metallothionein and flavanone

metallothionein has been researched along with flavanone* in 1 studies

Other Studies

1 other study(ies) available for metallothionein and flavanone

Article	Year
Naringenin inhibits pro‑inflammatory cytokine production in macrophages through inducing MT1G to suppress the activation of NF‑κB. Molecular immunology, 2021, Volume: 137 Naringenin (Nar) is a flavanone that has been suggested to provide human health benefits such as anti-inflammatory, anti-oxidant and anti-cancer properties. However, the mechanisms underlying these benefits are complex and still not fully understood. In this study, we investigated the effect of Nar on the inflammatory response of macrophages and its underlying mechanism. In lipopolysaccharide (LPS)-stimulated human macrophages, Nar inhibited the activation of NF-κB pathway and suppressed the downstream expression of pro-inflammatory factors. In addition, Nar was also able to induce metallothionein 1 G (MT1G) expression, and the inhibitory effects of Nar on the production of pro-inflammatory cytokines was dependent on MT1G. Mechanistically, we found that MT1G-mediated inhibition of pro-inflammatory cytokines responses might be through repressing NF-κB activation via zinc chelation. Overall, this study reveals a novel mechanism of Nar on inflammatory responses, the suppression of NF-κB activation through upregulation of MT1G. Topics: Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Cytokines; Flavanones; HEK293 Cells; Humans; Inflammation; Lipopolysaccharides; Macrophages; Metallothionein; NF-kappa B; Signal Transduction; THP-1 Cells; Up-Regulation	2021

Article

Year

Naringenin inhibits pro‑inflammatory cytokine production in macrophages through inducing MT1G to suppress the activation of NF‑κB.

Molecular immunology, 2021, Volume: 137

Naringenin (Nar) is a flavanone that has been suggested to provide human health benefits such as anti-inflammatory, anti-oxidant and anti-cancer properties. However, the mechanisms underlying these benefits are complex and still not fully understood. In this study, we investigated the effect of Nar on the inflammatory response of macrophages and its underlying mechanism. In lipopolysaccharide (LPS)-stimulated human macrophages, Nar inhibited the activation of NF-κB pathway and suppressed the downstream expression of pro-inflammatory factors. In addition, Nar was also able to induce metallothionein 1 G (MT1G) expression, and the inhibitory effects of Nar on the production of pro-inflammatory cytokines was dependent on MT1G. Mechanistically, we found that MT1G-mediated inhibition of pro-inflammatory cytokines responses might be through repressing NF-κB activation via zinc chelation. Overall, this study reveals a novel mechanism of Nar on inflammatory responses, the suppression of NF-κB activation through upregulation of MT1G.

Topics: Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Cytokines; Flavanones; HEK293 Cells; Humans; Inflammation; Lipopolysaccharides; Macrophages; Metallothionein; NF-kappa B; Signal Transduction; THP-1 Cells; Up-Regulation

2021