mesalamine has been researched along with trinitrobenzenesulfonic acid in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (14.55) | 18.2507 |
| 2000's | 16 (29.09) | 29.6817 |
| 2010's | 28 (50.91) | 24.3611 |
| 2020's | 3 (5.45) | 2.80 |
| Authors | Studies |
|---|---|
| Selve, N | 1 |
| Empey, LR; Fedorak, RN; Torsher, KJ | 1 |
| Guarner, F; Malagelada, JR; Rodriguez, R; Salas, A; Vilaseca, J | 1 |
| Hongyo, T; Kawase, S; Nakamaru, K; Sato, M; Sugai, T; Tanaka, Y; Taniguchi, S | 1 |
| Bass, P; Luck, MS | 1 |
| Bartolí, R; Bertrán, X; Castellá, E; Esteve, M; Fernández-Bañares, F; Gassull, MA; Mañé, J; Ojanguren, I | 1 |
| Hellström, PM; Ljung, T; Martinsson, T; Rubio, C | 1 |
| Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A | 1 |
| Cleary, CE; Malatjalian, DA; Peterson, TC; Shaw, AM; Veldhuyzen van Zanten, SJ | 1 |
| Gálvez, J; Garrido, M; Merlos, M; Torres, MI; Zarzuelo, A | 1 |
| Carceller, E; Escamilla, I; Ferrando, R; Forn, J; García-Rafanell, J; Giral, M; Merlos, M; Ramis, J; Salas, J | 1 |
| Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Okada, N; Suzuki, T; Terabe, A; Tozaki, H; Yamamoto, A | 1 |
| de Medina, FS; Gálvez, J; Garrido, M; Merlos, M; Ramis, I; Rodríguez-Cabezas, ME; Zarzuelo, A | 1 |
| An, MM; Fan, KX; Gao, PH; Jiang, YY; Li, HJ; Liu, BG; Song, SC; Zhang, JD; Zhou, Q | 1 |
| Cosenza, V; D'Argenio, G; Di Marzo, V; Scaglione, G; Sorrentini, I; Valenti, M | 1 |
| Choi, B; Jung, Y; Kim, H; Kim, HH; Kim, Y; Kong, H; Yang, Y | 1 |
| Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL | 1 |
| An, P; Liu, SQ; Liu, YF; Lv, P; Ming, M; Teng, XJ; Yu, HG; Yu, JP; Zhou, YH | 1 |
| Bhatt, L; Dhaneshwar, SS; Gairola, N; Kandpal, M; Vadnerkar, G | 1 |
| Berkó, A; Horváth, K; László, F; Pósa, A; Varga, C; Whittle, BJ | 1 |
| Daddaoua, A; González, M; Martínez-Augustin, O; Martínez-Plata, E; Requena, P; Sánchez de Medina, F; Suárez, MD; Zarzuelo, A | 1 |
| Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC | 2 |
| Cai, JT; Chen, Y; Du, Q; Liu, WL; Si, JM; Wang, LJ; Wu, JG; Zhou, TH | 1 |
| Dai, YC; He, XY; Tang, ZP; Wang, ZN; Zhang, YL | 1 |
| Carda, C; Diez-Sales, O; Fadda, AM; Loy, G; Manconi, M; Merino, V; Merino-Sanjuan, M; Mura, C; Nácher, A; Ruiz, A | 1 |
| Dai, SX; Feng, YL; Liu, HB; Zheng, XB; Zou, Y | 1 |
| Aziz, M; Bole-Feysot, C; Charpentier, C; Déchelotte, P; Guérin, C; Marion-Letellier, R; Mbodji, K; Querec, C; Savoye, G | 1 |
| Rana, V; Singh, K; Suri, R; Tiwary, AK | 1 |
| Alzoubi, KH; Jilani, JA; Shomaf, M | 1 |
| Gaurav, V; Himanshu, R; Suneela, D | 1 |
| Che, X; Fan, HY; Liu, K; Lv, WH; Song, WW; Xu, H; Yang, MY; Zhang, ZL | 1 |
| Cao, XN; Chen, C; Hu, JB; Li, J; Wang, GH; Wang, J | 1 |
| Elamin, ES; Ping, Q; Qiao, H; Sun, M; Xu, M | 1 |
| Agrogiannis, G; Douvi, G; Gikas, A; Papalois, AE; Patsouris, E; Triantafillidis, JK | 1 |
| Bae, H; Cha, JM; Jang, SE; Kim, DH; Kim, HJ; Lee, CH; Lim, SJ; Min, JK; Park, JW | 1 |
| Beghyn, T; Deprez, B; Desreumaux, P; Dubreuil, L; Dubuquoy, L; Flament, MP; Guerin-Deremaux, L; Karrout, Y; Moussa, E; Neut, C; Piveteau, C; Siepmann, F; Siepmann, J; Wils, D | 1 |
| Guo, Y; Lei, S; Li, C; Lun, W; Ma, J; Zhao, X; Zhi, F | 1 |
| Chen, Y; Li, Y; Shi, L; Song, G; Tang, Y; Wang, X | 1 |
| Bajaj, AN; Deshpande, SG; Nikam, VS; Sawarkar, SP | 1 |
| Jeong, S; Jung, Y; Kim, MS; Kim, W; Lee, S; Nam, J; Yoo, JW | 1 |
| Dai, ZH; Lv, H; Qian, JM; Tan, B; Wang, O; Yang, H | 1 |
| Bhattarai, G; Cho, SW; Choi, KC; Chun, SR; Kim, MK; Kook, SH; Lee, JC; Lee, KY; Poudel, SB | 1 |
| Jeong, S; Jung, Y; Kim, W; Lee, S; Nam, J | 1 |
| Cheng, SM; Huang, MF; Huang, XY; Liu, DY; Lu, AP; Wang, X; Xu, R; Yue, HY; Zhao, HM; Zou, Y | 1 |
| Almeida, LM; Dinis, TC; Figueiredo, I; Freitas, V; Pereira, R; Pereira, SR | 1 |
| Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G | 1 |
| Chiu, CT; Hung, SW; Kuo, SN; Yang, CY | 1 |
| Lakshmanan, P; Newton, AMJ | 1 |
| Anindya, AL; Damayanti, S; Kurniati, NF; Oktaviani, RD; Praevina, BR; Rachmawati, H; Riani, C | 1 |
| Altınay, S; Çelik, DS; Gökmen, ES; Küçük, SH; Şit, D; Yorulmaz, E; Yorulmaz, H; Zengi, O | 1 |
| Li, Y; Liu, Q; Tang, JH; Wen, JJ; Zhu, JQ | 1 |
| Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D | 1 |
| Du, YL; He, J; Huang, HL; Li, YF; Nie, YQ; Xu, HM; Xu, J; Zhao, C; Zhou, YJ; Zhou, YL | 1 |
| Guo, D; Han, Z; Wang, H; Zhang, J | 1 |
55 other study(ies) available for mesalamine and trinitrobenzenesulfonic acid
| Article | Year |
|---|---|
Chronic intrajejunal TNBS application in TNBS-sensitized rats: a new model of chronic inflammatory bowel diseases.
Topics: Aminosalicylic Acids; Animals; Disease Models, Animal; Female; Immunization; Inflammatory Bowel Diseases; Intestinal Mucosa; Jejunum; Mesalamine; Rats; Rats, Sprague-Dawley; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1992 |
Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing.
Topics: Aminosalicylic Acids; Animals; Betamethasone; Colitis; Intestinal Absorption; Intestinal Mucosa; Male; Mesalamine; Misoprostol; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1992 |
Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis.
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Animals; Colitis; Dinoprostone; Indomethacin; Leukotriene B4; Male; Mesalamine; Methacrylates; Pentanoic Acids; Prednisone; Pyridines; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxane-A Synthase; Trinitrobenzenesulfonic Acid | 1990 |
[Effect of mesalazine microgranules on experimental colitis].
Topics: Aminosalicylic Acids; Animals; Carrageenan; Colitis; Delayed-Action Preparations; Guinea Pigs; Male; Mesalamine; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1994 |
Effect of epidermal growth factor on experimental colitis in the rat.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Eicosanoids; Epidermal Growth Factor; Ethanol; Intestinal Mucosa; Male; Mesalamine; Peroxidase; Prednisolone; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1993 |
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Colon; Eicosanoids; Female; Hydroxyurea; Lipoxygenase Inhibitors; Mesalamine; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1996 |
Beneficial effects of ropivacaine in rat experimental colitis.
Topics: Acetylcholine; Amides; Anesthetics, Local; Animals; Budesonide; Colitis; Ethanol; Gastrointestinal Motility; In Vitro Techniques; Male; Mesalamine; Mucous Membrane; Peroxidase; Rats; Rats, Sprague-Dawley; Ropivacaine; Time Factors; Trinitrobenzenesulfonic Acid; Wound Healing | 1999 |
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chitin; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Carriers; Male; Mesalamine; Models, Biological; Rats; Rats, Wistar; Reproducibility of Results; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1999 |
Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Colitis; Female; Mesalamine; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Salicylates; Trinitrobenzenesulfonic Acid | 2000 |
Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat.
Topics: Acute Disease; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Chronic Disease; Colitis; Colon; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gastrointestinal Agents; Intestinal Mucosa; Intestines; Male; Mesalamine; Platelet Activating Factor; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2000 |
Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity.
Topics: Amines; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Azo Compounds; Colitis, Ulcerative; Drug Evaluation, Preclinical; Female; Hypotension; Imidazoles; Male; Mesalamine; Platelet Activating Factor; Platelet Aggregation; Prodrugs; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid | 2001 |
Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Carboxymethylcellulose Sodium; Chitin; Chitosan; Colitis, Ulcerative; Colon; Drug Carriers; Intestinal Absorption; Male; Mesalamine; Peroxidase; Rats; Rats, Wistar; Tissue Distribution; Trinitrobenzenesulfonic Acid | 2002 |
The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Azo Compounds; Cell Line; Colitis; Colon; Cytokines; Down-Regulation; Female; Inflammation Mediators; Interleukin-1; Interleukin-8; Mesalamine; Neutrophil Infiltration; Peroxidase; Platelet Activating Factor; Rats; Rats, Wistar; Secondary Prevention; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Lymphtoxin beta receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signaling.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Gene Expression Regulation; Immunoglobulins; Interleukin-1; Interleukin-8; Lymphotoxin beta Receptor; Lymphotoxin-alpha; Male; Membrane Proteins; Mesalamine; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 14; Receptors, Virus; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor-alpha | 2005 |
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.
Topics: Adult; Aged; Amidohydrolases; Animals; Arachidonic Acids; Benzenesulfonates; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Endocannabinoids; Female; Glycerides; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mesalamine; Mice; Mice, Inbred C57BL; Middle Aged; Peroxidase; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; Specific Pathogen-Free Organisms; Trinitrobenzenesulfonic Acid | 2006 |
Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Colitis; Colon; Drug Delivery Systems; Feces; Gastrointestinal Agents; Intestinal Absorption; Male; Mesalamine; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfasalazine; Taurine; Trinitrobenzenesulfonic Acid | 2006 |
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Colon; Cytokines; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Granulocytes; Hydrogen Sulfide; Mesalamine; Mice; Mice, Inbred BALB C; RNA, Messenger; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Base Sequence; Colitis; Ginkgo biloba; Inflammation Mediators; Interleukin-6; Male; Malondialdehyde; Mesalamine; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Azo Compounds; Body Weight; Colitis; Kinetics; Mesalamine; Molecular Structure; Organ Size; Prodrugs; Rats; Trinitrobenzenesulfonic Acid; Tryptophan | 2007 |
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blotting, Western; Colitis; Disease Models, Animal; Heme Oxygenase-1; Male; Mesalamine; Peroxidase; Protoporphyrins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanisms involving downregulation of interleukin 17.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cattle; Disease Models, Animal; Down-Regulation; Female; Glycopeptides; Ileitis; Interleukin-17; Macrophages; Mesalamine; Rats; Rats, Wistar; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2008 |
Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Colitis; Cyclic N-Oxides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Intestinal Mucosa; Male; Mesalamine; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Vitamin E | 2008 |
Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Therapy, Combination; Free Radical Scavengers; Intestinal Mucosa; Male; Membrane Proteins; Mesalamine; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2009 |
Therapeutic effects of rectal administration of muscovite on experimental colitis in rats.
Topics: Administration, Rectal; Aluminum Silicates; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; HT29 Cells; Humans; Interleukin-1beta; Mesalamine; Mucin-2; Neuropeptides; Rats; Rats, Sprague-Dawley; Trefoil Factor-3; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Influence of Shenqing Recipe on morphology and quantity of colonic interstitial cells of Cajal in trinitrobenzene sulfonic acid induced rat colitis.
Topics: Animals; Colitis; Colon; Drugs, Chinese Herbal; Interstitial Cells of Cajal; Male; Medicine, Chinese Traditional; Mesalamine; Peroxidase; Proto-Oncogene Proteins c-kit; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: in vivo study with TNBS-induced colitis model in rats.
Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Freeze Drying; Intestinal Mucosa; Lymphocyte Activation; Male; Mesalamine; Organ Size; Peroxidase; Polymers; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Baicalin down-regulates the expression of macrophage migration inhibitory factor (MIF) effectively for rats with ulcerative colitis.
Topics: Animals; Chemokine CCL2; Chemokine CCL20; Colitis, Ulcerative; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Flavonoids; Immunohistochemistry; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Macrophages; Mesalamine; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2012 |
Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis.
Topics: Animals; Colitis; Fatty Acids, Omega-3; Inflammation; Male; Mesalamine; NF-kappa B; PPAR gamma; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2013 |
Exploiting the synergistic effect of chitosan-EDTA conjugate with MSA for the early recovery from colitis.
Topics: Adhesiveness; Animals; Calorimetry, Differential Scanning; Chitosan; Colitis; Colon; Drug Synergism; Edetic Acid; Hydrogen-Ion Concentration; Mesalamine; Microscopy, Electron, Scanning; Powders; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Tablets; Trinitrobenzenesulfonic Acid | 2013 |
Synthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Colitis, Ulcerative; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mesalamine; Prodrugs; Rats; Rats, Wistar; Salicylates; Spectrophotometry, Infrared; Trinitrobenzenesulfonic Acid | 2013 |
Design and development of novel azo prodrugs using various permutations and combinations of 5- and 4-aminosalicylic acids for inflammatory bowel disease: a colon-targeted approach.
Topics: Aminosalicylic Acid; Animals; Azo Compounds; Colitis; Colon; Drug Design; Female; Humans; Inflammatory Bowel Diseases; Male; Mesalamine; Models, Animal; Prodrugs; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2013 |
Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Boraginaceae; Colitis, Ulcerative; Colon; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Gastrointestinal Agents; Goblet Cells; Inflammation Mediators; Male; Mesalamine; Naphthoquinones; Peroxidase; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Efficacy of topical versus oral 5-aminosalicylate for treatment of 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colon; Down-Regulation; Drug Administration Schedule; Gene Expression; Immunohistochemistry; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Male; Mesalamine; Peroxidase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Preparation and evaluation of colon adhesive pellets of 5-aminosalicylic acid.
Topics: Acrylic Resins; Adhesiveness; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cellulose; Chemistry, Pharmaceutical; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Carriers; Excipients; Kinetics; Male; Mesalamine; Polymethacrylic Acids; Rats, Sprague-Dawley; Solubility; Tablets, Enteric-Coated; Technology, Pharmaceutical; Trinitrobenzenesulfonic Acid | 2014 |
Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron.
Topics: Administration, Oral; Animals; Colitis; Dietary Supplements; Dose-Response Relationship, Drug; Intestinal Mucosa; Iron; Male; Malondialdehyde; Mesalamine; Prednisolone; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Inflammation Mediators; Male; Mesalamine; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Colitis; Colon; Dextrins; Drug Delivery Systems; Hydroxymethylglutaryl-CoA Synthase; Interleukin-1beta; Male; Mesalamine; Mice, Transgenic; Microbiota; Peroxidase; PPAR gamma; Rats, Wistar; RNA, Messenger; Starch; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells.
Topics: Animals; Caco-2 Cells; Disulfides; Humans; Inflammation; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Male; Mesalamine; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction; Sulfasalazine; Sulfinic Acids; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Combinatorial Intervention with Mesenchymal Stem Cells and Granulocyte Colony-Stimulating Factor in a Rat Model of Ulcerative Colitis.
Topics: Animals; Colitis, Ulcerative; Gene Expression Regulation; Granulocyte Colony-Stimulating Factor; Inflammation; Mesalamine; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2015 |
In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Galactans; Male; Mannans; Mesalamine; Pectins; Plant Gums; Prodrugs; Rats; Tablets; Trinitrobenzenesulfonic Acid | 2015 |
Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.
Topics: Administration, Oral; Animals; Benzocaine; Cecum; Colitis; Colon; Dextrans; Inflammation Mediators; Male; Mesalamine; Polymers; Prodrugs; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2016 |
1,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Inflammation; Male; Mesalamine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Toll-Like Receptor 9; Trinitrobenzenesulfonic Acid; Vitamin D | 2015 |
Intestinal anti-inflammatory activity of the seeds of Raphanus sativus L. in experimental ulcerative colitis models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Dose-Response Relationship, Drug; Inflammation Mediators; Male; Mesalamine; Plant Extracts; Raphanus; Rats; Rats, Sprague-Dawley; Seeds; Trinitrobenzenesulfonic Acid; Water | 2016 |
5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB.
Topics: Animals; Azo Compounds; Colitis; Colon; Male; Mesalamine; NF-kappa B; Procainamide; Prodrugs; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2016 |
Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colon; Curcumin; Cytokines; Dendritic Cells; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ethanol; Humans; Intestinal Mucosa; Lymphoid Tissue; Male; Mesalamine; Mice; Mice, Inbred C57BL; Random Allocation; Signal Transduction; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2016 |
Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model.
Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Antioxidants; Blueberry Plants; Colitis; Colon; Cyclooxygenase 2; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mesalamine; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Male; Mesalamine; Methylamines; Nitrates; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Hyaluronic Acid; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mesalamine; Peroxidase; Protective Agents; Rats; Trinitrobenzenesulfonic Acid | 2017 |
Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Colon; Disease Models, Animal; Drug Delivery Systems; Humans; Inflammatory Bowel Diseases; Mesalamine; Pectins; Rats; Rats, Wistar; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid; Ulcer | 2020 |
Xylan from Pineapple Stem Waste: a Potential Biopolymer for Colonic Targeting of Anti-inflammatory Agent Mesalamine.
Topics: Administration, Oral; Ananas; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopolymers; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Colon; Drug Delivery Systems; Male; Mesalamine; Plant Stems; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Trinitrobenzenesulfonic Acid; Xylans | 2019 |
Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis.
Topics: Animals; Colitis; Cytokines; Fish Oils; Intestinal Mucosa; Mesalamine; Oxidative Stress; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2019 |
Regulatory mechanism of mesalazine on TLR4/MyD88-dependent pathway in mouse ulcerative colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Colon; Disease Models, Animal; Down-Regulation; Ethanol; Humans; Intestinal Mucosa; Male; Mesalamine; Mice; MicroRNAs; Myeloid Differentiation Factor 88; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Up-Regulation | 2019 |
Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Chlorogenic Acid; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Liposomes; Male; Mesalamine; Mice; Mice, Inbred BALB C; Peroxidase; Quality of Life; Trinitrobenzenesulfonic Acid | 2019 |
Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Microbiome; Immune Checkpoint Inhibitors; Male; Mesalamine; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Protective Agents; Trinitrobenzenesulfonic Acid | 2021 |
Integrative transcriptomic and metabonomic profiling analyses reveal the molecular mechanism of Chinese traditional medicine huankuile suspension on TNBS-induced ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Profiling; Interleukin-10; Interleukin-1beta; Interleukin-4; Interleukin-6; Intestinal Mucosa; Mesalamine; Metabolomics; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |