mesna has been researched along with letosteine* in 1 studies
1 other study(ies) available for mesna and letosteine
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Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs.
Acute production of reactive oxygen species by polymorphonuclear neutrophils during the respiratory burst may induce tissue injuries. In this in vitro study, it was demonstrated that letosteine, a mucolytic agent containing two blocked thiol groups, had antioxidant activity, but only when it was first submitted to alkaline hydrolysis. In a cell-free system, hydrogen peroxide, hypochlorous acid and hydroxyl radical concentrations were reduced by half by letosteine concentrations of 200, 15 and 350 mumol/l, respectively. The mechanism of letosteine action may be related to the -SH group liberated in vitro by hydrolysis, which seemed to react by scavenging the reactive oxygen species in the same way as acetylcysteine and MESNA, free-thiol drugs known for their antioxidant properties. So, letosteine, a compound with blocked -SH groups which in vivo can metabolically become free, may have a therapeutic application in preventing oxidative tissue injury damage induced by the respiratory burst. Topics: Acetylcysteine; Antioxidants; Dose-Response Relationship, Drug; Drug Interactions; Expectorants; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxyl Radical; Hypochlorous Acid; Mesna; Reactive Oxygen Species; Respiratory Burst; Superoxides; Thiazoles; Thiazolidines | 1995 |