Page last updated: 2024-09-05

mesotrione and nitisinone

mesotrione has been researched along with nitisinone in 4 studies

Compound Research Comparison

Studies
(mesotrione)
Trials
(mesotrione)
Recent Studies (post-2010)
(mesotrione)
Studies
(nitisinone)
Trials
(nitisinone)
Recent Studies (post-2010) (nitisinone)
130210124212150

Protein Interaction Comparison

ProteinTaxonomymesotrione (IC50)nitisinone (IC50)
4-hydroxyphenylpyruvate dioxygenase Rattus norvegicus (Norway rat)0.04
4-hydroxyphenylpyruvate dioxygenaseSus scrofa (pig)0.04

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernardini, G; Braconi, D; Manetti, F; Petricci, E; Santucci, A1
Eksborg, S; Hall, MG; Lumholtz, B; Provan, WM; Wilks, MF1
Aldámiz-Echevarría, L; Andrade, F; Lage, S; Prieto, JA1
Dong, JQ; Hao, GF; Lin, HY; Wang, DW; Wang, YX; Wu, JW; Yang, GF; Yang, JF; Yang, WC; Zhan, CG1

Reviews

1 review(s) available for mesotrione and nitisinone

ArticleYear
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases.
    Journal of medicinal chemistry, 2017, 05-25, Volume: 60, Issue:10

    Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Alkaptonuria; Animals; Drug Discovery; Enzyme Inhibitors; Herbicides; Humans; Models, Molecular; Plants; Small Molecule Libraries; Tyrosinemias; Weed Control

2017

Trials

1 trial(s) available for mesotrione and nitisinone

ArticleYear
Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers.
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:2

    Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Administration, Oral; Area Under Curve; Chemistry, Pharmaceutical; Cyclohexanones; Enzyme Inhibitors; Half-Life; Humans; Male; Nitrobenzoates; Therapeutic Equivalency; Tyrosine; Tyrosinemias

2001

Other Studies

2 other study(ies) available for mesotrione and nitisinone

ArticleYear
Comparison of plasma and dry blood spots as samples for the determination of nitisinone (NTBC) by high-performance liquid chromatography-tandem mass spectrometry. Study of the stability of the samples at different temperatures.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Apr-01, Volume: 879, Issue:11-12

    Topics: Adolescent; Analysis of Variance; Blood Specimen Collection; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cyclohexanones; Drug Stability; Female; Humans; Male; Nitrobenzoates; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temperature; Time Factors; Tyrosinemias

2011
Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations.
    The FEBS journal, 2019, Volume: 286, Issue:5

    Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Amino Acid Sequence; Computer Simulation; Crystallography, X-Ray; Cyclohexanones; Enzyme Inhibitors; Herbicides; Kinetics; Mesylates; Molecular Structure; Nitrobenzoates; Sequence Homology, Amino Acid

2019