metadoxine has been researched along with pyrrolidonecarboxylic acid in 53 studies
| Studies (metadoxine) | Trials (metadoxine) | Recent Studies (post-2010) (metadoxine) | Studies (pyrrolidonecarboxylic acid) | Trials (pyrrolidonecarboxylic acid) | Recent Studies (post-2010) (pyrrolidonecarboxylic acid) |
|---|---|---|---|---|---|
| 60 | 18 | 12 | 3,005 | 101 | 671 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (11.32) | 18.7374 |
| 1990's | 16 (30.19) | 18.2507 |
| 2000's | 18 (33.96) | 29.6817 |
| 2010's | 11 (20.75) | 24.3611 |
| 2020's | 2 (3.77) | 2.80 |
| Authors | Studies |
|---|---|
| Annoni, G; Arosio, B; Caputo, A; Contu, L; Tronci, MA | 1 |
| Fadda, F; Garau, B; Gelso, E; Gessa, GL; Melis, F | 1 |
| Corsini, G; Gelso, E; Giuliano, G | 1 |
| Belloni, G; Bono, G; Gelso, E; Merlo, P; Sinforiani, E; Soldati, M | 1 |
| Mancinella, A | 1 |
| Bellini, M; Bertelli, A; Bonifazi, V; Costa, F; De Bartolo, G; Grassi, B; Marchi, S; Polloni, A; Romano, MR; Tumino, E | 1 |
| Camarri, F; Corradini, P; Santoni, S; Zocchi, M | 1 |
| Carboni, MA; Corsa, R | 1 |
| Ciancaglini, R; Delle Monache, G; Orlando, D; Pesa, O; Sergiacomo, L | 1 |
| Calabrese, V; de Bernardis, E; Rizza, V | 1 |
| De Mia, M; Di Paolo, N; Gaggiotti, E | 1 |
| Baldacci, M; Bartoli, C; Catalani, R; Mura, U | 1 |
| Annoni, G; Arosio, B; Gagliano, N; Santambrogio, D | 1 |
| Bombaci, G; Calabrese, V; Calderone, A; Rizza, V | 1 |
| Bonuccelli, U; Corsini, GU; Fornai, F; Grazia Alessandrì, M; Scalori, V | 1 |
| Breda, A; Dotta, C; Gelso, E; Moretto, F; Pace, M; Rizzo, A; Sanzuol, F; Tossani, C | 1 |
| Calabrese, V; Calderone, A; Ragusa, N; Rizza, V | 2 |
| Brú, C; Caballería, J; Caballería, L; Clemente, G; García Plaza, A; Mercader, J; Parés, A; Rodés, J; Rodrigo, L | 1 |
| Calabrese, V; Ragusa, N; Randazzo, G; Rizza, V | 1 |
| Addolorato, G; Bernardi, M; Caputo, F; Gasbarrini, G; Stefanini, GF | 1 |
| Iakovlev, VA | 1 |
| Pár, A | 1 |
| Gnezdilova, NIu; Vedrova, NN | 1 |
| Bucio, L; Correa, A; Gómez-Quiroz, LE; Gutiérrez-Ruiz, MC; Hernández, E; Kershenobich, D; Souza, V | 1 |
| Addolorato, G; Gasbarrini, G; Muzychenko, AP; Shpilenya, LS | 1 |
| Chen, JG; Lai, WQ; Mei, S; Wang, Y; Zhang, WY; Zhang, X; Zhu, HJ | 1 |
| Deheza, R; Muriel, P | 1 |
| Ke, XQ; Shi, H; Xue, ZY; Zheng, YF; Zhu, HJ; Zhu, XQ | 1 |
| Blázovics, A; Hagymási, K | 1 |
| Agrawal, H; Dhaneshwar, SR; Kakad, A; Kaul, N; Patil, B | 1 |
| Blázovics, A; Fehér, J; Váli, L | 1 |
| Gershanovich, ML; Safonova, SA | 1 |
| Gentili, C; Guazzelli, M; Guerrini, I; Nelli, G | 1 |
| Kang, ZS; Li, TY; Liu, Y; Lü, Y; Xiao, YH | 1 |
| Choi, JH; Ki, SH; Kim, CW; Kim, SG | 1 |
| Addolorato, G; Bertini, M; Ferrulli, A; Gasbarrini, G; Leggio, L; Vonghia, L | 1 |
| Cao, AP; Li, YM; Liu, JY; Lu, LG; Mao, YM; Shang, J; Shi, RH; Wang, BY; Zeng, MD | 1 |
| Ki, SH; Kim, HE; Kim, SG; Yang, YM | 1 |
| Eremina, AA; Gorbunova, EN; Khomchenko, TN; Kurganova, IV; Nikolaev, IuA; Pal'tsev, AI; Sharapov, IV; Soldatova, GS | 1 |
| Kang, HE; Kim, SG; Lee, DY; Lee, MG | 1 |
| Addolorato, G; Caputo, F; Ferrulli, A; Kenna, GA; Leggio, L; Swift, RM; Zywiak, WH | 1 |
| Drozdov, TF; Fedotova, SIu; Petrakov, AV; Sil'vestrova, SIu | 1 |
| Bukshuk, AA; Maslovskiĭ, LV; Minushkin, ON | 1 |
| Adler, LA; Aharon-Peretz, J; Ben-Hayun, R; Biederman, J; Daniely, Y; Manor, I; Megiddo, D; Newcorn, JH; Salomy, D; Weizman, A | 1 |
| Adler, LA; Faraone, SV; Manor, I; Newcorn, JH | 1 |
| Adler, LA; Daniely, Y; Manor, I; Rubin, J | 1 |
| Abdo-Francis, JM; Cruz-Herrera, J; Higuera-de la Tijera, F; Pérez-Hernández, JL; Pérez-Torres, E; Salas-Gordillo, F; Serralde-Zúñiga, AE; Servín-Caamaño, AI | 1 |
| Borro, P; Leone, S; Testino, G | 1 |
| Buoli, M; Cahn, W; Serati, M | 1 |
| Goh, ET; Morgan, MY | 1 |
| Paradesi, D; Suresh Babu, K | 1 |
| Addolorato, G; Mirijello, A | 1 |
6 review(s) available for metadoxine and pyrrolidonecarboxylic acid
| Article | Year |
|---|---|
[Treatment of alcoholic liver diseases. Abstinence, nutritional support, drug therapy, liver transplantation].
Topics: Alcohol Deterrents; Antioxidants; Drug Combinations; Fatty Liver, Alcoholic; Hormones; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Liver Transplantation; Naltrexone; Narcotic Antagonists; Nutritional Support; Protective Agents; Pyridoxine; Pyrrolidonecarboxylic Acid; Silymarin | 2000 |
[Antioxidants in liver protection].
Topics: Antioxidants; Ascorbic Acid; Drug Combinations; Drug Therapy, Combination; Free Radical Scavengers; Free Radicals; Humans; Liver; Liver Diseases; Mixed Function Oxygenases; Organ Specificity; Oxidation-Reduction; Oxidative Stress; Pyridoxine; Pyrrolidonecarboxylic Acid; Silymarin; Vitamin A; Vitamin E | 2004 |
[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].
Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Drug Combinations; Fatty Liver; Fatty Liver, Alcoholic; Glutathione; Hepatitis; Hepatitis, Alcoholic; Humans; Pyridoxine; Pyrrolidonecarboxylic Acid; Quality of Life | 2005 |
Acute alcohol intoxication.
Topics: Acute Disease; Alcohol Deterrents; Alcoholic Intoxication; Ataxia; Coma; Diagnosis, Differential; Drug Combinations; Emergency Medical Services; Ethanol; Evidence-Based Medicine; Fluid Therapy; Gait; Humans; Impulsive Behavior; Memory Disorders; Mood Disorders; Pyridoxine; Pyrrolidonecarboxylic Acid; Randomized Controlled Trials as Topic; Stupor; Treatment Outcome | 2008 |
Alternative pharmacological strategies for adult ADHD treatment: a systematic review.
Topics: Adrenergic alpha-Agonists; Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Central Nervous System Stimulants; Desipramine; Dopamine Agents; Droxidopa; Drug Combinations; Duloxetine Hydrochloride; Guanfacine; Histamine Agents; Humans; Lisdexamfetamine Dimesylate; Lithium Compounds; Lobeline; Mecamylamine; Memantine; Modafinil; Morpholines; Nicotinic Agonists; Nicotinic Antagonists; Nomifensine; Paroxetine; Pyridines; Pyridoxine; Pyrrolidonecarboxylic Acid; Quinazolinones; Reboxetine; Venlafaxine Hydrochloride; Wakefulness-Promoting Agents | 2016 |
Review article: pharmacotherapy for alcohol dependence - the why, the what and the wherefore.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Baclofen; Disulfiram; Drug Combinations; Fructose; Humans; Naltrexone; Polymorphism, Single Nucleotide; Pyridoxine; Pyrrolidonecarboxylic Acid; Taurine; Topiramate; Treatment Outcome | 2017 |
16 trial(s) available for metadoxine and pyrrolidonecarboxylic acid
| Article | Year |
|---|---|
[Effects of metadoxine on main biohumoral changes induced by chronic alcoholism].
Topics: Adult; Aged; Alcoholism; Drug Combinations; Female; Humans; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Time Factors | 1992 |
Alcoholic abstinence syndrome: short-term treatment with metadoxine.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Drug Combinations; Ethanol; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Substance Withdrawal Syndrome | 1991 |
[Therapeutic use of metadoxine in chronic alcoholism. Double blind study of patients in a department of general medicine].
Topics: Alcoholic Intoxication; Alcoholism; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Hospital Departments; Humans; Italy; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Substance Withdrawal Syndrome | 1993 |
Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial. Spanish Group for the Study of Alcoholic Fatty Liver.
Topics: Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Bilirubin; Double-Blind Method; Drug Combinations; Fatty Liver, Alcoholic; Female; gamma-Glutamyltransferase; Humans; Liver; Liver Function Tests; Male; Middle Aged; Placebos; Pyridoxine; Pyrrolidonecarboxylic Acid; Ultrasonography | 1998 |
Treatment of alcoholic fatty liver: is the metabolic effect of metadoxine the only reason for improved liver function?
Topics: Drug Combinations; Fatty Liver, Alcoholic; Humans; Hydroxybutyrates; Liver Function Tests; Pyridoxine; Pyrrolidonecarboxylic Acid | 1999 |
[The treatment of alcoholism with metadoxil].
Topics: Adult; Alcohol Deterrents; Alcoholism; Drug Combinations; Drug Therapy, Combination; Ethanol; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Substance Withdrawal Syndrome; Time Factors | 1999 |
Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.
Topics: Adult; Alcohol Deterrents; Alcoholic Intoxication; Analysis of Variance; Chi-Square Distribution; Double-Blind Method; Drug Combinations; Ethanol; Female; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid | 2002 |
[Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Administration Schedule; Drug Combinations; Female; Humans; Liver; Liver Failure; Liver Neoplasms; Male; Protective Agents; Pyridoxine; Pyrrolidonecarboxylic Acid; Treatment Outcome | 2005 |
A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.
Topics: Adult; Alcohol Deterrents; Alcohol-Related Disorders; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Treatment Outcome | 2006 |
Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.
Topics: Adolescent; Adult; Drug Combinations; Humans; Injections; Male; Pyridoxine; Pyrrolidonecarboxylic Acid | 2007 |
[Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].
Topics: Administration, Oral; Adult; Aged; Alanine Transaminase; Alcohol Deterrents; Analysis of Variance; Aspartate Aminotransferases; Capsules; Double-Blind Method; Drug Combinations; Fatty Liver, Alcoholic; Female; Follow-Up Studies; gamma-Glutamyltransferase; Humans; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Treatment Outcome; Ultrasonography; Young Adult | 2009 |
[Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].
Topics: Adult; Aged; Aging; Drug Combinations; Fatty Liver; Humans; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Treatment Outcome | 2009 |
A randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy, safety, and tolerability of extended-release metadoxine in adults with attention-deficit/hyperactivity disorder.
Topics: Administration, Oral; Adolescent; Adult; Age of Onset; Attention Deficit Disorder with Hyperactivity; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid | 2012 |
Efficacy of metadoxine extended release in patients with predominantly inattentive subtype attention-deficit/hyperactivity disorder.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Agents; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Middle Aged; Psychological Tests; Pyridoxine; Pyrrolidonecarboxylic Acid; Treatment Outcome; Young Adult | 2013 |
Attention benefits after a single dose of metadoxine extended release in adults with predominantly inattentive ADHD.
Topics: Adolescent; Adult; Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Executive Function; Female; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Young Adult | 2014 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Glucocorticoids; Hepatitis, Alcoholic; Humans; Kaplan-Meier Estimate; Male; Mexico; Middle Aged; Pentoxifylline; Prednisone; Proportional Hazards Models; Pyridoxine; Pyrrolidonecarboxylic Acid; Risk Factors; Severity of Illness Index; Survival Rate; Time Factors; Treatment Outcome | 2015 |
31 other study(ies) available for metadoxine and pyrrolidonecarboxylic acid
| Article | Year |
|---|---|
Pyridoxol L,2-pyrrolidon-5 carboxylate prevents active fibroplasia in CCl4-treated rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Drug Combinations; Female; Injections, Intraperitoneal; Liver Cirrhosis; Procollagen-Proline Dioxygenase; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains | 1992 |
Metadoxine (pyrrolidone carboxylate of pyridoxine) antagonizes the locomotor-stimulatory effect of ethanol in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Ethanol; Male; Mice; Mice, Inbred BALB C; Motor Activity; Pyridoxine; Pyrrolidonecarboxylic Acid | 1992 |
[Steatosis and fibrosis: first stage of liver damage induced by chronic alcoholism. Our experience in 100 cases].
Topics: Colchicine; Drug Combinations; Fatty Liver, Alcoholic; Female; Humans; Liver; Liver Cirrhosis, Alcoholic; Male; Prognosis; Pyridoxine; Pyrrolidonecarboxylic Acid; Tiopronin; Vitamin K | 1991 |
Liver triglyceride accumulation after chronic ethanol administration: a possible protective role of metadoxina and ubiquinone.
Topics: Animals; Drug Combinations; Ethanol; Fatty Liver; Liver; Male; Osmolar Concentration; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Time Factors; Triglycerides; Ubiquinone | 1990 |
[Metadoxine in alcohol-related pathology].
Topics: Adult; Aged; Drug Combinations; Female; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid | 1989 |
[Therapeutic use of metadoxine in alcohol-related mental and behavioral disorders].
Topics: Adult; Aged; Alcoholism; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lorazepam; Male; Mental Disorders; Middle Aged; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Social Behavior Disorders | 1987 |
[Treatment of alcoholic hepatic steatosis with metadoxine. Preliminary results on the evaluation of the effects of the drug by an ultrasonographic study].
Topics: Adult; Aged; Drug Combinations; Fatty Liver, Alcoholic; Humans; Male; Middle Aged; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Ultrasonography | 1986 |
[Metadoxine in the control of oxidative stress caused by acute and chronic ethanol poisoning].
Topics: Alcohol Dehydrogenase; Alcoholic Intoxication; Alcoholism; Aldehyde Dehydrogenase; Animals; Drug Combinations; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Liver; Oxidation-Reduction; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Rats | 1986 |
[Metadoxine in the treatment of vomiting in uremic patients under dialysis treatment].
Topics: Adolescent; Adult; Aged; Domperidone; Drug Combinations; Humans; Middle Aged; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Renal Dialysis; Uremia; Vomiting | 1984 |
Effects of pyridoxine-pyrrolidone-carboxylate on hepatic adenosine triphosphate levels in rats.
Topics: Adenosine Triphosphate; Animals; Drug Combinations; Liver; Male; Models, Chemical; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Changes in expression of the albumin, fibronectin and type I procollagen genes in CCl4-induced liver fibrosis: effect of pyridoxol L,2-pyrrolidon-5 carboxylate.
Topics: Albumins; Animals; Blotting, Northern; Carbon Tetrachloride; Disease Models, Animal; Drug Combinations; Female; Fibronectins; Gene Expression Regulation; Liver Cirrhosis, Experimental; Procollagen; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA | 1993 |
Effects of metadoxine on cellular free fatty acid levels in ethanol treated rats.
Topics: Animals; Cells; Drug Combinations; Drug Evaluation, Preclinical; Ethanol; Fatty Acids; Fatty Acids, Nonesterified; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Wistar | 1993 |
Effect of metadoxine on striatal dopamine levels in C57 black mice.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Male; Mice; Mice, Inbred C57BL; Pyridoxine; Pyrrolidonecarboxylic Acid; Serotonin; Time Factors | 1993 |
Effects of Metadoxine on cellular status of glutathione and of enzymatic defence system following acute ethanol intoxication in rats.
Topics: Alcoholic Intoxication; Animals; Brain; Drug Combinations; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Kidney; Liver; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 1996 |
Effects of metadoxine on cellular formation of fatty acid ethyl esters in ethanol treated rats.
Topics: Animals; Drug Combinations; Esters; Ethanol; Fatty Acids; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Tissue Distribution | 1995 |
Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: protection by metadoxine.
Topics: Aging; Animals; Antioxidants; Brain; Drug Combinations; Ethanol; Glutathione; Glutathione Reductase; Glutathione Transferase; Kidney; Liver; Male; Oxidation-Reduction; Oxidative Stress; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 1998 |
[Metadoxyl in combined treatment of alcohol damage to the liver].
Topics: Alcohol Deterrents; Combined Modality Therapy; Drug Combinations; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid | 2001 |
Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.
Topics: Acetaldehyde; Alcohol Deterrents; Animals; Cell Survival; Cells, Cultured; Central Nervous System Depressants; Collagen; Drug Combinations; Ethanol; Glutathione; Glutathione Disulfide; Hepatocytes; Humans; Interleukin-6; Interleukin-8; Liver; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Tumor Necrosis Factor-alpha | 2001 |
[Reproductive toxicity of metadoxine in rats].
Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Female; Fertility; Fetal Weight; Male; Organ Size; Pregnancy; Pyridoxine; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Sperm Count; Testis | 2003 |
Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.
Topics: Administration, Oral; Alanine Transaminase; Alcohol Deterrents; Animals; Bilirubin; Cholestasis, Extrahepatic; Colchicine; Collagen; Disease Models, Animal; Drug Combinations; gamma-Glutamyltransferase; Hydroxyproline; Injections, Intraperitoneal; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Liver Glycogen; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 2003 |
[Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].
Topics: Androgen Antagonists; Animals; Drug Combinations; Endpoint Determination; Female; Genitalia, Male; Male; Mice; Orchiectomy; Ovariectomy; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats | 2004 |
Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.
Topics: Calibration; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Combinations; Drug Stability; Kinetics; Linear Models; Pyridoxine; Pyrrolidonecarboxylic Acid; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solutions; Tablets | 2005 |
Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.
Topics: Adenylate Kinase; Alcoholism; Allyl Compounds; Animals; Cytochrome P-450 CYP2E1; Drug Combinations; Enzyme Induction; Fatty Liver; Liver; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Sulfides; Triglycerides | 2007 |
Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Activation; Genes, Reporter; Luciferases; Mice; Molecular Structure; Phosphorylation; Pyridoxine; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Time Factors | 2009 |
Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.
Topics: Absorption; Administration, Oral; Allyl Compounds; Animals; Drug Combinations; Drug Interactions; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Sulfides | 2010 |
Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease.
Topics: Adult; Alcohol Deterrents; Alcoholism; Dose-Response Relationship, Drug; Drug Combinations; Female; Follow-Up Studies; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Retrospective Studies | 2011 |
[Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].
Topics: Adult; Alcohol Deterrents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Drug Combinations; Female; Humans; Liver; Liver Diseases, Alcoholic; Male; Middle Aged; Mixed Function Oxygenases; Pyridoxine; Pyrrolidonecarboxylic Acid; Saliva | 2011 |
[The use of hepatic protectors in clinical practice].
Topics: Amino Acids; Chemical and Drug Induced Liver Injury; Cytoprotection; Drug Combinations; Flavonoids; Hepatocytes; Humans; Liver; Phosphatidylcholines; Protective Agents; Pyridoxine; Pyrrolidonecarboxylic Acid; Ursodeoxycholic Acid | 2012 |
Liver Disease and Hepatocellular Carcinoma in Alcoholics: The Role of Anticraving Therapy.
Topics: Acamprosate; Alcohol Deterrents; Alcoholics; Alcoholism; Baclofen; Carcinoma, Hepatocellular; Drug Combinations; Humans; Liver Cirrhosis; Liver Neoplasms; Pyridoxine; Pyrrolidonecarboxylic Acid; Risk Factors; Taurine | 2016 |
Investigation of Related Impurities in Metadoxine by a Reversed Phase High Performance Liquid Chromatography Technique.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Combinations; Drug Contamination; Mass Spectrometry; Pyridoxine; Pyrrolidonecarboxylic Acid | 2021 |
Treatment of acute alcohol intoxication: The role of metadoxine.
Topics: Alcoholic Intoxication; Alcoholism; Drug Combinations; Humans; Pyridoxine; Pyrrolidonecarboxylic Acid | 2023 |