mesalamine has been researched along with sulfapyridine in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (47.25) | 18.7374 |
| 1990's | 27 (29.67) | 18.2507 |
| 2000's | 14 (15.38) | 29.6817 |
| 2010's | 6 (6.59) | 24.3611 |
| 2020's | 1 (1.10) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, JP; McGarraugh, GV; Onderdonk, AB; Parkinson, TM; Wingard, RE | 1 |
| Knuckley, B; Luo, Y; Thompson, PR | 1 |
| Collins, MT; Shin, SJ | 1 |
| Chail, M; Dhaneshwar, SS; Naqvi, S; Patil, M; Vadnerkar, G | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Alt, J; Ferraris, DV; Hin, N; Rojas, C; Sattler, R; Shukla, K; Slusher, BS; Thomas, AG; Tsukamoto, T | 1 |
| Drab, EA; Linder, JS; Rubin, DB; Sabesin, SM; Sharon, P; Weidman, SW | 1 |
| Giaffer, MH; Holdsworth, CD; O'Brien, CJ | 1 |
| Gaginella, TS; Walsh, RE | 1 |
| Karmeli, F; Rachmilewitz, D; Schwartz, LW; Simon, PL | 1 |
| Carlin, G; Djursäter, R; Smedegård, G | 1 |
| Bishop, JB; Kumaroo, V; McFee, AF; Witt, KL | 1 |
| Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR | 1 |
| Bjarnason, I; Hayllar, J | 1 |
| Gallagher, A; Hawkey, CJ; Hawthorne, AB; Lamming, CE; Mahida, YR | 1 |
| Grisham, MB | 1 |
| Cho, CH; Garg, GP; Ogle, CW | 1 |
| Bertovich, MJ; MacDermott, RP; Nash, GS; Peters, M; Schloemann, SR; Stenson, WF | 1 |
| Granger, DN; Grisham, MB; von Ritter, C | 1 |
| Edenius, C; Lindgren, JA; Sjöquist, B; Smedegård, G; Tornhamre, S | 1 |
| Chungi, VS; Dittert, LW; Shargel, L | 1 |
| Donowitz, M | 1 |
| van Hees, PA; van Hogezand, RA; van Rossum, JM; van Tongeren, JH; Zwanenburg, B | 1 |
| Becker, R; Kolassa, N; Wiener, H | 1 |
| Banatwala, N | 1 |
| Capell, HA; Hunter, JA; Pullar, T | 1 |
| Gibson, PR; Jewell, DP | 1 |
| Boughton-Smith, NK; Hawkey, CJ; Whittle, BJ | 1 |
| Lawson, M; Nance, S; Radcliffe, B; Roediger, W; Schapel, G | 1 |
| Kane, MG; MacDermott, RP; Niederlehner, A; Shanahan, F; Stenson, WF; Targan, S | 1 |
| Astbury, C; Bird, HA; Hill, J; Le Gallez, P; Neumann, VC; Taggart, AJ | 1 |
| Binder, V; Bondesen, S; Danø, P; Hansen, SH; Jensen, PH; Krasilnikoff, PA; Lassen, LB; Nielsen, OH; Rasmussen, SN; Schou, JB | 1 |
| Astbury, C; Dixon, JS; Hill, J; Le Gallez, P; Neumann, VC; Taggart, AJ | 1 |
| Imamura, S; Miyachi, Y; Niwa, Y; Yoshioka, A | 1 |
| Craven, PA; DeRubertis, FR; Pfanstiel, J; Saito, R | 1 |
| Cann, PA; Holdsworth, CD; Rao, SS | 1 |
| Asakura, H; Miura, S; Nagata, H; Oshio, C; Suematsu, M; Suzuki, M; Tsuchiya, M; Watanabe, M | 1 |
| Breiling, J; Franke, M; Gabbert, H; Goerg, KJ; Meyer zum Büschenfelde, KH; Wanitschke, R | 1 |
| Neal, TM; Vissers, MC; Winterbourn, CC | 1 |
| Aruoma, OI; Butler, J; Halliwell, B; Hoey, BM; Wasil, M | 1 |
| Dull, BJ; Goldman, P; Salata, K | 1 |
| Beninati, L; Buonato, CB; Nielsen, ST | 1 |
| Andersen, LP; Andreasen, JJ; Hartzen, SH | 1 |
| Bacon, PA; Farr, M; Salmon, M; Symmons, DP | 1 |
| Comer, SS; Jasin, HE | 1 |
| Grindulis, KA; Sheldon, P; Webb, C | 1 |
| Fardy, JM; Lloyd, DA; Reynolds, RP | 1 |
| Ide, T | 1 |
| Hoppe, U; Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR | 1 |
| Okada, M; Yao, T | 1 |
| Turunen, U | 1 |
| Bartholomew, TC; Jewell, DP; Rhodes, JM | 1 |
| Chastenay, BF; Holdstock, G; Krawitt, EL | 2 |
| Hawkey, CJ; Lo Casto, M | 1 |
| Aarons, L; Houston, JB; Shaw, PN; Sivner, AL | 1 |
| Das, KM | 1 |
| Allgayer, H; Eisenburg, J; Paumgartner, G | 1 |
| Dew, MJ; Evans, BK; Hughes, PJ; Lee, MG; Rhodes, J | 1 |
| Bruin, KF; Hommes, DW; Jansen, J; Tytgat, GN; van Deventer, SJ; Wouter ten Cate, J | 1 |
| Pell, P; Sheldon, P | 1 |
| Szumlanski, CL; Weinshilboum, RM | 1 |
| Almawi, W; Fabry, S; Keresztes, S; Lipman, M; Moscovitch-Lopatin, M; Peppercorn, MA; Stevens, C; Strom, TB | 1 |
| Ahnfelt-Rønne, I; Berild, D; Bouchelouche, PN; Nielsen, OH | 1 |
| Bird, HA | 1 |
| Bird, H; Gardiner, P; Hopkins, R; McEvoy, F; Taggart, A | 1 |
| Abdo, KM; Hart, RW; Iatropoulos, MJ; Kari, FW; Williams, GM | 1 |
| Kataoka, M; Kawasaki, M; Kimura, I; Nagahama, S; Sato, M | 1 |
| Adler, G; Liptay, S; Schmid, RM; Wahl, C | 1 |
| Asakura, H | 1 |
| Kataoka, M; Kimura, I; Kokuba, Y; Kumamoto, T; Matsuda, A | 1 |
| Kataoka, M; Kawasaki, M; Kimura, I; Kokuba, Y; Matsuda, A; Nagahama, S | 1 |
| Kataoka, M; Kawasaki, M; Kimura, I; Kokurba, Y; Matsuda, A | 1 |
| Amin, MA; Campbell, PL; Harlow, LA; Koch, AE; Tokuhira, M; Volin, MV; Woods, JM | 1 |
| Adler, G; Bachem, M; Debatin, KM; Häcker, G; Liptay, S; Schmid, RM | 1 |
| Blackburn, WD; Minghetti, PP | 1 |
| Liang, E; Proudfoot, J; Yazdanian, M | 1 |
| Deitch, EA; Haskó, G; Németh, ZH; Szabó, C | 1 |
| Campbell, PL; Connors, MA; Koch, AE; Volin, MV; Woodruff, DC | 1 |
| Hino, B; Iida, M; Itoh, Y; Joh, Y; Makino, K; Oishi, R; Teshima, D; Yano, T | 1 |
| Cwalina, B; Dzierzewicz, Z; Szczerba, J; Weglarz, L; Wiśniowska, B | 1 |
| Begue, B; Cerf-Bensussan, N; Doering, J; Goulet, O; Lentze, MJ; Rieux-Laucat, F; Ruemmele, FM; Schmitz, J | 1 |
| Joshi, R; Kumar, S; Mukherjee, T; Unnikrishnan, M | 1 |
| Bauchmuller, K; Bernt, C; Beuers, U; Fickert, P; Fuchsbichler, A; Rust, C; Vennegeerts, T | 1 |
| Brown, ST; Greenstein, RJ; Shahidi, A; Su, L | 1 |
| Hanauer, SB | 1 |
| Chen, J; Gu, GZ; Jiang, XG; Liu, ZY; Pang, ZQ; Xia, HM | 1 |
| Chidley, C; Haruki, H; Johnsson, K; Muller, E; Pedersen, MG | 1 |
| Jambhrunkar, S; Kleitz, F; Liu, J; Popat, A; Qiao, SZ; Ross, BP | 1 |
| Arito, M; Kato, T; Kurokawa, MS; Omoteyama, K; Sato, M; Sato, T; Suematsu, N | 1 |
| Chailapakul, O; Chotsuwan, C; Siangproh, W; Thangphatthanarungruang, J | 1 |
6 review(s) available for mesalamine and sulfapyridine
| Article | Year |
|---|---|
Sulfasalazine. Multiplicity of action.
Topics: Aminosalicylic Acids; Animals; Free Radical Scavengers; Humans; Hydroxyeicosatetraenoic Acids; Inflammatory Bowel Diseases; Leukocytes; Lipoxygenase Inhibitors; Mesalamine; Prostaglandin Antagonists; Sulfapyridine; Sulfasalazine | 1992 |
Sulphasalazine in ulcerative colitis: in memoriam?
Topics: Aminosalicylic Acids; Colitis, Ulcerative; Dose-Response Relationship, Drug; Humans; Mesalamine; Neutrophils; Sulfapyridine; Sulfasalazine | 1991 |
Salazopyrin and its newer analogues in the treatment of inflammatory bowel disease.
Topics: Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Double-Blind Method; Drug Combinations; Drug Interactions; Enema; Female; Folic Acid; Glucosamine; Humans; Mesalamine; Pregnancy; Sulfapyridine; Sulfasalazine | 1985 |
[Management of refractory and fulminating colitis].
Topics: Aminosalicylic Acids; Colitis; Crohn Disease; Glucocorticoids; Humans; Mesalamine; Severity of Illness Index; Sulfanilamides; Sulfapyridine | 1987 |
Sulphasalazine, sulphapyridine or 5-aminosalicylic acid--which is the active moiety in rheumatoid arthritis?
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Humans; Mesalamine; Sulfapyridine; Sulfasalazine | 1995 |
[Ulcerative colitis and intestinal bleeding].
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Diagnosis, Differential; Gastrointestinal Hemorrhage; Humans; Immunosuppressive Agents; Leukapheresis; Mesalamine; Prednisolone; Sulfapyridine | 1998 |
3 trial(s) available for mesalamine and sulfapyridine
| Article | Year |
|---|---|
Which component of sulphasalazine is active in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Humans; Mesalamine; Middle Aged; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1985 |
Clinical experience of the tolerance of mesalazine and olsalazine in patients intolerant of sulphasalazine.
Topics: Adult; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Female; Humans; Male; Mesalamine; Middle Aged; Sulfapyridine; Sulfasalazine | 1987 |
Which is the active moiety of sulfasalazine in ankylosing spondylitis? A randomized, controlled study.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Dermatologic Agents; Female; Humans; Male; Mesalamine; Middle Aged; Pain; Single-Blind Method; Spondylitis, Ankylosing; Sulfapyridine; Sulfasalazine | 1996 |
82 other study(ies) available for mesalamine and sulfapyridine
| Article | Year |
|---|---|
A polymeric drug for treatment of inflammatory bowel disease.
Topics: Aminosalicylic Acid; Animals; Biotransformation; Colitis, Ulcerative; Guinea Pigs; Intestines; Polymers; Salicylates; Sulfapyridine; Sulfasalazine | 1983 |
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Fluorescent Dyes; Hydrolases; Minocycline; Models, Biological; Molecular Structure; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Streptomycin; Tetracycline | 2008 |
Thiopurine drugs azathioprine and 6-mercaptopurine inhibit Mycobacterium paratuberculosis growth in vitro.
Topics: Animals; Azathioprine; Bacteriological Techniques; Cattle; Cattle Diseases; Colony Count, Microbial; Crohn Disease; Culture Media; Humans; Immunosuppressive Agents; Mercaptopurine; Microbial Sensitivity Tests; Mycobacterium avium subsp. paratuberculosis; Paratuberculosis; Reagent Kits, Diagnostic | 2008 |
Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Stability; Drug-Related Side Effects and Adverse Reactions; Liver; Pancreas; Prodrugs; Rats; Ulcer | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Inhibition of xc⁻ transporter-mediated cystine uptake by sulfasalazine analogs.
Topics: Amino Acid Transport System X-AG; Antiporters; Cell Line; Cystine; Humans; Structure-Activity Relationship; Sulfasalazine | 2011 |
The effect of sulfasalazine on bovine endothelial cell proliferation and cell cycle phase distribution. Comparison with olsalazine, 5-aminosalicylic acid, and sulfapyridine.
Topics: Aminosalicylic Acids; Animals; Cattle; Cell Count; Cell Cycle; Deoxyuridine; Endothelium, Vascular; Mesalamine; Sulfapyridine; Sulfasalazine; Tetrahydrofolates; Thymidine; Time Factors; Tritium | 1992 |
Clinical tolerance to three 5-aminosalicylic acid releasing preparations in patients with inflammatory bowel disease intolerant or allergic to sulphasalazine.
Topics: Aminosalicylic Acids; Drug Hypersensitivity; Female; Humans; Inflammatory Bowel Diseases; Male; Mesalamine; Phenylhydrazines; Sulfapyridine; Sulfasalazine | 1992 |
Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Humans; Interleukin-1; Male; Mesalamine; Rats; Rats, Inbred Strains; Sulfapyridine; Sulfasalazine | 1992 |
Sulphasalazine inhibition of human granulocyte activation by inhibition of second messenger compounds.
Topics: Aminosalicylic Acids; Calcium; Cells, Cultured; Cytosol; Depression, Chemical; Granulocytes; Guanosine Triphosphate; Humans; Inositol 1,4,5-Trisphosphate; Mesalamine; Phosphatidic Acids; Phosphatidylinositols; Second Messenger Systems; Sulfapyridine; Sulfasalazine | 1992 |
Induction of chromosomal damage in mammalian cells in vitro and in vivo by sulfapyridine or 5-aminosalicylic acid.
Topics: Aminosalicylic Acids; Animals; CHO Cells; Chromosome Aberrations; Cricetinae; Gene Rearrangement; Male; Mesalamine; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange; Sulfapyridine | 1992 |
[Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue].
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chondrocalcinosis; Culture Techniques; Dinoprostone; Humans; Knee Joint; Leukotriene B4; Leukotrienes; Mesalamine; Osteoarthritis; Prostaglandins; SRS-A; Sulfapyridine; Sulfasalazine; Synovial Membrane | 1991 |
5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease.
Topics: Adult; Aged; Aged, 80 and over; Aminosalicylic Acids; Colitis, Ulcerative; Colon; Crohn Disease; Dexamethasone; Female; Humans; Inflammatory Bowel Diseases; Interleukin-1; Leukotriene B4; Male; Mesalamine; Middle Aged; Organ Culture Techniques; Sulfapyridine; Thromboxane B2 | 1991 |
Effect of 5-aminosalicylic acid on ferrous sulfate-mediated damage to deoxyribose.
Topics: Aminosalicylic Acids; Deoxyribose; Drug Interactions; Ferrous Compounds; Mesalamine; Pentetic Acid; Sulfapyridine; Sulfasalazine | 1990 |
Inhibition of stress-induced gastric ulcers by sulphasalazine and its constituents (sulphapyridine and 5-aminosalicylic acid) in rats.
Topics: Aminosalicylic Acids; Animals; Cold Temperature; Drug Combinations; Female; Mesalamine; Premedication; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological; Sulfapyridine; Sulfasalazine; Time Factors | 1990 |
Inhibition of antibody secretion by 5-aminosalicylic acid.
Topics: Aminosalicylic Acids; Antibodies; Cell Division; Cell Survival; Humans; Immunoglobulin A; Indomethacin; Intestinal Mucosa; Intestines; Mesalamine; Monocytes; Pokeweed Mitogens; Sulfapyridine; Sulfasalazine | 1989 |
Sulfasalazine metabolites and dapsone attenuate formyl-methionyl-leucyl-phenylalanine-induced mucosal injury in rat ileum.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Dapsone; Ileitis; Intestinal Absorption; Intestinal Mucosa; Mesalamine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Rats; Rats, Inbred Strains; Sulfapyridine; Sulfasalazine | 1989 |
Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aminosalicylic Acid; Aminosalicylic Acids; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Chromatography, High Pressure Liquid; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase; Mesalamine; Prostaglandin-Endoperoxide Synthases; Sulfapyridine; Sulfasalazine; Zymosan | 1989 |
Pharmacokinetics of sulfasalazine metabolites in rats following concomitant oral administration of riboflavin.
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Drug Interactions; Half-Life; Male; Mesalamine; Rats; Riboflavin; Sulfapyridine; Sulfasalazine | 1989 |
Arachidonic acid metabolites and their role in inflammatory bowel disease. An update requiring addition of a pathway.
Topics: Aminosalicylic Acids; Arachidonic Acid; Arachidonic Acids; Biological Transport; Bradykinin; Colitis, Ulcerative; Crohn Disease; Diarrhea; Disease Models, Animal; Electrolytes; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Intestinal Diseases; Lipoxygenase; Mesalamine; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Sulfapyridine; Sulfasalazine | 1985 |
Disposition of disodium azodisalicylate in healthy subjects. A possible new drug for inflammatory bowel disease.
Topics: Administration, Oral; Aminosalicylic Acids; Crohn Disease; Half-Life; Humans; Kinetics; Mesalamine; Sulfapyridine; Sulfasalazine | 1985 |
Influence of sulfasalazine, 5-aminosalicylic acid and sulfapyridine on prostanoid synthesis and metabolism in rabbit colonic mucosa.
Topics: Aminosalicylic Acids; Animals; Arachidonic Acid; Arachidonic Acids; Colon; Cytosol; Glutathione; Intestinal Mucosa; Mesalamine; Microsomes; Prostaglandins; Rabbits; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1985 |
Sulphasalazine and derivatives, natural killer activity and ulcerative colitis.
Topics: Aminosalicylic Acids; Catechols; Cytotoxicity, Immunologic; Humans; In Vitro Techniques; Indomethacin; Killer Cells, Natural; Lipoxygenase Inhibitors; Masoprocol; Mesalamine; Monocytes; Sulfapyridine; Sulfasalazine | 1985 |
Modulation of human colonic arachidonic acid metabolism by sulfasalazine.
Topics: Aminosalicylic Acids; Arachidonic Acid; Arachidonic Acids; Autoradiography; Chromatography, Thin Layer; Colitis, Ulcerative; Colon; Humans; In Vitro Techniques; Intestinal Mucosa; Lipoxygenase; Mesalamine; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfapyridine; Sulfasalazine; Thromboxane B2 | 1985 |
Effect of 5-aminosalicylic acid (5-ASA) and other salicylates on short-chain fat metabolism in the colonic mucosa. Pharmacological implications for ulcerative colitis.
Topics: Aminosalicylic Acids; Animals; Cells, Cultured; Colon; Fatty Acids; Female; Humans; Intestinal Mucosa; Male; Mesalamine; Nitrites; Oxidation-Reduction; Rats; Salicylates; Structure-Activity Relationship; Sulfapyridine; Sulfasalazine | 1986 |
Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic processes.
Topics: Aminosalicylic Acids; Animals; Cytotoxicity, Immunologic; Humans; In Vitro Techniques; Killer Cells, Natural; Killer Factors, Yeast; Mesalamine; Mice; Proteins; Sulfanilamides; Sulfapyridine; Sulfasalazine; Time Factors | 1986 |
A study to determine the active moiety of sulphasalazine in rheumatoid arthritis.
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Female; Humans; Male; Mesalamine; Middle Aged; Nausea; Sulfapyridine; Sulfasalazine | 1986 |
Steady-state kinetics of 5-aminosalicylic acid and sulfapyridine during sulfasalazine prophylaxis in ulcerative colitis.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Colitis, Ulcerative; Female; Humans; Kinetics; Male; Mesalamine; Middle Aged; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1986 |
5-Aminosalicylic acid or sulphapyridine. Which is the active moiety of sulphasalazine in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Male; Mesalamine; Middle Aged; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1986 |
Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species.
Topics: Adult; Aminosalicylic Acids; Antioxidants; Cell-Free System; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Luminescent Measurements; Mesalamine; Neutrophils; Sulfapyridine; Sulfasalazine; Superoxides; Xanthine Oxidase; Xanthines; Zymosan | 1987 |
Actions of sulfasalazine and 5-aminosalicylic acid as reactive oxygen scavengers in the suppression of bile acid-induced increases in colonic epithelial cell loss and proliferative activity.
Topics: Aminosalicylic Acids; Animals; Cell Division; Colon; Deoxycholic Acid; DNA; Epithelium; Female; Free Radicals; Mesalamine; Ornithine Decarboxylase; Oxygen; Rats; Rats, Inbred Strains; Sulfapyridine; Sulfasalazine; Superoxide Dismutase; Thymidine; Xanthine; Xanthines | 1987 |
Sulfasalazine and its metabolites attenuate respiratory burst of leukocytes--a possible mechanism of anti-inflammatory effects.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Free Radicals; Humans; Luminescent Measurements; Mesalamine; Neutrophils; Oxygen; Sulfapyridine; Sulfasalazine | 1987 |
Azodisalicylate (azodisal sodium) causes intestinal secretion. Comparative study of the effect of azodisalicylate, sulfasalazine, 5-aminosalicylic acid and sulfapyridine on the water and electrolyte transfer and the morphology of the rat ileum and colon i
Topics: Aminosalicylic Acids; Animals; Colitis, Ulcerative; Colon; Ileum; Intestinal Absorption; Intestinal Mucosa; Mesalamine; Rats; Rats, Inbred Strains; Sulfapyridine; Sulfasalazine | 1987 |
Inhibition of neutrophil degranulation and superoxide production by sulfasalazine. Comparison with 5-aminosalicylic acid, sulfapyridine and olsalazine.
Topics: Aminosalicylic Acids; Antigen-Antibody Complex; Exocytosis; Humans; Mesalamine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sulfapyridine; Sulfasalazine; Superoxides | 1987 |
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Hydroxides; Hydroxyl Radical; Hypochlorous Acid; Mesalamine; Oxidation-Reduction; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1987 |
Role of the intestinal flora in the acetylation of sulfasalazine metabolites.
Topics: Acetylation; Aminosalicylic Acids; Animals; Guinea Pigs; Intestines; Male; Mesalamine; Rats; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1987 |
Sulfasalazine and 5-aminosalicylic acid inhibit contractile leukotriene formation.
Topics: Aminosalicylic Acids; Animals; Calcimycin; Cell Separation; Mesalamine; Muscle Contraction; Muscle, Smooth; Peritoneal Cavity; Rats; Rats, Inbred Strains; SRS-A; Sulfapyridine; Sulfasalazine | 1988 |
In vitro susceptibility of diarrhoea producing gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones. Brief report.
Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Enterobacteriaceae; Gram-Negative Bacteria; Mesalamine; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1988 |
Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Survival; Female; Humans; Lectins; Leukocyte Count; Leukocytes, Mononuclear; Lymphocytes; Male; Mesalamine; Sulfapyridine; Sulfasalazine; Thymidine | 1988 |
In vitro immunomodulatory effects of sulfasalazine and its metabolites.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Humans; Immune System; Immunoglobulin M; Immunoglobulins; Mesalamine; Rheumatoid Factor; Sulfanilamides; Sulfapyridine; Sulfasalazine | 1988 |
Effect of sulphasalazine and its metabolites on mitogen induced transformation of lymphocytes--clues to its clinical action?
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Female; Lymphocyte Activation; Mesalamine; Mice; Mice, Inbred CBA; Mitogens; Sulfapyridine; Sulfasalazine | 1988 |
Adverse effects with oral 5-aminosalicyclic acid.
Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Desensitization, Immunologic; Drug Hypersensitivity; Drug Tolerance; Humans; Male; Mesalamine; Middle Aged; Sulfapyridine; Sulfasalazine | 1988 |
[The effect of sulphasalazine, sulphapyridine, 5-aminosalicylic acid and prednisolone on superoxide production by human polymorphonuclear leukocytes: in vitro studies].
Topics: Aminosalicylic Acids; Cells, Cultured; Humans; Mesalamine; Neutrophils; Prednisolone; Sulfanilamides; Sulfapyridine; Superoxides | 1986 |
Release of eicosanoids from human synovial tissue and the effect of anti-inflammatory drugs.
Topics: Aminosalicylic Acids; Animals; Calcimycin; Chromones; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Mesalamine; Muscle Contraction; Prostaglandins; SRS-A; Sulfanilamides; Sulfapyridine; Synovial Membrane | 1987 |
[Inflammatory bowel disease; internal therapy].
Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Drug Combinations; Humans; Hydrocortisone; Immunosuppressive Agents; Mesalamine; Metronidazole; Parenteral Nutrition, Total; Prednisolone; Sulfapyridine | 1988 |
Inhibition of leucocyte motility by drugs used in ulcerative colitis.
Topics: Aminosalicylic Acids; Cell Movement; Chemotaxis, Leukocyte; Colitis, Ulcerative; Dose-Response Relationship, Drug; Humans; Indomethacin; Leukocytes; Mesalamine; Prednisolone; Sulfapyridine; Sulfasalazine | 1981 |
Increased suppressor cell activity in inflammatory bowel disease.
Topics: Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Humans; Hydrocortisone; In Vitro Techniques; Indomethacin; Lymphocyte Activation; Mesalamine; Mitogens; Sulfapyridine; Sulfasalazine; T-Lymphocytes, Regulatory | 1981 |
Functional suppressor T cell activity in Crohn's disease and the effects of sulphasalazine.
Topics: Aminosalicylic Acids; Concanavalin A; Crohn Disease; Humans; Lymphocyte Activation; Mesalamine; Sulfapyridine; Sulfasalazine; T-Lymphocytes, Regulatory | 1982 |
Inhibition of prostaglandin synthetase in human rectal mucosa.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Colitis, Ulcerative; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Indomethacin; Intestinal Mucosa; Mesalamine; Prednisolone; Rectum; Sulfapyridine; Sulfasalazine | 1983 |
A rapid method for the simultaneous determination of the major metabolites of sulphasalazine in plasma.
Topics: Aminosalicylic Acids; Chromatography, High Pressure Liquid; Humans; Mesalamine; Sulfanilamides; Sulfapyridine; Sulfasalazine; Time Factors | 1983 |
Pharmacotherapy of inflammatory bowel disease. Part 1. Sulfasalazine.
Topics: Aminosalicylic Acids; Bacteria; Colitis, Ulcerative; Colon; Crohn Disease; Humans; Kinetics; Mesalamine; Prostaglandins; Sulfapyridine; Sulfasalazine | 1983 |
Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine.
Topics: Aminosalicylic Acids; Colitis, Ulcerative; Dose-Response Relationship, Drug; Glycine max; Humans; In Vitro Techniques; Lipoxygenase Inhibitors; Mesalamine; Sulfanilamides; Sulfapyridine | 1984 |
An oral preparation to release drugs in the human colon.
Topics: Aminosalicylic Acids; Capsules; Colon; Delayed-Action Preparations; Digestive System; Female; Humans; Male; Mesalamine; Middle Aged; Radiography; Sulfapyridine | 1982 |
Modulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases.
Topics: Aminosalicylic Acids; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dexamethasone; Endotoxins; Humans; Hydroxyurea; In Vitro Techniques; Inflammatory Bowel Diseases; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Mesalamine; Sulfapyridine; Tumor Necrosis Factor-alpha | 1995 |
Comparison of the effects of sulphasalazine, 5-aminosalicylic acid and sulphapyridine on the humoral response to antigen in vivo.
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Antigens; Arthritis, Rheumatoid; Cholera Toxin; Female; Humans; Immunity, Mucosal; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Inflammatory Bowel Diseases; Injections, Subcutaneous; Intestinal Mucosa; Mesalamine; Mice; Mice, Inbred C57BL; Sulfapyridine; Sulfasalazine | 1995 |
Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Binding, Competitive; Drug Interactions; Gallic Acid; Humans; Kinetics; Mercaptopurine; Mesalamine; Methylation; Methyltransferases; Pyridines; Recombinant Proteins; Substrate Specificity; Sulfapyridine; Sulfasalazine | 1995 |
5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells.
Topics: Aminosalicylic Acids; Calcium; Cell Survival; Gene Expression; Humans; In Vitro Techniques; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Mesalamine; Receptors, Interleukin-2; RNA, Messenger; Sulfapyridine; Sulfasalazine; T-Lymphocytes | 1995 |
Effect of 5-aminosalicylic acid and analogous substances on superoxide generation and intracellular free calcium in human neutrophilic granulocytes.
Topics: Aminosalicylic Acids; Calcium; Free Radical Scavengers; Free Radicals; Humans; In Vitro Techniques; Mesalamine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sulfapyridine; Sulfasalazine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Mechanistic studies on genotoxicity and carcinogenicity of salicylazosulfapyridine an anti-inflammatory medicine.
Topics: Aminosalicylic Acids; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bone Marrow; Carcinogenicity Tests; DNA Adducts; Female; Folic Acid; Liver; Male; Mesalamine; Mice; Micronuclei, Chromosome-Defective; Mutagenicity Tests; Rats; Rats, Sprague-Dawley; Risk Assessment; Sulfapyridine; Sulfasalazine; Urinary Bladder | 1997 |
[Pharmacological studies of BX661A. 5-[4-(2-carboxyethylcarbamoyl)-phenylazo]-salicylic acid disodium salt dihydrate (1). Therapeutic effects on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) model in rats].
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Colitis, Ulcerative; Dextran Sulfate; Male; Mesalamine; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Sulfapyridine; Sulfasalazine | 1997 |
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Blotting, Western; Cells, Cultured; Colonic Diseases; Cystine; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Humans; Immunosuppression Therapy; Lipopolysaccharides; Mesalamine; NF-kappa B; Phorbol Esters; Phosphorylation; Plasmids; Proline; Recombinant Proteins; Recombination, Genetic; Sulfapyridine; Sulfasalazine; Thiocarbamates; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Effects of BX661A, a new therapeutic agent for ulcerative colitis, on reactive oxygen species in comparison with salazosulfapyridine and its metabolite sulfapyridine.
Topics: Aminosalicylic Acids; Anti-Ulcer Agents; Colitis, Ulcerative; Cytochrome c Group; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Mesalamine; Phenylhydrazines; Reactive Oxygen Species; Sulfapyridine; Sulfasalazine; Superoxides | 1998 |
Determination of the active moiety of BX661A, a new therapeutic agent for ulcerative colitis, by studying its therapeutic effects on ulcerative colitis induced by dextran sulfate sodium in rats.
Topics: Alanine; Aminosalicylic Acids; Animals; Anti-Ulcer Agents; Colitis, Ulcerative; Colon; Dextran Sulfate; Drug Interactions; Male; Mesalamine; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Sulfapyridine; Sulfasalazine | 1998 |
Effects of BX661A, a new therapeutic agent for ulcerative colitis, on chemotaxis and reactive oxygen species production in polymorphonuclear leukocytes in comparison with salazosulfapyridine and its metabolite sulfapyridine.
Topics: Aminosalicylic Acids; Animals; Anti-Ulcer Agents; Chemotaxis, Leukocyte; Colitis, Ulcerative; Guinea Pigs; Humans; In Vitro Techniques; Male; Mesalamine; Neutrophils; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfapyridine; Sulfasalazine | 1998 |
Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicyclic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biocompatible Materials; Cell Division; Chemokine CCL2; Chemotaxis; Collagen; Drug Combinations; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-8; Laminin; Mesalamine; Proteoglycans; Solubility; Sulfapyridine; Sulfasalazine | 1999 |
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Kinetics; Mesalamine; Mice; Mice, Inbred C57BL; NF-kappa B; Sulfapyridine; Sulfasalazine; T-Lymphocytes; Transcriptional Activation; Tumor Cells, Cultured | 1999 |
Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Fibroblasts; Homeostasis; Humans; Inflammation Mediators; Matrix Metalloproteinases; Mesalamine; Osmolar Concentration; RNA, Messenger; Sulfapyridine; Sulfasalazine; Synovial Membrane; Tissue Inhibitor of Metalloproteinases | 2000 |
Mechanisms of transport and structure-permeability relationship of sulfasalazine and its analogs in Caco-2 cell monolayers.
Topics: Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Cell Membrane Permeability; Cold Temperature; Energy Metabolism; Gastrointestinal Agents; Humans; Intestinal Absorption; Kinetics; Mesalamine; Multidrug Resistance-Associated Proteins; Structure-Activity Relationship; Sulfapyridine; Sulfasalazine | 2000 |
Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Histocompatibility Antigens Class II; Interferon-gamma; Interleukin-12; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mesalamine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Sulfapyridine; Sulfasalazine; Up-Regulation | 2001 |
The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL2; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Culture Media, Conditioned; Female; Fibroblasts; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1; Interleukin-8; Male; Mesalamine; Middle Aged; Sulfapyridine; Sulfasalazine; Synovial Membrane | 2002 |
Sulphasalazine-induced leucopenia in a patient with renal dysfunction.
Topics: Adult; Arylamine N-Acetyltransferase; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Kidney Diseases; Leukopenia; Male; Mesalamine; Polymerase Chain Reaction; Polymorphism, Genetic; Sulfapyridine; Sulfasalazine | 2003 |
Susceptibility of Desulfovibrio desulfuricans intestinal strains to sulfasalazine and its biotransformation products.
Topics: Biotransformation; Cell Division; Desulfovibrio desulfuricans; Drug Resistance, Bacterial; Humans; Intestines; Mesalamine; Sulfapyridine; Sulfasalazine | 2004 |
Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cells, Cultured; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Humans; Immunity, Mucosal; Intestinal Mucosa; Jurkat Cells; Lymphocyte Activation; Mesalamine; Sulfapyridine; Sulfasalazine; T-Lymphocytes | 2004 |
Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: mechanistic aspects and antioxidant activity.
Topics: Aminosalicylic Acids; Anions; Antioxidants; Electrons; Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen-Ion Concentration; Hydroxyl Radical; Inflammation; Inflammatory Bowel Diseases; Kinetics; Lipid Peroxidation; Mesalamine; Models, Chemical; Oxygen; Peroxides; Pulse Radiolysis; Spectrophotometry; Sulfapyridine; Sulfasalazine; Time Factors | 2005 |
Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Depression, Chemical; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Glycochenodeoxycholic Acid; Hepatocytes; Humans; Liver; Male; Mesalamine; NF-kappa B; Perfusion; Rats; Rats, Sprague-Dawley; Sulfapyridine; Sulfasalazine | 2006 |
On the action of 5-amino-salicylic acid and sulfapyridine on M. avium including subspecies paratuberculosis.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Drug Therapy, Combination; Humans; Mesalamine; Mycobacterium avium subsp. paratuberculosis; Paratuberculosis; Sulfapyridine | 2007 |
Mea culpa.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Humans; Mesalamine; Sulfapyridine | 2008 |
Determination of sulphasalazine and its main metabolite sulphapyridine and 5-aminosalicylic acid in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
Topics: Chromatography, Liquid; Dimenhydrinate; Drug Stability; Humans; Linear Models; Mesalamine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfapyridine; Sulfasalazine; Tandem Mass Spectrometry | 2011 |
A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopterins; Drug Evaluation, Preclinical; Enzyme Inhibitors; Mesalamine; Methods; Protein Binding; Saccharomyces cerevisiae; Sulfapyridine; Sulfasalazine; Two-Hybrid System Techniques | 2011 |
Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.
Topics: Drug Carriers; Hydrogen-Ion Concentration; Mesalamine; Nanospheres; Oxidoreductases; Porosity; Prodrugs; Silicon Dioxide; Sulfapyridine; Sulfasalazine | 2012 |
Effects of salazosulfapyridine on the profile of cell surface proteins, revealed by biotinylation of cell surface proteins and 2-dimentional electrophoresis.
Topics: Biotinylation; Cell Line, Tumor; Humans; Membrane Proteins; Mesalamine; Sarcoma, Synovial; Sulfapyridine; Sulfasalazine; Two-Dimensional Difference Gel Electrophoresis | 2019 |
Single-step electropolymerization on a printed sensor towards a conductive thin film polymer for the simultaneous determination of drug metabolites: 5-aminosalicylic acid and sulfapyridine.
Topics: Electrochemical Techniques; Electrodes; Graphite; Humans; Limit of Detection; Mesalamine; Polymers; Reproducibility of Results; Sulfapyridine | 2023 |