mesna and 4-hydroxycyclophosphamide

mesna has been researched along with 4-hydroxycyclophosphamide* in 1 studies

Other Studies

1 other study(ies) available for mesna and 4-hydroxycyclophosphamide

ArticleYear
Does 2-mercaptoethane sulphonate (mesna) prevent cyclophosphamide and azathioprine induced immunosuppression? In vitro studies.
    British journal of clinical pharmacology, 1986, Volume: 21, Issue:3

    The effect of 2-mercaptoethane sulphonate (mesna) on the inhibition of the human MLR by 4-hydroxycyclophosphamide or azathioprine was studied. 4-Hydroxycyclophosphamide (34 microM) completely inhibited the MLR and this inhibition was unaffected by 122 microM of 2-mercaptoethane sulphonate or its disulphide. At high concentrations (mM) 2-mercaptoethane sulphonate inhibited the MLR reaching 85% at 24 mM. 2-Mercaptoethane sulphonate (15-122 microM) had no effect on azathioprine (36 microM) inhibition. The results of these in vitro studies suggest that 2-mercaptoethane sulphonate does not interfere with cyclophosphamide or azathioprine induced suppression of cellular immunity.

    Topics: Azathioprine; Chromatography, Thin Layer; Cyclophosphamide; Humans; In Vitro Techniques; Lymphocyte Culture Test, Mixed; Mercaptoethanol; Mesna

1986