meropenem has been researched along with propionamide* in 1 studies
1 other study(ies) available for meropenem and propionamide
| Article | Year |
|---|---|
Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase-1 Inhibitory Activity and Low Toxicity.
The emergence and worldwide prevalence of New Delhi metallo-β-lactamase 1 (NDM-1) expressing Gram-negative bacteria with resistance against most β-lactam antibiotics pose a serious threat to human health. However, no NDM-1 inhibitors are clinically approved at present. Herein, based on the lead compound captopril, a series of compounds were designed, synthesized, and evaluated for NDM-1 inhibitory activities. All designed compounds showed single digit micromolar or submicromolar NDM-1 inhibitory activities, which were much more potent than that of captopril. Among them, compounds 14a and 14m exhibited excellent NDM-1 inhibitory activities, with IC Topics: Amides; Animals; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Captopril; Cell Line; Cell Survival; Crystallography, X-Ray; Female; Gram-Negative Bacteria; HEK293 Cells; Humans; Inhibitory Concentration 50; Meropenem; Mice; Mice, Inbred ICR | 2019 |