metaphit has been researched along with cocaine in 5 studies
| Studies (metaphit) | Trials (metaphit) | Recent Studies (post-2010) (metaphit) | Studies (cocaine) | Trials (cocaine) | Recent Studies (post-2010) (cocaine) |
|---|---|---|---|---|---|
| 68 | 0 | 4 | 32,461 | 1,096 | 9,400 |
| Protein | Taxonomy | metaphit (IC50) | cocaine (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.338 | |
| Fatty acid-binding protein, heart | Homo sapiens (human) | 0.367 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0855 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0855 | |
| D | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.2861 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.4321 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0855 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.5442 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.8885 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.3796 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5.541 | |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.05 | |
| Transporter | Rattus norvegicus (Norway rat) | 3.2277 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Philip, A; Rahman, MA | 1 |
| Jacobson, AE; Lajtha, A; Reith, ME; Rice, KC; Zimányi, I | 1 |
| Reith, ME | 1 |
| Berger, P; Jacobson, AE; Reith, ME; Rice, KC; Sershen, H | 1 |
| Berger, P; Jacobsen, AE; Lessor, RA; Reith, MA; Rice, KC | 1 |
5 other study(ies) available for metaphit and cocaine
| Article | Year |
|---|---|
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
Topics: Animals; Benzamides; Binding, Competitive; Brain Stem; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Thiocyanates | 1991 |
Long-term blockade of the dopamine uptake complex by metaphit, an isothiocyanate derivative of phencyclidine.
Topics: Animals; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Female; Hydrogen-Ion Concentration; Injections, Intraventricular; Kinetics; Male; Mazindol; Membrane Proteins; Mice; Nerve Tissue Proteins; Phencyclidine; Radioligand Assay | 1989 |
Cocaine receptors on monoamine transporters and sodium channels.
Topics: Animals; Biological Transport; Brain Chemistry; Cocaine; Dopamine; Drug Tolerance; Humans; Phencyclidine; Phosphatidylinositols; Receptors, Drug; Serotonin; Sodium Channels; Structure-Activity Relationship | 1988 |
Metaphit prevents locomotor activation induced by various psychostimulants and interferes with the dopaminergic system in mice.
Topics: Amphetamine; Animals; Biogenic Amines; Brain Chemistry; Cocaine; Dopamine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Phencyclidine; Receptors, Dopamine | 1988 |
Metaphit, a receptor acylator, inactivates cocaine binding sites in striatum and antagonizes cocaine-induced locomotor stimulation in rodents.
Topics: Animals; Binding Sites; Cocaine; Corpus Striatum; Female; Male; Motor Activity; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |