; Hill, J; Murphy, DL; Szemeredi, K; Zukowska-Grojec, Z1
Schechter, LE; Simansky, KJ1
Bagdy, G; Hill, JL; Murphy, DL; Szemeredi, K1
Insel, TR; Mueller, EA; Murphy, DL; Zohar, J; Zohar-Kadouch, RC1
Cervo, L; Rochat, C; Romandini, S; Samanin, R1
Miranda, GF; Roncucci, R; Verry, M1
Fuller, RW; Hahn, RA; Hynes, MD1
Bendotti, C; Borsini, F; Ferraris, A; Mennini, T; Samanin, R1
Bernstein, S; Grady, TA; Hill, JL; L'Heureux, F; Murphy, DL; Pigott, TA; Rubenstein, CS1

Reviews

1 review(s) available for metergoline and 1-(3-chlorophenyl)piperazine

ArticleYear
Central serotonin receptors as targets for drug research.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin

1987

Trials

5 trial(s) available for metergoline and 1-(3-chlorophenyl)piperazine

ArticleYear
Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder.
    Biological psychiatry, 1991, Mar-01, Volume: 29, Issue:5

    Topics: Administration, Oral; Adult; Double-Blind Method; Drug Interactions; Female; Humans; Hydrocortisone; Male; Metergoline; Obsessive-Compulsive Disorder; Piperazines; Placebos; Prolactin; Psychiatric Status Rating Scales; Receptors, Serotonin; Serotonin; Stimulation, Chemical

1991
Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects.
    Psychiatry research, 1990, Volume: 33, Issue:2

    Topics: Administration, Oral; Adult; Affect; Arousal; Brain; Humans; Hydrocortisone; Male; Metergoline; Methysergide; Piperazines; Prolactin; Receptors, Serotonin

1990
Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology.
    Biological psychiatry, 1987, Volume: 22, Issue:6

    Topics: Adult; Brain; Clomipramine; Depressive Disorder; Desipramine; Diagnosis, Differential; Female; Humans; Male; Metergoline; Middle Aged; Obsessive-Compulsive Disorder; Piperazines; Serotonin; Synaptic Transmission

1987
Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls.
    Archives of general psychiatry, 1987, Volume: 44, Issue:11

    Topics: Adult; Affect; Aged; Behavior; Body Temperature; Female; Humans; Male; Metergoline; Middle Aged; Obsessive-Compulsive Disorder; Piperazines; Prolactin; Serotonin; Serotonin Antagonists

1987
A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP.
    Biological psychiatry, 1993, Jan-01, Volume: 33, Issue:1

    Topics: Administration, Oral; Adult; Analysis of Variance; Compulsive Personality Disorder; Female; Humans; Injections, Intravenous; Male; Metergoline; Piperazines; Psychiatric Status Rating Scales; Serotonin Receptor Agonists

1993

Other Studies

21 other study(ies) available for metergoline and 1-(3-chlorophenyl)piperazine

ArticleYear
Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.
    Molecular pharmacology, 1991, Volume: 40, Issue:2

    Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cyclic AMP; GTP-Binding Proteins; Humans; Molecular Sequence Data; Pertussis Toxin; Receptors, Serotonin; Virulence Factors, Bordetella

1991
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain Chemistry; Cell Line; Cloning, Molecular; DNA; GTP-Binding Proteins; Lysergic Acid Diethylamide; Molecular Sequence Data; Polymerase Chain Reaction; Psychotropic Drugs; Rats; Receptors, Serotonin; RNA; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection

1993
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
    The Journal of biological chemistry, 1993, Aug-25, Volume: 268, Issue:24

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Cyclic AMP; Gene Expression; Kidney Tubules, Proximal; Lysergic Acid Diethylamide; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Serotonin; Recombinant Proteins; Serotonin; Transfection

1993
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature

1993
Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.
    European journal of pharmacology, 2004, Jan-26, Volume: 484, Issue:2-3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Chickens; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Gerbillinae; Guinea Pigs; Haplorhini; Humans; Molecular Sequence Data; Protein Binding; Rabbits; Receptors, Serotonin; Serotonin Agents; Swine

2004
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2

    Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists

2004
Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 308, Issue:2

    Topics: Animals; Appetite Depressants; Brain; Catecholamines; Dextroamphetamine; Feeding Behavior; Female; Fenfluramine; Metergoline; Piperazines; Rats; Serotonin; Synaptosomes

1979
Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2

    Topics: Animals; Corticosterone; Ergolines; Male; Metergoline; Mianserin; Neurosecretory Systems; Piperazines; Prolactin; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spiperone

1992
Blockade of conditioned avoidance responding by trazodone, etoperidone, and MCPP.
    Psychopharmacology, 1989, Volume: 99, Issue:1

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Conditioning, Psychological; Male; Metergoline; Piperazines; Rats; Rats, Inbred F344; Receptors, Serotonin; Trazodone

1989
MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.
    Neuroscience letters, 1989, Oct-23, Volume: 105, Issue:1-2

    Topics: Adrenocorticotropic Hormone; Animals; Antiparkinson Agents; Ergolines; Ketanserin; Male; Metergoline; Pindolol; Piperazines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone

1989
Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP).
    Journal of neural transmission. Parkinson's disease and dementia section, 1989, Volume: 1, Issue:3

    Topics: Animals; Ergolines; Exploratory Behavior; Male; Metergoline; Mianserin; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone

1989
Effects of serotonin receptor agonists and antagonists on schedule-controlled behavior of squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Cinanserin; Conditioning, Operant; Cyproheptadine; Electroshock; Female; Ketanserin; Male; Metergoline; Methysergide; Piperazines; Piperidines; Pyrazines; Quipazine; Receptors, Serotonin; Saimiri

1985
Increased sensitivity to serotonergic agonists after repeated electroconvulsive shock in rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:5

    Topics: 5-Hydroxytryptophan; 5-Methoxytryptamine; Animals; Brain; Chlorides; Cyproheptadine; Electroshock; Fenfluramine; Lithium; Lithium Chloride; Male; Metergoline; Motor Activity; Piperazines; Rats; Serotonin; Synaptic Transmission

1985
Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans.
    Psychopharmacology, 1986, Volume: 89, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Body Temperature; Female; Growth Hormone; Humans; Hydrocortisone; Metergoline; Piperazines; Prolactin; Receptors, Serotonin

1986
M-chlorophenylpiperazine increases blood pressure and heart rate in pithed and conscious rats.
    Life sciences, 1987, Aug-10, Volume: 41, Issue:6

    Topics: Adrenal Medulla; Animals; Blood Pressure; Brain; Heart Rate; Kinetics; Male; Metergoline; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spinal Cord

1987
Properties of some 1-arylpiperazines as antagonists of stereotyped behaviors mediated by central serotonergic receptors in rodents.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Male; Metergoline; Mice; Motor Activity; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Stereotyped Behavior; Syndrome; Thiazolidines; Thyrotropin-Releasing Hormone

1988
The serotonin agonist, M-chlorophenylpiperazine, markedly increases levels of plasma catecholamines in the conscious rat.
    Neuropharmacology, 1988, Volume: 27, Issue:10

    Topics: Animals; Catecholamines; Decerebrate State; Denervation; Dopamine; Epinephrine; Male; Metergoline; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Splanchnic Nerves

1988
Evidence that m-chlorophenylpiperazine inhibits some nociceptive responses of rats by activating 5-hydroxytryptamine mechanisms.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:5

    Topics: Animals; Male; Metergoline; Pain; Piperazines; Rats; Reaction Time; Serotonin; Time Factors

1982
Two novel agents affecting eating through an action on monoaminergic systems.
    International journal of obesity, 1984, Volume: 8 Suppl 1

    Topics: Animals; Appetite Depressants; Dextroamphetamine; Drug Tolerance; Eating; Female; Fenfluramine; Lethal Dose 50; Metergoline; Methysergide; Penfluridol; Phentolamine; Piperazines; Piperidines; Propranolol; Pyridines; Rats; Rats, Inbred Strains; Serotonin

1984
Apomorphine-induced aggression in rats chronically treated with oral clonidine: modulation by central serotonergic mechanisms.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:2

    Topics: Aggression; Animals; Apomorphine; Brain Chemistry; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Metergoline; Piperazines; Rats; Rats, Inbred Strains; Serotonin

1982
Repeated treatment with d-fenfluramine or metergoline alters cortex binding of 3H-serotonin and serotenergic sensitivity in rats.
    European journal of pharmacology, 1980, Jan-25, Volume: 61, Issue:2

    Topics: Animals; Appetite Depressants; Binding Sites; Cerebral Cortex; Ergolines; Female; Fenfluramine; Metergoline; Piperazines; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Time Factors

1980